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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy显示文摘Antiplatelet therapy is the standard of care for the secondary prevention of acute coronary syndrome and ischemic stroke, especially after coronary intervention. However, this therapy is associated with bleeding complications such as gastrointestinal bleeding, which is one of the most common life-threatening complications. Early endoscopy is recommended for most patients with acute upper gastrointestinal bleeding. After successful endoscopic hemostasis, immediate resumption of antiplatelet therapy with proton-pump inhibitors(PPIs) is recommended to prevent further ischemic events. PPI prophylaxis during antiplatelet therapy reduces the risk of upper gastrointestinal bleeding. The potential negative metabolic interaction between PPIs and clopidogrel is still unclear. | Hiroshi Yasuda Yasumasa Matsuo Yoshinori Sato Sun-ichiro Ozawa Shinya Ishigooka Masaki Yamashita Hiroyuki Yamamoto Fumio Itoh | 2015 | World Journal of Critical Care Medicine2015，4，1： | 13 |
| 3 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 4 | Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones显示文摘 | Ichiro Yasuda Naotaka Fujita Hiroyuki Maguchi Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro Tomoko Tada Takeshi Tsujino Yutaka Komatsu | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 5 | Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial显示文摘 | Naotaka Fujita Hiroyuki Maguchi Yutaka Komatsu Ichiro Yasuda Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro | 2003 | Gastrointestinal Endoscopy2003，，2： | 2 |
| 6 | Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion显示文摘Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding. | Muneji Yasuda Hideki Sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura Hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 7 | Syntheses of 4, 5-disubstitutedisoxazoles and their cleavage reaction with sodium ethoxide 显示文摘 | Hiroyuki Yasuda | 1959 | Yakugaku Zasshi1959，79，6： | 1 |
| 8 | Controlled Delivery of bFGF Remodeled Vascular Network in Muscle Flap and Increased Perfusion Capacity Via Minor Pediel 显示文摘 | Yo shihiro Yasuda Hiroyuki Koyama Yasuhiko Tabata | 2008 | Journal of Surgical Research2008，147，： | 1 |
| 9 | 查看详情显示文摘 | Sakakura Toshiyasu Choi Junchul Yasuda Hiroyuki | | 0，，： | 1 |
| 10 | PEG Modification effect of silica on the suzuki - miyaura coupling reaction using silica -immobilized palladium catalysts 显示文摘 | Shun - ya Onozawa Norihisa Fukaya Kaori Saitou Toshi- yasu Sakakura Hiroyuki Yasuda | 2011 | Catalysis Letters2011，19，141： | 1 |
| 11 | Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer显示文摘这研究调查了在一个帮助计算机的精液分析器和反应的氧种类的层次在未洗涤的精液获得的精子运动参数之间的关联。总共, 847 个病人,除了 azoospermic,病人们被调查。在每个病人的时候第一咨询,精液参数用 SMAS 被测量或反应的氧种类的 CellSoft 3000,和生产用一个计算机驱动的 LKB Wallac 光度计被测量 1251 分析器。病人被划分成二个组:反应的氧种类 - 积极、否定。在每个组以内的精液参数用二个帮助计算机的精液分析器系统之一被测量然后比较。在在从反应的氧种类的精液的反应的氧种类层次和精子运动参数之间的关联 - 积极的组也被调查。反应的氧种类在 282 个案例(33.3%) 的精液样品被检测。精子集中(P < 0.01;P < 0.01 ) ,活动性(P < 0.01;P < 0.05 ) ,并且进步活动性(P < 0.01;P < 0.01 ) 在反应的氧种类是显著地更低的 - 积极的组比在反应的氧种类 - 否定的组。在在反应的氧种类的精子运动参数之中 - 积极的组,精子集中(P < 0.01;P < 0.01 ) ,活动性(P < 0.05;P < 0.01 ) , mALH (P < 0.05;P < 0.01 ) ,并且进步活动性(P < 0.05;P < 0.01 ) 与对数的转变的反应的氧种类层次的也显示出的反的关联。因此,这研究在精液损坏精子集中,活动性,和另外的精子运动表明了那过多的反应的氧种参数。 | Teppei Takeshima Yasushi Yumura Kengo Yasuda Hiroyuki Sanjo Shinnosuke Kuroda Hiroyuki Yamanaka Akira Iwasaki | 2017 | Asian Journal of Andrology2017，19，3： | 1 |
| 12 | Preclinical Rationale for Use of the Clinically Available Multitargeted Tyrosine Kinase Inhibitor Crizotinib in ROS1-Translocated Lung Cancer显示文摘 | Hiroyuki Yasuda Lorena L. de Figueiredo-Pontes Susumu Kobayashi Daniel B. Costa | 2012 | Journal of Thoracic Oncology2012，，7： | 1 |
| 13 | The determi- nants of overseas RgD by Japanese firms: an empirical study at the industry and company levels 显示文摘 | HIROYUKI ODAGIRI HIDETO YASUDA | 1996 | Research Poli- cy1996，，25： | 1 |
| 14 | Multicenter retrospective study of endoscopic ultrasound‐guided biliary drainage for malignant biliary obstruction in J apan显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Hironari Kato Takao Itoi Hiroshi Kawakami Keiji Hanada Hirotoshi Ishiwatari Ichiro Yasuda Hirofumi Kawamoto Fumihide Itokawa Masaki Kuwatani Tomohiro Iiboshi Tsuyoshi Hayashi Shinpei Doi Yousuke Nakai | 2014 | J Hepatobiliary Pancreat Sci2014，，5： | 1 |
| 15 | The determinants of overseas R&D by Japanese firms:an empirical study at the industry and company levels 显示文摘 | Hiroyuki Odagiri & Hideto Yasuda | 1996 | Research Policy1996，25，： | 1 |
| 16 | Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC显示文摘 | Hideki Terai Kenzo Soejima Hiroyuki Yasuda Sohei Nakayama Junko Hamamoto Daisuke Arai Kota Ishioka Keiko Ohgino Shinnosuke Ikemura Takashi Sato Satoshi Yoda Ryosuke Satomi Katsuhiko Naoki Tomoko Betsuyaku | 2013 | Molecular Cancer Research2013，，7： | 1 |
| 17 | Fibrone- ctin inhibits cytokine production induced by CpG DNA in macropha- ges without direct binding to DNA 显示文摘 | Hiroyuki Yoshida Makiya Nishikawa Sachiyo Yasuda | 2012 | Cytokine2012，60，1： | 1 |
| 18 | Structure of diaikyhin diaryloxides and their reactivity toward carbon dioxide and isocyanate显示文摘 | YASUDA HIROYUKI CHOI JUN-CHUL LEE SANG-CHUL | 2002 | Journal of Organometallic Chemistry2002，659，12： | 1 |
| 19 | Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial显示文摘 | Naotaka Fujita Hiroyuki Maguchi Yutaka Komatsu Ichiro Yasuda Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro | 2003 | Gastrointestinal Endoscopy2003，，2： | 1 |
| 20 | A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hirofumi Kogure Keiji Hanada Hiroyuki Maguchi Naoki Sasahira Hideki Kamada Tsuyoshi Mukai Yoshihiro Okabe Osamu Hasebe Iruru Maetani Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
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