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| 1 | The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists显示文摘The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to characterize the expression of the structural(S,E,M,N)and accessory(ORF 3,ORF 4a,ORF 4b,ORF 5)proteins of MERS-CoV and to determine whether any of these pro-teins acts as an interferon antagonist.Individual structural and accessory protein-coding plasmids with an N-terminal HA tag were constructed and transiently transfected into cells,and their native expression and subcellular localiza-tion were assessed using Wes tern blotting and indirect immunofl uorescence.While ORF 4b demonstrated majorly nuclear localization,all of the other proteins demonstrated cytoplasmic localization.In addition,for the fi rst time,our experiments revealed that the M,ORF 4a,ORF 4b,and ORF 5 proteins are potent interferon antagonists.Further exami-nation revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production(IFN-βpromoter activity,IRF-3/7 and NF-κB activation)and ISRE promoter element signaling pathways.Together,our re-sults provide new insights into the function and pathogenic role of the structural and accessory proteins of MERS-CoV. | Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan | 2013 | Protein & Cell2013，4，12： | 25 |
| 2 | A novel human coronavirus:Middle East respiratory syndrome human coronavirus显示文摘In 2012,a novel coronavirus,initially named as human coronavirus EMC(HCoV-EMC) but recently renamed as Middle East respiratory syndrome human coronavirus(MERS-CoV),was identified in patients who suffered severe acute respiratory infection and subsequent renal failure that resulted in death.Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus,including 34 deaths to date.This novel coronavirus is culturable and two complete genome sequences are now available.Furthermore,molecular detection and indirect immunofluorescence assay have been developed.The present paper summarises the limited recent advances of this novel human coronavirus,including its discovery,genomic characterisation and detection. | GENG HeYuan TAN WenJie | 2013 | Science China(Life Sciences)2013，56，8： | 12 |
| 3 | On the Lorenz Systems for the Incompressible Flow between Two Concentric Rotating Cylinders显示文摘 | WANG Heyuan LI Kaitai | 2010 | Journal of Partial Differential Equations2010，23，3： | 9 |
| 4 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 5 | Navigation Map Data Representation and Parallel Display Algorithm in an Embedded Environment显示文摘地图数据显示是在嵌入的即时航行下面的基本信息表示模式。在有几种尺寸和相应数学描述公式的航行显示器数据集(NDIS_SET ) 被设计以后,一系列规则和算法被推进优化嵌入的航行数据并且支持数据索引和输入效率。在一个正常航行数据显示算法说出 NDIS,相关问题被分析以后,有数据说出 N_PDIS 的航行的一个新平行显示器算法然后被介绍适应计算和存储器的有限嵌入的资源。N_PDIS 能同时地由二个平行线程创造二张准备位图并且交换他们之一自动地屏蔽。与 NDIS 相比,结果证明 N_PDIS 在改进显示效率是更有效的。 | ZHANG Dong WANG Ling HUI Hongchao LI Heyuan | 2008 | Geo-Spatial Information Science2008，11，1： | 5 |
| 6 | Interleukin-12 and interferon-γacting on damp-heat of spleen-stomach syndrome triggered by helicobacter pylori显示文摘OBJECTIVE: To investigate the expression of and interleukin-12(IL-12) and interferon-γ(IFN-γ) in relation to the pathology of damp-heat of spleen-stomach syndrome(DHSS) induced by Helicobacter pylori(H. pylori) infection.METHODS: In total, 114 individual gastric mucosal specimens including 83 DHSS, 19 spleen-qi deficiency syndrome(SQD) and 12 from healthy volunteers(CON) were collected by gastroscopy. To explore the relationship between the two syndromes and H. pylori infection, individual samples were tested using rapid urease and methylene blue tests. Hematoxylin and eosin stained sections were examined to grade for the degree of inflammation and inflammatory activity, and expression of IL-12 and IFN-γ was investigated by immunohistochemistry.RESULTS: Statistically significant differences in the degree of inflammation and inflammatory activity were observed between the groups of specimens:DHSS, SQD and CON(P < 0.05). Additionally, greater intestinal metaplasia(IM) and dysplasia were observed in the DHSS group, especially those with H.pylori infection. Expression of both IFN-γ and IL-12 was higher in DHSS samples infected with H. pylori than in uninfected samples and in the CON(P <0.05) but not in the SQD(P > 0.05) groups. Intriguingly, in gastric specimens exhibiting IM and dysplasia, IL-12 translocated from the nucleus into the cytoplasm.CONCLUSION: Our findings suggest that IL-12 and IFN-γ are involved in DHSS pathology, but not in SQD, acting as healthy-Qi. DHSS is not just the consequence of those two cytokines but results from the cross-talk between a number of cytokines and/or other proteins, which may warrant further investigation in DHSS patients infected with H. pylori. | Chen Wanqun Hu Ling Li Heyuan Luo Qi Fan Dongmei Zhang Yunzhan | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 5 |
| 7 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 8 | A study of the effects of LCD glass sand on theproperties of concrete显示文摘 | WANG Heyuan | 2009 | Waste Manage2009，29，1： | 1 |
| 9 | A new catechin oxidation product and polymeric polyphenols of post-fermented tea显示文摘 | JIANG Heyuan TAKUYA S YOUSUKE M | 2011 | Food Chemistry2011，129，3： | 1 |
| 10 | Generation of broadly tunable mid-infrared femtose-cond pulses by a LiNbO_3 optical parametric amplifier显示文摘Combining the configurations of collinear and small-angle noncollinear phase-matching,a mid-infrared(MIR) femtosecond optical parametric amplifier(OPA) with extended tunability is proposed and demonstrated.A tuning range from 2.0 μm to 4.7 μm is demonstrated by a two-stage LiNbO3-based femto-second OPA,which well exceeds the typical tuning range reported so far.MIR femtosecond pulses with energy up to 30 μJ are obtained. | YANG Hua QIAN LieJia YUAN Peng LUO Hang ZHU HeYuan | 2009 | Chinese Science Bulletin2009，54，20： | 1 |
| 11 | An Adaptive Transmission Scheme in Cooperative Relay Networks with Energy Accumulation显示文摘We investigate a wireless-powered cooperative relay network, where an energy constrained relay node accumulates the energy harvested from radio frequency signals, and then assists source signal transmission. An adaptive cooperative transmission scheme for cooperative relay network is developed. The relay helps to transmit the source signal only if it has harvested enough energy and the channels between source and relay do not suffer from an outage. Before each transmission block, one out of two transmission modes, i.e., Half-duplex(HD) or Full-duplex(FD), is dynamically adopted based on the maximal instantaneous capacity of the system. A closed-form expression for the exact outage probability of the system with the proposed scheme is derived. Monte Carlo simulations are run to validate the accuracy of the mathematical analysis, and numerical results show that the proposed protocol outperforms the existing fixed cooperative transmission modes. | TANG Kun SHI Ronghua GUO Yabo SHI Heyuan DONG Jian | 2019 | Chinese Journal of Electronics2019，28，1： | 1 |
| 12 | A Practical Pattern Recovery Approach Based on Both Structural and Behavioral Analysis显示文摘 | Huang Heyuan Zhang Shensheng Cao Jian | 2005 | The Journal of Systems and Software2005，75，12： | 1 |
| 13 | The Study On The Blending The High School Tea- ching Sections With Science Research Sections 显示文摘 | Wang heyuan | 2004 | The Forum Of High School2004，，1： | 1 |
| 14 | Soliton pulse compression through cascaded quadratic nonlinearity in difference-frequency generation显示文摘Cascaded nonlinearity based soliton pulse compression in the process of femtosecond difference frequency generation is studied theoretically. A set of simplified coupled wave equations under the conditions of large phase mismatch and matched group velocities is obtained,which reveals the physical mechanism of soliton compression in this process. Numerical simulations demonstrate that in the presence of group velocity dispersion and equivalent cross phase modulation,both the pump and the signal pulses can be compressed with a high compression ratio. | WANG Ke QIAN LieJia ZHU HeYuan | 2008 | Chinese Science Bulletin2008，53，13： | 1 |
| 15 | Impacts of permeability anisotropy and pressure interference on coalbed methane(CBM)production显示文摘 | THOTSAPHON C CHEN Heyuan LAWRENCE W T | 2001 | SPE710692001，，： | 1 |
| 16 | High-strength hydrogels:Fabrication,reinforcement mechanisms,and applications显示文摘With the continuous appearance and expansion of high-strength hydrogels in emerging fields such as industry,medicine,and green development,the synthesis and application of high-strength hydrogels have developed dramatically and achieved remarkable results from the aspects of raw materials,preparation methods,and reinforcement mechanisms.However,there is still a lack of systematic reviews on high-strength hydrogels.Herein,we first discuss the advantages of natural and synthetic materials,and the characteristics of high-strength hydrogels prepared from different raw materials;we then expound on the influence mechanism of physical interactions or chemical bonds on the strength of the hydrogel from three aspects:physical cross-linking,chemical cross-linking,and dynamic chemical cross-linking;at last,we systematically expound the strengthening strategies,including double network/multi-network,nanocomposite,topology,supramolecular polymerization,and characteristics and strengthening mechanisms of such high-strength hydrogels.In addition,based on the development status of high-strength hydrogels,we combined the application requirements and the existing drawbacks of high-strength hydrogels to propose their possible development directions in the future. | Heyuan Huang Zhicheng Dong Xiaoyang Ren Ben Jia Guowei Li Shaowen Zhou Xin Zhao Wenzhi Wang | 2023 | Nano Research2023，16，2： | 1 |
| 17 | Laser-induced damage properties of antireflective porous glasses显示文摘 | Ying Du Shijie Liu Hongbo He Yunxia Jin Fanyu Kong Heyuan Guan | 2012 | Optics Communications2012，，24： | 1 |
| 18 | An Efficient Algorithm Based on Spectrum Migration for High Frame Rate Ultrasound Imaging显示文摘The high frame rate(HFR)imaging technique requires only one emission event for imaging.Therefore,it can achieve ultrafast imaging with frame rates up to the kHz regime,which satisfies the frame rate requirements for imaging moving tissues in scientific research and clinics.Lu’s Fourier migration method is based on a non-diffraction beam to obtain HFR images and can improve computational speed and efficiency.However,in order to obtain high-quality images,Fourier migration needs to make full use of the spectrum of echo signals for imaging,which requires a large number of Fast Fourier Transform(FFT)points and increases the complexity of the hardware when the echo frequency is high.Here,an efficient algorithm using the spectrum migration technique based on the spectrum’s distribution characteristics is proposed to improve the imaging efficiency in HFR imaging.Since the actual echo signal spectrum is of limited bandwidth,low-frequency and high-frequency parts with low-energy have little contribution to the imaging spectrum.We transform the effective part that provides the main energy in the signal spectrum to the imaging spectrum while the ineffective spectrum components are not utilized for imaging.This can significantly reduce the number of Fourier transform points,improve Fourier imaging efficiency,and ensure the imaging quality.The proposed method is evaluated on simulated and experimental datasets.Results demonstrated that the proposed method could achieve equivalent image quality with a reduced point number for FFT compared to the complete spectrum migration.In this paper,it only requires a quarter of the FFT points used in the complete spectrum migration,which can improve the computational efficiency;thus,it is more suitable for real-time data processing.The proposed spectrum migration method has a specific significance for the study and clinical application of HFR imaging. | Shuai Feng Liu Jin YadanWang Wei Zhao Hu Peng Heyuan Qiao | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 1 |
| 19 | Analysis of beam-quality degradation in nonlinear frequency conversion显示文摘 | Wang Tao Zhang Tingyu Zhu Heyuan | 2002 | Journal of the Optical Society of America B2002，19，5： | 1 |
| 20 | Impacts of permea- bility anisotropy and pressure interference on coalbed methane (CBM) production显示文摘 | Thotsaphon C Chen Heyuan Lawrence W T | 2001 | SPE 710692001，，： | 1 |
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