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| 1 | Synthesis of Pd Nanocrystals Enclosed by {100} Facets and with Sizes 〈10 nm for Application in CO Oxidation显示文摘 | Mingshang Jin Hongyang Liu Hui Zhang Zhaoxiong Xie Jingyue Liu Younan Xia | 2011 | Nano Research2011，4，1： | 24 |
| 2 | Construction of Pd-M (M = Ni, Ag, Cu) alloy surfaces for catalytic applications显示文摘合金作为异构的催化剂轰炸增加利用效率并且提高金属原子的催化活动的 ultrathin 的制造为有效金属 nanocatalysts 的构造作为一个有效方法被认出了,特别地高贵金属的 nanocatalysts。在这研究,我们表明 Pd-M 的成功的形成(M = Ni, Ag, Cu ) 有 preformed nanoscale Pd 种子上的悦耳的厚度的合金壳。这合成的成功主要依靠 M 离子和 M 广告原子的随后的散开的慢减小的联合进 Pd 种子的表面格子。Pd-M 合金壳的作文被改变增加的先锋的类型和数量容易调节,并且壳厚度根据反应时间被操作。更显著地,这些合金壳的表面结构在反应以后被维持,暗示 Pd-M 合金壳的任何需要的表面结构能被使用适当开始材料准备。这些合金表面显著地展出的 chloronitrobenzenes 表演的加氢的进一步催化的评估与 Pd 种子相比改进了选择。Pd-Ni 合金表面展出更好催化的选择(象一样高 >99%) 比 Pd 催化剂。 | Xiang Li Xixi Wang Maochang Liu Hongyang Liu Qiang Chen Yadong Yin Mingshang Jin | 2018 | Nano Research2018，11，2： | 4 |
| 3 | Development of Cryogenic Disinfectants Using in-18℃and-40℃Environments—Worldwide,2021显示文摘Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under low temperatures.Therefore,2 kinds of chlorine-containing disinfectants for−18℃and−40℃were developed in order to solve the problem of low temperature disinfection.Methods:The properties of two cryogenic disinfectants were evaluated by low-temperature test.Staphylococcus aureus and Escherichia coli were used as two indicator microorganisms to evaluate the effects of the two cryogenic disinfectants in the laboratory and field tests according to Technical Specifications for Disinfection(2002 version)and Test method for bactericidal effect of disinfectants in laboratory(GB/T 38502-2020).Results:Two disinfectants could remain in the liquid state at−18℃or−40℃in 72 hours without crystallization and precipitation,and the average log values of microbial reduction before and after disinfection(the average killing log value)both on Staphylococcus aureus and Escherichia coli were>3 in the laboratory and field tests.Discussion:The results showed that these two disinfectants remained functional at low temperature to disinfect the packaging of imported cold chain food and surrounding packaging to prevent transmission of COVID-19 from material to people. | Huihui Sun Hongyang Duan Wei Zhang Chen Liang Luyao Li Yuan Lyu Yanyan Chen Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，13： | 4 |
| 4 | m6A RNA methylation-mediated HNF3γreduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 6 | Monitoring the Effective Sterilization of Low-Temperature Hydrogen Peroxide Gas Plasma Sterilizers in 58 Hospitals——22 PLADs,China,June 2015-December 2019显示文摘Summary What is already known on this topic?Hydrogen peroxide sterilizeation is widely used for luminal devices.However,the low penetrability of the sterilant is of major concern.What is added by this report?This report investigated the effective sterilization of low-temperature hydrogen peroxide gas plasma sterilizers and compared the applicability of different biological monitoring methods based on medical luminal devices. | Jiaqi Wang Baoying Zhang Huihui Sun Jian Zhang Hongyang Duan Haiqun Ban Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，29： | 3 |
| 7 | A Deep Neural Network Coordination Model for Electric Heating and Cooling Loads Based on IoT Data显示文摘As the ubiquitous electric power internet of things(UEPIoT)evolves and IoT data increases,traditional scheduling modes for load dispatch centers have yielded a variety of chal-lenges such as calculation of real-time optimization,extraction of time-varying characteristics and formulation of coordinated scheduling strategy for capacity optimization of electric heating and cooling loads.In this paper,a deep neural network coor-dination model for electric heating and cooling loads based on the situation awareness(SA)of thermostatically controlled loads(TCLs)is proposed.First,a sliding window is used to adaptively preprocess the IoT node data with uncertainty.According to personal thermal comfort(PTC)and peak shaving contribution(PSC),a dynamic model for loads is proposed;meanwhile,personalized behavior and consumer psychology are integrated into a flexible regulation model of TCLs.Then,a deep Q-network(DQN)-based approach,using the thermal comfort and electricity cost as the comprehensive reward function,is proposed to solve the sequential decision problem.Finally,the simulation model is designed to support the validity of the deep neural network coordination model for electric heating and cooling loads,by using UEPIoT intelligent dispatching system data.The case study demonstrates that the proposed method can efficiently manage coordination with large-scale electric heating and cooling loads. | Hongyang Jin Yun Teng Tieyan Zhang Zedi Wang Zhe Chen | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 8 | Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers显示文摘microRNAs(miRNAs),particularly the exosomal miRNAs have been widely used as biomarkers and promising therapeutic targets in cancer.However,a comprehensive analysis of miRNA-gene regulatory network with clinical significance remains scarce.The emergence of high-throughput multi-omics data over large,well-characterized patient cohorts provides an unprecedented opportunity to address this problem.Herein,we performed a clinic-centered analysis to identify cancer-associated miRNAs,miRNA-target axis.We first calculated the correlation among miRNA,mRNA and 75 unique clinico-pathological characteristics(CPCs)in 26 cancer types,and established an online resource(4CR).Interestingly,we found that the high expression of several DNA methylation-related enzymes was associated with adverse outcomes of cancer patients,and these genes were regulated by a cluster of miRNAs.Furthermore,by integrating exosomal miRNA and m RNA databases,we identified exosomal miRNA biomarkers for non-invasive cancer surveillance and therapy monitoring.Finally,we explored the role of CPC-related miRNAs for therapeutic effect prediction of drugs based on their shared targets.Our analysis pipeline illustrated the significance of clinic-centered analysis in miRNA-gene pair identification and provided helpful clues for future cancer studies. | Xiuliang Cui Yang Liu Wen Sun Jin Ding Xiaochen Bo Hongyang Wang | 2020 | Science China(Life Sciences)2020，63，8： | 2 |
| 9 | Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis显示文摘 | Emilie A. Bard-Chapeau Shuangwei Li Jin Ding Sharon S. Zhang Helen H. Zhu Frederic Princen Diane D. Fang Tao Han Beatrice Bailly-Maitre Valeria Poli Nissi M. Varki Hongyang Wang Gen-Sheng Feng | 2011 | Cancer Cell2011，，5： | 2 |
| 10 | Low glucose promotes CD133mAb-elicited cell death via inhibition of autophagy in hepatocarcinoma cells显示文摘 | Haiyang Chen Zaili Luo Wen Sun Cunzhen Zhang Huanlin Sun Nanjie Zhao Jin Ding Mengchao Wu Zhong Li Hongyang Wang | 2013 | Cancer Letters2013，，1： | 1 |
| 11 | Cross-linking of polystyrene by Friedel-Crafts chemistry: multifunctional additives显示文摘 | Hongyang Yao Jin Zhu Michael A Mckinney | 2000 | Journal of Vinyl & Additive Technology2000，6，4： | 1 |
| 12 | Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood显示文摘Aristolochic acids(AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I(AAI) reacts with DNA to form covalent aristolactam(AL)-DNA adducts,leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether AAs exposure was the main cause of liver cancer in the context of HBV infection in China's Mainland. Totally 1256 liver cancer samples were randomly retrieved from 3 medical centers and a refined bioanalytical method was used to detect AAI-DNA adducts. 5.10% of these samples could be identified as AAI positive exposure. Whole genome sequencing suggested 8.41% of 107 liver cancer patients exhibited the dominant AA mutational signature, indicating a relatively low overall AAI exposure rate. In animal models, long-term administration of AAI barely increased liver tumorigenesis in adult mice, opposite from its tumor-inducing role when subjected to infant mice. Furthermore, AAI induced dose-dependent accumulation of AA-DNA adduct in target organs in adult mice, with the most detected in kidney instead of liver. Taken together, our data indicate that AA exposure was not the major threat of liver cancer in adulthood. | Shuzhen Chen Yaping Dong Xinming Qi Qiqi Cao Tao Luo Zhaofang Bai Huisi He Zhecai Fan Lingyan Xu Guozhen Xing Chunyu Wang Zhichao Jin Zhixuan Li Lei Chen Yishan Zhong Jiao Wang Jia Ge Xiaohe Xiao Xiuwu Bian Wen Wen Jin Ren Hongyang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 13 | Different Sensitivities to Apoptotic Induction by Camptothecin between Normal and Senescent Lens Epithelial Cells显示文摘Purpose: To investigate whether normal and senescent lens epithelial cells have different defense abilities to apoptotic induction factor in vitro.Methods: Rabbit lens epithelial cells were cultured, passed. When reaching confluence, cells from the first and seventh passage were stained by x-gal staining to detect cell senescence. Cell apoptosis was detected by TUNEL(Roche).10μmol/L camptothecin was used to induce cell apoptosis from the lens epithelial cells of the first and seventh passage to distinguish different sensitivities to apoptotic induction factor between normal and senescent cells.Results: The senescent cells (41.17% ± 5.24% ) were detected in the lens epithelial cell culture of the seventh passage, which are higher than those of the first passage (0.98% ±0. 39% ). There was no apoptotic cell detected in the cell cultures undisturbed. Exposure of the first passage cells to camptothecin resulted in death of approximately 23.87% ± 3.45% of the cells during a 36 hour exposure period. In contrast, significantly more lens epithelial cells died through the apoptosis (38.29% ±4. 01% ) from the seventh passage.Conclusion: Senescent cells increased with cell passage. Senescence lens epithelial cells do not undergo apoptosis if they were not disturbed. But the vulnerabilities to apoptotic induction between health and senescence cells were different. | Haike Guo, Haiying Jin, Liya Wang, Hongyang Zhang, Xin YangDepartment of Ophthalmology, Guangdong Provincial People’s Hospital, Guangzhou 510080, ChinaThe First Affiliated Hospital of Medical College, Jinan University, Guangzhou 510632, ChinaHenan Institute of Ophthalmology, Zhengzhou 450003, China | 2002 | 眼科学报2002，18，3： | 1 |
| 14 | Involvement of β3A Subunit of Adaptor Protein-3 in Intracellular Trafficking of Receptor-like Protein Tyrosine Phosphatase PCP-2显示文摘PCP-2 是人的像受体的蛋白质酷氨酸磷酸酶和在人的胰腺的腺癌房间克隆的 MAM 领域家庭的一个成员。以前的研究证明 thatPCP-2 直接通过 juxtamembrane 领域与β - catenin 交往了, dephosphorylated β - catenin 并且在房间粘附的规定起了一个重要作用。显示出的 thatPCP-2 也是的最近的学习在β - 的压抑包含了导致 catenin 的 transcriptional 活动。这里,我们与β 3 描述 PCP-2 的相互作用适配器蛋白质(AP ) 的一个子单元 -3 和排序的[微管] 连接蛋白(SNX ) 3。这些蛋白质建筑群用酵母被检测有 thejuxtamembrane 和是的 PCP-2 的膜近似的催化领域的二混血儿的试金“诱饵”。AP-3 和 SNX3 是涉及膜受体的细胞内部的交通国王的分子。在β 3 之间的协会 AP-3 和 PCP-2 的一个子单元进一步在哺乳动物的房间被证实。我们的结果建议 PCP-2 的细胞内部的交通国王的可能的机制由可能参予 PCP-2 功能的规定的 AP-3 和 SNX3 调停了。 | Hui DONG Hong YUAN Weirong JIN Yan SHEN Xiaojing XU Hongyang WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 0 |
| 15 | Preliminary Study of Pulsed Ultraviolet Technology for Low-Temperature Disinfection显示文摘Introduction:To explore the feasibility of pulsed ultraviolet(UV)light technology for low-temperature disinfection,a series of experiments were conducted.Methods:Pulsed UV technology’s effectiveness in disinfecting Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli on different carriers were studied under varying temperatures.Results:Under different temperatures and constant radiation illumination(i.e.,distance),the disinfection effect was correlated with irradiation time;among the three carriers,the disinfection effect of cloth sheets was the best,followed by stainless steel sheets,and corrugated paper sheet.The disinfection effect on Gram-negative bacteria Escherichia coli was better than that on Gram-positive bacteria Staphylococcus aureus overall.Discussion:Temperature has a limited effect on pulsed UV disinfection.Irradiation times and carrier types are influencing factors. | Luyao Li Tao Li Jin Shen Huihui Sun Hongyang Duan Changping Zhu Wei Zhang Chen Liang Baoying Zhang Yan Li Liubo Zhang | 2022 | China CDC weekly2022，4，16： | 0 |
| 16 | SOX9-transactived long non-coding RNA NEAT1 promotes the self-renewal of liver cancer stem cells through PKA/Hippo signaling显示文摘Dear Editor,Hepatocellular carcinoma(HCC),the most common pathological type of primary liver cancer,ranks as the third deadliest cancer.Despite the progress of surgical resection in recent years,the 5-year survival of HCC patients is still unsatisfactory due to the frequent relapse and chemoresistance.Accumulating evidence has demonstrated that liver cancer stem cells(CSCs)are critical for HCC chemoresistance and recurrence.Nevertheless,the molecular mechanisms of liver CSC regulation remain unclear,which hampers the development of the therapeutic strategy that targets liver CSCs. | Zhuo Cheng Xijun Liang Cheng Zhang Ruoyu Wang Tingting Wei Beifang Ning Elzbieta Poreba Liang Li Hongyang Wang Jin Ding | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 0 |
| 17 | m6A RNA methylation-mediated HNF3γ reduction rendershepatocellular carcinoma dedifferentiation and sorafenibresistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 18 | Key Points of the Program for Disinfection Technology in Special Places During the Coronavirus Disease-2019(COVID-19)Outbreak显示文摘Since January 2020,the coronavirus disease 2019(COVID-19)epidemic has been prevalent throughout China.Disinfection,as an effective measure to cut off routes of transmission,is crucial in addressing epidemics of infectious diseases.To further guide prevention and control of COVID-19 and on-site disinfection nationwide,the Program for Disinfection Technology in Special Places(first edition)has been developed on January 28. | Jiaqi Wang Baoying Zhang Hongyang Duan Chen Liang Huihui Sun Jian Zhang Jin Shen Liubo Zhang | 2020 | China CDC weekly2020，2，9： | 0 |
| 19 | Model architecture level privacy leakage in neural networks显示文摘Privacy leakage is one of the most critical issues in machine learning and has attracted growing interest for tasks such as demonstrating potential threats in model attacks and creating model defenses.In recent years,numerous studies have revealed various privacy leakage risks(e.g.,data reconstruction attack,membership inference attack,backdoor attack,and adversarial attack)and several targeted defense approaches(e.g.,data denoising,differential privacy,and data encryption).However,existing solutions generally focus on model parameter levels to disclose(or repair)privacy threats during the model training and/or model interference process,which are rarely applied at the model architecture level.Thus,in this paper,we aim to exploit the potential privacy leakage at the model architecture level through a pioneer study on neural architecture search(NAS)paradigms which serves as a powerful tool to automate a neural network design.By investigating the NAS procedure,we discover two attack threats in the model architecture level called the architectural dataset reconstruction attack and the architectural membership inference attack.Our theoretical analysis and experimental evaluation reveal that an attacker may leverage the output architecture of an ongoing NAS paradigm to reconstruct its original training set,or accurately infer the memberships of its training set simply from the model architecture.In this work,we also propose several defense approaches related to these model architecture attacks.We hope our work can highlight the need for greater attention to privacy protection in model architecture levels(e.g.,NAS paradigms). | Yan LI Hongyang YAN Teng HUANG Zijie PAN Jiewei LAI Xiaoxue ZHANG Kongyang CHEN Jin LI | 2024 | Science China(Information Sciences)2024，67，3： | 0 |
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