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| 1 | Assessment of genetic diversity in broomcorn millet (Panicum miliaceum L.) using SSR markers显示文摘The genetic diversity of 118 accessions of broomcorn millet(Panicum miliaceum L.),collected from various ecological areas,was analyzed.Using 46 SSR(Simple Sequence Repeat) polymorphic markers from rice,wheat,oat and barley,a total of 226 alleles were found,which exhibited moderate level of diversity.The number of alleles per primer ranged from two to nine,with an average of 4.91.The range of polymorphism information content(PIC) was 0.284-0.980(average,0.793).The expected heterozygosity(He) varied from 0.346 to 0.989,with an average of 0.834.The average coefficient of the genetic similarity of SSR markers among the 118 accessions was 0.609,and it ranged from 0.461 to 0.851.The UPGMA(Unweight Pair Group Method with Arithmetic Mean) clustering analysis at the genetic similarity value of 0.609 grouped the 118 accessions into five groups.Mantel test meant that geographical origin and genetic distance presented positive correlation.The clustering results were consistent with known information on ecological growing areas.The genetic similarity coefficient of the accessions in the Loess Plateau ecotype was significantly lower than those in the other ecotypes.It indicates that the highest level of genetic diversity occurred in the Loess Plateau,which is probably the original site of Panicum miliaceum. | Xingyu Hu Jianfei Wang Ping Lu Hongsheng Zhang | 2009 | Journal of Genetics and Genomics2009，36，8： | 44 |
| 2 | Clinical effects of innovative tuina manipulations on treating cervical spondylosis of vertebral artery type and changes in cerebral blood flow显示文摘OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twenty six cervical spondylosis patients(vertebral artery type) were randomly divided into test and control groups.Patients in the test group were treated with innovative Tuina manipulations,while those in the control group were treated with the routine Tuina manipulations according to the textbook of Chinese Massage for Acupuncture and Moxibustion majors.The clinical effects,treatment times,clinical symptoms,and cerebral blood flow were measured.RESULTS:The response to the treatment was 100% in the test group and 88.71% in the control group.Patients in the test group required(7 ± 4) treatments before recovery,while those in the control group required(15 ± 7) treatments before recovery(P<0.05).The clinical symptoms exhibited greater improvement in the test group compared to the control group(P<0.05).There were no differences in cerebral blood flow between the two groups.CONCLUSION:Both innovative Tuina manipulations and routine Tuina manipulations produced satisfactory therapeutic results in vertebral artery type cervical spondylosis patients.However,the innovative manipulation was more effective in improving the functional symptoms,although there were no changes in the cerebral blood flow. | Quanmao Ding Mingru Yan Ji Zhou Lu Yang Jiang Guo Jun Wang Zhiyong Shi Yixi Wang Hongsheng Zhao | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 24 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 5 | Added Value of Quantitative Apparent Diffusion Coefficients for Identifying Small Hepatocellular Carcinoma from Benign Nodule Categorized as LI-RADS 3 and 4 in Cirrhosis显示文摘Background and Aims:Correct identification of small hepa-tocellular carcinomas(HCCs)and benign nodules in cirrhosis remains challenging,quantitative apparent diffusion coeffi-cients(ADCs)have shown potential value in characterization of benign and malignant liver lesions.We aimed to explore the added value of ADCs in the identification of small(≤3 cm)HCCs and benign nodules categorized as Liver Imag-ing Reporting and Data System(LI-RADS)3(LR-3)and 4(LR-4)in cirrhosis.Methods:Ninety-seven cirrhosis patients with 109 small nodules(70 HCCs,39 benign nodules)of LR-3 and 4 LR-4 based on major and ancillary magnetic resonance imaging features were included.Multiparametric quantitative ADCs of the lesions,including the mean ADC(ADCmean),min-imum ADC(ADCmin),maximal ADC(ADCmax),ADC standard deviation(ADCstd),and mean ADC value ratio of lesion-to-liv-er parenchyma(ADCratio)were calculated.Regarding the joint diagnosis,a nomogram model was plotted using multivariate logistic regression analysis.The performance was assessed using the area under the receiver operating characteristic curve(AUC).Results:The ADCmean,ADCmin,ADCratio,and ADCstd were significantly associated with the identification of small HCC and benign nodules(p<0.001).For the joint diagnosis,the LI-RADS category(odds ratio[OR]=12.50),ADCmin(OR=0.14),and ADCratio(OR=0.12)were identified as independent factors for distinguishing HCCs from benign nodules.The joint nomogram model showed good calibration and discrimination,with a C-index of 0.947.Compared with the LI-RADS category alone,this nomogram model demon-strated a significant improvement in diagnostic performance,with AUC increasing from 0.820 to 0.967(p=0.001).Con-clusions:The addition of quantitative ADCs could improve the identification of small HCC and benign nodules catego-rized as LR-3 and 4 LR-4 in patients with cirrhosis. | Xi Zhong Hongsheng Tang Tianpei Guan Bingui Lu Chuangjia Zhang Danlei Tang Jiansheng Li Shuzhong Cui | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 6 |
| 6 | Review of Chinese atmospheric science research over the past 70 years: Atmospheric physics and atmospheric environment显示文摘Since the founding of the People’s Republic of China 70 years ago,the subject of atmospheric physics and atmospheric environment has developed rapidly in China,providing important support for the development of atmospheric science and guarantee for the development of national economy.In this paper,the general advancement of atmospheric physics and atmospheric environment in last 70 years was described.The main research progress of atmospheric physics and atmospheric environment in the past 40 years of reform and opening-up was reviewed,the outstanding research achievements since the 21 st century were summarized,the major problems and challenges are pointed out,and the key directions and suggestions for future development are put forward. | Tijian WANG Taichang GAO Hongsheng ZHANG Maofa GE Hengchi LEI Peichang ZHANG Peng ZHANG Chunsong LU Chao LIU Hua ZHANG Qiang ZHANG Hong LIAO Haidong KAN Zhaozhong FENG Yijun ZHANG Xiushu QIE Xuhui CAI Mengmeng LI Lei LIU Shengrui TONG | 2019 | Science China Earth Sciences2019，62，12： | 5 |
| 7 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 8 | Sunway supercomputer architecture towards exascale computing:analysis and practice显示文摘In recent years,the improvements of system performance and energy efficiency for supercomputers have faced increasing challenges,which create more intensive demands on the architecture design for realizing exascale computing.This paper first analyzes the main requirements of exascale computing on the aspects of the parallel computing application and supercomputing center operation.Afterwards,a mapping scheme of'demands-challenges-architecture'is proposed.Then,the major challenges of exascale supercomputer,such as scalability,power consumption,data movement,programming and availability,are thoroughly analyzed,and the corresponding appropriate solutions are proposed.Moreover,this paper proposes the Sunway computer architecture towards exascale computing in which the many-core processor,network chipset and software system are all domestically-designed.The technology roadmap of Sunway supercomputer will hold the comprehensive design methods for the architecture,including the processor,interconnect network,assembly structure,power supply,cooling system,system software,parallel algorithm and application support,promising great advances for exascale supercomputing. | Jiangang GAO Fang ZHENG Fengbin QI Yajun DING Hongliang LI Hongsheng LU Wangquan HE Hongmei WEI Lifeng JIN Xin LIU Daoyong GONG Fei WANG Yan ZHENG Honghui SUN Zhou ZHOU Yong LIU Hongtao YOU | 2021 | Science China(Information Sciences)2021，64，4： | 3 |
| 9 | STUDIES ON PATHOGENESIS OF WAARDENBURG SYNDROME TYPE Ⅱ AND TIETZ SYNDROME RESULTING FROM MITF GENE MUTATIONS显示文摘Microphthalmia-associated transcription factor(MITF) controls melanocyte survival and differentiation through directly regulating the expression of the tyrosinase(TYR) and tyrosinase- related proteins 1 and 2(TYRP1 and TYRP2) genes. MITF mutations have been reported to result in an abnormal melanocyte development and lead to Waardenburg syndrome type 2(WS2), characterized by variable degrees of sensorineural hearing loss and patchy regional distribution of hypopigmentation. Recently, MITF was also indicated as a causative gene for a more severe syndrome, the Tietz Syndrome(TS), characterized by generalized hypopigmentation and complete hearing loss. However, few functional studies have been performed to compare the diseases-causing mutations. Here, we analyzed the in vitro activity of two recent identified WS2-associated mutation(p.R217I and p.T192fsX18) and one TS-associated mutation p.N210K. The R217I MITF retained partial activity, normal DNA-binding ability and nuclear distribution, whereas the T192fsX18 MITF failed to activate TYR promoter due to loss of DNA-binding activity, and aberrant subcellular localization.The aberrant subcellular localization of T192fsX18 MITF may be caused by deletion of a putative nuclear localization signal(NLS) at aa 213-218(ERRRRF). Indeed, MITF with deletion of the NLS fragment failed to translocate into the nucleus and activated the TYR promoter. Tagging this NLS to GFP promoted the green fluorescence protein(GFP) translocated into the nucleus. The surprising finding of our study is that a TS-associated MITF mutation, N210K, showed comparable in vitro activity as WT. Thus, the possible involvement of MITF in TS and its underlying mechanisms still need further investigation. | ZHANG Hua LI Jiada LUO Hunjin CHEN Hongsheng MEI Lingyun HE Chufeng JIANG Lu FENG Yong | 2013 | Journal of Otology2013，8，2： | 2 |
| 10 | Closed-loop endo-atmos- pheric ascent guidance显示文摘 | Ping Lu HongSheng Sun Bruce Tsai | 2002 | AIAA2002，4558，： | 1 |
| 11 | Studies on the closed circular groove guide 显示文摘 | Jun Qian Yang Hongsheng Lu Zhongzuo | 1993 | International Journal of Infrared and Millimeter Waves1993，14，10： | 1 |
| 12 | Synthesis and acid solution properties of a novel betaine zwitterionic surfactant显示文摘 | Hongping Quan Xuan Zhang Hongsheng Lu Zhiyu Huang | 2012 | Central European Journal of Chemistry2012，，5： | 1 |
| 13 | Solution and adsorption properties of hydrophobically associating polyacrylamide prepared in inverse microemulsion polymerization显示文摘 | Lu Hongsheng Huang Zhiyu | 2009 | J Macromol Sci A2009，46，： | 1 |
| 14 | Circular groove guide for short millimeter and submillimeter waves显示文摘 | Yang Hongsheng Ma Jianglei Lu Zhongzuo | 1995 | IEEE Trans on Microwave Theory and Techniques1995，43，2： | 1 |
| 15 | Circular groove guide for short millimeter and submillimeter waves 显示文摘 | YANG Hongsheng MA Jianglei LU Zhongzuo | 1995 | IEEE Transaction on Microwave Theory and Techniques1995，43，2： | 1 |
| 16 | Circular groove guide for short millimeter and submillimeter waves显示文摘 | Ma Jianglei Lu Zhongzuo | 1995 | IEEE Transactions Microwave Theory Techniques1995，43，： | 1 |
| 17 | Novel mutations of PAX3, MITF, and SOX10 genes in Chinese patients with type I or type II Waardenburg syndrome显示文摘 | Hongsheng Chen Lu Jiang Zhiguo Xie Lingyun Mei Chufeng He Zhengmao Hu Kun Xia Yong Feng | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 18 | Closed-loop endoatmospheric ascent guidance 显示文摘 | Lu Ping Sun Hongsheng Tsai B | 2003 | Journal of Guidance Control and Dynam- ics2003，26，2： | 1 |
| 19 | Buckling of stepped beams with elastic supports 显示文摘 | Zhang Hongsheng Lu Nianli Lan Peng | 2009 | Journal of Harbin Institute of Technology2009，16，： | 1 |
| 20 | Microforming Experimental Investigation of the Extrusion Process for Micropins and its Numerical Simulation Using RKEM显示文摘 | Jian Cao Neil Krishnan Zhong Wang Hongsheng Lu Wing K Liu Anthony Swanson | 2004 | Journal of Manufacturing Science and Engineering2004，126，： | 1 |
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