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| 1 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 2 | Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and targeted therapy显示文摘Locoregional therapies(LRTs)of hepatocellular carcinoma(HCC)represented by ablation and TACE has become the main means for the clinical treatment of unresectable HCC.Among these,TACE is used throughout the stageⅠb toⅢb of HCC treatment.In recent years,immunotherapy led by immune checkpoint inhibitors has become a hot direction in clinical research.At the same time,targeted drugs such as Sorafenib and Apatinib have played an important role in the treatment and complementary therapy of advanced HCC,and their clinical application has been quite mature.HCC is the sixth most common malignant tumor in the world.When it comes to its treatment,different therapies have different indications,and their individual efficacies are not satisfactory,which makes the exploration of the use of combination therapy in HCC treatment become a new trend.In this paper,the status of the three therapies and the progress of their combined application are briefly reviewed. | Jian Xue Hongbo Ni Fan Wang Ke Xu Meng Niu | 2021 | Journal of Interventional Medicine2021，4，3： | 21 |
| 3 | Energy Efficiency and Spectrum Efficiency in Underlay Device-to-Device Communications Enabled Cellular Networks显示文摘In this paper, we investigate the energy efficiency and spectrum efficiency, including one-hop device-to-device(D2D) communications mode and two-way amplify-and-forward(AF) relaying D2D communications mode in underlay D2D communications enabled cellular networks. An analysis of average energy efficiency and spectrum efficiency are developed and closed-form expressions are obtained for two types of D2D communications modes under the effect of Rayleigh fading channel, path loss, and co-channel interference. Analytical results are validated through numerical simulations. Based on the simulation, the effects of the interference, the distance between D2D pair and the position of relay node on the energy efficiency and spectrum efficiency of D2D communications are investigated. The optimal D2D transmission powers of these two modes to maximize the energy efficiency are also investigated. | Yan Cai Yiyang Ni Jun Zhang Su Zhao Hongbo Zhu | 2019 | China Communications2019，16，4： | 5 |
| 4 | Beamforming and Interference Cancellation for D2D Communication Assisted by Two-Way Decode-and-Forward Relay Node显示文摘This paper investigates the device-to-device(D2D) communication underlaying cellular network assisted by a two-way decode-and-forward relay node. We assume the base station(BS) is equipped with M-antenna and serves its own cellular user while the D2D users communicate via a two-way decode-and-forward relay node. Both beamforming(BF) and interference cancellation(IC) strategies at the BS are considered to improve the performance for the cellular link and D2D link, respectively. We first analyze the received signal-to-interference-plus-noise for the cellular link under BF and IC strategies and then derive the exact closed-form expressions for the cellular link. Asymmetric and symmetric cases are discussed for various locations of each user. Finally, the approximations for high signal-to-noise regime are also presented. Numerical results demonstrate the accuracy of the analytical and asymptotic results. | Yiyang Ni Jie Zhao Yuxi Wang Hongbo Zhu | 2018 | China Communications2018，15，3： | 4 |
| 5 | Power Allocation for NOMA in D2D Relay Communications显示文摘Non-orthogonal multiple access(NOMA)is considered as one of the key technologies for the fifth generation(5G)wireless communications.The integration of NOMA and device-to-device(D2D)communications has recently attracted wide attention.In this paper,a relaying D2D communications assisted with cooperative relaying systems using NOMA(DRC-NOMA)is considered.We analyze the ergodic sum-rate for the proposed system and then derive the closed-form expressions.In addition,an optimal power allocation strategy maximizing the ergodic sum-rate is proposed based on these analysis results.Numerical results show the good agreement between the results of analysis and Monte Carlo method.The proposed DRC-NOMA has a great improvement of the ergodic sum-rate in the small regime of average channel gain of D2D pair. | Yan Cai Chunhua Ke Yiyang Ni Jun Zhang Hongbo Zhu | 2021 | China Communications2021，18，1： | 4 |
| 6 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 7 | Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells显示文摘Whereas the critical roles of innate lymphoid cells(ILCs)in adult are increasingly appreciated,their developmental hierarchy in early human fetus remains largely elusive.In this study,we sorted human hematopoietic stem/progenitor cells,lymphoid progenitors,putative ILC progenitor/precursors and mature ILCs in the fetal hematopoietic,lymphoid and non-lymphoid tissues,from 8 to 12 post-conception weeks,for single-cell RNA-sequencing,followed by computational analysis and functional validation at bulk and single-cell levels.We delineated the early phase of ILC lineage commitment from hematopoietic stem/progenitor cells,which mainly occurred in fetal liver and intestine.We further unveiled interleukin-3 receptor as a surface marker for the lymphoid progenitors in fetal liver with T,B,ILC and myeloid potentials,while IL-3RA–lymphoid progenitors were predominantly B-lineage committed.Notably,we determined the heterogeneity and tissue distribution of each ILC subpopulation,revealing the proliferating characteristics shared by the precursors of each ILC subtype.Additionally,a novel unconventional ILC2 subpopulation(CRTH2–CCR9+ILC2)was identified in fetal thymus.Taken together,our study illuminates the precise cellular and molecular features underlying the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity. | Chen Liu Yandong Gong Han Zhang Hua Yang Yang Zeng Zhilei Bian Qian Xin Zhijie Bai Man Zhang Jian He Jing Yan Jie Zhou Zongcheng Li Yanli Ni Aiqing Wen Yu Lan Hongbo Hu Bing Liu | 2021 | Cell Research2021，31，10： | 2 |
| 8 | Performance for Device-to-Device Communication with Three-Time-Slot Two-Way Amplify-and-Forward Relay Protocol显示文摘Multi-hop device-to-device(D2D) communication can significantly improve the system performance. This paper studied the outage performance of D2 D communication assisted by another D2 D user using three-timeslot two-way amplify-and-forward relaying protocol over Rayleigh fading channels. Considering the co-channel interference from cellular user at the D2 D node,the approximate expression for the overall outage probability was derived. Furthermore,a power allocation optimum method to minimize the outage probability was developed,and the closed form expression for the optimal power allocation coefficient at the relay was derived. Simulation results demonstrate accuracy of the derived outage probability expressions. Simulation results also demonstrate that the outage performance can be improved using the proposed optimal power allocation method. | CAI Yan NI Yiyang ZHU Hongbo | 2015 | China Communications2015，12，11： | 2 |
| 9 | Triangulation of red sprites observed above a mesoscale convective system in North China显示文摘The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke. | YongPing Wang GaoPeng Lu Ming Ma HongBo Zhang YanFeng Fan GuoJin Liu ZheRun Wan Yu Wang Kang-Ming Peng ChangZhi Peng FeiFan Liu BaoYou Zhu BinBin Ni XuDong Gu Long Chen Juan Yi RuoXian Zhou | 2019 | Earth and Planetary Physics2019，3，2： | 2 |
| 10 | Interference Cancellation in Device-to-Device Communications underlying MU-MIMO Cellular Networks显示文摘This paper investigates the device-to-device(D2 D) communication underlaying multi-user multi-input multi-output(MU-MIMO) cellular networks. It is assumed that D2 D users reuse the downlink time-frequency resources of cellular links, and the base station(BS) is assumed to be equipped with multiple antennas. We investigate the ergodic achievable sum rate of the system when the interference cancellation(IC) precoding strategy is employed at the BS. The distributions of the received signal-to-interference-plus-noise ratio(SINR) for each link are firstly analyzed, and an exact ergodic achievable sum rate of the whole system with closedform expressions is then derived. Furthermore, we present novel upper and lower bounds with simpler expressions, which are later verified to be fairly close to the Monte-Carlo simulations. All the expressions we presented are suitable for arbitrary network topology and arbitrary number of antennas at BS. Based on the derived bounds, the influence of the antennas at BS on system performance is then analyzed. We reveal that the system performance increases along with the number of antennas at BS in a logarithmic way. The accuracy of our analytical results is validated via comparisons with Monte-Carlo simulations. | Yiyang Ni Yuxi Wang Hongbo Zhu | 2019 | China Communications2019，16，4： | 2 |
| 11 | Prophet address allocation for large scale MANETs显示文摘 | Hongbo Zhou Lionel M Ni Matt W Mutka | 2003 | Ad Hoc Networks2003，1，： | 1 |
| 12 | Prophet address allocation for large scale MANETs显示文摘 | Hongbo Zhou Lionel M Ni Mattw Mutk | 2003 | Ad Hoc Networks2003，，1： | 1 |
| 13 | Performance Analysis for Large Intelligent Surface Assisted Vehicular Networks显示文摘Large intelligent surface(LIS)is considered as a new solution to enhance the performance of wireless networks[1].LIS comprises low-cost passive elements which can be well controlled.In this paper,a LIS is invoked in the vehicular networks.We analyze the system performance under Weibull fading.We derive a novel exact analytical expression for outage probability in closed form.Based on the analytical result,we discuss three special scenarios including high SNR case,low SNR case,as well as weak interference case.The corresponding approximations for three cases are provided,respectively.In order to gain more insights,we obtain the diversity order of outage probability and it is proved that the outage probability at high SNR depends on the interference,threshold and fading parameters which leads to 0 diversity order.Furthermore,we investigate the ergodic achievable rate of LIS-assisted vehicular networks and present the closed-form tight bounds.Similar to the outage performance,three special cases are studied and the asymptotic expressions are provided in simple forms.A rate ceiling is shown for high SNRs due to the existence of interference which results 0 high SNR slope.Finally,we give the energy efficiency of LIS-assisted vehicular network.Numerical results are presented to verify the accuracy of our analysis.It is evident that the performance of LIS-assisted vehicular networks with optimal phase shift scheme exceeds that of traditional vehicular networks and random phase Received:Aug.6,2020 Revised:Nov.17,2020 Editor:Caijun Zhong shift scheme significantly. | Yiyang Ni Yaxuan Liu Jin Zhou Qin Wang Haitao Zhao Hongbo Zhu | 2021 | China Communications2021，18，3： | 1 |
| 14 | Prophet Address Allocation for Large Scale MANETs显示文摘 | Zhou Hongbo Ni L M Mutka M W | 2000 | Ad Hoc Networks Journal2000，1，4： | 1 |
| 15 | Synthesis and characterization ofp-perfluoroethylated poly(a-methylstyrene)显示文摘 | Ni Hongbo Yang Jicheng Zhao Chengxue | 2005 | Reactive & Functional Polymers2005，66，： | 1 |
| 16 | Clinical Study on the Treatment of Low Anal Fistula in Infants and Young Children by Anal Gland Excision and Virtual Hanging Procedure显示文摘Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision. | Hongbo Su Linmei Sun Yimiao Liang Jiansheng Hu Yongli Zhang Ni Wei Chaoyang Li Lin Tang | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 17 | Bioinspired iron porphyrins with appended poly-pyridine/amine units for boosted electrocatalytic CO_(2) reduction reaction显示文摘Developing highly efficient electrocatalysts for the CO_(2) reduction reaction(CO_(2)RR)has attracted increasing interest in the past decade.Herein,we report on the design and synthesis of Fe porphyrin 1 with an appended N,N-di(2-picolyl)ethylenediamine(DPEN)unit that boosts electrocatalytic activity for CO_(2)-to-CO conversion in acetonitrile with water as the proton source.By mimicking carbon monoxide dehydrogenase(CODH),1 has poly-pyridine/amine units located at the active site to form hydrogen-bonded water-containing networks that enable fast proton transfer.The protonated and positively charged DPEN unit can also stabilize CO_(2) reduction intermediates through electrostatic and hydrogen-bonding interactions.These factors make 1 a highly active electrocatalyst for the CO_(2)RR by achieving a TOFmax of 5.0×10^(4)s^(−1) with water providing the protons.These critical roles of the DPEN unit in the CO_(2)RR are further supported by theoretical studies.This work is significant to highlight the benefits of using molecular catalysts to elucidate structural effects. | Jinxiu Han Ni Wang Xialiang Li Haitao Lei Yabo Wang Hongbo Guo Xiaotong Jin Qingxin Zhang Xinyang Peng Xue-Peng Zhang Wei Zhang Ulf-Peter Apfel Rui Cao | 2022 | eScience2022，2，6： | 0 |
| 18 | Global scientific trends on portal hypertension and cirrhosis in the 21st century: A bibliometric and visualized analysis显示文摘To the Editor,Cirrhosis develops histologically as regenerative nodules surrounded by fibrous bands because of chronic liver injury,resulting in portal hypertension and end‐stage liver failure.Liver cirrhosis imposes a heavy health and economic burden on many countries.In 2014,Mokdad et al.1 reported the results of the 2010 Global Burden of Disease Study(GBD).Global deaths from cirrhosis increased monotonically from just over 676,000 deaths in 1980(1.54%of global deaths)to more than 1 million deaths in 2010,or 1.95%.Portal hypertension is a group of disorders characterized by symptoms,such as hepatic encephalopathy.Cirrhosis is the main cause of portal hypertension,accounting for 80%–90%of cases.In addition,cirrhosis has fatal complications that greatly affect the quality of life of patients. | Haozhuo Guo Hongbo Ni Jian Xue Fan Wang Xiaohan Sun Zhongqing Wang Meng Niu | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 19 | Development of a simplified and inexpensive RNA depletion method for plasmid DNA purification using size selection magnetic beads(SSMBs)显示文摘Plasmid DNA(pDNA)isolation from bacterial cells is one of the most common and critical steps in molecular cloning and biomedical research.Almost all pDNA purification in-volves disruption of bacteria,removal of membrane lipids,proteins and genomic DNA,purifi-cation of pDNA from bulk lysate,and concentration of pDNA for downstream applications.While many liquid-phase and solid-phase pDNA purification methods are used,the final pDNA preparations are usually contaminated with varied degrees of host RNA,which cannot be completely digested by RNase A.To develop a simple,cost-effective,and yet effective method for RNA depletion,we investigated whether commercially available size selection magnetic beads(SSMBs),such as Mag-Bind®TotalPure NGS Kit(or Mag-Bind),can completely deplete bacterial RNA in pDNA preparations.In this proof-of-principle study,we demonstrated that,compared with RNase A digestion and two commercial plasmid affinity purification kits,the SSMB method was highly efficient in depleting contaminating RNA from pDNA minipreps.Gene transfection and bacterial colony formation assays revealed that pDNA purified from SSMB method had superior quality and integrity to pDNA samples cleaned up by RNase A digestion and/or commercial plasmid purification kits.We further demonstrated that the SSMB method completely depleted contaminating RNA in large-scale pDNA samples.Furthermore,the Mag-bind-based SSMB method costs only 5-10%of most commercial plasmid purification kits on a per sample basis.Thus,the reported SSMB method can be a valuable and inexpensive tool for the removal of bacterial RNA for routine pDNA preparations. | Xi Wang Ling Zhao Xiaoxing Wu Huaxiu Luo Di Wu Meng Zhan Jing Zhang Mikhail Pakvasa William Wagstaff Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Kelly Hynes Jason Strelzow Mostafa El Dafrawy Tong-Chuan He Hongbo Qi Zongyue Zeng | 2021 | Genes & Diseases2021，8，3： | 0 |
| 20 | Leaf recognition using BP-RBF hybrid neural network显示文摘Plant recognition has great potential in forestry research and management.A new method combined back propagation neural network and radial basis function neural network to identify tree species using a few features and samples.The process was carried out in three steps:image pretreatment,feature extraction,and leaf recognition.In the image pretreatment processing,an image segmentation method based on hue,saturation and value color space and connected component labeling was presented,which can obtain the complete leaf image without veins and back-ground.The BP-RBF hybrid neural network was used to test the influence of shape and texture on species recogni-tion.The recognition accuracy of different classifiers was used to compare classification performance.The accuracy of the BP-RBF hybrid neural network using nine dimensional features was 96.2%,highest among all the classifiers. | Xin Yang Haiming Ni Jingkui Li Jialuo Lv Hongbo Mu Dawei Qi | 2022 | Journal of Forestry Research2022，33，2： | 0 |
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