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| 1 | Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘The p53 signaling pathway works as a potent barrier to tumor progression.Two single nucleotide polymor-phisms(SNPs)in the gene loci of p53 pathway,p53 codon 72 Arg72Pro and MDM2 SNP309(T>G),have been shown to cause perturbation of p53 function,but the effect of the two SNPs on the risk of hepatocellular carcinoma(HCC)remains inconsistent.This study in-vestigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of developing HCC in pa-tients with chronic hepatitis B virus infection,and evaluated the significance of the two combined SNPs on patient prognosis.In total,350 HCC patients,230 non-HCC patients,and 96 healthy controls were geno-typed for the p53 Arg72Pro and MDM2 SNP309.The combined p53 Pro/Pro and MDM2 G/G genotype was significantly associated with HCC risk(P=0.047).Mul-tivariate analysis indicated that combined p53 Pro/Pro and MDM2 G/G genotype was an independent factor affecting recurrence and survival(P<0.05).Patients with combined p53 Pro/Pro and MDM2 G/G genotypes had a poorer prognosis than other genotypes,P<0.01 for both disease-free survival(DFS)and overall survival(OS).DFS and OS rates also differed significantly be-tween Barcelona Clinic Liver Cancer(BCLC)stage A patients with combined p53 Pro/Pro and MDM2 G/G and other genotypes(P<0.05).Thus,the combined p53 Pro/Pro and MDM2 G/G genotype is associated with increased risk of developing HCC and is an independ-ent adverse prognostic indicator in early stage HCC. | Yun Yang Tian Xia Ning Li Jin Zhang Yuan Yang Wenming Cong Qiang Deng Ke Lan Weiping Zhou | 2013 | Protein & Cell2013，4，1： | 8 |
| 2 | Low-frequency sea level variation and its correlation with climate events in the Pacific显示文摘Global mean sea level(GMSL) has not only significant secular trend and seasonal variations,but also inter-annual and decadal variations.This paper reconstructs the time series of GMSL variations between 1948 and 2007 by combining satellite altimeter measurements and tide gauge observations.Based on the time series,the acceleration of GMSL rise in the second half of 20th century is estimated to be 0.010±0.009 mm/a 2,and multi-scale low frequency sea level oscillations including decadal variations are detected,and the high-rate of GMSL rise during 1993-2003 is locate in the ascending phase of low frequency oscillation.Then,using the reconstructed GMSL time series after removing the secular trend from satellite altimetry and tide gauges measurements,it shows that low frequency signal of sea level variation has strong correlations with the index of El Ni o/Southern Oscillation(ENSO) and Pacific Decadal Oscillation(PDO).But in several time periods,they have large difference due to effects of both high frequency occurrence of El Ni o and La Ni a phenomenon and short term switch of PDO events. | JIN TaoYong LI JianCheng JIANG WeiPing CHU YongHai | 2012 | Chinese Science Bulletin2012，57，27： | 6 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | The global mean sea surface model WHU2013显示文摘The mean sea surface(MSS) model is an important reference for the study of charting datum and sea level change. A global MSS model named WHU2013, with 20? 20 spatial resolution between 80S and 84N, is established in this paper by combining nearly 20 years of multi-satellite altimetric data that include Topex/Poseidon(T/P), Jason-1, Jason-2, ERS-2,ENVISAT and GFO Exact Repeat Mission(ERM) data, ERS-1/168, Jason-1/C geodetic mission data and Cryosat-2 low resolution mode(LRM) data. All the ERM data are adjusted by the collinear method to achieve the mean along-track sea surface height(SSH), and the combined dataset of T/P, Jason-1 and Jason-2 from 1993 to 2012 after collinear adjustment is used as the reference data. The sea level variations in the non-ERM data(geodetic mission data and LRM data) are mainly investigated, and a combined method is proposed to correct the sea level variations between 66S and 66N by along-track sea level variation time series and beyond 66S or 66N by seasonal sea level variations. In the crossover adjustment between multi-altimetric data, a stepwise method is used to solve the problem of inconsistency in the reference data between the high and low latitude regions. The proposed model is compared with the CNES-CLS2011 and DTU13 MSS models, and the standard derivation(STD) of the differences between the models is about 5 cm between80S and 84N, less than 3 cm between 66S and 66N, and less than 4 cm in the China Sea and its adjacent sea. Furthermore, the three models exhibit a good agreement in the SSH differences and the along-track gradient of SSH following comparisons with satellite altimetry data. | Taoyong Jin Jiancheng Li Weiping Jiang | 2016 | Geodesy and Geodynamics2016，7，3： | 4 |
| 5 | Optimal Control of Slurry Pressure during Shield Tunnelling Based on Random Forest and Particle Swarm Optimization显示文摘The control of slurry pressure aiming to be consistent with the external water and earth pressure during shield tunnelling has great significance for face stability,especially in urban areas or underwater where the surrounding environment is very sensitive to the fluctuation of slurry pressure.In this study,an optimal control method for slurry pressure during shield tunnelling is developed,which is composed of an identifier and a controller.The established identifier based on the random forest(RF)can describe the complex non-linear relationship between slurry pressure and its influencing factors.The proposed controller based on particle swarm optimization(PSO)can optimize the key factor to precisely control the slurry pressure at the normal state of advancement.A data set from Tsinghua Yuan Tunnel in China was used to train the RF model and several performance measures like R2,RMSE,etc.,were employed to evaluate.Then,the hybrid RF-PSO control method is adopted to optimize the control of slurry pressure.The good agreement between optimized slurry pressure and expected values demonstrates a high identifying and control precision. | Weiping Luo Dajun Yuan Dalong Jin Ping Lu Jian Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，7： | 3 |
| 6 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 7 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 8 | miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway显示文摘 | Weiguo Cao Weiping Yang Rong Fan Hao Li Jinsong Jiang Mei Geng Yening Jin Yunlin Wu | 2014 | Tumor Biology2014，，2： | 2 |
| 9 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 10 | The Feasibility of Total or Near-Total Bilateral Thyroidectomy for the Treatment of Bilateral Multinodular Goiter显示文摘 | Weiping Yang Tanglei Shao Jiazeng Ding Xiaotai Jin Qinyu Li Peiguo G. Chu Yun Yen Weihua Qiu | 2009 | Investigative Surgery2009，，3： | 1 |
| 11 | Enantiomeric separation of organophosphorus pesticides by high-performance liquid chromatography, gas chromatography and capillary electrophoresis and their applications to environmental fate and toxicity assays显示文摘 | Ling Li Shanshan Zhou Lixia Jin Cheng Zhang Weiping Liu | 2009 | Journal of Chromatography B2009，，17： | 1 |
| 12 | TLR4 is required for the obesity-induced pancreatic beta cell dysfunction显示文摘肥胖是为类型 2 糖尿病的一个重要导致因素。然而,位于 high-fat-(HF ) 下面的机制在胰腺的贝它房间机能障碍的导致食谱的肥胖仍然是不清楚的。像使用费的 receptor-4 (TLR4 ) 是天生的免疫的一个关键调停人。在导致肥胖的胰腺的贝它房间机能障碍调查 TLR4 的效果,我们使用了男糖尿病患者(db/db ) ,肥胖(ob/ob ) 老鼠, TLR4 野的类型(WT ) ,和用正常饮食或 HF 被喂的 TLR4 大美人老鼠节食 24 个星期。在胰腺的小岛的 TLR4 和 TLR4 mRNA 水平的 Immunostaining 被估计。从生物特征,葡萄糖忍耐测试,胰岛素忍耐测试,和胰岛素版本测试的结果证明胰腺的小岛的功能在喂 HF 的 TLR4 WT 老鼠被损害,但是在喂 HF 的 TLR4 被保护缺乏(TLR4/) 老鼠。由电子显微镜察觉,我们观察了能分泌的泡在喂 HF 的 TLR4 WT 老鼠增加了的那贝它房间胰岛素。在喂 HF 的 TLR4/ 老鼠的贝它房间的超微结构在正常食物类似于那喂食谱的 TLR4 WT 老鼠。然后,由使用主要胰腺的小岛的刺激葡萄糖的胰岛素分泌物试金证明在喂 HF 的 TLR4/ 鼠标的胰腺的小岛的分泌物函数在喂 HF 的 TLR4 WT 鼠标比那好。而且,在喂 HF 的 TLR4/ 老鼠, IL-6 的 mRNA 层次, TNF- ,和 MCP-1,在胰腺的小岛的基因是比在喂 HF 的 TLR4 WT 老鼠的那些显著地低的。与在基因表示,喂 HF 的 TLR4 WT 老鼠然而并非喂 HF 的 TLR4/ 的变化一致老鼠在胰腺的岛展出了巨噬细胞侵略。一起拿,我们的数据显示了那 HF 导致食谱的肥胖能刺激在胰腺的贝它房间的表面上定位的 TLR4 的起来规定,并且随后导致巨噬细胞的招募进胰腺的小岛,它最后导致胰腺的贝它房间机能障碍。这个过程是涉及导致肥胖的胰腺的贝它房间机能障碍的可能的机制。 | Juan Li Lei Chen Ye Zhang Weiping J. Zhang Wenyan Xu Yi Qin Jin Xu Dajin Zou | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 1 |
| 13 | The role of fast-track surgery in pancreaticoduodenectomy: A retrospective cohort study of 635 consecutive resections显示文摘 | Zhuo Shao Gang Jin Weiping Ji Li Shen Xiangui Hu | 2015 | International Journal of Surgery2015，，： | 1 |
| 14 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 15 | Diffusion coefficients of some solutes in fcc and liquid Al: critical evaluation and correlation显示文摘 | Yong Du Y.A Chang Baiyun Huang Weiping Gong Zhanpeng Jin Honghui Xu Zhaohui Yuan Yong Liu Yuehui He F.-Y Xie | 2003 | Materials Science & Engineering A2003，，1： | 1 |
| 16 | Preparation and characterization of ovalbumin and carboxymethyl cellulose conjugates via glycosylation显示文摘 | Xiaopeng Geng Bing Cui Yan Li Weiping Jin Yaping An Bin Zhou Ting Ye Lei He Hongshan Liang Ling Wang Yijie Chen Bin Li | 2014 | Food Hydrocolloids2014，，： | 1 |
| 17 | A transfer matrix approach based on local normal modes for coupled waveguide with periodic perturbations 显示文摘 | Weiping HUANG Jin HONC | 1992 | Lightwave Technology1992，10，10： | 1 |
| 18 | A thermodynamic description of the Al-Mn-Si system over the entire composition and temperature ranges显示文摘 | Yong Du Zhanpeng Jin Baiyun Huang Weiping Gong Honghui Xu Zhaohui Yuan Julius C. Schuster Franz Weitzer Nataliya Krendelsberger | 2004 | Metallurgical and Materials Transactions A2004，，5： | 1 |
| 19 | AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism显示文摘Type 2 diabetes mellitus(T2 DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2 DM and found that rs3743121, located 1 kb downstream of AQR,was a novel susceptibility SNP associated with T2 DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2 DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2,increased the phosphorylation of GSK-3β, and restored the insulin sensitivity. Furthermore, the suppression of AQR inhibited the mTOR pathway and the protein ubiquitination process. Our study suggests that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. | Chun Song Han Yan Hanming Wang Yan Zhang Huiqing Cao Yiqi Wan Lingbao Kong Shenghan Chen Hong Xu Bingxing Pan Jin Zhang Guohuang Fan Hongbo Xin Zicai Liang Weiping Jia Xiao-Li Tian | 2018 | Journal of Genetics and Genomics2018，45，2： | 1 |
| 20 | Variability of the Kuroshio extension system in 1992-2013 from satellite altimetry data显示文摘The Kuroshio Extension(KE) plays an important role in climate and environmental change in the North Pacific. In this paper, more than 20 years of merged absolute dynamic topography and merged sea level anomaly products from satellite altimetry are used to analyze the stability of the KE system. By analyzing the annually averaged sea surface topography, the variations of inter-annual path and annually averaged eddy kinetic energy at the KE region, the KE's two dynamic states are given as: the relatively stable state during 1993e1995, 2002e2005, and 2010e2012, and the unstable dynamic state among 1996e2001 and2006e2009. During the stable state, the KE spindle had a shorter path length and smaller time-varying amplitude, as well as a trend to move northward. While during the unstable state, the KE spindle had a longer path length and an integral southward transport trend, and was observed to oscillate significantly over time. The analysis on the KE's upstream and downstream region gives the same variations, indicating that they are significantly affected by the El Nino events. The power spectrum of the mean latitudinal position variation of the KE's upstream and downstream shows significant quasi-decadal oscillation characteristics and strong annual signals. Furthermore, the correlation of the strength variation between the southern RG and the KE's upstream is calculated to be 0.50 after low-pass filtering,and that of the mean latitudinal position variation between the southern RG and the KE's upstream/downstream are 0.75/0.69 after low-pass filtering, respectively. The strong correlations demonstrated that the southern RG and the KE are closely linked. | Weiping Jiang Lifeng Peng Taoyong Jin Shengjun Zhang | 2017 | Geodesy and Geodynamics2017，8，2： | 1 |
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