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| 1 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | The fusarium wilt resistance locus Fom-2 of melon contains a single resistance gene with complex features显示文摘 | TAREK J JOSEPH J K SHELLY J N CLAUDE E T RALPH A D | 2004 | The Plant Journal2004，39，： | 1 |
| 4 | Studies on polyisobuty- lene bound paraphenylene diamine antioxidant in natural rubber 显示文摘 | Sulekha P B Joseph R George K E | 1999 | Polym Degrad Stab1999，63，2： | 1 |
| 5 | Validation of a sensitive LC-MS/MS method for the determination of zidovudine and lamivudine in human plasma显示文摘 | JOSEPH E R BRANDON K LANE R B | 2012 | Biomed Chromatogr2012，26，1： | 1 |
| 6 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 7 | Dividend taxation and intertemporal tax arbitrage 显示文摘 | Anton K Joseph E S | 2009 | Journal of Public Economics2009，，93： | 1 |
| 8 | Reaction kinetics and optimization of the copper-catalyzed oxidation of ApoA-1M 显示文摘 | Sa V H Joseph K M Kristen E T | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 9 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 10 | Evidence for mediating econeurocardiologic mechanisns显示文摘 | BELKIC K JOSEPH E SCHNAL P | 2000 | Occup Med2000，15，1： | 1 |
| 11 | The peptidyl-prolyl isomerase Pin1 显示文摘 | JOSEPH J D YEH E S SWENSON K I | 2003 | Prog Cell Cycle Res2003，5，： | 1 |
| 12 | Designing climate mitigation policy显示文摘 | Joseph E A Alan J K Richard G N | 2010 | Journal of Economic Literature2010，48，4： | 1 |
| 13 | Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals显示文摘 | Klos K J Ahlskog J E Josephs K A | 2006 | Neurology2006，66，： | 1 |
| 14 | HPLC/UV quantitation of retinal,retinol,and retinyl esters in serum and tissues显示文摘 | Maureen A K Alexandra E F Joseph L N | 2008 | Anal Biochem2008，378，1： | 1 |
| 15 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 16 | Nodal ratios in node positive breast cancer-long-term study to clarify discrepancy of role of supr- aclavicular and axillary regional radiotherapy显示文摘 | Tai P Joseph K Sadikov E | 2007 | Int J Radiat On- col Biol Phys2007，68，3： | 1 |
| 17 | Surgical Neuropathology Update: A Review of Changes Introduced by the WHO Classification of Tumours of the Central Nervous System, 4th Edition显示文摘 | Brat Daniel J Parisi Joseph E Kleinschmidt-DeMasters Bette K Yachnis Anthony T Montine Thomas J Boyer Philip J Powell Suzanne Z Prayson Richard A McLendon Roger E | 2008 | Archives of Pathology & Laboratory Medicine2008，，6： | 1 |
| 18 | A radix 4 delay commutator for fast Fourier transform processor implementation 显示文摘 | SWARTZLANDER E E YOUNG W K W JOSEPH S J | 1984 | IEEE Journal of Solid-State Circuits1984，19，5： | 1 |
| 19 | 显示文摘 | Joseph R Martyn M T Tanner K E | 2001 | Plastics Rubber and Composites2001，30，5： | 1 |
| 20 | Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals显示文摘 | Klos K J Ahlskog J E Josephs K A | | 0，，07： | 1 |
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