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| 1 | Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer显示文摘 | Liu Qian Liu Yinhua Xu Ling Duan Xuening Li Ting Qin Naishan Kang Hua Jiang Hongchuan Yang Deqi Qu Xiang Jiang Zefei Yu Chengze | 2014 | Chinese Medical Journal2014，，13： | 6 |
| 2 | A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population. | Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 3 | Relationships between hemorrhage, angioarchitectural factors and collagen of arteriovenous malformations显示文摘Objective While associations between the angioarchitecture of arteriovenous malformations (AVMs) in the brain and pathological features have been described, here we investigated the relationship between the angioarchitecture, the pathological features of the vessel wall, and hemorrhagic events. Methods The study was conducted on 43 patients: 16 with ruptured AVM (rAVM), 15 with non-ruptured AVM (nrAVM), 6 with craniocerebral trauma (control) and 6 with epilepsy (control). The diagnosis of AVM was confirmed by preoperative digital subtraction angiography. Tissues were stained with hematoxylin and eosin and Masson's trichrome (for collagen fibers) to evaluate the vessel wall structure and endothelial integrity. The content and distribution of collagen types I and III in the vessel wall were assessed by immunohistochemical staining. Results In the nrAVM group, the nidus had more draining veins than the rAVM group (P <0.05). Severely damaged endothelial cells, significantly fewer smooth muscle cells in the media, and hyperplasic type-I and -III collagen fibers were found in the rAVM group. The content of collagen types I and III in rAVMs was higher than that in the nrAVM (P <0.05) and control groups (P <0.01). Conclusion There is an association between angioarchitectural features such as the number of draining veins and the pathological structure of the AVM wall. These abnormalities may contribute to AVM rupture. | Hongchuan Niu Yong Cao Xuejiang Wang Xiaowei Xue Lanbing Yu Ming Yang Rong Wang | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 4 | Complete invariants for robust face recognition显示文摘 | Yu Hongchuan Bennamoun M | 2006 | The Journal of the Pattern Recognition Society2006，，： | 1 |
| 5 | Level Set Methods and Image Segmentation显示文摘 | Yu Hongchuan Wang Dejun Tan Zesheng | 2001 | Medical Imaging and Augmented Reality2001，，： | 1 |
| 6 | An extension of min/max flow framework 显示文摘 | Yu Hongchuan Bennamoun Mohammed Chua Chin-Seng | 2009 | Image and Vision Computing(S0262-8856)2009，27，34： | 1 |
| 7 | Level set methods and image segmentation显示文摘 | Dejun Wang Zesheng lan | 2001 | Medical Imaging and Augmented Reality2001，，： | 1 |
| 8 | Mean Value Coordinates-Based Caricature and Expression Synthesis 显示文摘 | Hongchuan Yu Jian J Zhang | 2013 | Signal Image and Video Processing (S 1863-1703)2013，7，5： | 1 |
| 9 | An Extension of Min/max Flow Framework 显示文摘 | Yu Hongchuan Bennamoun M Seng C C | 2009 | Image and Vision Computing2009，27，4： | 1 |
| 10 | An extension of Min/Max flow framework 显示文摘 | Yu Hongchuan Bennamoun M Chua C S | 2009 | Image and Vision Computing2009，27，4： | 1 |
| 11 | Preparation of Giant Mangetostrictive Sintered Compacts by Powder Metallurgy显示文摘Powder metallurgy technique was applied to prepare rare earth giant magnetostrictive materials. This preparation process consists of casted Tb_ 0.30Dy_ 0.70Fe_ 1.80 alloy, which is pulverized by ball mill, aligned in magnetic field, compacted and sintered in inertial atmosphere. The experimental results indicate that when the magnetic field is 240 kA·m -1, the sample with particle size less than 0.147 mm being compacted in magnetic field exhibits 1613×10 -3 magnetostriction under a compressive pre-stress 8.0 MPa after being sintered at 1200 ℃ for 2 h and annealed at 950 ℃ for 24 h. | Xu Jianlin Li Hongwei Yang Hongchuan Zhang Shirong Li Kuoshe Yu Dunbo | 2006 | Journal of Rare Earths2006，24，3： | 1 |
| 12 | A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT显示文摘T cell immunoglobulin and ITIM domain(TIGIT)is a novel immune checkpoint that has been considered as a target in cancer immunotherapy.Current available bioassays for measuring the biological activity of therapeutic antibodies targeting TIGIT are restricted to mechanistic investigations because donor primary T cells are highly variable.Here,we designed a reporter gene assay comprising two cell lines,namely,CHO-CD112-CD3 scFv,which stably expresses CD 112(PVRL2,nectin-2)and a membranebound anti-CD3 single-chain fragment variable(scFv)as the target cell,and Jurkat-NFAT-TIGIT,which stably expresses TIGIT as well as the nuclear factor of activated T-cells(NFAT)response element-controlled luciferase gene,as the effector cell.The anti-CD3 scFv situated on the target cells activates Jurkat-NFATTIGIT cells through binding and crosslinking CD3 molecules of the effector cell,whereas interactions between CD 112 and TIGIT prevent activation.The presence of anti-TIGIT mAbs disrupts their interaction,which in turn reverses the inactivation and luciferase expression.Optimization and validation studies have demonstrated that this assay is superior in terms of specificity,accuracy,linearity,and precision.In summary,this reliable and effective reporter gene assay may potentially be utilized in lot release control,stability assays,screening,and development of novel TIGIT-targeted therapeutic antibodies. | Zhihao Fu Hongchuan Liu Lan Wang Chuanfei Yu Yalan Yang Meiqing Feng Junzhi Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
| 13 | Heat Transfer Analysis During 'One-Step' Directional Solidification Process for Giant Magnetostrictive Materials显示文摘By theoretical analysis of heat transfer during the 'one-step' directional solidification process, the functional relation between the temperature in solid-liquid interface and its effect factor was studied. The thermal gradient in solid liquid interface and heat transfer coefficient between the samples and surroundings were also calculated. On the basis of the above analysis, some suggestions for improving the thermal gradient in solid-liquid interface were put forward. It will provide a theoretical instruction for preparing high performance giant magnetostrictive materials (GMM). | Li Kuoshe Yang Hongchuan Xu Jing Yuan Yongqiang Yu Dunbo Li Hongwei | 2004 | Journal of Rare Earths2004，22，z2： | 0 |
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