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| 1 | Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection显示文摘Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence. | Akiko Sasaki Takeshi Nakajima Hideto Egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi Takeshi Kinbara Taku Sakamoto Yutaka Saito Makoto Kako | 2016 | World Journal of Gastroenterology2016，22，8： | 11 |
| 2 | Hand-assisted laparoscopic restorative proctocolectomy for ulcerative colitis显示文摘AIM To evaluate the utility of hand-assisted laparoscopic restorative proctocolectomy(HALS-RP) compared with the conventional open procedure(OPEN-RP).METHODS Fifty-one patients who underwent restorative total proctocolectomy with rectal mucosectomy and ileal pouch anal anastomosis between January 2008 and July 2015 were retrospectively analyzed.Twentythree patients in the HALS-RP group and twentyfour patients in the OPEN-RP group were compared.Four patients who had purely laparoscopic surgery were excluded.Restorative total proctocolectomy was performed with mucosectomy and a hand-sewn ilealpouch-anal anastomosis.Preoperative comorbidities,intraoperative factors such as blood loss and operative time,postoperative complications,and postoperative course were compared between two groups.RESULTS Patients in both groups were matched with regards to patient age,gender,and American Society of Anesthesiologists score.There were no significant differences in extent of colitis,indications for surgery,preoperative comorbidities,and preoperative medications in the two groups.The median operative time for the HALS-RP group was 369(320-420) min,slightly longer than the OPEN-RP group at 355(318-421) min; this was not statistically significant.Blood loss was significantly less in HALS-RP [300(230-402) m L] compared to OPEN-RP [512(401-1162) m L,P = 0.003].Anastomotic leakage was noted in 3 patients in the HALS-RP group and 2 patients in the OPEN-RP group(13% vs 8.3%,NS).The rates of other postoperative complications and the length of hospital stay were not different between the two groups.CONCLUSION HALS-RP can be performed with less blood loss and smaller skin incisions.This procedure is a feasible technique for total proctocolectomy for ulcerative colitis. | Norimitsu Shimada Hiroki Ohge Raita Yano Naoki Murao Norifumi Shigemoto Shinnosuke Uegami Yusuke Watadani Kenichiro Uemura Yoshiaki Murakami Taijiro Sueda | 2016 | World Journal of Gastrointestinal Surgery2016，8，8： | 4 |
| 3 | Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study显示文摘AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients.METHODS A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic drugs.RESULTS A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites. | Haruki Uojima Hisashi Hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda Akiko Sasaki Kazuya Koizumi Hideto Egashira Makoto Kako | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 4 | Predictive factors for body weight loss and its impact on quality of life following gastrectomy显示文摘AIM To determine the predictive factors and impact of body weight loss on postgastrectomy quality of life(QOL). METHODS We applied the newly developed integrated questionnaire postgastrectomy syndrome assessment scale-45, which consists of 45 items including those from the Short Form-8 and Gastrointestinal Symptom Rating Scale instruments, in addition to 22 newly selected items. Between July 2009 and December 2010, completed questionnaires were received from 2520 patients with curative resection at 1 year or more after having undergone one of six types of gastrectomy for Stage Ⅰ gastric cancer at one of 52 participating institutions. Of those, we analyzed 1777 eligible questionnaires from patients who underwent total gastrectomy with Roux-en-Y procedure(TGRY) or distal gastrectomy with Billroth-I(DGBI) or Roux-en-Y(DGRY) procedures. RESULTS A total of 393, 475 and 909 patients underwent TGRY, DGRY, and DGBI, respectively. The mean age of patients was 62.1 ± 9.2 years. The mean time interval between surgery and retrieval of the questionnaires was 37.0 ± 26.8 mo. On multiple regression analysis, higher preoperative body mass index, total gastrectomy, and female sex, in that order, were independent predictors of greater body weight loss after gastrectomy. There was a significant difference in the degree of weight loss(P < 0.001) among groups stratified according to preoperative body mass index(< 18.5, 18.5-25 and > 25 kg/m2). Multiple linear regression analysis identified lower postoperative body mass index, rather than greater body weight loss postoperatively, as a certain factor for worse QOL(P < 0.0001) after gastrectomy, but the influence of both such factors on QOL was relatively small(R2, 0.028-0.080).CONCLUSION While it is certainly important to maintain adequate body weight after gastrectomy, the impact of body weight loss on QOL is unexpectedly small. | Kazuaki Tanabe Masazumi Takahashi Takashi Urushihara Yoichi Nakamura Makoto Yamada Sang-Woong Lee Shinnosuke Tanaka Akira Miki Masami Ikeda Koji Nakada | 2017 | World Journal of Gastroenterology2017，23，26： | 2 |
| 5 | Overexpression of MdMADS5,an APETALAI like gene of apple,causes early flowering in transgenic Arabidopsis显示文摘 | NOBUHIRO K MASATO W SHINNOSUKE K | 2002 | Plant Science2002，162，： | 1 |
| 6 | Ex- perimental and numerical analysis of roller leveler straight- ening for coiled bar and wire显示文摘 | Hamada Ryota Asakawa Motoo lrisawa Shinnosuke | 2009 | Journal of the Iron and Steel Institute of Japan2009，95，11： | 1 |
| 7 | Intelligent vehicle and advanced safety technology 显示文摘 | KAWAI Makoto TAKAYUKI Shinnosuke | 2004 | Review of Automotive Engineering2004，25，2： | 1 |
| 8 | Coupled-cellularautomata study on stochastic and pattern-formation dynamics under spatiotemporal fluctuation of temperature显示文摘 | Yaguma Shinnosuke Odagiri Kenta | 2004 | Physica D:Nonlinear Phenomena2004，197，1： | 1 |
| 9 | Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer显示文摘这研究调查了在一个帮助计算机的精液分析器和反应的氧种类的层次在未洗涤的精液获得的精子运动参数之间的关联。总共, 847 个病人,除了 azoospermic,病人们被调查。在每个病人的时候第一咨询,精液参数用 SMAS 被测量或反应的氧种类的 CellSoft 3000,和生产用一个计算机驱动的 LKB Wallac 光度计被测量 1251 分析器。病人被划分成二个组:反应的氧种类 - 积极、否定。在每个组以内的精液参数用二个帮助计算机的精液分析器系统之一被测量然后比较。在在从反应的氧种类的精液的反应的氧种类层次和精子运动参数之间的关联 - 积极的组也被调查。反应的氧种类在 282 个案例(33.3%) 的精液样品被检测。精子集中(P < 0.01;P < 0.01 ) ,活动性(P < 0.01;P < 0.05 ) ,并且进步活动性(P < 0.01;P < 0.01 ) 在反应的氧种类是显著地更低的 - 积极的组比在反应的氧种类 - 否定的组。在在反应的氧种类的精子运动参数之中 - 积极的组,精子集中(P < 0.01;P < 0.01 ) ,活动性(P < 0.05;P < 0.01 ) , mALH (P < 0.05;P < 0.01 ) ,并且进步活动性(P < 0.05;P < 0.01 ) 与对数的转变的反应的氧种类层次的也显示出的反的关联。因此,这研究在精液损坏精子集中,活动性,和另外的精子运动表明了那过多的反应的氧种参数。 | Teppei Takeshima Yasushi Yumura Kengo Yasuda Hiroyuki Sanjo Shinnosuke Kuroda Hiroyuki Yamanaka Akira Iwasaki | 2017 | Asian Journal of Andrology2017，19，3： | 1 |
| 10 | Effect of copper pretreatment on the double zincate processof aluminum alloy films显示文摘 | KAZUHISAA SHINNOSUKE E SATOSHI K | 2007 | Journal of The Electrochemical Society2007，154，4： | 1 |
| 11 | Neurological Complications of Cervical Laminoplasty for Patients With Ossification of the Posterior Longitudinal Ligament—A multi-Institutional Retrospective Study显示文摘 | Atsushi Seichi Yuichi Hoshino Atsushi Kimura Shinnosuke Nakahara Masahiko Watanabe Tsuyoshi Kato Atsushi Ono Yoshihisa Kotani Mamoru Mitsukawa Kosei Ijiri Norio Kawahara Satoshi Inami Hirotaka Chikuda Katsushi Takeshita Yukihiro Nakagawa Toshihiko Taguchi | 2011 | Spine2011，，15： | 1 |
| 12 | Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC显示文摘 | Hideki Terai Kenzo Soejima Hiroyuki Yasuda Sohei Nakayama Junko Hamamoto Daisuke Arai Kota Ishioka Keiko Ohgino Shinnosuke Ikemura Takashi Sato Satoshi Yoda Ryosuke Satomi Katsuhiko Naoki Tomoko Betsuyaku | 2013 | Molecular Cancer Research2013，，7： | 1 |
| 13 | Onsets of schooling behavior and social transmission in chub mackerel Scomber japonicus 显示文摘 | Shinnosuke N Reiji M Masaru T | 2006 | Behavioral Ecology and Sociobiology2006，9，： | 1 |
| 14 | Characterization of group C and streptococcal strains that cause streptococcal toxic shock syndrome显示文摘 | SHINNOSUKE HASHIKAWA YOSHITSUGU IINUMA MANABU FURUSHITA | | 0，，01： | 1 |
| 15 | A gen- eral anaesthetic propofol inhibits aquaporin-4 in the presence of Zn2+ 显示文摘 | Jungo Kato Mariko Kato Hayashi Shinnosuke Aizu | 2013 | Biochem2013，454，2： | 1 |
| 16 | Coupled cellular automata study on stochastic and pattern formation dynamics under spatiotemporal fluctuation of temperature显示文摘 | Yaguma Shinnosuke Odagiri Kenta | 2004 | Physica D:Nonlinear Phenomena2004，197，1： | 1 |
| 17 | Abstract 11890: Serial Changes of Inflammatory Markers in Patients Treated With Rivarox- aban or Dabigatran : An Interim Report of the RIVAL - AF Study 显示文摘 | Shinnosuke K Kengo T Yukiko M | 2014 | Circulation2014，130，： | 1 |
| 18 | Experimental and theoretical characteristics of terahertzoscillations of resonant tunneling diodes integratedwith slotantennas显示文摘 | ORIHASHI Naoyuki HATTORI Shinnosuk SUZUKI Safumi | 2005 | Janpanses Journal of Applied Physics2005，44，11： | 1 |
| 19 | Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer显示文摘 | Miwako Nishio Takeshi Yoneshiro Masako Nakahara Shinnosuke Suzuki Koichi Saeki Mamoru Hasegawa Yuko Kawai Hidenori Akutsu Akihiro Umezawa Kazuki Yasuda Kazuyuki Tobe Akira Yuo Kazuo Kubota Masayuki Saito Kumiko Saeki | 2012 | Cell Metabolism2012，，3： | 1 |
| 20 | Intravesical Seeding of Upper Urinary Tract Urothelial Carcinoma Cells During Nephroureterectomy: An Exploratory Analysis from the THPMG Trial显示文摘 | Akihiro Ito Ichiro Shintaku Makoto Satoh Naomasa Ioritani Tatsuo Tochigi Isao Numata Takashige Namima Koichi Kambe Atsushi Kyan Seiji Ueno Shinnosuke Katoh Hisanobu Adachi Shinichi Yamashita Takuhiro Yamaguchi Yoichi Arai Masataka Aizawa Sadafumi Kawamura | 2013 | Japanese Journal of Clinical Oncology2013，，11： | 1 |
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