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| 1 | Therapeutic strategies for targeting the ovarian tumor stroma显示文摘Epithelial ovarian cancer is the most lethal type of gynecologic malignancy. Sixty percent of women who are diagnosed with ovarian cancer present with advancedstage disease that involves the peritoneal cavity and these patients have a 5-year survival rate of less than 30%. For more than two decades, tumor-debulking surgery followed by platinum-taxane combination chemotherapy has remained the conventional first-line treatment of ovarian cancer. Although the initial response rate is 70%-80%, most patients with advancedstage ovarian cancer eventually relapse and succumb to recurrent chemoresistant disease. A number of molecular aberrations that drive tumor progression have been identified in ovarian cancer cells and intensive efforts have focused on developing therapeutic agents that target these aberrations. However, increasing evidence indicates that reciprocal interactions between tumor cells and various types of stromal cells also play important roles in driving ovarian tumor progression and that these stromal cells represent attractive therapeutic targets. Unlike tumor cells, stromal cells within the tumor microenvironment are in general geneticallystable and are therefore less likely to become resistant to therapy. This concise review discusses the biological significance of the cross-talk between ovarian cancer cells and three major types of stromal cells(endothelial cells, fibroblasts, macrophages) and the development of new-generation therapies that target the ovarian tumor microenvironment. | Song Yi Ko Honami Naora | 2014 | World Journal of Clinical Cases2014，2，6： | 4 |
| 2 | Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms显示文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations. | Tamami Haraguchi Miyako Yoshida Honami Kojima Takahiro Uchida | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 2 |
| 3 | Behavior of the laterally injected jet in film cooling:measurements of surface temperature and velocity temperature field within the jet显示文摘 | Honami S Shizawa T Uchiyama A | 1994 | Journal of Turbo machinery1994，，116： | 1 |
| 4 | Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction显示文摘 | Honami T Shimo T Okui T | | 0，，01： | 1 |
| 5 | Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo显示文摘 | Naito Kurio Tsuyoshi Shimo Takuya Fukazawa Munenori Takaoka Tatsuo Okui Nur Mohammad Monsur Hassan Tatsuki Honami Shinji Hatakeyama Masahiko Ikeda Yoshio Naomoto Akira Sasaki | 2011 | Experimental Cell Research2011，，： | 1 |
| 6 | Behavior of the laterally injected jet in film cooling:measurements of surface temperature and velocity temperature field within the jet显示文摘 | Shizawa T Uchiyama A | 1994 | Journal of Turbo machinery1994，116，： | 1 |
| 7 | Microcomputer control system for tractor implements显示文摘 | Jiang Y Honami N Umeda S | 1992 | J JSAM1992，54，3： | 1 |
| 8 | Monocyte chemoattractant protein-1 A-2518G gene polymorphine and renal survival of Japanese patients with immunoglobulin A nephropathy显示文摘 | Yoshikatsu K Ichiei N | 2005 | Clin Exp Nephrol2005，9，： | 1 |
| 9 | A three-dimensional turbulent de tached flow with a horseshoe vortex 显示文摘 | Ishii J Honami S | 1986 | ASME Journal of Engineering for Gas Turbines and Power1986，108，1： | 1 |
| 10 | Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone de- struction 显示文摘 | Honami T Shimo T Okui T | 2012 | Oeal Oncol2012，48，1： | 1 |
| 11 | Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction显示文摘 | Honami T Shimo T Okui T | | 0，，01： | 1 |
| 12 | Dynamic characteristics of rice transplanting mechanisms:I:Theoretical analysis of a four bar linkage transplanting mech anism显示文摘 | Umeda S Honami N Chau V D | 1980 | Journal of the Society of Agricultural Machinery Japan1980，，： | 1 |
| 13 | Gamma ray dose response of ESR signals in tooth enamel of cows and mice显示文摘 | Toyoda Shin Tanizawa Honami Romanyukha Alexander | 2003 | Radiation Meastares2003，37，45： | 1 |
| 14 | A three-dimensional turbulent detached flow with a horseshoe vortex 显示文摘 | Ishii J Honami S | 1986 | ASME Journal of Engineering for Gas Turbines and Power1986，108，1： | 1 |
| 15 | Application of loop-mediated isothermal amplification technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures显示文摘 | Yoshiki Misawa Atsushi Yoshida Ryoichi Saito Honami Yoshida Katsuko Okuzumi Nobue Ito Mitsumasa Okada Kyoji Moriya Kazuhiko Koike | 2007 | Journal of Infection and Chemotherapy2007，，3： | 1 |
| 16 | A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells显示文摘 | Honami N Yang YQ Fredrick J | 2001 | PANS2001，98，7： | 1 |
| 17 | Homeobox gene expression in cancer: Insights from developmental regulation and deregulation显示文摘 | Shaija Samuel Honami Naora | 2005 | European Journal of Cancer2005，，16： | 1 |
| 18 | Journal of Histochemistry & Cytochemistry显示文摘 | Honami Kobayashi Seiji Nomura Takashi Mitsui Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy | 2004 | 52(1):1132004，52，1： | 1 |
| 19 | Microcomputer control system for tractor implements 显示文摘 | Jiang Y Honami N Umeda S | 1992 | JSAM1992，54，3： | 1 |
| 20 | Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy显示文摘 | Honami Mori Yoshikatsu Kaneko Ichiei Narita Shin Goto Noriko Saito Daisuke Kondo Fuminori Sato Junya Ajiro Daisuke Saga Asa Ogawa Minoru Sakatsume Mitsuhiro Ueno Kaoru Tabei Fumitake Gejyo | 2005 | Clinical and Experimental Nephrology2005，，4： | 1 |
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