|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 2 | Diversity characterization and association analysis of agronomic traits in a Chinese peanut (Arachis hypogaea L.) mini-core collection显示文摘Association mapping is a powerful approach for exploring the molecular basis of phenotypic variations in plants.A peanut(Arachis hypogaea L.)mini-core collection in China comprising 298 accessions was genotyped using 109 simple sequence repeat(SSR)markers,which identified 554 SSR alleles and phenotyped for 15 agronomic traits in three different environments,exhibiting abundant genetic and phenotypic diversity within the panel.A model-based structure analysis assigned all accessions to three groups.Most of the accessions had the relative kinship of less than 0.05,indicating that there were no or weak relationships between accessions of the mini-core collection.For 15 agronomic traits in the peanut panel,generally the Q t K model exhibited the best performance to eliminate the false associated positives compared to the Q model and the general linear model-simple model.In total,89SSR alleles were identified to be associated with 15 agronomic traits of three environments by the Q t K model-based association analysis.Of these,eight alleles were repeatedly detected in two or three environments,and 15 alleles were commonly detected to be associated with multiple agronomic traits.Simple sequence repeat allelic effects confirmed significant differences between different genotypes of these repeatedly detected markers.Our results demonstrate the great potential of integrating the association analysis and marker-assisted breeding by utilizing the peanut mini-core collection. | Huifang Jiang Li Huang Xiaoping Ren Yuning Chen Xiaojing Zhou Youlin Xia Jiaquan Huang Yong Lei Liying Yan Liyun Wan Boshou Liao | 2014 | Journal of Integrative Plant Biology2014，56，2： | 14 |
| 3 | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response显示文摘Hypoxic-ischemic brain damage(HIBD)is a common cause of infant death.The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD treatment.Seven-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control groups.Forty-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups.The TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot analysis.Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments.The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury.Compared with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group.Moreover,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression. | Hongfang Ding Hui Zhang Huifang Ding Dong Li Xinhao Yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju | 2017 | Cellular & Molecular Immunology2017，14，8： | 10 |
| 4 | The role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of myocardial ischemia-reperfusion显示文摘Myocardial damage caused by myocardial ischemia-reperfusion injury (MIRI)is difficult to be alleviated because cardiomyocyte necrosis is an irreversible and unregulated death form.Recently, necroptosis,a necrosis form caused by tumor necrosis factor-α (TNF-α)and Fas ligand (FasL),was found to be regulated by receptor interacting protein 3 (RIP3)and RIP3-receptor interacting protein 1 (RIP1)-mixed lineage kinase domain like protein (MLKL)pathway.But it is unclear whether they also play a regulatory role in MIRI-induced necroptosis.Our previous results showed that in rat MIRI,RIP3 could translocate and express highly in mitochondria.Therefore,it is important to explore proteins that interact with RIP3 which was translocated to mitochondria.The aim of this study was to explore the role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of hypoxia/reoxygenation (H/R).Our results showed that H/R could cause RIP3-depended mitochondrial fragmentation and necrosis-based death;and RIP3-promoted H/R-induced necroptosis in H9c2 cells through increasing lactate dehydrogenase release and inhibiting cell viability.This process did not require RIP1 or MLKL but dynamin-related protein 1 (Drp1),which was related to Drpl activation,reactive oxygen species elevation,and △Ψm decline.This study provides novel insights into the role of RIP3 in cardiomyocyte injury during H/R.RIP3 may serve as a potential target for the treatment of MIRI. | Huifang Hou Yongling Wang Qiong Li Zaibing Li Yan Teng Jingyu Li Xiaoying Wang Junli Chen Ning Huang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 10 |
| 5 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘Cockayne syndrome(CS)is a rare autosomal recessive inherited disorder characterized by a variety of clinical features,including increased sensitivity to sunlight,progressive neurological abnormalities,and the appearance of premature aging.However,the pathogenesis of CS remains unclear due to the limitations of current disease models.Here,we generate integration-free induced pluripotent stem cells(iPSCs)from fibroblasts from a CS patient bearing mutations in CSB/ERCC6 gene and further derive isogenic genecorrected CS-iPSCs(GC-iPSCs)using the CRISPR/Cas9 system.CS-associated phenotypic defects are recapitulated in CS-iPSC-derived mesenchymal stem cells(MSCs)and neural stem cells(NSCs),both of which display increased susceptibility to DNA damage stress.Premature aging defects in CS-MSCs are rescued by the targeted correction of mutant ERCC6.We next map the transcriptomic landscapes in CS-iPSCs and GC-iPSCs and their somatic stem cell derivatives(MSCs and NSCs)in the absence or presence of ultraviolet(UV)and replicative stresses,revealing that defects in DNA repair account for CS pathologies.Moreover,we generate autologous GC-MSCs free of pathogenic mutation under a cGMP(Current Good Manufacturing Practice)-compliant condition,which hold potential for use as improved biomaterials for future stem cell replacement therapy for CS.Collectively,our models demonstrate novel disease features and molecular mechanisms and lay a foundation for the development of novel therapeutic strategies to treat CS. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2020 | Protein & Cell2020，11，1： | 7 |
| 6 | Polymorphism-Dependent Dynamic Ultralong Organic Phosphorescence显示文摘Developing ultralong organic phosphorescence(UOP)materials with smart response to external stimuli is of great interest in photonics applications,whereas the manipulation of molecular stacking on tuning such dynamic UOP is still a formidable challenge.Herein,we have reported two polymorphs with distinct photoactivated dynamic UOP behavior based on a pyridine derivative for the first time.Our experiment revealed that the dynamic UOP behavior including photoactivation and deactivation feature is highly dependent on irradiation intensity and environmental atmosphere.Additionally,given the unique dynamic UOP feature,these phosphors have been successfully applied to phosphorescence-dependent molecular logic gate and timing data storage.This result not only paves a way to design smart functional materials but also expands the scope of the applications on organic phosphorescence materials. | Mingxing Gu Huifang Shi Kun Ling Anqi Lv Kaiwei Huang Manjeet Singh He Wang Long Gu Wei Yao Zhongfu An Huili Ma Wei Huang | 2020 | Research2020，，1： | 5 |
| 7 | The electromagnetic response of composition-regulated honeycomb structural materials used for broadband microwave absorption显示文摘The undesirable absorption bandwidth is the main limitation for the application of microwave absorbing materials.Noting that the design of structure and composition of absorbing coating allows it to obtain a satisfying absorption bandwidth and to avoid weight increasing,honeycomb and its sandwich structures coated by various absorbant have been developed and measured using an arch measurement system over2-18 GHz.To further understand the absorption mechanisms of honeycomb structural materials,simulation based on finite element method and transmission line theory is performed to analyze the different responses to the applied microwave between honeycomb structural materials and uniform-medium slab materials.The proper composition design allows control over the microwave loss mechanisms,which optimize the coating to possess both of the dielectric and magnetic advantages.For the honeycomb structural materials,the magnetic resonation is found for the first time,which is resulting from the periodic honeycomb walls on both sides of the dielectric cavity(consisting of the aramid paper interlayer and vacuum hexagonal prisms).In addition,the conversion of structure from solid to honeycomb brings about changes in impedance,propagating path,effective wavelength,effective attenuation area,microwave phases,and inductive coupling effect,etc.,which result in a better microwave absorbing performance.The honeycomb sandwich structure coated by CIP/CB/EP with the weight ratio of 4:0.03:1 shows the absorption bandwidth of~9.8 GHz for reflection loss(RL)lower than-10 dB which covers part of the S and C bands and almost the whole X and Ku bands. | Huifang Pang Yuping Duan Xuhao Dai Lingxi Huang Xuan Yang Tuo Zhang Xiaoji Liu | 2021 | Journal of Materials Science & Technology2021，，29： | 4 |
| 8 | Color-tunable ultralong organic phosphorescence materials for visual UV-light detection显示文摘Ultralong organic phosphorescence(UOP)materials have roused considerable attention in the field of photonics and optoelectronics owing to the feature of long-lived emission lifetimes.However,to develop UOP materials with color-tunability is still a formidable challenge.Here,we report a class of UOP materials containing carbonyl,amino or amide groups,exhibiting colortunable persistent luminescence ranging from blue(458 nm)to yellow-green(508 nm)under different UV wavelength excitation.Taken theoretical and experimental results together,we conclude that the excitation dependent color-tunable UOP emission is ascribed to multiple emission centers from single molecular and aggregated states in crystal.Given color-tunable UOP feature,these materials are used to successfully realize visual UV-light detection.This finding not only provides a strategy to design new organic phosphorescent molecules with colorful emission,but also extends the scope of the applications of purely organic phosphorescent materials. | Lifang Bian Huili Ma Wenpeng Ye Anqi Lv He Wang Wenyong Jia Long Gu Huifang Shi Zhongfu An Wei Huang | 2020 | Science China Chemistry2020，63，10： | 3 |
| 9 | Safe conservation and utilization of peanut germplasm resources in the Oil Crops Middle-term Genebank of China显示文摘Peanut(Arachis hypogaea L.)is an important oil and cash crop in the world.Peanut germplasm collected in China are abundant,which provides important material guarantee for peanut breeding and industrial development.Here,the safe conservation technology and indicators of peanut germplasm resources in the Oil Crops Middleterm Genebank of China were expounded from three processes of storage,monitoring,reproduction and renewal.We summarized and reviewed the situation of conservation and utilization of peanut germplasm resources in the Middle-term Genebank in the past 20 years.The future research direction of peanut resources in the Oil Crops Middle-term Genebank of China is prospected. | Xiaojing Zhou Xiaoping Ren Huaiyong Luo Li Huang Nian Liu Weigang Chen Yong Lei Boshou Liao Huifang Jiang | 2022 | Oil Crop Science2022，7，1： | 3 |
| 10 | Magnetic beads-based multicolor colorimetric immunoassay for ultrasensitive detection of aflatoxin B_(1)显示文摘Aflatoxin B_(1)(AFB_(1))is one of the most toxic,mutagenic and carcinogenic mycotoxin,widely exists in contaminated food,grains and feedstuff products.In this study,a novel magnetic beads multicolor colorimetric immunoassay(MBMCIA)based on Au@Ag nanorods(Au@Ag NRs)is proposed to visual detect ultralow concentration of AFB_(1)with high-resolution by the naked-eye.To design the MBMCIA system,AFB_(1)-BSA conjugates were first coated on the surface of magnetic beads(MBs),then alkaline phosphatase(ALP)as a bridge between immunoassay a nd color reaction was used for catalytic hydrolysis of ascorbic acid-phosphate to generate reductive ascorbic acid.Finally,the yielded ascorbic acid could reduce silver ions to grow a silver coating on the surface of gold nanorods to generate Au@Ag NRs,which leads to the bule-shifted longitudinal absorption peak of Au NRs,accompanying with a series of perceptible color change.Under the optimal conditions,the proposed MBMCIA exhibited go od sensitivity and specificity for the detection of AFB_(1)with the detection limit as low as 5.7 pg/mL Meanwhile,the MBMCIA was also applied for the analysis of AFB_(1)in spiked wheat samples,the obtained recoveries range from 99.1%to 104.3%with relative standard deviation(RSD)less than 7.05%were acceptable.The proposed MBMCIA integrates separated,enriched,anti-interfe rence and signal read-out into one,which opens up a new avenue for an on-site visual food safety inspection or environmental monitoring. | Shan He Qitong Huang Ying Zhang Huifang Zhang Huifeng Xu Xun Li Xiaoming Ma | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 11 | Activated carbon fibers with manganese dioxide coating for flexible fiber supercapacitors with high capacitive performance显示文摘Fiber supercapacitor(FSC)is a promising power source for wearable/stretchable electronics and high capacitive performance of FSCs is highly desirable for practice flexible applications.Here,we report a composite of manganese dioxide(Mn O_2)and activated carbon fibers(ACFs)with high MnO_2mass loading and microporous structure(abbreviated as Mn O_2@ACF),which is used as a fiber electrode to produce a FSC with a high capacitive performance and a good flexibility.The MnO_2@ACF composite electrode in FSCs delivers an ultrahigh specific capacitance of 410 mF/cm^2at 0.1 mA/cm^2,corresponding to a high energy density of 36μWh/cm^2and high power density of 726μW/cm^2.Such high capacitive performance and simple fabrication method indicates that the Mn O_2@ACF composite is a very promising electrode material for flexible fiber supercapacitors. | Huifang Li Jiachen Liang Huan Li Xiaoyu Zheng Ying Tao Zheng-Hong Huang Quan-Hong Yang | 2019 | Journal of Energy Chemistry2019，28，4： | 3 |
| 12 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 13 | Study on Ni/C catalysts for vapor phase carbonylation of ethanol显示文摘激活支持碳的 Ni 催化剂让乙醇的蒸汽阶段 carbonylation 当倡导者被调查,面对乙醇碘化物支撑离子的酸。在最佳反应条件下面,当时,碳一氧化物和乙醇的变换被测量分别地,是 81.4% 和 98.4% 选择为支撑离子的酸被发现是 98.65% 。催化剂在溪流上的 48 h 以内是稳定的。XRD 和 XPS 方法被用来描绘结构和新鲜、测试的催化剂的表面性质。描述结果显示镍粒子和催化剂表面上的镍碘化物的形成的聚集应该为催化剂的释放负责。 | Qing Zhang Huifang Wang Guosong Sun Kelin Huang Weiping Fang Yiquan Yang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 3 |
| 14 | Direct van der Waals epitaxial growth of 1D/2D Sb2Se3/WS2 mixed-dimensional p-n heterojunctions显示文摘The mixed-dimensional integration of two-dimensional (2D) materials with non-2D materials can give rise to prominent advances in performance or function.To date,the mixed-dimensional one-dimensional (1D)/2D heterostructures have been fabricated using various physical assembly approaches.However,direct epitaxial growth method which has notable advantages in preparing large-scale products and obtaining perfect interfaces is rarely investigated.Herein,we demonstrate for the first time the direct synthesis of the 1D/2D mixed-dimensional heterostructures by sequential vapor-phase growth of Sb2Se3 nanowires on WS2 monolayers.X-ray diffraction (XRD) pattern and Raman spectrum confirm the composition of the Sb2Se3/NS2 heterostructures.Transmission electron microscope (TEM) measurement demonstrates high quality of the heterostructures.Electrical transport characterization reveals that Sb2Se3 nanowire exhibits p-type characteristic and that WS2 monolayer exhibits n-type behavior,and that the p-n diode from 1D/2D mixed-dimensional Sb2Se3/WS2 heterostructure possesses obvious current rectification behavior.Optoelectronic measurements of the heterostructures show apparent photovoltaic response with an open-circuit voltage of 0.19 V,photoresponsivity of 1.51 A/W (Vds =5 V) and fast response time of less than 8 ms.The van der Waals epitaxial growth mode of Sb2Se3 nanowires on WS2 monolayers is verified by stripping the Sb2Se3 nanowire from the heterostructures using tape.Together,the direct van der Waals epitaxy opens a facile pathway to 1D/2D mixed-dimensional heterostructures for functional electronic and optoelectronic devices. | Guangzhuang Sun Bo Li Jia Li Zhengwei Zhang Huifang Ma Peng Chen Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Xuwan Tang Chen Dai Ziwei Huang Yuan Liu Xidong Duan Xiangfeng Duan | 2019 | Nano Research2019，12，5： | 2 |
| 15 | A Weighted Threshold Secret Sharing Scheme for Remote Sensing Images Based on Chinese Remainder Theorem显示文摘The recent advances in remote sensing and computer techniques give birth to the explosive growth of remote sensing images.The emergence of cloud storage has brought new opportunities for storage and management of massive remote sensing images with its large storage space,cost savings.However,the openness of cloud brings challenges for image data security.In this paper,we propose a weighted image sharing scheme to ensure the security of remote sensing in cloud environment,which takes the weights of participants(i.e.,cloud service providers)into consideration.An extended Mignotte sequence is constructed according to the weights of participants,and we can generate image shadow shares based on the hash value which can be obtained from gray value of remote sensing images.Then we store the shadows in every cloud service provider,respectively.At last,we restore the remote sensing image based on the Chinese Remainder Theorem.Experimental results show the proposed scheme can effectively realize the secure storage of remote sensing images in the cloud.The experiment also shows that no matter weight values,each service providers only needs to save one share,which simplifies the management and usage,it also reduces the transmission of secret information,strengthens the security and practicality of this scheme. | Qi He Shui Yu Huifang Xu Jia Liu Dongmei Huang Guohua Liu Fangqin Xu Yanling Du | 2019 | Computers, Materials & Continua2019，，2： | 2 |
| 16 | Detection of inter-patient left and right bundle branch block heartbeats in ECG using ensemble classifiers 显示文摘 | HUANG Huifang LIU Jie ZHU Qiang | 2014 | Biomed Eng Online2014，13，： | 1 |
| 17 | A new bier archical method for inter-patient heartbeat classification using random projections and RR intervals 显示文摘 | HUANG Huifang LIU Jie ZHU Qiang | 2014 | Biomed Eng On line2014，13，： | 1 |
| 18 | Regioisomerism effect(RIE) on optimizing ultralong organic phosphorescence lifetimes显示文摘Organic phosphorescence materials demonstrate potential optoelectronic applications due to their remarkably ultralong organic phosphorescence(UOP)lifetime and abundant optical characteristics prior to the fluorescence materials.For a better insight into the intrinsic relationship among regioisomeric molecules,crystalline interactions,and phosphorescence properties,three crystalline dicarbazol-9-yl pyrazine-based regioisomers with para-,meta-and ortho-convergent substitutions(p-DCzP,m-DCzP,and o-DCzP)were designed and presented gradually increased UOP lifetimes prolonging from 63.14,127.93 to 350.46 ms,respectively,due to the regioisomerism effect(RIE)which would be an effective strategy for better understanding of structure-property of UOP materials. | Yanni Zhang Jianfeng Zhao Caixia Zhu Lifang Bian Huifang Shi Shiming Zhang Huili Ma Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 19 | Collagen fiber membrane-derived chemically and mechanically durable superhydrophobic membrane for high- performance emulsion separation显示文摘Developing high-performance separation membrane with good durability is a highly desired while challenging issue.Herein,we reported the successful fabrication of chemically and mechanically durable superhydrophobic membrane that was prepared by embedding UiO-66 as size-sieving sites within the supramolecular fiber structure of collagen fiber membrane(CFM),followed by the polydimethylsiloxane(PDMS)coating.The as-prepared CFM/UiO-66(12)/PDMS membrane featured capillary effect-enhanced separation flux and homogeneous porous channels guaranteed high separation efficiency.When utilized as double-layer separation membranes,this new type of composite membranes separated various surfactant stabilized water-in-oil microemulsions and nanoemulsions,with the separation efficiency high up to 99.993%and the flux as high as 973.3 L m−2 h−1.Compared with commercial polytetrafluoro ethylene(PTFE)membrane,the advantage of the double-layer CFM/UiO-66(12)/PDMS membranes in separation flux was evident,which exhibited one order of magnitude higher than that of commercial PTFE membrane.The CFM/UiO-66(12)/PDMS membrane was acid-alkali tolerant,UV-aging resistant and reusable for emulsion separation.Notably,the CFM/UiO-66(12)/PDMS membrane was mechanically durable against strong mechanical abrasion,which was still capable of separating diverse water-in-oil emulsions after the abrasion with sandpaper and assembled as double-layer separation membranes.We anticipate that the combination of CFM and metal organic frameworks(MOFs)is an effective strategy for fabricating high-performance separation membrane with high mechanical and chemical durability. | Huifang Li Wan Zheng Hanzhong Xiao Baicun Hao Yujia Wang Xin Huang Bi Shi | 2021 | Journal of Leather Science and Engineering2021，3，1： | 1 |
| 20 | Halogenated Thermally Activated Delayed Fluorescence Materials for Efficient Scintillation显示文摘Organic scintillators,materials with the ability to exhibit luminescence when exposed to X-rays,have aroused increasing interest in recent years.However,the enhancement of radioluminescence and improving X-ray absorption of organic scintillators lie in the inherent dilemma,due to the waste of triplet excitons and weak X-ray absorption during scintillation.Here,we employ halogenated thermally activated delayed fluorescence materials to improve the triplet exciton utilization and X-ray absorption simultaneously,generating efficient scintillation with a low detection limit,which is one order of magnitude lower than the dosage for X-ray medical diagnostics.Through experimental study and theoretical calculation,we reveal the positive role of X-ray absorption,quantum yields of prompt fluorescence,and intersystem crossing in promoting the radioluminescence intensity.This finding offers an opportunity to design diverse types of organic scintillators and expands the applications of thermally activated delayed fluorescence. | Xiao Wang Guowei Niu Zixing Zhou Zhicheng Song Ke Qin Xiaokang Yao Zhijian Yang Xiaoze Wang He Wang Zhuang Liu Chengzhu Yin Huili Ma Kang Shen Huifang Shi Jun Yin Qiushui Chen Zhongfu An Wei Huang | 2023 | Research2023，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员