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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Effect of biomass addition on the surface and adsorption characterization of carbon-based adsorbents from sewage sludge显示文摘Sewage sludge with the additive corn cob was used as prescusor to prepare sludge-based carbon adsorbents by pyrolysis method. And then, the carbonizated products were activated with potassium hydroxide. The mixing ratio of the corn cob to sewage sludge was investigated. The surface area and pore size distribution, elemental composition, surface chemistry structure and the surface physical morphology were determined and compared. The results demonstrated that the addition of corn cob into the sewage sludge sample could effectively improve the surface area (from 287 to 591 m 2 /g) and the microporosity (from 5% to 48%) of the carbon based adsorbent, thus enhancing the adsorption behavior. The sulfur dioxide adsorption capacity was measured according to breakthrough test. It was found that the sulfur dioxide adsorption capacity of the adsorbents was obviously enhanced after the addition of the corn cob. It is presumed that not only highly porous adsorbents, but also a high metallic content of these materials are required to achieve good performances. | Changzi Wu Min Song Baosheng Jin Yimin Wu Yaji Huang | 2013 | Journal of Environmental Sciences2013，25，2： | 11 |
| 3 | Structural effects of three-dimensional angle-interlock woven composite undergoing bending cyclic loading显示文摘This paper reports the structural effects of three-dimensional(3-D)angle-interlock woven composite(3DAWC)undergoing three-point bending cyclic loading from experimental and finite element analysis(FEA)approaches.In experiment,the fatigue tests were conducted to measure the bending deflection and to observe the damage morphologies.By the FEA approach,a micro-structural unit-cell model of the 3DAWC was established at the yarn level to simulate the fatigue damage.The stress degradation at the loading condition of constant deformation amplitude was calculated to show the degradation of mechanical properties.In addition,the stress distribution,fatigue damage evolution and critical damage regions were also obtained to qualitatively reveal the structural effects and damage mechanisms of the 3DAWC subjected to three-point bending cyclic loading. | JIN LiMin YAO Yao YU YiMin ROTICH Gideon SUN BaoZhong GU BoHong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 5 |
| 4 | Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca^(2+) channel internalization in mesenchymal stem cells显示文摘The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain,chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells(BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific(Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δsubunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP. | Bei Li Xiaoning He Zhiwei Dong Kun Xuan Wei Sun Li Gao Shiyu Liu Wenjia Liu Chenghu Hu Yimin Zhao Songtao Shi Yan Jin | 2020 | Bone Research2020，8，2： | 4 |
| 5 | Radical versus conservative surgical treatment of liver hydatid cysts: a meta-analysis显示文摘 | Qing Pang Hao Jin Zhongran Man Yong Wang Song Yang Zongkuang Li Yimin Lu Huichun Liu Lei Zhou | 2018 | Frontiers of Medicine2018，12，3： | 4 |
| 6 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 7 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 8 | Two-dimensional characterization of three-dimensional magnetic bubbles in Fe_(3)Sn_(2) nanostructures显示文摘We report differential phase contrast scanning transmission electron microscopy(TEM) of nanoscale magnetic objects in Kagome ferromagnet Fe_(3)Sn_(2) nanostructures. This technique can directly detect the deflection angle of a focused electron beam, thus allowing clear identification of the real magnetic structures of two magnetic objects including three-ring and complex arch-shaped vortices in Fe_(3)Sn_(2) by Lorentz-TEM imaging. Numerical calculations based on real material-specific parameters well reproduced the experimental results, showing that the magnetic objects can be attributed to integral magnetizations of two types of complex three-dimensional(3D) magnetic bubbles with depth-modulated spin twisting. Magnetic configurations obtained using the high-resolution TEM are generally considered as two-dimensional(2D)magnetic objects previously. Our results imply the importance of the integral magnetizations of underestimated 3D magnetic structures in 2D TEM magnetic characterizations. | Jin Tang Yaodong Wu Lingyao Kong Weiwei Wang Yutao Chen Yihao Wang Y.Soh Yimin Xiong Mingliang Tian Haifeng Du | 2021 | National Science Review2021，8，6： | 2 |
| 9 | A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19:The Artificial-Liver Blood-Purification System显示文摘The coronavirus disease 2019(COVID-19)pan-epidemic,resulting from infection with the 2019 novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is currently the source of public health concern worldwide;however,treatment of this infection has been clinically challenging in many patients[1].Importantly,2019-nCoV is the third fatal coronavirus that has emerged in the past two decades,following SARS-CoV and the Middle East respiratory syndrome(MERS)-CoV[2].The numbers of confirmed cases of COVID-19 infection and related deaths are still rising.As of 9 March 2020. | Yimin Zhang Liang Yu LingLing Tang Mengfei Zhu Yanqi Jin Zhouhan Wang Lanjuan Li | 2021 | Engineering2021，7，1： | 2 |
| 10 | Crystallization of Al-based Amorphous Alloys in Good Conductivity Solution显示文摘The corrosion-induced crystallization of Al94 exNixGd6(x=6 and 10, in at.%) metallic glasses as well as phase separation, oxidation and cracking in good conductivity solution has been investigated by various techniques.The transmission electronic microscopy(TEM) result reveals that crystalline intermetallics and oxides present on the electrochemically thinned hole edge, and the phase separation occurs in the matrix of the as-spun ribbons with the circumferential speed Rcof 29.3 m/s. In addition, the bending and cracking of the samples occur after corrosion. The influence of Ni content on the phase separation, bending and cracking can be explained by the fact that the percolation of the backbone clusters in the amorphous alloy melts and glasses is enhanced by increasing the composition of Ni. | Yonggang Wang Yan Liu Yingjie Li Bang An Guanghui Cao Shifeng Jin Yimin Sun Weimin Wang | 2014 | Journal of Materials Science & Technology2014，30，12： | 1 |
| 11 | Synthesis, structure and characterization of binuclear copper(I) complexes显示文摘 | Ruina Yang Kunhua Lin Yimin Hou Dongmei Wang Douman Jin Baosheng Luo Liaorong Chen | 1997 | Transition Metal Chemistry1997，，3： | 1 |
| 12 | Investigations and assessment of the landslide hazards of Fengdu county in the reservoir region of the Three Gorges Project on the Yangtze River显示文摘 | WU Shuren JIN Yimin ZHANG Yongshuang | 2004 | Environmental Geology2004，，45： | 1 |
| 13 | Investigations and assessment of the landslide hazards of Fengdu county in the reservoir region of the Three Gorges Project on the Yangtze River 显示文摘 | WU Shuren JIN Yimin ZHANG Yongshuang | 2004 | Environmental Geology2004，45，： | 1 |
| 14 | Simultaneous determination of 45 pesticides in fruit and vegetable using an improved QuEChERS method and on-line gel permeation chromatography–gas chromatography/mass spectrometer显示文摘 | Dasheng Lu Xinlei Qiu Chao Feng Yu’e Jin Yuanjie Lin Libei Xiong Yimin Wen Dongli Wang Guoquan Wang | 2012 | Journal of Chromatography B2012，，： | 1 |
| 15 | investigation and assessment of Landslide hazards of Fengdu county in the reservoir region of Three Corges Project on the Yangtize River显示文摘 | Wu Shuren Jin Yimin Zhang Yongshuang | 2004 | Environmental Geology2004，45，： | 1 |
| 16 | Investigations and assessment of the landslide hazards of Fengdu County in the reservoir region of the Three Gorges Project on the Yangtze River显示文摘 | WU Shuren JIN Yimin ZHANG Yongshuang | 2004 | Environmental Geology2004，45，： | 1 |
| 17 | Investigation and assessment of landslide hazards of Fengdu County in the reservoir region of Three Gorges Project on the Yangtize RAver显示文摘 | Wu Shuren Jin Yimin Zhang Yongshuang | 2004 | Environ mental Geology2004，45，： | 1 |
| 18 | Lignin Characterization of Triploid Clones of Populus tomentosa Cart显示文摘 | Jin Xiaojuan Pu Junwen Xie Yimin | 2006 | Foresty Studies in China2006，7，： | 1 |
| 19 | Investigations and assessment of the landslide hazards of Fengdu county in the reservoir region of the Three Gorges project on the Yangtze River显示文摘 | Shuren Wu Yimin Jin Yongshuang Zhang Jusong Shi Chen Dong Weizhi Lei Ling Shi Chengxuan Tan Daogong Hu | 2004 | Environmental Geology2004，，4： | 1 |
| 20 | Color Image Segmentation Based on Mean Shift and Normalized Cuts 显示文摘 | Wenbing Tao Hai Jin Yimin Zhang | 2007 | IEEE Transactions on Systems Man and Cyber- netics - Part B : Cybernetics2007，37，5： | 1 |
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