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| 1 | Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis显示文摘间充质的干细胞(MSC ) 试验性地被使用了对待煽动性的混乱,部分由于他们的抑制免疫力的性质。尽管 interleukin-1β(IL-1β) 是最重要的煽动性的调停人之一,成长证据显示那 IL-1β发信号得到 MSC 的抑制免疫力的性质。然而,它仍然保持不清楚怎么 IL-1β发信号完成这项活动。这里,我们集中于 IL-1β 的治疗学的功效;在葡聚糖硫酸盐钠(决策支持系统) 的告知的 MSC 劝诱了大肠炎模型,除了加重的机制。我们首先发现了那 IL-1β没有在 vitro 的任何看得见的显型变化,告知的 MSC 显著地稀释了导致决策支持系统的鼠科的大肠炎的发展。而且, IL-1β告知的 MSC 通过提高 cyclooxygenase-2 (COX-2 ) 在怒气和 mesenteric 淋巴节点(MLN ) 调制了有免疫力的房间的平衡, IL-6 和 IL-8 表示并且影响腹巨噬细胞的极化。重要地, IL-1β告知的 MSC 拥有了一个提高的能力经由 chemokine 受体类型 4 的 upregulation (CXCR4 ) 移居到内脏的煽动性的地点表示。在摘要, IL-1β告知的 MSC 在对待导致决策支持系统的大肠炎改进了功效,它部分至少取决于他们的增加的抑制免疫力的能力和提高的迁居能力。 | Hongye Fan Guangfeng Zhao Liu Liu Fei Liu Wei Gong Xianqin Liu Liu Yang Jianjun Wang Yayi Hou | 2012 | Cellular & Molecular Immunology2012，9，6： | 21 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 5 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 6 | Chitosan-mediated synthesis of mesoporous α-Fe_(2)O_(3)nanoparticles and their applications in catalyzing selective oxidation of cyclohexane显示文摘This paper reports the chitosan-mediated synthesis of porous hematite nanoparticles with FeCl3 as the precursor via a hydrothermal approach at 160℃.A series of porous chitosan/iron oxide hybrid nanoparticles were obtained via changing the ratio of chitosan to FeCl3,FeCl3 concentration and pH value of the reaction solution,and producing porous iron oxide nanoparticles after calcination.The as-prepared samples were characterized by means of X-ray diffraction,transmission electron microscopy,thermal gravimetric analysis,Fourier transform infrared,and N2 sorption.The particle sizes of these metal oxides were less than 100 nm,and the pore sizes were in the range of 2-16 nm.It was demonstrated that chitosan played a key role in the formation of the porous structures.The resultant α-Fe2O3 nanoparticles were used as the support to immobilize Au or Pd nanoparticles,producing Au/α-Fe2O3 or Pd/α-Fe2O3 nanoparticles.The as-prepared α-Fe2O3 nanocatalyst exhibited high selectivity towards cyclohexanone and cyclohexanol for catalyzing cyclohexane oxidation with O2 at 150℃. | HUANG ChangLiang ZHANG HongYe SUN ZhenYu LIU ZhiMin | 2010 | Science China Chemistry2010，53，7： | 4 |
| 7 | N-doped carbon supported Pd catalysts for N-formylation of amines with CO2/H2显示文摘Using mesoporous N-doped carbons(NCs)derived from glucose and melamine as the supports,a series of Pd/NC catalysts were prepared,in which Pd nanoparticles with average size<2.0 nm were uniformly distributed on the supports.It was indicated that the resultant Pd/NC catalysts were effective for N-formylation of amines with CO_2and H_2in ethanol without any additives.Especially,the catalyst Pd/NC-800-6.9%containing quaternary N showed the best performance,affording a series of formylamides in good or even excellent yields.Further investigation reveals that the interaction between the Pd nanoparticles and quaternary nitrogen in the NC support was responsible for the good performance of the catalyst. | Xiaoying Luo Hongye Zhang Zhengang Ke Cailing Wu Shien Guo Yunyan Wu Bo Yu Zhimin Liu | 2018 | Science China Chemistry2018，61，6： | 4 |
| 8 | Investigation of frost heave prevention using permeable subgrade structure显示文摘This paper set up a series of comprehensive targets based on the concept of 'anti-freeze filler', which include reasonable water retention rate, frost heave characteristics, and compaction characteristics of filling material. Then, a type of permeable graded gravel is proposed, suitable for high-speed railway subgrade. A series of in-door water retention, permeability, and frost heave tests were performed under different graded conditions. Water retention, permeability, and frost heave characteristic of different graded filling materials can be determined, in order to define the gradation range of permeable graded gravel. Relying on the frost-heave monitoring record of high speed railway in Northeast China, a series of experimental studies were performed, which included on-site filler production, compaction test, and the anti-frost effect test, in order to improve the production and compaction techniques of permeable graded gravel. From the research of this paper, the use of permeable graded gravel subgrade as the anti-frost structure for the high-speed railway subgrade in cold areas is feasible. | DeGou Cai JianPing Yao HongYe Yan QianLi Zhang AiJun Cheng Jie Liu | 2015 | Research in Cold and Arid Regions2015，7，5： | 3 |
| 9 | Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications显示文摘To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. | Hongye Hao Ya Deng Yingke Wu Siyuan Liu Weiwei Lin Jiehua Li Feng Luo | 2017 | Regenerative Biomaterials2017，4，2： | 3 |
| 10 | Pd nanoparticles immobilized on graphite oxide modified with a base: Highly efficient catalysts for selective hydrogenation of citral显示文摘In this work, the Pd-based catalysts were designed via immobilizing Pd nanoparticles on graphite oxide (GO) modified with organic base, 1,1,3,3-tetramethylguanidine (TMG), which was used for the selective hydrogenation of citral. These catalysts were characterized by various techniques including IR, X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy. It was demonstrated that the Pd particles with size less than 5 nm were uniformly distributed throughout the support, and they were in the electron-deficient state due to the strong interactions with the modified support. The resultant Pd-TMG/GO catalyst displayed high efficiency for the selective hydrogenation of citral with a turnover frequency of 7100 h-1 as well as superior selectivity to citronellal of 89.6%. Moreover, the catalyst can be reused for five times without obvious activity loss, which may result from its stable structure. | ZHAO YanFei ZHANG HongYe HUANG ChangLiang CHEN Sha YU Bo XU JiLei LIU ZhiMin | 2013 | Science China Chemistry2013，56，2： | 3 |
| 11 | Estimating leaf mercury content in Phragmites australis based on leaf hyperspectral reflectance显示文摘Introduction:Highmercury(Hg)concentrations affect the chlorophyll in leaves,therebymodifying leaf spectra.Hyperspectra is a promising technique for the rapid,nondestructive evaluation of leaf Hg content.In this study,we investigated Hg contents and reflective hyperspectra of reed leaves(Phragmites communis)in a gold mining(Jilin province,China).Spectral parameters sensitive to Hg content were identified through basic spectral transformations,continuous wavelet transformation(CWT),and spectral indices techniques.Leaf Hg inversion models were developed using stepwise multiple linear regression,partial least squares regression,and random forest algorithms.Outcomes:The results indicated that:1)leaf Hg content decreased with increasing distance from the mine:Jiapigou(JPG)>Erdaocha(EDC)>Laojingchang(LJC)>Erdaogou(EDG)>Lingqian(LQ)>Weishahe(WSH).2)Hg–sensitive wavelengths were primarily in the visible region;CWT increased the correlation between hyperspectral data and leaf Hg content,and improved the regression and accuracy of inversion;3)the continuumremoval–CWT–stepwise multiple linear regression was better for estimating low leaf Hg content;while the differential spectral index–partial least squares regression was better for estimating high leaf Hg content.Conclusion:These hyperspectral inversion methods could be used for rapid,nondestructive monitoring of wetland plants. | Weiwei Liu Mengjie Li Manyin Zhang DaanWang Ziliang Guo Songyuan Long Si Yang Henian Wang Wei Li Yukun Hu Yuanyun Wei Hongye Xiao | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
| 12 | Design and demonstration of a dynamic wireless power transfer system for electric vehicles显示文摘The usage of electric vehicles is being globally promoted with the development of clean energy. However, the development of electric vehicles is limited by the battery capacity and the charging techtechnology.Traditional charging facilities mainly involve plugging invehicles in an electrical interface,which is inconvenient and inherently hazardous.When compared with the traditional charging methods,the wireless charging method can solve several problems,such as the interface limitation,and will be gradually developed as the main charging mode for elec trie vehicles[1].Based on the driving stales of electric vehicles,the wireless charging technologies can be mainly classified as static wireless charging and dynamic wireless charging. | Ze ZHOU Liyan ZHANG Zhitao LIU Longhua MA Miao HUANG Hongye SU | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 13 | A Pipeline Approach to Free-Description Question Answering in Chinese Gaokao Reading Comprehension显示文摘This study attempted to answer complicated free-description questions in Chinese Gaokao Reading comprehension(RC) tasks. We found that quite a few questions can be answered by extracting sentences from the document and combining them, so we used a pipeline approach with two components:Answer sentence extraction(ASE) and Answer sentence fusion(ASF). Semantic vector similarity and topical distribution similarity were explored for ASE. Integer linear programming strategy was used for ASF, which combined dependencies with the language model, based on word importance. As a first step towards the new challenge, we obtained some encouraging results on actual exam questions in Chinese subject's RC tasks of Beijing Gaokao, which helped us obtain insights into techniques needed to solve real-word complex questions. | TAN Hongye ZHAO Honghong LI Ru LIU Bei | 2019 | Chinese Journal of Electronics2019，28，1： | 2 |
| 14 | Distributed event-triggered adaptive control for second-order nonlinear uncertain multi-agent systems显示文摘In this paper,the event-triggered consensus control problem for nonlinear uncertain multi-agent systems subject to unknown parameters and external disturbances is considered.The dynamics of subsystems are second-order with similar structures,and the nodes are connected by undirected graphs.The event-triggered mechanisms are not only utilized in the transmission of information from the controllers to the actuators,and from the sensors to the controllers within each agent,but also in the communication between agents.Based on the adaptive backstepping method,extra estimators are introduced to handle the unknown parameters,and the measurement errors that occur during the event-triggered communication are well handled by designing compensating terms for the control signals.The presented distributed event-triggered adaptive control laws can guarantee the boundness of the consensus tracking errors and the Zeno behavior is avoided.Meanwhile,the update frequency of the controllers and the load of communication burden are vastly reduced.The obtained control protocol is further applied to a multi-input multi-output second-order nonlinear multi-agent system,and the simulation results show the effectiveness and advantages of our proposed method. | Ming XIAO Zhitao LIU Hongye SU | 2021 | Chinese Journal of Aeronautics2021，34，10： | 2 |
| 15 | One-step preparation of branched PEG functionalized AIE-active luminescent polymeric nanoprobes显示文摘The synthesis of amphiphilic aggregation-induced emission(AIE) dyes based organic nanoparticles has recently attracted increasing attention in the biomedical fields. These AIE dyes based nanoparticles could effectively overcome the aggregation caused quenching effect of conventional organic dyes, making them promising candidates for fabrication of ultrabright organic luminescent nanomaterials. In this work, AIE-active luminescent polymeric nanoparticles(4-NH_2-PEG-TPE-E LPNs) were facilely fabricated through Michael addition reaction between tetraphenylethene acrylate(TPE-E) and 4-arm-poly(ethylene glycol)-amine(4-NH_2-PEG) in rather mild ambient. The 4-NH_2-PEG can not only endow these AIE-active LPNs good water dispersibility, but also provide functional groups for further conjugation reaction. The size, morphology and luminescent properties of 4-NH_2-PEG-TPE-E LPNs were characterized by a series of techniques in detail. Results suggested that these AIE-active LPNs showed spherical morphology with diameter about 100–200 nm. The obtained 4-NH_2-PEG-TPE-E LPNs display high water dispersibility and strong fluorescence intensity because of their self assembly and AIE properties of TPE-E.Biological evaluation results demonstrated that 4-NH_2-PEG-TPE-E LPNs showed negative toxicity toward cancer cells and good fluorescent imaging performance. All of these features make 4-NH_2-PEG-TPE-E LPNs promising candidates for biological imaging and therapeutic applications. | Jun Chu Qiulan Lv Chunliang Guo Dazhuang Xu Ke Wang Meiying Liu Hongye Huang Xiaoyong Zhang Yen Wei | 2016 | Science China Chemistry2016，59，8： | 2 |
| 16 | The propagation of coupled Lamb waves in multilayered arbitrary anisotropic composite laminates显示文摘 | He Cunfu Liu Hongye Liu Zenghua Wu Bin | 2013 | Journal of Sound and Vibration2013，，： | 1 |
| 17 | A self-powered temperature-sensitive electronic-skin based on tribotronic effect of PDMS/PANI nanostructures显示文摘A new self-powered temperature-sensitive electronic-skin(e-skin) for real-time monitoring body temperature without external electricity power was fabricated from patterned polydimethylsiloxane/polyaniline(PDMS/PANI) nanostructures. The e-skin can be feasibly attached on the human body and driven by the mechanical motion energy through triboelectric effect. The outputting triboelectric impulse of the PDMS/PANI units is significantly dependent on the local surface temperature of the eskin, serving as both the power source and temperature sensing signal. The outputting current of the e-skin increases with increasing surface temperature of the device. Under applied bending deformation,the response of the e-skin is up to 63.6 for 38.6℃. The e-skin can detect minimum temperature change of 0.4℃. The working mechanism can be ascribed to the coupling effect of triboelectric and semiconductor properties(tribotronic effect). A practical application of the e-skin attaching on the human body for detecting the body temperature range of 36.5–42.0℃ has been simply demonstrated. This work provides a viable method for real-time monitoring body temperature, and can promote the development of wearable temperature sensors and self-powered multifunctional nanosystems. | Zize Liu Tianming Zhao Hongye Guan Tianyan Zhong Haoxuan He Lili Xing Xinyu Xue | 2019 | Journal of Materials Science & Technology2019，35，10： | 1 |
| 18 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，： | 1 |
| 19 | Immersion and invariance adaptive control of nonlinearly parameterized nonlinear systems\显示文摘 | LIU Xiangbin ORTEGA R SU Hongye | 2010 | IEEE Transactions on Automatic Control2010，55，9： | 1 |
| 20 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，4： | 1 |
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