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| 1 | 相对病情指数划分棉花品种抗病性的统计学基础显示文摘对多年棉花品种的黄萎病抗病性鉴定资料分析表明,同一个品种的黄萎病病情指数年度间差异变化较大。8年的鉴定资料统计结果表明,中棉所12的病情指数年度间变异系数为37.4%,冀棉11为33.3%,方差分析表明它们的病情指数年度间变异极显著。对1992—1997年中棉所12的病情指数进行概率统计,其总体平均数的估计值为62.0,95%置信区间为[58.4,65.6];99%置信区间为[57.2,66.8]。利用本文方法计算的相对病情指数来表示棉花品种的黄萎病感病性,与利用病情指数表示方法相比,可以将年度间变异降低60%,发生概率p=0.997。本方法划分的抗病性不同于目前通用的以一个年度田间病情指数划分的品种抗病性,而是概率保证下的抗病性,具有深层的数理统计的意义。 | 李社增 马平 HUANG H C 陈新华 | 2003 | 棉花学报2003，15，6： | 33 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 4 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 5 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 6 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 7 | 血浆7-酮胆固醇与冠状动脉疾病患者心血管结局和总死亡率的关系显示文摘7-酮胆固醇(7-ketocholesterol,7-KC)是胆固醇氧化产物的一种形式,在动物动脉粥样硬化模型的形成中起重要作用。该文研究人员试图确定循环7-KC与稳定型冠状动脉疾病(coronary artery disease,CAD)患者的临床心血管结局和总死亡率的关系。 | 刘莉 叶鹏 Song J Wang D Chen H Huang X Zhong Y Jiang N Chen C Xia M | 2017 | 中华高血压杂志2017，25，6： | 4 |
| 8 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 9 | 纳米碳化钒强化TWIP钢加工硬化机制研究显示文摘弥散分布的纳米碳化钒颗粒能明显提高TWIP钢的屈服强度,但同时将在一定程度上降低加工硬化率。采用一个修正的物理模型来研究纳米碳化钒颗粒对一种实验室等级的FeMnC奥氏体TWIP钢加工硬化率的影响。试验发现在塑性变形过程中弥散分布的纳米碳化钒颗粒会加快位错累积速率,但也会降低孪晶形成速率。与不含析出相的TWIP钢相比,在小应变时含纳米碳化钒颗粒的TWIP钢加工硬化率较高,但随着应变量的增加其硬化率减小的速度高于不含析出相的TWIP钢,因此在高应变条件下含纳米碳化钒颗粒的TWIP显示出较低的钢加工硬化率。 | Liang ZY Huang M X Yen H W Scott C P 魏世同(翻译) | 2014 | 钢铁钒钛2014，35，1： | 3 |
| 10 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 11 | Evaluating the inter-lobe clearance of twin-screw compressor by the iso-clearance contour diagram(ICCD) 显示文摘 | Fong Z H Huang F C Fang H S | 2001 | Mechanism and Machine Theory2001，36，6： | 2 |
| 12 | Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bc1-2 mRNA 显示文摘 | Hsu M J Cheng J S Huang H C | 2000 | Br J Pharmacol2000，131，7： | 2 |
| 13 | Consistency condition and convergence criteria of incompatible element: General formulation of incompatible functions and its application显示文摘 | WU C C Huang M G Pian T H H | 1987 | Computer & Structures1987，27，： | 2 |
| 14 | 显示文摘 | Huang J H Lin C H Chen Hayden | 1999 | Materials Chemistry and Physics1999，59，： | 2 |
| 15 | Fuzzy logic approach to multisensor data association显示文摘 | Chen Y M Huang H C | 2000 | Mathematics and Computers in Simulation2000，52，： | 1 |
| 16 | Determining eight colorants in milk beverages by capillary electrophoresis显示文摘 | Huang H Y Shih Y C Chen Y C | 2002 | J Chromatogr A2002，959，12： | 1 |
| 17 | Stress corrosion cracking of pipeline steel in soil environments of eastern china显示文摘 | Li G F Huang C B Guo H | 2007 | Key Engineering Materials2007，，： | 1 |
| 18 | Developmental expression of key steroidogenie enzymes in the brain of protandrous black porgy fisb, Acanthopagrus sehlegeli 显示文摘 | Tomy S Wu G C Huang H R | 2007 | Neuroendoerinol2007，9，8： | 1 |
| 19 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 20 | Highly Selective DNA-Based Sensor for Lead (Ⅱ) and Mercury (Ⅱ) ions显示文摘 | Liu C W Huang C C Chang H T | 2009 | Anal Chem2009，81，6： | 1 |
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