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| 1 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 2 | Emergency material scheduling optimization model and algorithms:A review显示文摘In the emergency management of disruptions,efficient emergency material scheduling(EMS) is a key factor to save people’s lives and reduce loss.Based on the literature of EMS and related areas in recent years,the research was summarized from two aspects of EMS optimization model and algorithms.It is concluded that the EMS optimization models mainly aim at the shortest time,shortest distance,minimum cost,maximum satisfaction and fairness,etc.The constraints usually include the quantity of supply depots,relief supply and vehicles,the types of commodities,the road network conditions,the budgets and the demand forecast of emergency materials.Multi-objective model is more complex and it usually considers more than one objective.To find the optimized solution,the multiobjective model with complex constraints needs more efficient algorithms.The existing algorithms,including mathematic algorithm and heuristic algorithm,have been categorized.For NP-hard(non-deterministic polynomial hard) problems,heuristic algorithms should be designed,which mainly include genetic algorithm(GA),ant colony optimization(ACO),particle swarm optimization(PSO),etc.Based on the characteristics of the optimization model and various algorithms,appropriate algorithm or tools should be chosen and designed to obtain the optimized solution of EMS model.Finally,the development trends of EMS optimization model and algorithm in the future are proposed. | Hui Hu Jing He Xiongfei He Wanli Yang Jing Nie Bin Ran | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，5： | 11 |
| 3 | Quality of information disclosure, property rights, and bank loans: A bank heterogeneity perspective显示文摘Using the context of the financial reform and the development of the non-state sector in China in the past decade, we examine the roles that the quality of information disclosure and property rights play in the allocation of different types of bank credit. We find that foreign banks and policy banks exercise ‘‘financial discrimination,' and that local commercial banks, large state- owned commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks not only exercise financial discrimination but also provide significant ‘‘financial support' to non-state-owned enterprises by providing more lending opportunities and larger loans. However, when enterprises commit information disclosure violations, the local commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks reverse their credit decisions and begin to exercise financial dis- crimination against non-state-owned enterprises. At the same time, large stateowned commercial banks continue to provide financial support to non-state-owned enterprises. We also find that the quality of the information disclosed by enterprises has a moderating effect rather than an intermediary effect on the relationship between property rights and bank loans. Overall, the results of this paper shine new light on the market-oriented reform of the banking industry, and provide new empirical evidence for the presence of financial discrimination in the supply of bank credit. Our findings also have practical implications for solving the financing difficulties of non-state-owned enterprises. | Xichan Chen Wanli Li Shiyang Hu Xing Liu | 2019 | China Journal of Accounting Research2019，，1： | 2 |
| 4 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 5 | Ultrafiltration of dissolved organic matter in surface water by a polyvinylchloride hollow fiber membrane显示文摘 | Guo Xiaoya Li Qilin Hu Wanli | 2009 | Joumal of Membrane Science2009，327，12： | 1 |
| 6 | Developing in situ electron paramagnetic resonance characterization for understanding electron transfer of rechargeable batteries显示文摘Electrochemical energy storage devices are pivotal in achieving“carbon neutrality”by enabling the storage of energy generated from renewable sources.To facilitate the development of these devices,it is important to gain insight into the underlying the single-/multi-electron transfer process.This can be achieved through in-time detection under operational conditions,but there are limited tools available for monitoring electron transfer under operando conditions.Electron paramagnetic resonance(EPR)is a powerful technique that can meet these expectations,as it is highly sensitive to unpaired electrons and can detect changes of paramagnetic centres.Despite the long history of in situ electrochemical EPR research,its potential has been surprisingly underutilized due to the need for strict operando cell design under special testing conditions.This review comprehensively summarizes recent efforts to understand energy storage mechanisms using in situ/operando EPR,with the aim of drawing researchers’attention to this powerful technique.After introducing the fundamental principles of EPR,we describe the critical advances made in detecting batteries using operando EPR,along with the remaining challenges and opportunities for future development of this technology in batteries.We emphasize the need for strict operando cell design and the importance of designing experiments that closely mimic real-world conditions.We believe that this review will provide innovative solutions to solve tough problems that researchers may encounter during their battery research,and ultimately contribute to the development of more efficient and sustainable energy storage devices. | Bin Wang Wanli Wang Kang Sun Yujie Xu Yi Sun Qiang Li Han Hu Mingbo Wu | 2023 | Nano Research2023，16，10： | 1 |
| 7 | Study on Uhrafiltration for Surface Water by a Polyvinylchloride Hollow Fiber Membrane 显示文摘 | Guo X Chen Xi Hu Wanli | 2009 | Desalination2009，238，： | 1 |
| 8 | In Situ Synthesis of Cuprous Oxide/Cellulose Nanofibers Gel and Antibacterial Properties显示文摘Cellulose nanofibers were synthesized by acetobacter xylinum(xylinum 1.1812).The cellulose nanofibers with 30-90 nm width constructed three-dimension network gel,which could be used as a wound dressing since it can provide moist environment to a wound.However,cellulose nanofibers have no antimicrobial activity to prevent wound infection.To achieve antimicrobial activity,the cellulose nanofibers can load cuprous oxide(Cu2O)particles on the surface.The cuprous oxide is a kind of safe antibacterial material.The copper ions can be reduced into cuprous oxides by reducing agents such as glucose,N2H4 and sodium hypophosphite.The cellulose nanofibers network gel was soaked in CuSO4 solution and filled with copper ions.The cuprous oxide nanoparticles were in situ synthesized by glucose and embedded in cellulose nanofibers network.The morphologies and structure of the composite gel were analyzed by FESEM,FTIR,WAXRD and inductively coupled plasma(ICP).The sizes of Cu2O embedded in cellulose nanofibers network are 200-500 nm wide.The peak at 605 cm−1 attributed to Cu(I)-O vibration of Cu2O shits to 611 cm−1 in the Cu2O/cellulose composite.The Cu2O/cellulose nanofibers composite reveals the obvious characteristic XRD pattern of Cu2O and the results of ICP show that the content of Cu2O in the composite is 13.1%.The antibacterial tests prove that the Cu2O/cellulose nanofibers composite has the high antibacterial activities which is higher against S.aureus than against E.coli. | Ying Hu Qinfei Ke Zhe Li Wanli Han Zhiyong Yan | 2018 | Computers, Materials & Continua2018，，9： | 1 |
| 9 | Fabrication and conductive characteristic of highly oriented LaNiO3 thin films显示文摘 | Hu Wencheng Yang Chuanren Zhang Wanli | 2007 | Integrated Ferr0electr2007，91，1： | 1 |
| 10 | Ultrafiltration of dissolved organic matter in surface water by a polyvinylchloride hollow fiber membrane显示文摘 | Guo Xiaoyan Li Qilin Hu Wanli | 2009 | Membr Sci2009，，327： | 1 |
| 11 | Digital twins in smart farming:An autoware-based simulator for autonomous agricultural vehicles显示文摘Digital twins can improve the level of control over physical entities and help manage complex systems by integrating a range of technologies.The autonomous agricultural machine has shown revolutionary effects on labor reduction and utilization rate in field works.Autonomous vehicles in precision agriculture have the potential to improve competitiveness compared to current crop production methods and have become a research hotspot.However,the development time and resources required in experiments have limited the research in this area.Simulation tools in unmanned farming that are required to enable more efficient,reliable,and safe autonomy are increasingly demanding.Inspired by the recent development of an open-source virtual simulation platform,this study proposed an autoware-based simulator to evaluate the performance of agricultural machine guidance based on digital twins.Oblique photogrammetry using drones is used to construct threedimensional maps of fields at the same scale as reality.A communication format suitable for agricultural machines was developed for data input and output,along with an inter-node communication methodology.The conversion,publishing,and maintenance of multiple coordinate systems were completed based on ROS(Robot Operating System).Coverage path planning was performed using hybrid curves based on Bézier curves,and it was tested in both a simulation environment and actual fields with the aid of Pure Pursuit algorithms and PID controllers. | Xin Zhao Wanli Wang Long Wen Zhibo Chen Sixian Wu Kun Zhou Mengyao Sun Lanjun Xu Bingbing Hu Caicong Wu | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 12 | Electronic band energy of a bent ZnO piezoelectric semiconductor nanowire显示文摘The electric band energy variation in a bent piezoelectric semiconductor(PSC) nanowire of circular cross-section induced by the mechanical force is analyzed based on a six-band k · p method. The electric-mechanical fields are first obtained analytically in a cantilever bent PSC nanowire by solving the fully-coupled electro-mechanical equations. Then, the band energy is acquired numerically via the six-band Hamiltonian.By considering further the nonlinear coupling between the piezoelectric and semiconducting quantities, the contribution of the redistribution carriers to the electric field is analyzed from the Gauss’ s law. Numerical examples are carried out for an n-type Zn O nanowire in different locations induced by an applied concentrated end force. They include the electric potential, heavy hole(HH), light hole(LH), spin-orbit split-off(SO),and conduction band(CB) edges along the axial and thickness directions. Our results show that the applied force has a significant effect on the band energies. For instance, on the bottom surface along the axial direction, the bandgaps near the fixed end are greater than those near the loading end, and this trend is reversed on the top surface. Moreover,at a fixed axial location, the energy level of the lower side can be enhanced by applying a bending force at the end. The present results could be of significant guidance to the electronic devices and piezotronics. | Wanli YANG Yuantai HU E.N.PAN | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，6： | 0 |
| 13 | A full-coupling model of PN junctions based on the global-domain carrier motions with inclusion of the two metal/semiconductor contacts at endpoints显示文摘A full-coupling model on the current-voltage(J-V)characteristics of PN junctions is put forward in the paper by taking into account both the whole junction and the two electrode regions consisting of metal/semiconductor(M/S)contacts.The depletion layer assumption proposed by the Shockley model is discarded.Gauss’law on the electric potential and the electric field is applied in the whole junction region such that the majority-carrier currents inside and outside the P/N barrier region are able to be exactly defined and clearly calculated.Then,the stable continuity equations of the electron and hole currents are established to show the current conversion between minority-and majority-carriers inside the whole PN junction region.By analyzing all the conversion procedure,the J-V characteristics of a PN junction are obtained with good agreement to the experimental results,which are closely dependent on the minority-carrier lifetime and doping concentrations.Obviously,the study on this topic possesses referential significance to mechanically tuning the performance of piezoelectric PN junctions and piezotronic devices. | Wanli YANG Jinxi LIU Yongliang XU Yuantai HU | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，6： | 0 |
| 14 | erbB4/HER4在非小细胞NSCLC中的表达研究(英文)显示文摘Objective: To test the expression of HER4 in non-small cell lung cancer (NSCLC) and elucidate the relationship between its over-expression and the clinical pathology of NSCLC. Methods: 70 cases of paraffin-embedded tissues from informative NSCLC were tested for the expression of HER4 by means of immunohistochemical assay. Results: HER4 were overexpressed in NSCLC in 91.4%. The overexpression of HER4 correlated only with the lymph node metastasis, TNM staging and survival after operation. Conclusion: ErbB4 is one of the genes to regulate the growth of NSCLC in advanced stages and artificial interference of the overexpression of HER4 in NSCLC might be a good way for the treatment of NSCLC in advanced stages. | Zaichun Deng Wenying Yu Guoping Hu Ruheng Zheng Dunhua Zhang Yunshan Tan Yonghua Xu Wanli Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 0 |
| 15 | Interlayer and intralayer co-modified flexible V_(2)CT_(X) MXene@SWCNT films for high-power Li-ion capacitors显示文摘As an emerging member of the two-dimensional(2D)material family,V_(2)CT_(X)MXene shows great potential in the application of lithium-ion capacitors(LICs)due to its unique structure and excellent electrical conductivity.However,severe nanosheets stacking and intra-layer transport barriers have limited the further development of V_(2)CT_(X)MXene-based materials.Herein,we prepared Kions and–O functional group co-modified V_(2)CT_(X)MXene(VCT-K)and further incorporated it with single-walled carbon nanotube(SWCNT),obtaining freestanding V_(2)CT_(X)composite films(VCT-K@C)with the 3D conductive network.Significantly,K+ions were introduced into V_(2)CT_(X)MXene to stabilize the interlayer structure and prevent the aggregation of nanosheets,the terminal group of–O was controllably modified on the surface of MXene to improve the Li+ions storage reversible capacities and the SWCNT acted as the bridge between MXene nanosheets to opens up the channels for ion/electron transportation in the longitudinal direction.Benefited from the synergistic effect of VCT-K and SWCNT,the VCT-K@C exhibits superior reversible specific capacities of 671.8 mA h g^(-1)at 0.1 A g^(-1)and 318 mA h g^(-1)at 1.0 A g^(-1).Furthermore,the assembled LICs with VCT-K@C anode coupling activated carbon(AC)cathode deliver an outstanding power density of 19.0 kW kg^(-1)at 67.4 Wh kg^(-1),a high energy density of 140.5 Wh kg^(-1)at 94.8 W kg^(-1)and a stable capacitance retention of 86%after 6000 cycles at 10 A g^(-1).Such unique structures and excellent electrochemical properties are expected to pave the way for the large-scale application in LICs of MXene-based materials. | Wanli Wang Min Feng Enze Hu Zhaowei Hu Cheng Fan Huifang Li Peng Wang Xiaojun Wang Zhiming Liu | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 16 | Correlation between level of serum prolactin and epileptic discharges of electroencephalogram from 24 to 36 hours after epileptic onset显示文摘BACKGROUND: Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value 2 hours after the seizure occurred. The mechanism might result in an increase of serum prolactin concentrations with the activation of the hypothalamic-pituitary axis. OBJECTIVE:To probe into the correlation between changes of serum prolactin and incidence of epileptic discharges of electroencephalogram (EEG) at 24-36 hours after epileptic onset of patients with secondary epilepsy. DESIGN: Clinical observational study. SETTING: Department of Neurology, First Hospital affiliated to Soochow University. PARTICIPANTS: A total of 21 patients with secondary epilepsy were selected from the Department of Neurological Emergency or Hospital Room of the First Hospital affiliated to Soochow University from November 2005 to April 2006. There were 14 males and 7 females aged from 25 to 72 years. All patients met International League Anti-epileptic (ILAE) criteria in 1981 for secondary generalized tonic clonic seizure through CT or MRI and previous EEG. All patients were consent. Primary diseases included cerebral trauma (3 cases), tumor (2 cases), stroke (7 cases) and intracranial infeion (9 cases). METHODS: Venous blood of all patients was collected at 24-36 hours after epileptic onset. Serum prolactin kit (Beckman Coulter, Inc in USA) was used to measure value of serum prolactin according to kit instruction. Then, value of serum prolactin was compared with the normal value (male: 2.64-13.13 mg/L; female: 3.34-26.72 mg/L); meanwhile, EEG equipment (American Nicolet Incorporation) was used in this study. MAIN OUTCOME MEASURES: ① Abnormal rate of serum prolactin of patients with secondary epilepsy; ②Comparison between normal and abnormal level of serum prolactin and incidence of EEG epileptic discharge of patients with secondary epilepsy. RESULTS:All 21 patients with secondary epilepsy were involved in the final analysis. ① Results of serum prolactin level: Among 21 patients with of secondary epilepsy, 10 of them had normal serum prolactin and 11 had abnormal one, and the abnormal rate was 52% (11/21). ② Detecting results of EEG: EEG results showed that 6 cases were normal and 15 were abnormal, and the abnormal rate was 71% (15/21). The symptoms were sharp wave, spike wave or sharp slow wave, spike slow wave of epileptic discharges in 8 cases, which was accounted for 38%. ③ Correlation between abnormality of serum prolactin and EEG epileptic wave: Eleven cases had abnormal serum prolactin, and the incidence was 64% (7/11), which was higher of epileptic wave than that of non-epileptic wave [36% (4/11), P < 0.05]; however, 10 cases had normal serum prolactin, and the incidence was 10% (1/10). Epileptic wave was lower than non-epileptic wave [90% (9/10), P < 0.01]. CONCLUSION: The level of serum prolactin of patients with secondary epilepsy is abnormally increased at 24-36 hours after epileptic onset; in addition, incidence of epileptic discharge is also increased remarkably. | Xiaowei Hu Wanli Dong Min Xu | 2006 | Neural Regeneration Research2006，1，3： | 0 |
| 17 | The mechanism to reform dynamic performance of an elastic wave-front in a piezoelectric semiconductor by the wave-carrier interaction induced from static biasing fields显示文摘The propagation of an elastic wave(EW)in a piezoelectric semiconductor(PSC)subjected to static biasing fields is investigated.It is found that there exist two coupling waves between electric field and charge carriers.One is stimulated by the action of the polarized electric field in the EW-front on charge carriers(EFC),and the other is stimulated by the action of initial electric field in biasing fields on dynamic carriers(IEC).Obviously,the latter is a man-made and tunable wave-carrier interaction.A careful study shows that IEC can play a leading role in remaking dynamic performance of the wave-front and an inter-medium role in transferring energy from biasing fields to EW-fronts.Hence,a method is proposed to reform the EW performance by biasing-fields:reforming the dispersivity of EW-fronts by promoting competition between IEC and EFC and inverting the dissipation by the IEC to transfer energy from biasing fields to EWfronts.The corresponding tuning laws on the phase-frequency characteristics of an EW show that the wave velocity can be regulated smaller than the pure EW velocity at a lowfrequency and larger than the pure piezoelectric wave velocity at a high-frequency.As for regulating the amplitude-frequency characteristics of the EW by the IEC,analyses show that EWs can obtain amplification only for those with relatively high vibration frequencies(small wave lengths).The studies will provide guidance for theoretical analysis of waves propagating in PSCs and practical application and design of piezotronic devices. | Wanli YANG Jinxi LIU Yizhan YANG Yuantai HU | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，3： | 0 |
| 18 | Triboelectric nanogenerators:the beginning of blue dream显示文摘Wave energy is inexhaustible renewable energy.Making full use of the huge ocean wave energy resources is the dream of mankind for hundreds of years.Nowadays,the utilization of water wave energy is mainly absorbed and transformed by electromagnetic generators(EMGs)in the form of mechanical energy.However,waves usually have low frequency and uncertainty,which means low power generation efficiency for EMGs.Fortunately,in this slow current and random direction wave case,the triboelectric nanogenerator(TENG)has a relatively stable output power,which is suitable for collecting blue energy.This article summarizes the main research results of TENG in harvesting blue energy.Firstly,based on Maxwell’s displacement current,the basic principle of the nanogenerator is expounded.Then,four working modes and three applications of TENG are introduced,especially the application of TENG in blue energy.TENG currently used in blue energy harvesting is divided into four categories and discussed in detail.After TENG harvests water wave energy,it is meaningless if it cannot be used.Therefore,the modular storage of TENG energy is discussed.The output power of a single TENG unit is relatively low,which cannot meet the demand for high power.Thus,the networking strategy of large-scale TENG is further introduced.TENG’s energy comes from water waves,and each TENG’s output has great randomness,which is very unfavorable for the energy storage after large-scale TENG integration.On this basis,this paper discusses the power management methods of TENG.In addition,in order to further prove its economic and environmental advantages,the economic benefits of TENG are also evaluated.Finally,the development potential of TENG in the field of blue energy and some problems that need to be solved urgently are briefly summarized. | Wanli Wang Dongfang Yang Xiaoran Yan Licheng Wang Han Hu Kai Wang | 2023 | Frontiers of Chemical Science and Engineering2023，17，6： | 0 |
| 19 | RNA interference affects tumorigenicity and expression of insulin-like growth factor-1,insulin-like growth factor-1 receptor,and basic fibroblast growth factor-2 in rat C6 glioma cells显示文摘BACKGROUND:Human gliomas are more likely to express basic fibroblast growth factor-2(FGF-2), insulin-like growth factor-1(IGF-1),and IGF-1 receptor(IGF-1R) than normal brain tissue.These factors activate signal transduction systems of Ras/MAPK and PI3K/Akt,which promote glioma growth. OBJECTIVE:To utilize RNA interference(RNAi) technique to down-regulate FGF-2,IGF-1,and IGF-1R gene expression,and to investigate the effects of these genes on rat C6 glioma cells,as well as the feasibility of RNAi for treating glioma. DESIGN,TIME AND SETTING:This neurooncological,randomized,controlled,in vivo and in vitro experiment,which used RNAi methodology,was performed at the Laboratory of Molecular Biology, Institute of Biochemistry,Chinese Academy of Sciences between August 2005 and February 2008. MATERIALS:Rat C6 cell lines were purchased from Shanghai Institute of Cellular Biology Affiliated to Chinese Academy of Sciences.Small interfering RNA(siRNA) was synthesized by Shanghai GenePharma.Anti-IGF-1,anti-IGF-1R,anti-FGF-2,anti-mouse and anti-rabbit IgG G1-HRP antibodies were provided by Santa Cruz Biotechnology,USA.Four to six week-old BALB/c nude mice were purchased from the Laboratory Animal Center,Chinese Academy of Sciences. METHODS:C6 glioma cells were transfected with siRNA,which was chemically synthesized in vitro to correspond to endogenous FGF-2,IGF-1,and IGF-1R genes.The inhibition ratio of targeting mRNA expression was detected by semiquantitative RT-PCR,and protein expression was determined by Western blot analysis.C6 glioma cell proliferation was observed using a growth curve. C6 glioma cell apoptosis rate and cell cycle were detected by flow cytometry.C6 glioma cell growth regression was observed by transwell migration assay.In addition,nude mouse subcutaneous tumor models were used in this study.For studying the anti-tumor effects of IGF-1 and IGF-1R siRNA,two blank control groups,with six mice each,were set up:A(2.5μg siRNA was injected one week after C6 cells were inoculated,i.e.,when tumor volume reached 8 mm×8 mm) and B(siRNA was injected at the same time with C6 cells were inoculated.To study the effects of FGF-2 siRNA, the groups consisted of a blank control group,negative control group,2.6μg siRNA group,4μg siRNA group,and 5.3μg siRNA group,with six mice each. MAIN OUTCOME MEASURES:mRNA and protein inhibition ratio of FGF-2,IGF-1,and IGF-1R;C6 glioma cell proliferation,apoptosis,and cycle growth arrest;C6 glioma cell growth regression and subcutaneous tumorigenicity rates. RESULTS:All siRNA constructs proved to be effective.After 48 hours,transfection of 200 nmol/L siRNA resulted in a FGF-2 or IGF-1R gene inhibition ratio>80%and an IGF-1 gene inhibition ratio of approximately 70%.Protein expression levels for FGF-2,IGF-1,and IGF-1R decreased in a dose-dependent manner following siRNA transfection,with an inhibition rate>85%,60%,and 50%, respectively.C6 glioma cell proliferation and apoptosis rates increased in proportion to siRNA.The apoptosis rate of C6 glioma cells induced by FGF-2,IGF-1,and IGF-1R siRNA was 39.96%,15.07%, and 22.47%,respectively(P<0.01).Transfection of 200 nmol/L IGF or IGF-1R siRNA for 48 hours suppressed C6 glioma cell migration.At 30 days after intratumoral injection of 2.6,4,and 5.3μg FGF-2 siRNA,tumor growth regression rate of FGF-2 siRNA was 56%,67%,and 86%,respectively. The tumor growth regression rate was 71.88%and 45.71%,respectively,when IGF-1 or IGF-1R siRNA was intratumorally injected 1 week after C6 glioma cell transplantation.When IGF-1 or IGF-1R siRNA was intratumorally injected during C6 glioma cell transplantation,the tumor growth regression rate was 78.13%and 74.29%,respectively. CONCLUSION:siRNA transfection downregulated gene expression of FGF-2,IGF-1,and IGF-1R. In addition,siRNA treatment markedly suppressed glioma cell proliferation,growth,and migration, and concomitantly reduced subcutaneous tumorigenicity. | Wanli Dong Jin Hu Shaoyan Hu Yuanyuan Wang Juean Jiang Youxin Jin | 2009 | Neural Regeneration Research2009，4，8： | 0 |
| 20 | Effects of mechanical loadings on the performance of a piezoelectric hetero-junction显示文摘A fully-coupled model for a piezoelectric hetero-junction subjected to a pair of stresses is proposed by discarding the depletion layer approximation.The effect of mechanical loadings on PN junction performance is discussed in detail.Numerical examples are carried out for a p-Si/ZnO-n hetero-junction under a pair of stresses acting on the ntype ZnO portion near the PN interface,where ZnO has the piezoelectric property while Si is not.It is found that the bottom of conduction band is lowered/raised near the two loading points due to the decrease/increase in the electron potential energy there induced by a tensile-stress mode via sucking in majority-carriers from two outside regions,which implies appearance of a potential barrier and a potential well near two loading points.Furthermore,the barrier height and well depth gradually become large with increasing tensile stress such that more and more electrons/holes are inhaled in loading region from the n-/p-zone,respectively.Conversely,rising/dropping of conduction band bottom is brought out near the two loading points by a compressive-stress mode due to the increase/decrease in the potential energy of electrons by pumping out the majority-carriers from the loading region to the two outside regions.Therefore,a potential well and a potential barrier are induced near the two loading points,such that more and more electrons/holes are driven away from the loading region to the n-zone/p-zone,respectively,with the increasing compressive stress.These effects are important to tune the carrier recombination rate near the PN interface.Thus,the present study possesses great referential significance to piezotronic devices. | Wanli YANG Renzhong HONG Yunbo WANG Yuantai HU | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，5： | 0 |
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