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| 1 | Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection显示文摘Endoscopic submucosal dissection(ESD)is a common procedure to treat early and precancerous gastrointestinal lesions.Via submucosal injection,a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic incision.Saline is a most common submucosal injection liquid,but the formed liquid pad lasts only a short time,and thus repeated injections increase the potential risk of adverse events.Hydrogels with high osmotic pressure and high viscosity are used as an alternate;however,with some drawbacks such as tissue damage,excessive injection resistance,and high cost.Here,we reported a nature derived hydrogel of gelatin-oxidized alginate(G-OALG).Based on the rheological analysis and compare to commercial endoscopic mucosal resection(EMR)solution(0.25%hyaluronic acid,HA),a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability,higher viscosity and more stable structures.The G-OALG gel also showed lower propulsion resistance than 0.25%HA in the injection force assessment under standard endoscopic instruments,which eased the surgical operation.In addition,the G-OALG hydrogel showed good in vivo degradability biocompatibility.By comparing the results acquired via ESD to normal saline,the G-OALG shows great histocompatibility and excellent endoscopic injectability,and enables create a longer-lasting submucosal cushion.All the features have been confirmed in the living both pig and rat models.The G-OALG could be a promising submucosal injection agent for esophageal ESD. | Chaoqiang Fan Kaige Xu Yu Huang Shuang Liu Tongchuan Wang Wei Wang Weichao Hu Lu Liu Malcolm Xing Shiming Yang | 2021 | Bioactive Materials2021，6，4： | 3 |
| 2 | Anionic formulation of electrolyte additive towards stable electrocatalytic oxygen evolution in seawater splitting显示文摘Hydrogen generation through seawater electrolysis provides a promising,attractive pathway towards the utilization of sustainable energy.However,the catalytic activity and stability of oxygen evolution anode are severely limited by the chloride-induced corrosion and competitive oxidation reactions.In this work,we demonstrate an anion-assisted performance improvement strategy by quick and universal screening of electrolyte additive via correlating Cl-repellency with the anionic properties.Particularly,the addition of phosphate ions is found to enable highly stable alkaline seawater splitting at industry-level current density(0.5 A cm^(-2))over 500 h using transition metal hydroxides as anodic electrocatalysts.In situ experiments and theoretical simulations further reveal that the dynamic anti-corrosion behaviors of surface-adsorbed phosphate ions are attributed to three factors including repelling Cl-ions without significantly blocking OH-diffusion,preventing transition metal dissolution and acting as a local pH buffer to compensate the fast OH-consumption under high current electrolysis. | Meng Yu Jinhan Li Fangming Liu Jiuding Liu Wence Xu Honglu Hu Xijie Chen Weichao Wang Fangyi Cheng | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
| 3 | Direct radial sus- pension force control algorithm of bearingless synchronous reluctance motor 显示文摘 | Hu Weichao Li Yanchao Zhu Huangqiu | 2011 | Advance Electrical and Electronics Engineering2011，87，： | 1 |
| 4 | Spectral and biodistributional engineering of deep near-infrared chromophore显示文摘Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging. | Yan Dong Xicun Lu Yi Li Weichao Chen Lei Yin Jie Zhao Xinru Hu Xinran Li Zuhai Lei Yuyang Wu Hao Chen Xiao Luo Xuhong Qian Youjun Yang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 5 | 11S蛋白酶体PSME3通过正反馈调节NF-κB信号通路调节机体抗菌反应与宿主防御显示文摘巨噬细胞在宿主防御以及机体内环境稳定的维持中发挥着至关重要的作用。当机体受到外来病原微生物入侵时,巨噬细胞能够通过分泌促炎因子和杀伤物质,杀死入侵的病原菌。然而,关于巨噬细胞在宿主防御过程中是如何被严格调控的,至今仍不是很清楚。 | Jinxia Sun Yi Luan Dong Xiang Xiao Tan Hui Chen Qi Deng Jiaojiao Zhang Minghui Chen Hongjun Huang Weichao Wang Tingting Niu Wenjie Li Hu Peng Shuangxi Li Lei Li Wenwen Tang 李晓涛 Dianqing Wu 王平 | 2017 | 科学新闻2017，19，4： | 0 |
| 6 | Perioperative dexmedetomidine administration does not reduce the risk of acute kidney injury after non-cardiac surgery:a meta-analysis显示文摘Background:Post-operative acute kidney injury(AKI)is one of the most common and serious complications after major surgery and is significantly associated with increased risks of morbidity and mortality.This meta-analysis was conducted to evaluate the effects of perioperative dexmedetomidine(Dex)administration on the occurrence of AKI and the outcomes of recovery after non-cardiac surgery.Methods:The PubMed,Embase,Web of Science,and Cochrane Library databases were systematically searched for studies comparing the effects of Dexvs.placebo on kidney function after non-cardiac surgery,and a pooled fixed-effect meta-analysis of the included studies was performed.The primary outcome was the occurence of post-operative AKI.The secondary outcomes included the occurence of intra-operative hypotension and bradycardia,intensive care unit(ICU)admission,duration of ICU stay,and hospital length of stay(LOS).Results:Six studies,including four randomized controlled trials(RCTs)and two observational studies,with a total of 2586 patients were selected.Compared with placebo,Dex administration could not reduce the odds of post-operative AKI(odds ratio[OR],0.44;95%confidence interval(CI),0.18-1.06;P=0.07;I^(2)=0.00%,P=0.72)in RCTs,but it showed a significant renoprotective effect(OR,0.67;95%CI,0.48-0.95;P=0.02;I^(2)=0.00%,P=0.36)in observational studies.Besides,Dex administration significantly increased the odds of intra-operative bradycardia and shortened the duration of ICU stay.However,there was no significant difference in the odds of intra-operative hypotension,ICU admission,and hospital LOS.Conclusions:This meta-analysis suggests that perioperative Dex administration does not reduce the risk of AKI after non-cardiac surgery.However,the quality of evidence for this result is low due to imprecision and inconsistent types of non-cardiac operations.Thus,large and high-quality RCTs are needed to verify the real effects of perioperative Dex administration on the occurrence of AKI and the outcomes of recovery after non-cardiac surgery. | Bin Hu Tian Tian Xintao Li Weichao Liu Yinggui Chen Tianyu Jiang Peishan Chen Fushan Xue | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 7 | A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment显示文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage. | Huixia Yang Tao Tang Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang | 2015 | Science Bulletin2015，60，16： | 0 |
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