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| 1 | Role of regulatory T cell in the pathogenesis of inflammatorybowel disease显示文摘Regulatory T(Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease(IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports. | akiko yamada rieko arakaki masako saito takaaki tsunematsu yasusei kudo naozumi ishimaru | 2016 | World Journal of Gastroenterology2016，22，7： | 24 |
| 2 | Preparation and incubation conditions affect the DNA integrity of ejaculated human spermatozoa显示文摘适当精液处理和评价为成功的不孕处理是批评的。我们调查了实验室过程包括精液准备和孵化是否影响精子 DNA 正直。153 个不肥沃的人的一个总数被包含。常规精液参数和精子染色质结构试金(SCSA ) 参数,也就是说 DNA 破碎索引(% DFI ) 和高 DNA stainability (% HDS ) ,在新鲜呼喊的精液样品上被估计,它在不同条件下面被对待并且孵化。否定关联在 % DFI 和精子集中,活动性,进步活动性和形态学之间被识别。DFI 的一个更低的百分比在精子被检测密度坡度 centrifugation (DGC ) 是否被游泳起来处理独自与 DGC 比较跟随(P < 0.01 ) 。尽管 % DFI 在空中在房间温度(RT ) 并且在 37 掳 C 与孵化以一种时间依赖者方式增加了,在在 RT 的 24 h 以后的 % DFI 在 37 掳 C 是比那显著地低的(P < 0.05 ) 。有 5% CO2 的孵化在维持精子活动性是有效的(P < 0.01 ) ;然而,它导致了 % DFI 的进一步的举起(P < 0.001 ) 。因此,精子 DNA 损坏与更长的潜伏期被联系。有趣地,普通文化条件例如维持 pH 和温度,损害了精子 DNA 正直。 | Rieko Matsuura Takumi Takeuchi Atsumi Yoshida | 2010 | Asian Journal of Andrology2010，12，5： | 10 |
| 3 | EUS-guided hepaticogastrostomy combined with fine-gauge antegrade stenting: a pilot study显示文摘 | Takeshi Ogura Daisuke Masuda Akira Imoto Toshihisa Takeushi Rieko Kamiyama Malak Mohamed Eiji Umegaki Kazuhide Higuchi | 2014 | Endoscopy2014，，： | 3 |
| 4 | Endoscopic removal of foreign bodies:A retrospective study in Japan显示文摘BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical problems.Methods to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success rate.However,to date,no studies have evaluated the endoscopic management of FBs in Japan.AIM To elucidate level of safety and efficacy in the endoscopic management of FBs and FBI.METHODS A total of 215 procedures were performed at Keio University Hospital between November 2007 and August 2018.Data were collected from medical charts,and endoscopic details were collected from an endoscopic reporting system.Procedures performed with a flexible gastrointestinal endoscope were only taken into account.Patients who underwent a technique involving FB or FBI from the digestive tract were only included.Data on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed retrospectively.RESULTS Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in outpatients.The most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the cases.The most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was 100%,and complication were observed in only one case(0.5%).CONCLUSION Endoscopic management of FBs and FBI in our Hospital is extremely safe and effective. | Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，1： | 3 |
| 5 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 6 | Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries显示文摘AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two patients.CONCLUSION: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG. | Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 2 |
| 7 | Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach After Early Cancer Surgery显示文摘 | Isao Nozaki Junichirou Nasu Yoshiro Kubo Minoru Tanada Rieko Nishimura Akira Kurita | 2010 | World Journal of Surgery2010，，7： | 2 |
| 8 | Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese显示文摘 | Naoki Hosoe Manabu Nakashita Hiroyuki Imaeda Tomohisa Sujino Rieko Bessho Riko Ichikawa Nagamu Inoue Takanori Kanai Toshifumi Hibi Haruhiko Ogata | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 2 |
| 9 | Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen, deficiency in rats 显示文摘 | Rieko Mitamura Hiroshi Hara | 2006 | European Journal of Nutrition2006，45，： | 1 |
| 10 | Inflammatory pseudotumor of the liver in a patient with early gastric cancer: CT-histopathological correlation 显示文摘 | Rieko N Hiroshi M Norihiro T | 2005 | Jpn J Clin Oneol2005，35，4： | 1 |
| 11 | Gastric carcinogenesis and the cancer stem cell hypothesis显示文摘 | Yoshiro Saikawa Kazumasa Fukuda Tsunehiro Takahashi Rieko Nakamura Hiroya Takeuchi Yuko Kitagawa | 2010 | Gastric Cancer2010，，1： | 1 |
| 12 | Arsenic speciation in marine product samples:Comparison of extraction HPLC method and digestion-cryogenic trap method显示文摘 | Geng Wenhua Komine Rieko Ohta Toshiharu | | 0，，02： | 1 |
| 13 | Bcl-2 positively regulates sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway 显示文摘 | Rieko Y Denise M Walter EH | 2005 | J Biol Chem2005，280，30： | 1 |
| 14 | Codon 201Arg/Gly Polymorphism of DCC (Deleted in Colorectal Carcinoma) Gene in Flat- and Polypoid- Type Colorectal Tumors显示文摘 | Rieko Minami Nobuo Aoyama Yoichiro Honsako | 1997 | Digestive Diseases and Sciences1997，42，： | 1 |
| 15 | Lentinan augments skin reaction induced by bradykinin:its correlation with vascular dilatation and hemorrhage responses and antitumor activities显示文摘 | RIEKO NAMIKI TOMOKOKIKUCHI | 1995 | Intemational Journal of Immunopharmacology1995，17，6： | 1 |
| 16 | Obmrator bernia: the usefulness of ecnaputer tmnography in diagnosis 显示文摘 | Rieko Ijiri Hitoshi Kanamaru Hidetaro Yokoyama MD | 1996 | Surgery1996，119，2： | 1 |
| 17 | Dopaminergic neuronal loss in transgenic mice expressing the Parkinson’s disease-associated UCH-L1 I93M mutant显示文摘 | Rieko Setsuie Yu-Lai Wang Hideki Mochizuki Hitoshi Osaka Hideki Hayakawa Nobutsune Ichihara Hang Li Akiko Furuta Yae Sano Ying-Jie Sun Jungkee Kwon Tomohiro Kabuta Kenji Yoshimi Shunsuke Aoki Yoshikuni Mizuno Mami Noda Keiji Wada | 2006 | Neurochemistry International2006，，1： | 1 |
| 18 | Correlation between Detection Rates of Periodontopathic Bacterial DNA in Carotid Coronary Stenotic Artery Plaque and in Dental Plaque Sample显示文摘 | Kazuyuki Ishihara Akihiro Nabuchi Rieko Ito | 2004 | Journal of Clinical Microbiology2004，42，3： | 1 |
| 19 | Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer显示文摘 | Kyoichi Kaira Tateaki Naito Toshiaki Takahashi Eriko Ayabe Rai Shimoyama Rieko Kaira Akira Ono Satoshi Igawa Takehito Shukuya Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Masahiro Endo Nobuyuki Yamamoto | 2009 | Lung Cancer2009，，1： | 1 |
| 20 | Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers显示文摘 | Rieko Hamaoka Yuji Yaginuma Tomoaki Takahashi Junichi Fujii Masahiko Koizumi Han Geuk Seo Yutaka Hatanaka Kaoru Hashizume Kunio Ii Jun-ichiro Miyagawa Toshiaki Hanafusa Yuji Matsuzawa Mutsuo Ishikawa Naoyuki Taniguchi | 1999 | Journal of Cancer Research and Clinical Oncology1999，，6： | 1 |
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