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| 1 | Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET)显示文摘This is a retrospective,observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET).11830 IVF-ET cycles from 10268 women were included.Four groups of different maternal age periods were compared.The groups were 21 30 years old group(4549 cycles),31-35 years old group(4424 cycles),36-40 years old group(2429 cycles),and over 40 years old group(428 cycles).The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher(P<0.01),while the mean retrieved oocyte number was significantly lower(P<0.01) in groups of higher maternal age period than those in each of the lower groups.The biochemical pregnancy rate and the clinical pregnancy rate were significantly lower(P<0.01),while the miscarriage rate was significantly higher(P<0.01) in groups of higher maternal age period than those in the lower groups.No difference was found in two-pronuclear zygotes(2PN) rate and good quality embryo rate among different groups.Birth defect rate was also comparable in the born babies in different groups.In the group with patients' age over 40 years old,the pregnancy rate was 26.87%,the clinical pregnancy rate was 19.39%,while the miscarriage rate after clinical pregnancy was 36.14%.To draw the conclusion,patients with higher maternal age had worse IVF outcomes.In women of fertile age,patients between 20 and 30 years old have the best IVF outcomes.Patients over 40 years old have poor IVF outcome and high miscarriage rate,which suggested the necessity of preimplantation genetic screening(PGS). | YAN JunHao WU KeLiang TANG Rong DING LingLing CHEN Zi-Jiang | 2012 | Science China(Life Sciences)2012，55，8： | 23 |
| 2 | Pore characterization of different types of coal from coal and gas outburst disaster sites using low temperature nitrogen adsorption approach显示文摘To characterize the pore features of outburst coal samples and investigate whether outburst coal has some unique features or not, one of the authors, working as the member of the State Coal Mine Safety Committee of China, sampled nine outburst coal samples(coal powder and block) from outburst disaster sites in underground coal mines in China, and then analyzed the pore and surface features of these samples using low temperature nitrogen adsorption tests. Test data show that outburst powder and block coal samples have similar properties in both pore size distribution and surface area. With increasing coal rank, the proportion of micropores increases, which results in a higher surface area. The Jiulishan samples are rich in micropores, and other tested samples contain mainly mesopores, macropores and fewer micropores. Both the unclosed hysteresis loop and force closed desorption phenomena are observed in all tested samples. The former can be attributed to the instability of the meniscus condensation in pores,interconnected pore features of coal and the potential existence of ink-bottle pores, and the latter can be attributed to the non-rigid structure of coal and the gas affinity of coal. | Qi Lingling Tang Xu Wang Zhaofeng Peng Xinshan | 2017 | International Journal of Mining Science and Technology2017，27，2： | 15 |
| 3 | Multichannel vectorial holographic display and encryption显示文摘Since its invention,holography has emerged as a powerful tool to fully reconstruct the wavefronts of light including all the fundamental properties(amplitude,phase,polarization,wave vector,and frequency).For exploring the full capability for information storage/display and enhancing the encryption security of metasurface holograms,smart multiplexing techniques together with suitable metasurface designs are highly demanded.Here,we integrate multiple polarization manipulation channels for various spatial phase profiles into a single birefringent vectorial hologram by completely avoiding unwanted cross-talk.Multiple independent target phase profiles with quantified phase relations that can process significantly different information in different polarization states are realized within a single metasurface.For our metasurface holograms,we demonstrate high fidelity,large efficiency,broadband operation,and a total of twelve polarization channels.Such multichannel polarization multiplexing can be used for dynamic vectorial holographic display and can provide triple protection for optical security.The concept is appealing for applications of arbitrary spin to angular momentum conversion and various phase modulation/beam shaping elements. | Ruizhe Zhao Basudeb Sain Qunshuo Wei Chengchun Tang Xiaowei Li Thomas Weiss Lingling Huang Yongtian Wang Thomas Zentgraf | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 4 | Interaction of sleep quality and sleep duration on glycemic control in patients with type 2 diabetes mellitus显示文摘 | Tang Yunzhao Meng lingling Li Daiqing Yang Min Zhu Yanjuan Li Chenguang Jiang Zhenhuan Yu Ping Li Zhu Song Hongna Ni Changlin | 2014 | Chinese Medical Journal2014，，20： | 9 |
| 5 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 6 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘Cockayne syndrome(CS)is a rare autosomal recessive inherited disorder characterized by a variety of clinical features,including increased sensitivity to sunlight,progressive neurological abnormalities,and the appearance of premature aging.However,the pathogenesis of CS remains unclear due to the limitations of current disease models.Here,we generate integration-free induced pluripotent stem cells(iPSCs)from fibroblasts from a CS patient bearing mutations in CSB/ERCC6 gene and further derive isogenic genecorrected CS-iPSCs(GC-iPSCs)using the CRISPR/Cas9 system.CS-associated phenotypic defects are recapitulated in CS-iPSC-derived mesenchymal stem cells(MSCs)and neural stem cells(NSCs),both of which display increased susceptibility to DNA damage stress.Premature aging defects in CS-MSCs are rescued by the targeted correction of mutant ERCC6.We next map the transcriptomic landscapes in CS-iPSCs and GC-iPSCs and their somatic stem cell derivatives(MSCs and NSCs)in the absence or presence of ultraviolet(UV)and replicative stresses,revealing that defects in DNA repair account for CS pathologies.Moreover,we generate autologous GC-MSCs free of pathogenic mutation under a cGMP(Current Good Manufacturing Practice)-compliant condition,which hold potential for use as improved biomaterials for future stem cell replacement therapy for CS.Collectively,our models demonstrate novel disease features and molecular mechanisms and lay a foundation for the development of novel therapeutic strategies to treat CS. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2020 | Protein & Cell2020，11，1： | 7 |
| 7 | Large-eddy simulation of the generation and propagation of internal solitary waves显示文摘A modified large-eddy simulation model,the dynamic coherent eddy model(DCEM)is employed to simulate the generation and propagation of internal solitary waves(ISWs)of both depression and elevation type,with wave amplitudes ranging from small,medium to large scales.The simulation results agree well with the existing experimental data.The generation process of ISWs is successfully captured by the DCEM method.Shear instabilities and diapycnal mixing in the initial wave generation phase are observed.The dissipation rate is not equal at different locations of an ISW.ISW-induced velocity field is analyzed in the present study.The structure of the bottom boundary layer(BBL)of internal wave packets is found to be different from that of a single ISW.A reverse boundary jet instead of a separation bubble exists behind the leading internal wave while separation bubbles appear in other parts of the wave-induced velocity field.The boundary jet flow resulting from the adverse pressure gradients has distinctive dynamics compared with free shear jets. | ZHU Hai WANG LingLing TANG HongWu | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 6 |
| 8 | A novel dynamic coherent eddy model and its application to LES of a turbulent jet with free surface显示文摘We has developed a novel dynamic coherent eddy model,in which the coherent structure-Q criterion introduced by Hunt et al(1988)-is taken into account in the subgrid-scale turbulent viscosity based on the eddy viscosity model.One proposed method is to combine the resolved-scale velocity-gradient tensor in the classical Smagorinsky model with Q criterion weighted.A kind of dynamic procedure which was averaged in a general process at temporal direction based on the autocorrelations of the characteristic resolved scales of turbulence was taken for the coefficient of subgrid model.The model is implemented in the σ-coordinate and the filtered Navier-Stokes equations are solved by the operator splitting method.The validation was explored to 2-D turbulent slot jet both in ambient environment and in regular waves.The prediction of the present model was compared with the experiment data,including the averaged velocity profiles,the velocity fluctuations and the Reynolds stress.The model performance is shown to be satisfactory. | LU Jun,TANG HongWu,WANG LingLing & PENG Feng College of water conservancy of hydro-power engineering,Hohai University,Nanjing 210098,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 6 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 11 | Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges显示文摘The 2050 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment innovation.Insulating material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and opportunities.The goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first discussed.The engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are investigated.Insulating materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being discussed.In the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material level.It is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality rules.The authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision. | Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin Wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang Yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao Wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng Wang Yunlong Zi | 2022 | High Voltage2022，7，4： | 4 |
| 12 | Preparation, microstructure and degradation performance of biomedical magnesium alloy fine wires显示文摘With the development of new biodegradable Mg alloy implant devices, the potential applications of biomedical Mg alloy fine wires are realized and explored gradually. In this study, we prepared three kinds of Mg alloy fine wires containing 4 wt% RE(Gd/Y/Nd) and 0.4 wt% Zn with the diameter less than 0.4 μm through casting, hot extruding and multi-pass cold drawing combined with intermediated annealing process. Their microstructures, mechanical and degradation properties were investigated. In comparison with the corresponding as-extruded alloy, the final fine wire has significantly refined grain with an average size of 3–4 μm, and meanwhile shows higher yield strength but lower ductility at room temperature. The degradation tests results and surface morphologies observations indicate that Mg–4Gd–0.4Zn and Mg–4Nd–0.4Zn fine wires have similar good corrosion resistance and the uniform corrosion behavior in SBF solution. By contrast, Mg–4Y–0.4Zn fine wire shows a poor corrosion resistance and the pitting corrosion behavior. | Jing Bai Lingling Yin Ye Lu Yiwei Gan Feng Xue Chenglin Chu Jingli Yan Kai Yan Xiaofeng Wan Zhejun Tang | 2014 | Progress in Natural Science:Materials International2014，24，5： | 3 |
| 13 | Intelligent technologies help operating mobile cabin hospitals effectively cope with COVID-19显示文摘Coronavirus disease 2019(COVID-19)has spread fast,and the number of confirmed cases worldwide reaches 167511,in which 81077 are recorded in China until March 16,2020(WHO,2020a).In response to the situation,the Chinese government has marshalled the full resources and efforts of the country to reduce the COVID-19 morbidity and mortality.As the number of confirmed cases decreases considerably every day,China’s control approach for COVID-19 epidemic has been proven to be agile and productive(National Health Commission,2020;WHO,2020b).Among all interventions,operating Chinese mobile cabin hospitals is considered one of the most effective measures because it holds many patients simultaneously at the outbreak stage;as such,this strategy quickly and effectively contains the spread of the virus(WHO,2020b;Zhang,2020b). | Ying ZHOU Lingling WANG Lieyun DING Zhouping TANG | 2020 | Frontiers of Engineering Management2020，7，3： | 2 |
| 14 | A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19:The Artificial-Liver Blood-Purification System显示文摘The coronavirus disease 2019(COVID-19)pan-epidemic,resulting from infection with the 2019 novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is currently the source of public health concern worldwide;however,treatment of this infection has been clinically challenging in many patients[1].Importantly,2019-nCoV is the third fatal coronavirus that has emerged in the past two decades,following SARS-CoV and the Middle East respiratory syndrome(MERS)-CoV[2].The numbers of confirmed cases of COVID-19 infection and related deaths are still rising.As of 9 March 2020. | Yimin Zhang Liang Yu LingLing Tang Mengfei Zhu Yanqi Jin Zhouhan Wang Lanjuan Li | 2021 | Engineering2021，7，1： | 2 |
| 15 | Designing HVDC GIS/GIL spacer to suppress charge accumulation显示文摘To suppress the charge accumulation on the spacer surface in direct current(DC)gas insulated transmission line(GIL)is an important and emergent issue for the development of a clean,safe and economic smart grid.A design method of the DC spacer is proposed,and a spacer prototype is prepared and evaluated both by simulation and type test.The DC withstand voltage test and polarity reversal test are performed using the new DC spacer compared with a commercialised 220 kVAC spacer.The simulation results indicate that the surface electric field and surface charge of the DC spacer are lower than those of the alternating current(AC)spacer under DC voltage.The test results verify that the surface flashover voltage of this DC spacer is higher than that of the AC spacer.The potential feasibility of the spacer design for HVDC is discussed.It is hoped that the content of this paper can bring new ideas in the development of HVDC gas insulated equipment. | Zuodong Liang Chuanjie Lin Fangwei Liang Weijian Zhuang Yujia Xu Lingling Tang Yulin Zeng Jun Hu Bo Zhang Chuanyang Li Jinliang He | 2022 | High Voltage2022，7，4： | 2 |
| 16 | A carbon-sup- ported Pd-P catalyst as the anodic catalyst in a direct formic acid fuel cell显示文摘 | Lingling Zhang Yawen Tang Jianchun Bao et a/ | 2006 | Power Sources2006，162，： | 1 |
| 17 | Technical feasibility study of an onshore ballast water treatment system显示文摘To fulfill the requirements of Guidelines forapproval of ballast water management system(G8),a setof onshore ballast water treatment equipment utilizingmicro-pore ceramic filtration(MPCF)and UV radiation(MPCF&UV)system was designed and set up with amaximum flow rate of 80 m^(3)·h^(-1).Technical feasibilities ofMPCF&UV system were evaluated in three areas:removalefficiencies of indicator organism and oceanic bacteria,perdurability of a ceramic filter,and application on nativeseawater.The results showed that no indicator organism(Dunaliella)or oceanic bacteria was detected aftertreatment of 20 L MPCF and UV radiation at 1.3×10^(4)μW·s·cm^(-2).A 20 L ceramic filter can run continuouslyfor 5.3 h at the flow rate of 15 m3·h-1 before itspressure drop up to 0.195 MPa.The removal percentage oftotal plankton amounts were 91.9%at a flow rate of70 m^(3)·h^(-1)by 80 L MPCF and UV radiation at 1.3×10^(4)μW·s·cm^(-2). | Shengjie LIU Manxia ZHANG Xiang LI Xiaojia TANG Lingling ZHANG Yimin ZHU Chengyu YUAN | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 1 |
| 18 | Oil-importing optimal decision considering country risk with extreme events: A multi-objective programming approach显示文摘 | Li Jianping Tang Lingling Sun Xiaolei | 2014 | Computers & Operations Research2014，42，： | 1 |
| 19 | Usefulness of 18 F-FDG PET, combined FDG-PET/CT and EUS in diagnosing primary pancreatic carcinoma: A meta-analysis显示文摘 | Shuang Tang Gang Huang Jianjun Liu Tao Liu Lyndal Treven Saoli Song Chenpeng Zhang Lingling Pan Ting Zhang | 2009 | European Journal of Radiology2009，，1： | 1 |
| 20 | Local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics显示文摘Medical image segmentation is of pivotal importance in computer-aided clinical diagnosis. Many factors, including noises, bias field effect, local volume effect, as well as tissue movement may affect the medical image, thus causing blurring or uneven characteristics when forming a picture. Such quality defects will inevitably impair the gray-scale difference between adjacent tissues and lead to insufficient segmentation or even leakage during tissue or organ segmentation. In the present investigation, a local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics(LARFS) was proposed. By combining segmentation algorithm principles for traditional region growing(RG) and robust feature statistics(RFS), the location and neighborhood image information of input seed point can be comprehensively analyzed by LARFS.Results show that, for different segmentation objects, under controlling the input parameter of growing factor within certain range, LARFS segmentation algorithm can adapt well to the regional geometric shape. And because the robust feature statistics is applied in the contour evolution process, LARFS algorithm is not sensitive to noises and not easily influenced by image contrast and object topology. Hence, the leakage and excessive segmentation effects are ameliorated with a smooth edge, and the accuracy can be controlled within the effective error range. | ZHUO ZiHan ZHAI WeiMing LI Xin LIU LingLing TANG JinTian | 2014 | Science China(Information Sciences)2014，57，10： | 1 |
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