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| 1 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors显示文摘Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms. | Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li | 2021 | Nano Research2021，14，3： | 4 |
| 3 | Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY-Modified β-Cyclodextrin显示文摘Comprehensive Summary The fluorescence sensing of intracellular glutathione thiyl radical(GS·)is in great demand to seek the GS·-related pathophysiological events.Herein,boron-dipyrromethene(BODIPY)-modified β-cyclodextrin was developed for high-efficiency sensing of GS·,accompanied by a fast response time(t_(1/2)=218 s),with the detection limit of 468 nmol/L.Cell experiments indicated that the BODIPY-modified p-cyclodextrin could be applied to detect the GS· in live A549 cells. | Zhixue Liu Xianyin Dai Qiaoyan Xu Xiaohan Sun Yu Liu | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 4 | Maillard reaction-derived laser lithography for printing functional inorganics显示文摘Photopolymerization-based additive printing of functional inorganics has drawn great attention in recent years and one important challenge is the photoresin loading with diverse inorganics. Here, we introduce a Maillard reaction-derived laser lithography strategy for an unprecedented direct printing of diverse inorganic compounds. The sugar-assisted laser lithography(SLL) is powerful to carry choice metal ions and versatile for the generation of patterned inorganic materials comprising metal oxides,metal sulfides, and metal nitrides, characterized by ferroelectric, magnetic, semiconductivity, superconductivity, or other properties. The material architecture is flexibly manipulated by the laser intensity, power, printing speed, precursor solution, and computer-aided design to satisfy the practical requirements. This work demonstrates a new possibility for the further development of laser lithography in the directly printing of feature-rich inorganic materials and devices. | Xiao Dai Yining Jiang Xiaohan Wang Fengnan Chen Liang Gao Xiaofeng Li Guifu Zou | 2022 | Science China Chemistry2022，65，7： | 0 |
| 5 | Absolute bioavailability,dose proportionality,and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method显示文摘Rotundic acid(RA),an ursane-type pentacyclic triterpene acid isolated from the dried barks of Ilex rotunda Thunb.(Aquifoliaceae),possesses diverse bioactivities.To further study its pharmacokinetics,a simple and sensitive liquid chromatography with triple quadrupole mass spectrometry(LC-QqQ-MS/MS)method was developed and validated to quantify RA concentration in rat plasma and tissue using etofesalamide as an internal standard(IS).Plasma and tissue samples were subjected to one-step protein precipitation.Chromatographic separation was achieved on a ZORBAX Eclipse XDB-C_(18) column(4.6mm×50mm,5μm)under gradient conditions with eluents of methanol:acetonitrile(1:1,V/V)and 5mM ammonium formate:methanol(9:1,V/V)at 0.5mL/min.Multiple reaction monitoring transitions were performed at m/z 487.30→437.30 for RA and m/z 256.10→227.10 for IS in the negative mode.The developed LC-QqQ-MS/MS method exhibited good linearity(2-500 ng/mL)and was fully validated in accordance with U.S.Food and Drug Administration bioanalytical guidelines.Dose proportionality and bioavailability in rats were determined by comparing pharmacokinetic data after single oral(10,20,and 40mg/kg)and intravenous(10mg/kg)administration of RA.Tissue distribution was studied following oral administration at 20mg/kg.The results showed that the absolute bioavailability of RA after administration at different doses ranged from 16.1%to 19.4%.RA showed good dose proportionality over a dose range of 10-40 mg/kg.RA was rapidly absorbed in a dose-dependent manner and highly distributed in the liver.In conclusion,this study is the first to systematically elucidate the absorption and distribution characteristics of RA in rats,which can provide additional information for further development and evaluation of RA in drug metabolism and pharmacokinetic studies. | Haihua Shang Xiaohan Dai Mi Li Yueyi Kai Zerong Liu Min Wang Quansheng Li Yuan Gu Changxiao Liu Duanyun Si | 2022 | Journal of Pharmaceutical Analysis2022，12，2： | 0 |
| 6 | Saturation efficiency for detecting 1550 nm photons with a 2×2 array of Mo0.8Si0.2 nanowires at 2.2 K显示文摘Amorphous materials are attractive candidates for fabricating the superconducting nanowire single-photon detectors(SNSPDs) due to their superior tolerance and scalability over crystalline niobium nitride. However, the reduced superconducting transition temperature degenerates both operating temperature and saturation efficiency. Herein, the SNSPD(6.5 nm thickness and 50 nm width) based on the amorphous Mo0.8Si0.2 film with a high optical absorption coefficient demonstrates close-to-unity intrinsic detection efficiency for 1550 nm photons from 75 m K to 2.2 K. Further, a high-performance array SNSPD with optimized 90 nm-width wires is also demonstrated. As-fabricated uniform 4-pixel SNSPD exhibits a saturation plateau for the photon counts at 2.2 K,which overcomes the limitation of operation at low temperature(< 1 K) for traditional amorphous SNSPDs.Coupled with superior intrinsic quantum efficiency, highly efficient photon counts, and low dark count ratio, this detector paves a way for achieving high efficiency and superior yield for large array systems. | Feiyan Li Hang Han Qi Chen Biao Zhang Han Bao Yue Dai Rui Ge Shuya Guo Guanglong He Yue Fei Shuchao Yang Xiaohan Wang Hao Wang Xiaoqing Jia Qingyuan Zhao Labao Zhang Lin Kang Peiheng Wu | 2021 | Photonics Research2021，9，3： | 0 |
| 7 | Multifunctional catalytic activity of Cu 3 N(001)surface:A first-principles study显示文摘Multifunctional catalysts that exhibit high catalytic performance for the hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and oxygen reduction reaction(ORR)in a single material hold great promise for broad-spectrum applications,including overall water splitting,fuel cells,and metal-air batteries.In this first-principles study,Cu_(3) N is computationally demonstrated as a multifunctional electrocatalyst for the HER,OER,and ORR owing to the unique coordination of N and Cu atoms on the(001)surface.Cu_(3) N exhibits better HER catalytic activity than noble Pt-based catalysts.Furthermore,its OER and ORR catalytic activity is comparable to that of commercialized unifunctional catalysts,and its 4e-pathway selectivity is high during the ORR.The catalytic performance of the ORR is significantly improved by the introduction of vacancy defects.The integration of highly efficient HER,OER,and ORR catalytic performance in earth-abundant Cu_(3) N not only opens an avenue for developing cost-efficient omnipotent catalysts but also facilitates advances in clean and renewable energy. | Junru Wang Zhichao Liu Zhenhong Dai Xiaohan Song Xiaobiao Liu | 2023 | ChemPhysMater2023，2，3： | 0 |
| 8 | Genetic segregation analysis of unsaturated fatty acids content in the filial generations of high-linolenic-acid rapeseed(Brassica napus)显示文摘Alpha linolenic acid(ALA)is an essential polyunsaturated fatty acids that can improve human health.Rapeseed is the second largest oil crop in the world but the ALA content in its seed fatty acids is only about 10%.Two rapeseed germplasms YH25005 and R8Q10 with high content(up to 21%)ALA were developed by intervarietal crossing.They were used as the maternal parent(P_(1))when crossed with a low ALA parent SW(P2)to produce the seeds of the F1 hybrid,F2,and backcrosses to P1(BCP1)and P2(BCP2).A multigeneration joint segregation analysis was conducted to determine major gene t polygene effects of the content of three major unsaturated fatty acids including oleic(OA),linoleic(LA)and ALA.The results showed that,although some genes favorable to ALA accumulation were not allelic in R8Q10 and YH25005,all the inheritances of OA,LA and ALA in YH25005×SW and R8Q10×SW followed a genetic model of‘two pairs of additive major genes t additive-dominant polygenes’.It is suggested that the contents of OA,LA and ALA are closely related and the major genes in the parent SW containing loss-of-function mutations in FAD2 and FAD3 loci had strong effect to reduce ALA and elevate OA.However,total genetic effect of the polygenes was greater than that of the two major genes,especial on ALA content.It indicated that it is necessary to employ a larger F2 population to find the plant that accumulate enough minor-effect polygenes for high ALA content.The results are useful for high ALA rapeseed breeding and future work of gene mapping. | Xiaohan Zhang Jinglong Lian Chunyan Dai Xiaoli Wang Mingzheng Zhang Xing Su Yaohua Cheng Chengyu Yu | 2021 | Oil Crop Science2021，6，4： | 0 |
| 9 | The feasibility of continuous basalt fibre-reinforced polymer application to composite cross-arms显示文摘Composite cross-arms have the advantages of high lightning resistance but impose onerous requirements on mechanical and insulation reliability.Traditional glass fibre composites fail to meet the needs of practical applications.Basalt fibre exhibits better mechanical properties and stability than glass fibre and has potential application value.This study aims to evaluate the feasibility of its application to composite cross-arms.The mechanical,electrical,and physical properties of basalt fibre-reinforced polymer(BFRP)were investigated and compared with glass fibre-reinforced polymer(GFRP).The results indicate that BFRP has better thermal stability and mechanical properties than GFRP.Among them,the temperature at the maximum weight loss rate of BFRP is 14℃ higher than that of GFRP,and the tensile and flexural modulus of BFRP is 43%and 29%higher than those of GFRP.Furthermore,the dielectric losses of BFRP and GFRP at 50 Hz are 2%,and the breakdown field strength is 22 kV/mm,both of which have the same insulation properties.BFRP meets the requirements of composite cross-arm for quality and reliability to ensure the safety and stability of transmission lines.However,the interlaminar shear test and SEM show weak interfacial bonding strength between basalt fibre and resin.Furthermore,micro-computed tomography scanning of BFRP and GFRP and 3D construction of their internal microstructures indicate that the pore defect content of BFRP reaches 0.034%,which far exceeds that of GFRP.These findings show that the wettability and adhesion between basalt fibre and resin must be improved.Developing special sizing agents for basalt fibre is necessary further to improve the mechanical and electrical properties of BFRP. | Yunpeng Liu Mingjia Zhang Hechen Liu Yunfan Ma Wanxian Wang Xiaohan Dai Jie Liu | 2023 | High Voltage2023，8，3： | 0 |
| 10 | Desalted duck egg white nanogels as Pickering stabilizers for food-grade oil-in-water emulsion显示文摘Achieving the reuse of traditional egg by-products,salted duck egg whites(SEW),is an urgent problem to be solved.In this current work,we constructed a heat-induced gel-assisted desalination method for SEW.Subsequently,a top-down way was utilized to prepare desalted duck egg protein nanogels(DEPN)with uniformly distributed diameters and their application in the oil/water(O/W)interface system was explored.The results revealed that the increase of DEPN concentration could lower the droplet size,however,the size was negatively correlated with the oil phase fraction.Moreover,the effect of pH,ionic strength,and temperature on the emulsion stability demonstrated that the DEPN-stabilized emulsion displayed superior physical stability under different conditions.The addition of NaCl resulted in the significant decrease in droplet size of the emulsion,while further increasing the NaCl concentration,the droplet size did not decrease accordingly.Besides,heat-treatment and cold-treatment had little negative effect on the stability of the emulsion.Even if the droplet size of the emulsion increased at 80℃for 3 h,the morphology of the emulsion remained unchanged.Our study demonstrated DEPN had great potential as a stabilizer for food-grade Pickering emulsions. | Jingyun Zhao Xiaohan Guo Ze Chen Yalei Dai Hongshan Liang Qianchun Deng Shugang Li Bin Zhou | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
| 11 | Confucius’ New Teaching Idea “Sharing Teachers’ Errors” and New Development for Chinese Pedagogy显示文摘Learning from errors is a very fundamental way of learning.Many a teacher in schools,and even colleges and universities mostly concentrates on encouraging students to learn from their own errors,but not so much from their teachers’.Confucius’educational thought observed through the scientific method of trial and error demonstrates the new teaching idea,sharing teachers’errors with students,which is expressed implicitly in The Analects more than 2,500 years ago.The new teaching idea“sharing teachers’errors”systematically we find in Confucius’thoughts can provide a new problem domain for Chinese pedagogy,which will lead to the change of understanding teacher concept,moral education,democratic education,teaching evaluation system,etc.,and invite further research. | ZHOU Zhifa TAN Xiaohan DAI Weifen | 2020 | US-China Education Review(B)2020，10，5： | 0 |
| 12 | Macrophage-derived exosomal miR-342-3p promotes the progression of renal cell carcinoma through the NEDD4L/CEP55 axis显示文摘Due to its difficulty in early diagnosis and lack of sensitivity to chemotherapy and radiotherapy,renal cell carcinoma(RCC)remains to be a frequent cause of cancer-related death.Here,we probed into new targets for its early diagnosis and treatment for RCC.microRNA(miRNA)data of M2-EVs and RCC were searched on the Gene Expression Omnibus database,followed by the prediction of the potential downstream target.Expression of target genes was measured via RT-qPCR and Western blot,respectively.M2 macrophage was obtained viaflow cytometry with M2-EVs extracted.The binding ability of miR-342-3p to NEDD4L and to CEP55 ubiquitination was studied with their roles in the physical abilities of RCC cells assayed.Subcutaneous tumor-bearing mouse models and lung metastasis models were prepared to observe in vivo role of target genes.M2-EVs induced RCC growth and metastasis.miR-342-3p showed high expression in both M2-EVs and RCC cells.M2-EVs carrying miR-342-3p promoted RCC cell abilities to proliferate,invade and migrate.In RCC cells,M2-EV-derived miR-342-3p could specifically bind to NEDD4L and consequently elevate CEP55 protein expression via suppressing NEDD4L,thereby exerting tumor-promoting effects.CEP55 could be degraded by ubiquitination under the function of NEDD4L,and miR-342-3p delivered by M2-EVs facilitated the RCC occurrence and development by activating the PI3K/AKT/mTOR signaling pathway.In conclusion,M2-EVs promote RCC growth and metastasis by delivering miR-342-3p to suppress NEDD4L and subsequently inhibit CEP55 ubiquitination and degradation via activation of the PI3K/AKT/mTOR signaling pathway,strongly driving the proliferative,migratory and invasive of RCC cells. | JIAFU FENG BEI XU CHUNMEI DAI YAODONG WANG GANG XIE WENYU YANG BIN ZHANG XIAOHAN LI JUN WANG | 2021 | Oncology Research2021，29，5： | 0 |
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