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| 1 | Role of secondary aerosols in haze formation in summer in the Megacity Beijing显示文摘A field experiment from 18 August to 8 September 2006 in Beijing, China, was carried out. A hazy day was defined as visibility < 10 km and RH(relative humidity) < 90%. Four haze episodes, which accounted for ~ 60% of the time during the whole campaign, were characterized by increases of SNA(sulfate, nitrate, and ammonium) and SOA(secondary organic aerosol) concentrations. The average values with standard deviation of SO2-+4, NO-3, NH4 and SOA were 49.8(± 31.6), 31.4(±22.3), 25.8(±16.6) and 8.9(±4.1) μg/m3, respectively, during the haze episodes, which were 4.3, 3.4, 4.1, and 1.7 times those in the non-haze days. The SO2-4,NO-3, NH+4, and SOA accounted for 15.8%, 8.8%, 7.3%, and 6.0% of the total mass concentration of PM10 during the non-haze days. The respective contributions of SNA species to PM10 rose to about27.2%, 15.9%, and 13.9% during the haze days, while the contributions of SOA maintained the same level with a slight decrease to about 4.9%. The observed mass concentrations of SNA and SOA increased with the increase of PM10 mass concentration, however, the rate of increase of SNA was much faster than that of the SOA. The SOR(sulfur oxidation ratio) and NOR(nitrogen oxidation ratio) increased from non-haze days to hazy days, and increased with the increase of RH. High concentrations of aerosols and water vapor favored the conversion of SO2 to SO2-4and NO2 to NO-3, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing. | Tingting Han Xingang Liu Yuanhang Zhang Yu Qu Limin Zeng Min Hu Tong Zhu | 2015 | Journal of Environmental Sciences2015，27，5： | 22 |
| 2 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 3 | Pretreatment with Danhong injection protects the brain against ischemia-reperfusion injury显示文摘Danhong injection(DHI),a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii,is widely used in China for treating acute ischemic stroke.In the present study,we explored the neuroprotective efficacy of DHI in a rat model of temporary middle cerebral artery occlusion,and evaluated the potential mechanisms underlying its effects.Pretreatment with DHI(0.9 and 1.8 mL/kg)resulted in a significantly smaller infarct volume and better neurological scores than pretreatment with saline.Furthermore,DHI significantly reduced the permeability of the blood-brain barrier,increased occludin protein expression and decreased neutrophil infiltration,as well as profoundly suppressing the upregulation of matrix metallopeptidase-9 expression seen in rats that had received vehicle.Matrix metallopeptidase-2 expression was not affected by ischemia or DHI.Moreover,DHI(1.8 mL/kg)administered 3 hours after the onset of ischemia also improved neurological scores and reduced infarct size.Our results indicate that the neuroprotective efficacy of DHI in a rat model of cerebral ischemia-reperfusion injury is mediated by a protective effect on the blood-brain barrier and the reversal of neutrophil infiltration. | Shaoxia Wang Hong Guo Xumei Wang Lijuan Chai Limin Hu Tao Zhao Buchang Zhao Xiaoxu Tan Feifei Jia | 2014 | Neural Regeneration Research2014，9，15： | 12 |
| 4 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 5 | Investigation of carbonyl compound sources at a rural site in the Yangtze River Delta region of China显示文摘Carbonyl compounds are important intermediates in atmospheric photochemistry, but their primary sources are still not understood well. In this work, carbonyls, hydrocarbons,and alkyl nitrates were continuously measured during November 2011 at a rural site in the Yangtze River Delta region of China. Mixing ratios of carbonyls and hydrocarbons showed large fluctuations during the entire measurement. The average level for total measured volatile organic compounds during the pollution episode from 25 th to 27 th November, 2011 was 91.6 ppb, about 7 times the value for the clean period of 7th–8th, November, 2011. To preliminarily identify toluene sources at this site, the emission ratio of toluene to benzene(T/B) during the pollution episode was determined based on photochemical ages derived from the relationship of alkyl nitrates to their parent alkanes. The calculated T/B was5.8 ppb/ppb, significantly higher than the values of 0.2–1.7 ppb/ppb for vehicular exhaust and other combustion sources, indicating the dominant influence of industrial emissions on ambient toluene. The contributions of industrial sources to ambient carbonyls were then calculated using a multiple linear regression fit model that used toluene and alkyl nitrates as respective tracers for industrial emission and secondary production. During the pollution episode, 18.5%, 69.0%, and 52.9% of measured formaldehyde, acetaldehyde, and acetone were considered to be attributable to industrial emissions. The emission ratios relative to toluene for formaldehyde, acetaldehyde, and acetone were determined to be 0.10, 0.20 and0.40 ppb/ppb, respectively. More research on industrial carbonyl emission characteristics is needed to understand carbonyl sources better. | Ming Wang Wentai Chen Min Shao Sihua Lu Limin Zeng Min Hu | 2015 | Journal of Environmental Sciences2015，27，2： | 8 |
| 6 | Oxygen adsorption/desorption behavior of YBaCo4O7+δ and its application to oxygen removal from nitrogen显示文摘A new medium-temperature (200-400℃) adsorbent material for oxygen removal and air separation, YBaCo4O7+β, was prepared by the solid-state reaction method. This new adsorbent could adsorb a large quantity of oxygen in the temperature range of 200-370 ℃. Ad-sorbed oxygen could be released by raising temperature over 400 ℃ or by switching the atmosphere from oxygen to nitrogen. This oxygen adsorption and desorption process had good reproducibility. Taking advantage of this unique oxygen intake/release behavior, a nitrogen puri-fication process was investigated. The results showed that YBaCo4O7+δ material was a promising candidate for the oxygen sorption process and could be used to produce high-purity nitrogen or to remove trace oxygen from other gases. | HAO Haoshan ZHAO Limin FIU Jie HU Xing HOU Hongwei | 2009 | Journal of Rare Earths2009，27，5： | 8 |
| 7 | Daytime HONO formation in the suburban area of the megacity Beijing, China显示文摘Nitrous acid(HONO),as a primary precursor of OH radicals,has been considered one of the most important nitrogencontaining species in the atmosphere.Up to 30%of primary OH radical production is attributed to the photolysis of HONO.However,the major HONO formation mechanisms are still under discussion.During the Campaigns of Air Quality Research in Beijing and Surrounding Region(CAREBeijing2006)campaign,comprehensive measurements were carried out in the megacity Beijing,where the chemical budget of HONO was fully constrained.The average diurnal HONO concentration varied from 0.33 to 1.2 ppbv.The net OH production rate from HONO,POH(HONO)net,was on average(from 05:00 to 19:00)7.1×106 molecule/(cm3 s),2.7 times higher than from O3 photolysis.This production rate demonstrates the important role of HONO in the atmospheric chemistry of megacity Beijing.An unknown HONO source(Punknown)with an average of 7.3×106molecule/(cm3 s)was derived from the budget analysis during daytime.Punknown provided four times more HONO than the reaction of NO with OH did.The diurnal variation of Punknown showed an apparent photo-enhanced feature with a maximum around 12:00,which was consistent with previous studies at forest and rural sites.Laboratory studies proposed new mechanisms to recruit NO2 and J(NO2)in order to explain a photo-enhancement of of Punknown.In this study,these mechanisms were validated against the observation-constraint Punknown.The reaction of exited NO2 accounted for only 6%of Punknown,and Punknown poorly correlated with[NO2](R=0.26)and J(NO2)[NO2](R=0.35).These results challenged the role of NO2 as a major precursor of the missing HONO source. | YANG Qiang SU Hang LI Xin CHENG YaFang LU KeDing CHENG Peng GU JianWei GUO Song HU Min ZENG LiMin ZHU Tong ZHANG YuanHang | 2014 | Science China Chemistry2014，57，7： | 8 |
| 8 | Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models显示文摘Objective: Triple-negative breast cancer(TNBC) is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu(TBM), the rhizome of Bolbostemma paniculatum(Maxim.) Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu(ETBM) on TNBC orthotopic mouse models and cell lines.Methods: We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis applied to explore the pathways influenced by ETBM.Moreover, quantitative real-time polymerase chain reactions(q RT-PCR) and Western blot were delivered to confirm the gene expression changes.Results: ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1(ITGβ1), integrin β8(ITGβ8) and Rho GTPase activating protein 5(ARHGAP5), which disabled the focal adhesion pathway and caused change in cell morphology.Conclusions: This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC. | Jingxiao Wang Xinjie Yang Haibo Han Limin Wang Weiqian Bao Shanshan Wang Robert M.Hoffman Meng Yang Hui Qi Chao An Kaiwen Hu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 8 |
| 9 | Superior CO2 uptake on nitrogen doped carbonaceous adsorbents from commercial phenolic resin显示文摘In this study,N-doped porous carbons were produced with commercial phenolic resin as the raw material,urea as the nitrogen source and KOH as the activation agent.Different from conventional carbonization-nitriding-activation three-step method,a facile two-step process was explored to produce N-incorporated porous carbons.The as-obtained adsorbents hold superior CO2 uptake,i.e.5.01 and 7.47 mmol/g at 25℃and 0℃under 1 bar,respectively.The synergistic effects of N species on the surface and narrow micropores of the adsorbents decide their CO2 uptake under 25℃and atmospheric pressure.These phenolic resin-derived adsorbents also possess many extremely promising CO2 adsorption features like good recyclability,quick adsorption kinetics,modest heat of adsorption,great selectivity of CO2 over N2 and outstanding dynamic adsorption capacity.Cheap precursor,easy preparation strategy and excellent CO2 adsorption properties make these phenolic resin-derived N-doped carbonaceous adsorbents highly promising in CO2 capture. | Shenfang Liu Linli Rao Pupu Yang Xinyi Wang Linlin Wang Rui Ma Limin Yue Xin Hu | 2020 | Journal of Environmental Sciences2020，32，7： | 6 |
| 10 | Recent advances in persulfate-based advanced oxidation processes for organic wastewater treatment显示文摘In recent years,with the emergence of new pollutants,the effective treatment of wastewater has become very important.Persulfate-based advanced oxidation processes have been successfully applied to the treatment of wastewater,such as wastewater containing antibiotics,pharmaceuticals and personal care products,dyes,endocrine-disrupting chemicals,chlorinated organic pollutants,and phenolics,for the degradation of refractory organic contaminants.This paper summarizes the production of sulfate radicals,which can be generated by the activation of persulfate via conventional and emerging approaches.The existing problems of persulfate-based advanced oxidation processes were analyzed in detail,including residual sulfates,coexisting factors(coexisting inorganic anions and natural organic matter),and energy consumption.This paper proposes corresponding possible solutions to the problems mentioned above,and this paper could provide a reference for the application of persulfate-based advanced oxidation processes in actual wastewater treatment. | Ke Tian Limin Hu Letian Li Qingzhu Zheng Yanjun Xin Guangshan Zhang | 2022 | Chinese Chemical Letters2022，33，10： | 5 |
| 11 | The Effect of Home-Based Cardiac Rehabilitation on Functional Capacity,Behavior,and Risk Factors in Patients with Acute Coronary Syndrome in China显示文摘Aim:To investigate the effect of home-based cardiac rehabilitation on functional capacity,health behavior,and risk factors in patients with acute coronary syndrome in China.Methods:Eighty patients with acute coronary syndrome were enrolled in this prospective randomized controlled study.Patients in the cardiac rehabilitation group(n=52)received home-based cardiac rehabilitation with a heart manual and a home exercise video for 3 months and patients in the control group(n=28)received only routine secondary prevention.The 6-min walk distance,laboratory test results,healthy behavior(questionnaire),quality of life(12-item Short Form Health Survey),anxiety(7-item Generalized Anxiety Disorder Questionnaire),and depression(9-item Patient Health Questionnaire)were evaluated at the beginning and after treatment for 3 months.Results:Compared with baseline data,52 patients who participated in cardiac rehabilitation had longer 6-min walk distance(515.26±113.74 m vs 0.445.30±97.92 m,P<0.0002),higher proportions of“always exercise”(78.26% vs.28%,P<0.05),“always limit food with sugar”(65.22% vs 12%,P<0.05),“always eat fruits 200–400 g every day”(82.61% vs.4%,P<0.05).and“always eat vegetables 300–500 g every day”(21.74%vs.12%,P<0.06)after treatment for 3 months.The low-density lipoprotein cholesterol control rate(52.17% vs.28%,P<0.05)and the systolic blood pressure control rate(100%vs.68%,P<0.05)were also signifi cantly increased after treatment for 3 months in the cardiac rehabilitation group.No signifi cant increase was found in the control group after treatment for 3 months.No cardiac-event related to home exercise was reported in both groups.Conclusion:Home-based cardiac rehabilitation is a feasible and available cardiac rehabilitation mode in China. | Rongjing Ding Jianchao Li Limin Gao Liang Zhu Wenli Xie Xiaorong Wang Qin Tang Huili Wang Dayi Hu | 2017 | Cardiovascular Innovations and Applications2017，，B02： | 5 |
| 12 | A looped heat-driven thermoacoustic refrigeration system with direct-coupling configuration for room temperature cooling显示文摘Heat-driven thermoacoustic refrigeration has drawn extensive concern in the past decades due to its advantages of high reliability and external heat-driven mechanism.In such a system,heat can be firstly converted into acoustic power and then the acoustical power drives a refrigerator to generate cooling effect without any moving mechanical components.So far,most of researches on heat-driven thermoacoustic refrigeration have focused on cryo- genic application,such as natural gas liquefaction [1,2].In addition, heat-driven thermoacoustic refrigeration also plays important roles in recovering waste heat and provides an environment- friendly alternative to the current abso'rption chiller especially in the small-scale power range [3-7].However,two main obstacles to use the thermoacoustic technology in practice are its relatively low cooling capacity and low cooling efficiency.Either the two-loop configuration proposed by Luo et al.[5]or the configuration of a one-unit refrigerator driven by a three-unit engine brought forward by Kees [6],they both suffer from phase-shifting tube and mismatch between the thermoacoustic engine (TAE)and thermoacoustic refrigerator (TAR). | Huizhi Wang Limin Zhang Guoyao Yu Jianying Hu Ercang Luo Ying Ma Chao Jiang Xianxian Liu | 2019 | Science Bulletin2019，64，1： | 4 |
| 13 | Phase boundary engineering of metal-organic-framework-derived carbonaceous nickel selenides for sodium-ion batteries显示文摘Nano Research volume 13,pages2289–2298(2020)Cite this article 347 Accesses 1 Altmetric Metrics details Abstract Sodium-ion batteries(SIBs)are promising power sources due to the low cost and abundance of battery-grade sodium resources,while practical SIBs suffer from intrinsically sluggish diffusion kinetics and severe volume changes of electrode materials.Metal-organic framework(MOFs)derived carbonaceous metal compound offer promising applications in electrode materials due to their tailorable composition,nanostructure,chemical and physical properties.Here,we fabricated hierarchical MOF-derived carbonaceous nickel selenides with bi-phase composition for enhanced sodium storage capability.As MOF formation time increases,the pyrolyzed and selenized products gradually transform from a single-phase Ni3Se4 into bi-phase NiSex then single-phase NiSe2,with concomitant morphological evolution from solid spheres into hierarchical urchin-like yolk-shell structures.As SIBs anodes,bi-phase NiSex@C/CNT-10h(10 h of hydrothermal synthesis time)exhibits a high specific capacity of 387.1 mAh/g at 0.1 A/g,long cycling stability of 306.3 mAh/g at a moderately high current density of 1 A/g after 2,000 cycles.Computational simulation further proves the lattice mismatch at the phase boundary facilitates more interstitial space for sodium storage.Our understanding of the phase boundary engineering of transformed MOFs and their morphological evolution is conducive to fabricate novel composites/hybrids for applications in batteries,catalysis,sensors,and environmental remediation. | Shiyao Lu Hu Wu Jingwei Hou Limin Liu Jiao Li Chris J.Harris Cheng-Yen Lao Yuzheng Guo Kai Xi Shujiang Ding Guoxin Gao Anthony K.Cheetham R.Vasant Kumar | 2020 | Nano Research2020，13，8： | 4 |
| 14 | Influence of external electric field on piezotronic effect in ZnO nanowires显示文摘In this work, the piezotronic effect is investigated for the first time in external electric fields ranging from 0 V·cm-I to 2,000 V·cm-1 by using n-type ZnO nanowires supported by a flexible substrate. In the presence of an external electric field, the Schottky barrier height (SBH) is lowered by the image force, allowing more free carriers to pass through the metal-semiconductor junction and enhancing the screening effect on positive piezoelectric polarization charges. As the strength of the external electric field increases, the piezotronic effect is significantly suppressed and the metal-semiconductor contact finally exhibits Ohmic behavior. The experimental results show that devices can be classified into three groups, corresponding to low, moderate, and high carrier densities of the nanowires used. This work not only helps us to explicate the basic physical mechanism of the piezotronic effect in a harsh environment in an electric field but also provides guidelines for future design and fabrication of piezotronic devices. | Fei Xue Limin Zhang Xiaolong Feng Guofeng Hu Feng Ru Fan Xiaonan Wen Li Zheng Zhong Lin Wang | 2015 | Nano Research2015，8，7： | 4 |
| 15 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication显示文摘Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein(GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A(VAP-A) in competition with the HCV NS5 A, causing an interruption of the complex formation between VAP-A and HCV NS5 A. As the formation of VAP-A/NS5 A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5 A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents(DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication. | Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 16 | Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America显示文摘Comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA;see definitions of EA and NA in Fig. S1 A) share similar geographical environments with comparable latitude, land area and climate. | Haihua Hu Jianfei Ye Bing Liu Lingfeng Mao Stephen A.Smith Russell L.Barrett Pamela S.Soltis Douglas E.Soltis Zhiduan Chen Limin Lu | 2022 | National Science Review2022，9，6： | 3 |
| 17 | Effects of carrier and Mn loading on supported manganese oxide catalysts for catalytic combustion of methane显示文摘支持的锰氧化物催化剂被早期的湿受精方法为甲烷作好准备支持的催化燃烧,和效果(艾尔 2 装载的 O 3, SiO 2 和 TiO 2) 和 Mn 被调查。这些催化剂与 N 2 吸附, X 光检查衍射, X 光检查光电子光谱学和规划温度的减小技术被描绘。甲烷变换在取决于支持或 Mn 装载的一个大范围变化了。艾尔 2 O 3 支持了更好展出的 15% Mn 催化剂向甲烷的活动催化氧化。锰状态和氧种类在催化表演起了一个重要作用。 | Jinyan Hu Wei Chu Limin Shi | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 18 | S-wave Q structure of the crust and upper mantle beneath Yunnan from surface waves显示文摘A phase-matched filtering technique is applied to extract fundamental mode signals from Rayleigh waves recorded at 62 digital seismic stations in the Yunnan and Sichuan regions.We use the fundamental mode of vibrations at two stations that are located on the same great circle as the focus to calculate an inter-station attenuation coefficient of the Rayleigh wave with periods between 0.40 and 80.64 s,and invert for the inter-station S-wave Q-factor (Qβ) at depths of 0-200 km.The results indicate that Qβ in Yunnan is 20-140,presenting a low Qβ background with apparent lateral variation.Taking the Honghe Fault as the boundary,Qβ of the crust is only 20 on the west side,extending to a depth of 120 km.The distribution of Qβ is consistent with large-scale Cenozoic volcanic and intrusive rocks in western Yunnan,implying that the crust and mantle are in the thermally active state.In the eastern Yunnan Block,east of the Xiaojiang Fault,Qβ in the upper 120 km is 140 in the south but only 20 in the north.Additionally,around the Dukou-Chuxiong in the mid-Yunnan Block,Qβ in the lithosphere is relatively high at 60-100,corresponding to a stiff crust.This is because the suture between the Indian and Eurasian plates reversed the tension in the rifting stage into the compression of orogenesis,leading to the closure of a gap in the crust.After some time,interstitial fluids gradually disappeared,resulting in a high velocity layer in the crust and low heat flow on the surface.The Yunnan region consists of an obvious block of elevated Qβ,distributed within the low background,consistent with the distribution of heat-flow values on the surface.The Honghe and Xiaojiang faults are tectonic boundaries in addition to being boundaries between regions of high and low crustal Qβ.The low Qβ is probably the result of crustal rupture and disturbance caused by strong earthquakes and the upwelling of hot substances along the deep fault zones. | CHEN Jia HU JiaFu YANG HaiYan ZHANG XiaoMan WEN LiMin PENG HengChu | 2012 | Science China Earth Sciences2012，55，5： | 3 |
| 19 | Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population:a case-control study显示文摘Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) risk.This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.Methods:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese population.Results:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC risk.Conclusion:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population. | Limin Miao Lihua Wang Longbiao Zhu Jiangbo Du Xun Zhu Yuming Niu Ruixia Wang Zhibin Hu Ning Chen Hongbing Shen Hongxia Ma | 2016 | Chinese Journal of Cancer2016，35，11： | 2 |
| 20 | The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosisthrough inhibition of de novo lipogenesis in high-fructose-fed rats显示文摘 | Lu-Ping Ren Guang-Yao Song Zhi-Juan Hu Mingming Zhang Lanbo Peng Shu-Chun Chen Limin Wei Fan Li Wen Sun | 2013 | International Journal of Molecular Medicine2013，，： | 2 |
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