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| 1 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 2 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 3 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 4 | High-performance Zn battery with transition metal ions co-regulated electrolytic MnO_(2)显示文摘Electrolytic MnO_(2)/Zn batteries have attracted extensive attention for use in large-scale energy storage applications due to their low cost,high output voltage,safety,and environmental friendliness.However,the poor electrical conductivity of MnO_(2)limits its deposition and dissolution at large capacities,which leads to sluggish reaction kinetics and drastic capacity decay.Here,we report a theory-guided design principle for an electrolytic MnO_(2)/Zn battery co-regulated with transition metal ions that has improved electrochemical performance in terms of deposition and stripping chemistries.We start with first-principles calculations to predict the electrolytic effects of regulating transition metal ions in the deposition/stripping chemistry of the MnO_(2)cathode.The results indicate that with the simultaneous incorporation of strongly electronegative Co and Ni,the MnO_(2)cathode tends to possess more active electron states,faster charge-transfer kinetics,and better electrical conductivity than either MnO_(2)regulated with Co or Ni on their own,or pristine MnO_(2);hence,this co-regulation is beneficial for the cathode solid/liquid MnO_(2)/Mn2t reactions.We then fabricate and demonstrate a novel Co2t and Ni2t coregulated MnO_(2)/Zn(Co-Ni-MnO_(2)/Zn)battery that yields significantly better electrochemical performance,finding that the synergistic regulation of Co and Ni on MnO_(2)can significantly increase its intrinsic conductivity and achieve high rates and Coulombic efficiencies at large capacities.The aqueous Co-Ni-MnO_(2)/Zn battery exhibits a high rate(10C,100 mA cm^(-2)),high Coulombic efficiency(91.89%),and excellent cycling stability(600 cycles without decay)at a large areal capacity of 10 mAh cm^(-2).Our proposed strategy of co-regulation with transition metal ions offers a versatile approach for improving the electrochemical performance of aqueous electrolytic MnO_(2)/Zn batteries in large-scale energy storage applications. | Mingyan Chuai Jinlong Yang Mingming Wang Yuan Yuan Zaichun Liu Yan Xu Yichen Yin Jifei Sun Xinhua Zheng Na Chen Wei Chen | 2021 | eScience2021，1，2： | 8 |
| 5 | Modeling of delta-wing type vortex generators显示文摘A numerical model of delta-wing type vortex generator was developed in two steps.The first step was to obtain a parameterized model of the shedding vortex based on delta-wing theory,which relates the geometry parameters and flow field parameters to the strength of shedding vortex which directly decides the source term.In the second step,a method was proposed to add source terms into the flow control equations so that the shedding vortex could be simulated numerically.As soon as the numerical model was completed,two cases:One for a plate and another for an airfoil segment were investigated for test.Comparison showed that the flow field structure and aerodynamic performance agreed well with those obtained from cases with real vortex generators. | ZHANG Lei YANG Ke XU JianZhong ZHANG MingMing | 2011 | Science China(Technological Sciences)2011，54，2： | 8 |
| 6 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 7 | Sheep manure application increases soil exchangeable base cations in a semi-arid steppe of Inner Mongolia显示文摘The long-term productivity of a soil is greatly influenced by cation exchange capacity(CEC).Moreover,interactions between dominant base cations and other nutrients are important for the health and stability of grassland ecosystems.Soil exchangeable base cations and cation ratios were examined in a 11-year experiment with sheep manure application rates 0–1,500 g/(m2?a) in a semi-arid steppe in Inner Mongolia of China,aiming to clarify the relationships of base cations with soil p H,buffer capacity and fertility.Results showed that CEC and contents of exchangeable calcium(Ca2+),magnesium(Mg2+),potassium(K+) and sodium(Na+) were significantly increased,and Ca2+ saturation tended to decrease,while K+ saturation tended to increase with the increases of sheep manure application rates.The Ca2+/Mg2+ and Ca2+/K+ ratios decreased,while Mg2+,K+ and Na+ saturations increased with increasing manure application rates.Both base cations and CEC were significantly and positively correlated with soil organic carbon(SOC) and soil p H.The increases of SOC and soil p H would be the dominant factors that contribute to the increase of cations in soil.On a comparison with the initial soil p H before the experiment,we deduced that sheep manure application could partly buffer soil p H decrease potentially induced by atmospheric deposition of nitrogen and sulfur.Our results indicate that sheep manure application is beneficial to the maintenance of base cations and the buffering of soil acidification,and therefore can improve soil fertility in the semi-arid steppes of northeastern China. | YuGe ZHANG Shan YANG MingMing FU JiangPing CAI YongYong ZHANG RuZhen WANG ZhuWen XU YongFei BAI Yong JIANG | 2015 | Journal of Arid Land2015，7，3： | 7 |
| 8 | Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells(MSCs)显示文摘Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the treatment of cartilage injuries.Bone morphogenetic protein 2(BMP2)induces effective chondrogenesis of mesenchymal stem cells(MSCs)and can thus be explored as a potential therapeutic agent for cartilage defect repair.However,BMP2 also induces robust endochondral ossification.Although the precise mechanisms through which BMP2 governs the divergence of chondrogenesis and osteogenesis remain to be fully understood,blocking endochondral ossification during BMP2-induced cartilage formation may have practical significance for cartilage tissue engineering.Here,we investigate the role of Sox9-donwregulated Smad7 in BMP2-induced chondrogenic differentiation of MSCs.We find that overexpression of Sox9 leads to a decrease in BMP2-induced Smad7 expression in MSCs.Sox9 inhibits BMP2-induced expression of osteopontin while enhancing the expression of chondrogenic marker Col2a1 in MSCs.Forced expression of Sox9 in MSCs promotes BMP2-induced chondrogenesis and suppresses BMP2-induced endochondral ossification.Constitutive Smad7 expression inhibits BMP2-induced chondrogenesis in stem cell implantation assay.Mouse limb explant assay reveals that Sox9 expands BMP2-stimulated chondrocyte proliferating zone while Smad7 promotes BMP2-intitated hypertrophic zone of the growth plate.Cell cycle analysis indicates that Smad7 induces significant early apoptosis in BMP2-stimulated MSCs.Taken together,our results strongly suggest that Sox9 may facilitate BMP2-induced chondrogenesis by downregulating Smad7,which can be exploited for effective cartilage tissue engineering. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L.Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M.Tsai Tong-Chuan He Wei Huang | 2017 | Genes & Diseases2017，4，4： | 7 |
| 9 | Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil显示文摘与化学疗法的药相结合的 Angiogenesis 禁止者在许多癌症的治疗有重要功效。金钱松属酸 B (PAB ) 是一个传统的终止怀孕的代理人,它以前被显示了减少肿瘤生长和 angiogenesis。在这研究,我们使用了高满意的屏蔽试金在人的脐的静脉 endothelial 房间(HUVEC ) 上检验 PAB 的效果。二个 hepatocarcinoma 22-transplanted 老鼠模型被用来与 5 氟尿嘧啶(5-Fu ) 在联合决定 PAB 功效。我们的结果建议没有明显的 cytotoxicity, PAB (0.1561.250 M ) 在 vitro 以一种集中依赖者方式禁止了 HUVEC 活动性。在 vivo, PAB (25 mg/kg/day ) 在联合治疗支持了 5-Fu (5 mg/kg/2 天) 的反肿瘤功效,导致显著地更高的肿瘤抑制率,更低的 microvessel 密度价值,和延长幸存时间。PAB 由在 G1/S 边界和 M 阶段堵住细胞周期行动了,这也被表明,脉管的 endothelial 生长因素的下面规定,组织缺氧可诱导的因素 1 并且 cdc2 的 cyclin E 表示,和起来规定表示。这些观察提供在有 5-Fu 的联合的 PAB 可能在癌症治疗是有用的第一条证据。 | Jingtao Liu Wei Guo Bo Xu Fuxiang Ran Mingming Chu HongzhengFu Jingrong Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 6 |
| 10 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 11 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 12 | Effect of internal bubbly flow on pipe vibrations显示文摘This paper presents an experimental investigation on wall vibrations of a pipe due to injection of a uniform bubble cloud into the pipe flow. For different bubble void fractions and averaged bubble sizes, the vibrations were measured using accelerometers. To understand the underlying physics, the evolution of the vibration spectra along the streamwise direction was examined. Results showed that wall vibrations were greatly enhanced up to 25 dB, compared with no bubble case. The characteristics of the vibration were mainly dependent on void fraction. These vibrations were believed to be caused by two mechanisms: acoustic resonance and normal modes of the bubble cloud. The former, originating from the interaction between the first mode of the bubble cloud and the first acoustic mode of the pipe, persisted along the entire pipe to enhance the vibration over a broad band frequency range, while the later, due to the process of bubble formation, successively decayed in the streamwise direction. | ZHANG MingMing & XU JianZhong Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Technological Sciences)2010，53，2： | 4 |
| 13 | Salt-Gathering and Potassium Formation of Potassium-Rich Brine during the Triassic in the Sichuan Basin, China显示文摘Potassium-rich brine in the Sichuan Basin has been much studied in recent years, but few studies have focused on the distribution and migration of salt basin and the differences of potassium formation mechanisms. This work examined the salt-gathering and potassium formation of potassiumrich brine during the Triassic in the Sichuan Basin using lithofacies palaeogeographic depiction and geochemical analyses.(1) The favorable sedimentary facies controlling the formation of potassium-rich brine during the Triassic in the Sichuan Basin are evaporation platform and restricted platform, whereas the salt basin is one of the main factors controlling the poly-salt center.(2) The distribution and migration of this salt basin were affected by certain factors. The salt basin of the Jialingjiang Formation was mainly distributed in the east and central Sichuan Basin, whereas that of the Leikoupo Formation was mainly distributed in the central and west Sichuan Basin. The sedimentary centers have gradually moved westward and become smaller.(3) Three main formation mechanisms were identified for the potassium-rich brine during the Triassic in the Sichuan Basin, i.e., evaporation and concentration of seawater, surface fresh water leaching, and deep water-rock reaction. Fresh water leaching was characterized by low anomaly δ18 O and δ13 C values. Water-rock reaction was mainly related to temperature, and high temperature environment(caused by burial depth, overthrust and deep hydrothermal fluids) was beneficial to water-rock reaction. The characteristics of water-rock reaction do not correspond to the increase ratio of K·103/Cl and Br·103/Cl in brine, and the Rb+ content of the brine was high.(4) The formation mechanisms of potassium-rich brine differed between different areas of the Sichuan Basin. In east Sichuan, the evaporation and concentration of seawater, together with meteoric fresh water leaching, was the main formation factor, whereas the evaporation and concentration of seawater and water–rock reaction predominated in west Sichuan. This study of the sedimentary environment and formation mechanisms is of significance to the exploration and exploitation of potassium-rich brine in the Sichuan Basin. | ZHANG Bing YANG Kai WANG Xuben XU Zhengqi YANG Hongyu ZHANG Saimin CHEN Jinchao ZHANG Mingming LIU Wei | 2018 | Acta Geologica Sinica(English Edition)2018，92，6： | 4 |
| 14 | Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer显示文摘Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications. | Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu Jifei Sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen | 2022 | eScience2022，2，5： | 4 |
| 15 | Crustal S-velocity structure and radial anisotropy beneath the southern part of central and western North China Craton and the adjacent Qilian Orogenic Belt from ambient noise tomography显示文摘The crustal S-velocity structure and radial anisotropy along a dense linear portable seismic array with 64 broadband seismic stations were investigated from ambient noise tomography with about one-year-long ambient noise recordings. The array transverses the southern part of the central North China Craton(CNCC) and western NCC(WNCC) from east to west and reaches the adjacent Qilian Orogenic Belt(QOB). The phase velocity structures of Rayleigh waves at 5–35 s and Love waves at 5–30 s were measured. The crustal S-velocity structures(Vsv and Vsh) were constructed from the dispersion data(Rayleigh and Love waves,respectively) from point-wise linear inversion with prior information of the Moho depth and average crustal Vp/Vs ratio. The radial anisotropy along the profile was calculated based on the discrepancies between Vsv and Vsh as 2×(Vsh.Vsv)/(Vsh+Vsv). The results show distinct structural variations in the three major tectonic units. The crustal architecture in the southern CNCC is complicated and featured with wide-distributed low-velocity zones(LVZs), which may be a reflection of crustal modification resulting from Mesozoic-Cenozoic tectonics and magmatic activities. The pronounced positive radial anisotropy in the lower-lowermost crust beneath the Shanxi-Shaanxi Rift and the neighboring areas could be attributed to the underplating of mantle mafic-ultramafic materials during the Mesozoic-Cenozoic tectonic activation. In southern Ordos, the overall weak lateral velocity variations, relative high velocity and large-scale positive radial anisotropy in mid-lower crust probably suggest that the current crustal structure has preserved its Precambrian tectonic characteristics. The low-velocity westward-dipping sedimentary strata in the Ordos Block could be attributed to the Phanerozoic whole-basin tilting and the uneven erosion since late Cretaceous. Integrated with previous studies, the systematic comparison of crustal architecture was made between the southern and northern part of CNCC-WNCC. The similarities and differences may have a relation with the tectonic events and deformation histories experienced before and after the Paleoproterozoic amalgamation of the NCC. The nearly flat mid-crustal LVZ beneath the southern QOB weakens gradually as it extends to the east, which is a feature probably associated with crustal vertical superpositionand ductile shear deformation under the intensive compressional regime due to the northeastward growth and expansion of the Tibetan Plateau. | LING Yuan CHEN Ling WEI ZiGen JIANG MingMing WANG Xu | 2017 | Science China Earth Sciences2017，60，10： | 4 |
| 16 | Qualitatively and quantitatively assessing the aggregation ability of sludge during aerobic granulation process combined XDLVO theory with physicochemical properties显示文摘Inexact mechanism of aerobic granulation still impedes optimization and application of aerobic granules. In this study, the extended Derjaguin, Landau, Verwey, and Overbeek(XDLVO) theory and physicochemical properties were combined to assess the aggregation ability of sludge during aerobic granulation process qualitatively and quantitatively. Results show that relative hydrophobicity of sludge and polysaccharide content of extracellular polymeric substances(EPS) increased, while electronegativity of sludge decreased during acclimation phase. After 20 days' acclimation, small granules began to form due to high aggregation ability of sludge. Since then, coexisted flocs and granules possessed distinct physicochemical properties during granulation and maturation phase. The relative hydrophobicity decreased while electronegativity increased for flocs, whereas that for granules presented reverse trend. Through analyzing the interaction energy using the XDLVO theory, small granules tended to self-grow rather than self-aggregate or attach of flocs due to poor aggregation ability between flocs and granules during the granulation phase. Besides, remaining flocs were unlikely to self-aggregate owing to poor aggregation ability, low hydrophobicity and high electronegativity. | Shasha Yuan Mingming Gao Hui Ma Muhammad Zaheer Afzal Yun-Kun Wang Mingyu Wang Hai Xu Shu-Guang Wang Xin-Hua Wang | 2018 | Journal of Environmental Sciences2018，30，5： | 4 |
| 17 | Active control of fluctuating pressure induced by blade-vortex interaction显示文摘It is well known that interactions between the leading edge of a blade and incoming vortical structures produce a sharp rise in fluctuating pressure nearby,contributing significantly to the noise production in various types of rotorcrafts.To suppress this fluctuating pressure and subsequently induced noise,as the first step,active control of interactions between an airfoil and incoming cylinder-generated vortices,which mimics the practical phenomenon,was experimentally investigated.The essence of the control is to create a local perturbation,using piezo-ceramic actuators,on the surface near the leading edge of the airfoil,thus modifying the airfoil-vortex interactions.Both open-and closed-loop methods were used,where the surface perturbation was controlled by an external sinusoidal wave and a feedback pressure signal from a pressure transducer installed at the leading edge,respectively.It was observed that the closed-loop control was superior to the open-loop one;the closed-and open-loop controls achieve a maximum reduction in the pressure fluctuation at the dominant vortex frequency by 32% and 11%,respectively.The detailed physics behind the observations was discussed. | ZHANG MingMing XU JianZhong | 2011 | Science China(Technological Sciences)2011，54，4： | 4 |
| 18 | Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis显示文摘Endothelial tip cell outgrowth of blood-vessel sprouts marks the initiation of angiogenesis which is critical in physiological and pathophysiological procedures.However,how mechanical characteristics of extracellular matrix(ECM)modulates tip cell formation has been largely neglected.In this study,we found enhanced CD31 expression in the stiffening outer layer of hepatocellular carcinoma than in surrounding soft tissues.Stiffened matrix promoted sprouting from endothelial cell(EC)spheroids and upregulated expressions of tip cell-enriched genes in vitro.Moreover,tip cells showed increased cellular stiffness,more actin cytoskeleton organization and enhanced YAP nuclear transfer than stalk and phalanx ECs.We further uncovered that substrate stiffness regulates FAK and Paxillin phosphorylation in focal adhesion of ECs promoting Rac1 transition from inactive to active state.YAP is subsequently activated and translocated into nucleus,leading to increased tip cell specification.p-Paxillin can also loosen the intercellular connection which also facilitates tip cell specification.Collectively our present study shows that matrix stiffness modulates tip cell formation through p-PXN-Rac1-YAP signaling axis,shedding light on the role of mechanotransduction in tip cell formation.This is of special significance in biomaterial design and treatment of some pathological situations. | Yaru Guo Feng Mei Ying Huang Siqin Ma Yan Wei Xuehui Zhang Mingming Xu Ying He Boon Chin Heng Lili Chen Xuliang Deng | 2022 | Bioactive Materials2022，7，1： | 4 |
| 19 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 20 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
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