|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Mutagenicity of medicinal plant extracts in-Salmonella/microsome assay显示文摘 | Isabel CristinaFernandes de Sá Ferreira Vera MariaFerr?o Vargas | 1999 | Phytother Res1999，，5： | 1 |
| 5 | Photolytic and photoeatalytie transformation of methadone in aqueous solutions under solar irradiation : Kinetics, characterization of major intermediate products and toxicity evaluation 显示文摘 | Cristina P Carla S Isabel O | 2011 | Water Res2011，45，16： | 1 |
| 6 | Hepatitis D and B virus genotypes in chronically infected patients from the Eastern Amazon Basin显示文摘 | Michele Soares Gomes-Gouvêa Manoel do Carmo Pereira Soares Isabel Maria Vicente Guedes de Carvalho Mello Elisabete Maria Figueiredo Brito Lizomar de Jesus Maués Pereira Moia Gilberta Bensabath Heloisa Marceliano Nunes Flair José Carrilho Jo?o Renato Rebel | 2008 | Acta Tropica2008，，3： | 1 |
| 7 | Safety and feasibility of catheter ablation for atrioventricular nodal re-entrant tachycardia without fluoroscopic guidance显示文摘 | Miguel álvarez Luís Tercedor Isabel Almansa Natalia Ros Ricardo S. Galdeano Francisco Burillo Pablo Santiago Rocío Pe?as | 2009 | Heart Rhythm2009，，12： | 1 |
| 8 | Seasonal and spatial variability of free-living bacterial community eomposition along an estuarine gradient (Ria de Aveiro, Portugal) 显示文摘 | Henriques Isabel S Alves Artur Tac a o Marta | 2006 | Estuarine Coastal and Shelf Science2006，68，12： | 1 |
| 9 | Effects of high- intensity pulsed electric field processing conditions on lycopene, vitarain C and antioxidant capacity of watermelon juice显示文摘 | GEMMA O O ISABEL O S ROBERT S F | 2009 | Food Chemistry2009，115，4： | 1 |
| 10 | Effect of High- Intensity Pulsed Electric Field Processing Condisions on Lycopene, Vitamin C and Antioxidant Capacity of Watermelon Juice 显示文摘 | GEMMA O O ISABEL O S ROBERT S F | 2009 | Food Chemistry2009，115，4： | 1 |
| 11 | Inactivation of tomato juice peroxidase by high-intensity pulsed electric fields as affected by process conditions显示文摘 | Ingrid A A Isabel O S Luciano J | 2008 | Food Chemistry2008，107，： | 1 |
| 12 | Antihypertensive Effects of Peroxisome Proliferator-Activated Receptor-β Activation in Spontaneously Hypertensive Rats显示文摘 | María José Zarzuelo Rosario Jiménez Pilar Galindo Manuel Sánchez Ana Nieto Miguel Romero Ana María Quintela Rocío López-Sepúlveda Manuel Gómez-Guzmán Elvira Bailón Isabel Rodríguez-Gómez Antonio Zarzuelo Julio Gálvez Juan Tamargo Francisco Pérez-Vizcaíno | 2011 | Hypertension2011，，4： | 1 |
| 13 | A complete set of maize individual chromosome addition to the oat genome显示文摘 | Kynast R G Riera-Lizarazu O Isabel Vales M Okagaki R J Maquieira S B Chen G Ananiev E V Odland W E Russell C D Stec A O Livingston S M Zaia H A Rines H W Phillips R L | 2001 | Plant Physiol2001，125，： | 1 |
| 14 | ESTIMACIóN DEL IMPACTO ECONóMICO Y SANITARIO DE LAS COMPLICACIONES DE LA DIABETES MELLITUS DE TIPO 2 EN LA COMUNIDAD AUTóNOMA DE MADRID显示文摘 | Francisco ARRIETA Carlos RUBIO-TERRéS Darío RUBIO-RODRíGUEZ Ana MAGA?A Marbella PI?ERA Pedro IGLESIAS Pedro NOGALES Alfonso CALA?AS Blanca NOVELLA José Ignacio BOTELLA-CARRETERO Carlos DEBáN Isabel ZAMARRóN Gustavo MORA José Antonio BALSA Clotilde VáZQUEZ | 2013 | Endocrinologia y Nutricion2013，，： | 1 |
| 15 | Effect of high-oxygen atmospheres on the Antioxidant potential of fresh-cut tomatoes显示文摘 | ISABEL O S GEMMA O O ROBERT S F | 2009 | Agric Food Chem2009，57，15： | 1 |
| 16 | Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence显示文摘 | Javier O Isabel S Fernando A | 2003 | Virology2003，308，1： | 1 |
| 17 | Modeling O2 and CO2 exchange for development of perforation mediated modified atmosphere packaging显示文摘 | Fonseca S C Fernanda A R O Isabel B M L | 2000 | Journal of Food Engineering2000，43，1： | 1 |
| 18 | Innate Invariant NKT Cells recognize mycobaeterium tuberculosis-infected maerophages, pro- duce interferon-3, and kill intracellular bacteria 显示文摘 | Isabel S O Asako C Adaena G | 2008 | Plos Pathog2008，4，10： | 1 |
| 19 | Comparative evaluation of UV-HPLC methods and reducing agents to determine vitaminC in fruits 显示文摘 | Isabel O S Teresa H J Olga M B | 2007 | Food Chemistry2007，105，3： | 1 |
| 20 | Effect of High-Oxygen Atmospheres on the Antioxidant Potential of Fresh-Cut Tomatoes 显示文摘 | Isabel O S Gemma O O Robert S F | 2009 | Journal Agricultural and Food Chemistry2009，57，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员