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| 1 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 2 | Chemoradiotherapy for a patient with a giant esophageal fistula显示文摘我们为巨大的食道的恶意的管描述我们治疗的经验,它没以前被报导。作为与转移有巨大的食道的小房间癌被诊断的一个 36 岁的女人与 chemoradiotherapy 被对待。然而,巨大的 esophagomediastinal 管由于巨大的肿瘤的收缩出现了,并且所有反癌症治疗被推迟。然而,尽管有管的存在, chemoradiotherapy 在病人的请求被重启。在重启治疗以后,尽管有集中的 chemoradiotherapy,巨大的食管瘘自然地被关上,并且病人变得有能力吃并且喝。尽管病人最后死了,她的 QOL 和预后似乎被 chemoradiotherapy 改善。尽管有巨大的管的存在,反癌症治疗能安全地被执行。当集中的化疗予病人被以时,巨大的管关门了。因此,管的存在不能是为药品 chemoradiotherapy 的禁止徵候。有病人的合适的管理和维护的治疗的结束将具有有管的病人的利益。 | Takuma Nomiya Kazuhide Teruyama Hitoshi Wada Kenji Nemoto | 2007 | World Journal of Gastroenterology2007，13，15： | 2 |
| 3 | Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor for elderly patients with previously untreated acute myeloid leukemia显示文摘 | Hitoshi Suzushima Naoko Wada Hiroshi Yamasaki Kenichiro Eto Taizo Shimomura Michiko H. Kugimiya Kentaro Horikawa Shintaro Nishimura Hiroyuki Tsuda Hiroaki Mitsuya Norio Asou | 2009 | Leukemia Research2009，，5： | 1 |
| 4 | Value of general surgical risk models for predicting postoperative liver failure and mortality following liver surgery显示文摘 | Yoshio Haga Koji Ikejiri Hitoshi Takeuchi Masakazu Ikenaga Yasuo Wada | 2012 | J Surg Oncol2012，，7： | 1 |
| 5 | Dopaminergic neuronal loss in transgenic mice expressing the Parkinson’s disease-associated UCH-L1 I93M mutant显示文摘 | Rieko Setsuie Yu-Lai Wang Hideki Mochizuki Hitoshi Osaka Hideki Hayakawa Nobutsune Ichihara Hang Li Akiko Furuta Yae Sano Ying-Jie Sun Jungkee Kwon Tomohiro Kabuta Kenji Yoshimi Shunsuke Aoki Yoshikuni Mizuno Mami Noda Keiji Wada | 2006 | Neurochemistry International2006，，1： | 1 |
| 6 | Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants显示文摘 | Kaori Nishikawa Hang Li Ryoichi Kawamura Hitoshi Osaka Yu-Lai Wang Yoko Hara Takatsugu Hirokawa Yoshimasa Manago Taiju Amano Mami Noda Shunsuke Aoki Keiji Wada | 2003 | Biochemical and Biophysical Research Communications2003，，1： | 1 |
| 7 | Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy显示文摘 | Tameyoshi Yamamoto Hiroaki Nagano Yasuharu Imai Kazuto Fukuda Hitoshi Matsumoto Motoi Kondo Hideo Ota Masato Nakamura Hiroshi Wada Takehiro Noda Bazarragchaa Damdinsuren Keizo Dono Koji Umeshita Shoji Nakamori Masato Sakon Kenichi Wakasa Morito Monden | 2007 | International Journal of Clinical Oncology2007，，2： | 1 |
| 8 | Novel narrow-band imaging magnifying endoscopic classification for early gastric cancer显示文摘 | Akira Yokoyama Haruhiro Inoue Hitomi Minami Yoshiki Wada Yoshitaka Sato Hitoshi Satodate Shigeharu Hamatani Shin-ei Kudo | 2010 | Digestive and Liver Disease2010，，10： | 1 |
| 9 | Spontaneous perforation of the rectosigmoid colon: a report of 2 cases显示文摘 | 杨玉波 潘克勤 Hitoshi Hikita Gengo Kaneko Naoto Horigome Osamu Senga Yuoko Wada | 2001 | Chinese Medical Journal2001，，4： | 1 |
| 10 | Genetic Differences in the Osteogenic Differentiation Potency According to the Classification of Ossification of the Posterior Longitudinal Ligament of the Cervical Spine显示文摘 | Hitoshi Kudo Ken-Ichi Furukawa Toru Yokoyama Atsushi Ono Takuya Numasawa Kanichiro Wada Sunao Tanaka Toru Asari Kazumasa Ueyama Shigeru Motomura Satoshi Toh | 2011 | Spine2011，，12： | 1 |
| 11 | Crystal quality and optical properties for Nd:GdVO4 single crystals by floating zone method显示文摘 | Koichi Onodera Takayo Ogawa Hitoshi Itagaki Hiroshi Machida Satoshi Wada | 2004 | Optical Materials2004，26，4： | 1 |
| 12 | Long-Term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy显示文摘 | Miho Shimizu Kengo Furuichi Tadashi Toyama Shinji Kitajima Akinori Hara Kiyoki Kitagawa Yasunori Iwata Norihiko Sakai Toshinari Takamura Mitsuhiro Yoshimura Hitoshi Yokoyama Shuichi Kaneko Takashi Wada | 2013 | Diabetes Care2013，，11： | 1 |
| 13 | Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTORpathway显示文摘 | Michiko Sugiyama Hirokazu Takahashi Kunihiro Hosono Hiroki Endo Shingo Kato Kyoko Yoneda Yuichi Nozaki Koji Fujita Masato Yoneda Koichiro Wada Hitoshi Nakagama Atsushi Nakajima | 2009 | International Journal of Oncology2009，，2： | 1 |
| 14 | Bi-Cu film deposition in aqueous solutions显示文摘The relatively uniform bismuth-copper film was electrodeposited between -15 and -20 mV in the sulfate electrolyte containing 4 mmol/L bismuth ion and 2 mmol/L copper ion.Only copper was electrodeposited at -5 mV.The dendritic bismuth-copper film was electrodeposited under -20 mV.The cathodic current became constant between -20 and -400 mV.Therefore,bismuth-copper electrodeposition changes from charge transfer controlling to diffusion controlling at -20 mV.On the other hand,the uniform bismuth-copper film was electrodeposited between -5 and -35 mV in the methanesulfonate electrolyte containing 4 mmol/L bismuth ion and 2 mmol/L copper ion.The dendritic bismuth-copper film was electrodeposited under -35 mV.The potential region for good electrodepositon in methanesulfonate electrolyte is wider than that in sulfate electrolyte.Therefore,it is easy to control electrodeposition conditions by using methanesulfonate electrolyte. | Hitoshi WADA Yasuhiro NISHISAKA Ryoichi ICHINO Masazumi OKIDO | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 0 |
| 15 | Spectroscopic Detection of Chiral Aggregation at Liquid-Liquid Interfaces显示文摘Two new spectroscopic methods to detect the optical activity of liquid-liquid interfaces have been developed. The first one is the centrifugal liquid membrane (CLM) method combined with a conventional cir-cular dichroism (CD) spectropolarimetry and the second one is a more interfacial specific second harmonic generation CD (SHG-CD) spectrometry. In the CLM-CD method, a cylindrical glass cell containing small amounts of organic and aqueous phases was rotated at about 7000 r/min in a sample chamber of a CD spectropolarimeter to generate an interface with a high specific interfacial area between the two-phase liquid membranes. The CD spectra of the J-aggregate of protonated 5,10,15, 20-tetraphenylporphyrin formed at the toluene-sulfuric acid interface have been measured. As for the SHG-CD, a circularly polarized wave-length-variable fs-laser system was constructed to measure the interfacial SHG spectra of a flat liquid-liquid interface. The ion-associated aggregation of a water-soluble anionic porphyrin promoted with a cationic am-phiphile at the heptane-water interface was observed by this technique and the observed SHG-CD spectra proved the generation of a characteristic optical activity accompanied by the formation of the interfacial ag-gregate of inherently achiral porphyrin molecules. These methods will pioneer a new field of interfacial chiral chemistry in the studies of solvent extraction mechanisms. | Hitoshi Watarai Sayaka Wada Kazuhiko Fujiwara | 2006 | Tsinghua Science and Technology2006，11，2： | 0 |
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