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| 1 | DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain显示文摘几机制为获得的 fluconazole (FLC ) 负责在 Candida albicans 的抵抗。在这研究,我们开发了 FLC 抵抗的 C。通过 FLC 易受影响的 C 的连续文化的 albicans 紧张。有 FLC 的禁止的集中的 albicans 紧张。赞美 DNA 微数组分析和即时反向的抄写聚合酶链反应被用来在易受影响的父母紧张和抵抗女儿紧张在 azole 抵抗的获得期间调查基因表示变化。表示基因代表了的差别工作象运输 ers 一样多样(例如 CDR1, PDR17 ) ,麦角固醇生合成(例如 ERG2, ERG9 ) ,甾醇新陈代谢(例如 ARE2, IPF6464 ) ,精力新陈代谢(例如 ADH3, AOX2 ) 并且抄写因素(例如 FCR1, ECM22 ) 。功能的分析表明膜运输 ers 的那项精力依赖者流出活动增加了,那个麦角固醇内容作为与易受影响的紧张相比在抵抗紧张与甾醇中介的累积减少了。我们发现在导致了 Tac1 的活动过度的抄写因素 TAC1 的一个点变化(N977K ) 能是原因为在在抵抗紧张的 CDR1, CDR2,和 PDR17 的表示上。而且,在导致的 ERG3 的单个氨基酸差别(D19E ) 在里面 Erg3 的激活能在这抵抗紧张在麦角固醇生合成基因的表示说明两甾醇先锋累积和变化。这些调查结果在临床的 C 扩展 FLC 抵抗的潜在的新奇分子的目标的理解。albicans 孤立。 | Lan Yan Jundong Zhang Miaohai Li Yongbing Cao Zheng Xu Yingying Cao Pinghui Gao Yan Wang Yuanying Jiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 11 |
| 2 | Controlled TiO2 coating on hollow glass microspheres and their reflective thermal insulation properties显示文摘Hollow glass microspheres(HGMs)have great potential in building energy-saving and industrial insulation.Anatase TiO2-modified HGMs were prepared by a sol-gel method in acetic acid-ethanol solution.Scanning electron microscopy,X-ray diffraction,zeta-potential measurements,nitrogen-sorption measurements,and Fourier-transform infrared and ultraviolet-visible-near-infrared diffuse reflectance spectroscopies showed that the alkali modification of the HGMs greatly influenced the loading and microstructure of the TiO2 film.The TiO2 loading could be accurately controlled by ethanol addition and the TiO2 coating time.A mechanism for the TiO2 coating of the HGM surface is proposed.The synergistic action of hydrogen bonding and electrostatic forces resulted in close contact between the HGMs and TiO2 sol at pH 3.5.The effects of different TiO2 loading rates on the reflective and thermal insulation properties were studied.The near-infrared reflectance of 15.9%TiO2 coated on HGMs was 96.27%,and the inner surface temperature of the composite pigment coated on aluminum board was reduced by 22.4℃.The TiO2/HGM composite pigments exhibited excellent solar reflective and thermal insulation properties,so have potential in the construction of exterior walls and roofs. | Jie Long Chongwen Jiang Jundong Zhu Quzhi Song Jiang Hu | 2020 | Particuology2020，18，2： | 10 |
| 3 | The Late Pleistocene activity of the eastern part of east Kunlun fault zone and its tectonic significance显示文摘The nearly EW-trending East Kunlun fault zone is the north boundary of the Bayan Har block.The activity characteristics and the position of the eastern end of its eastward extension are of great significance to probing into the dynamic mechanism of formation of the east edge of the Tibetan Plateau,and also lay the foundation for seismic risk assessment of the fault zone.The following results are obtained by analysis based on satellite image interpretation of landforms,surface rupture survey,terrace scarp deformation survey,and terrace dating data on the eastern part of the East Kunlun fault zone:(1)the Luocha segment is a Holocene active fault,where a reverse L-shape paleoearthquake surface rupture zone of about 50 km long is located;(2)the Luocha segment is characterized by left-lateral slip movement under the compression-shear condition since the later period of the Late Pleistocene,with a rate of 7.68–9.37 mm/a and a vertical slip rate of 0.7–0.9 mm/a,which are basically in accord with the activity rate of segments on its west side.The results indicate that it is a part of eastward extension of the East Kunlun fault zone;(3)the high-speed linear horizontal slip of the nearly EW-trending East Kunlun fault zone is blocked by the South China block at east,and transforms into the vertical movement of the nearly SN-NNE trending Minjiang fault zone and the Longmenshan fault zone,and the uplift of Longmenshan and Minjiang.The area where transform of the two tectonic systems occurred confines the position of the east end;(4)Luocha segment and Maqu segment constitute the'Maqu seismic gap',so,seismic risk at Maqu segment is higher than that at Luocha segment,which should attract more attention. | ZHANG JunLong REN JinWei CHEN ChangYun FU JunDong YANG PanXin XIONG RenWei HU ChaoZhong | 2014 | Science China Earth Sciences2014，57，3： | 8 |
| 4 | Allele-aware chromosome-scale assembly of the allopolyploid genome of hexaploid Ma bamboo(Dendrocalamus latiflorus Munro)显示文摘Dendrocalamus latiflorus Munro is a woody clumping bamboo with rapid shoot growth.Both genetic transformation and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing techniques are available for D.latiflorus,enabling reverse genetic approaches.Thus,D.latiflorus has the potential to be a model bamboo species.However,the genome sequence of D.latiflorus has remained unreported due to its polyploidy and large genome size.Here,we sequenced the D.latiflorus genome and assembled it into three allele-aware subgenomes(AABBCC),representingthe largest genome of a major bamboo species.We assembled 70 allelic chromosomes(2,737 Mb)for hexaploid D.latiflorus using both singlemolecule sequencing from the Pacific Biosciences(Pac Bio)Sequel platform and chromosome conformation capture sequencing(Hi-C).Repetitive sequences comprised 52.65%of the D.latiflorus genome.We annotated 135231 protein-coding genes in the genome based on transcriptomes from eight different tissues.Transcriptome sequencing using RNA-Seq and Pac Bio singlemolecule real-time long-read isoform sequencing revealed highly differential alternative splicing(AS)between non-abortive and abortive shoots,suggesting that AS regulates the abortion rate of bamboo shoots.This high-quality hexaploid genome and comprehensive strand-specific transcriptome datasets for this Poaceae family member will pave the way for bamboo research using D.latiflorus as a model species. | Yushan Zheng Deming Yang Jundong Rong Liguang Chen Qiang Zhu Tianyou He Lingyan Chen Jing Ye Lili Fan Yubang Gao Hangxiao Zhang Lianfeng Gu | 2022 | Journal of Integrative Plant Biology2022，64，3： | 6 |
| 5 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 6 | Decrease in the Ki67 index during neoadjuvant chemotherapy predicts favorable relapse-free survival in patients with locally advanced breast cancer显示文摘Objective: The purpose of this study was to explore the optimal cutoffs of the three parameters of Ki67 during NAC for predicting patient prognosis and investigate whether the optimal cutoffs of the Ki67 values were associated with relapse-free survival(RFS) or breast cancer-specific survival(BCSS).Methods: A total of 92 patients with locally advanced breast cancer(LABC), who had residual disease after NAC were retrospectively investigated.The optimal cutoff values of the Ki67 parameters were assessed by the online algorithm Cutoff Finder.Kaplan-Meier analysis, the log-rank test and Cox regression analysis were carried out to analyze survival.Results: The optimal cutoff values for the postsurgical Ki67 level and the decrease in the Ki67 level during NAC were defined as 25% and 12.5%, respectively.According to the univariate survival analysis, a higher Ki67 level in residual disease was associated with poor RFS(P = 0.004) and BCSS(P = 0.014).In addition, a Ki67 expression decrease > 12.5% during NAC was related to favorable RFS(P = 0.007), but was not related to BCSS(P = 0.452).Cox regression analysis showed that the Ki67 expression decrease(> 12.5% vs.≤ 12.5%) and histological grade(grade 3 vs.grade 1-2) were the independent factors associated with RFS(P =0.020 and P = 0.023, respectively), with HR values of 0.353(95% CI: 0.147-0.850) and 3.422(95% CI: 1.188-9.858), respectively.Conclusions: The Ki67 decrease was one of the independent factors associated with RFS in LABC patients with residual disease after receiving NAC. | Chunfa Chen Yuling Zhang Ziyi Huang Jundong Wu Wenhe Huang Guojun Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 7 | Theory and application of stability for stochastic reaction diffusion systems显示文摘So far,the Lyapunov direct method is still the most effective technique in the study of stability for ordinary differential equations and stochastic differential equations. Due to the shortage of the corresponding It formula,this useful method has not been popularized in stochastic partial differential equations.The aim of this work is to try to extend the Lyapunov direct method to the It stochastic reaction diffusion systems and to establish the corresponding Lyapunov stability theory,including stability in probablity,asymptotic stability in probablity,and exponential stability in mean square.As the application of the obtained theorems,this paper addresses the stability of the Hopfield neural network and points out that the main results ob- tained by Holden Helge and Liao Xiaoxin et al.can be all regarded as the corollaries of the theorems presented in this paper. | LUO Qi DENG FeiQi MAO XueRong BAO JunDong ZHANG YuTian | 2008 | Science in China(Series F)2008，51，2： | 3 |
| 8 | The ring-substituted phthalo-cyanines and its metal complexes:Crystal structure of 1,4,8,11,15,18,22,25-octa-butoxyphthalocyani- natocopper(Ⅱ)显示文摘Crystal structure of 1, 4, 8, 11, 15, 18, 22, 25-octa-butoxyphthalocyaninatocopper (Ⅱ) (1) was determined by X-ray diffraction methods. The crystal system is mono-clinic, space group is P21/c, Z = 4, a = 1.3741(1) nm, b = 2.6737(1) nm, c = 1.6690(1) nm, β=101.278(1)°. The steric congestion between the neighbouring butoxyl groups causes the distortion of the ring core of phthalocyanine (Pc) into a saddle shape conformation. In the crystal structure, molecules stack along a axis forming one-dimensional packing structure and there are two molecular overlap types which appear in turn with different distances between molecules, overlap area and angle. | CAI Jinwan, WANG Jundong, HUANG Jinling & CHEN NaishengInstitute of Research on Functional Materials, Department of Chemistry, Fuzhou University, Fuzhou 350002, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Struct | 2002 | Chinese Science Bulletin2002，47，8： | 3 |
| 9 | Crystal plasticity model to predict fatigue crack nucleation based on the phase transformation theory显示文摘A crystal plasticity model is developed to predict the fatigue crack nucleation of polycrystalline materials,in which the accumulated dislocation dipoles are considered to be the origin of damage.To describe the overall softening behavior under cyclic loading,a slip system-level dislocation density-related damage model is proposed and implemented in the finite element analysis with Voronoi tessellation.The numerical model is applied to calibrate the stress-strain relationship at different cycles before fatigue crack nucleation.The parameters determined from the numerical analysis are substituted into a modified phase transformation model to predict the critical fatigue crack nucleation cycle.Comparing with the experimental results of Sn-3.0Ag-0.5Cu(SAC305)alloy and P91 steel,the proposed method can describe the constitutive behavior and predict the fatigue crack nucleation accurately. | Lu Liu Jundong Wang Tao Zeng Yao Yao | 2019 | Acta Mechanica Sinica2019，35，5： | 3 |
| 10 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 11 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 12 | Sex-specific responses of tree-ring growth to climate in the dioecious tree Populus cathayana显示文摘Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examine whether(i)there are sex-related responses of tree-ring growth to climate in dioecious trees;(ii)these responses could be changed with altitude elevation.Methods The tree-ring width and basal area increment(BAI)were measured over the past 30 years(1982-2011),and the sexual differences in relationship between BAI and time span and correlations between ring width and climatic factors were investigated in Populus cathayana trees at two altitude sites(1,450 m and 1,750 m a.s.l.)in Xiaowutai Mountain,Hebei,north China.Important Findings The BAI was increased over the past 30 years.Trees at high-altitude sites had significantly lower mean ring width and mean BAI than those trees at low-altitude sites(P<0.001).In addition,sexual dif-ferences in tree-ring growth and its response to climate were more pronounced by altitude elevation.Male trees had a significantly larger mean ring width and mean BAI than did females at high-alti-tude sites,whereas no significant sexual differences in these traits were detected at low-altitude sites.Female trees were sensitive to previous October-November temperatures at high altitude but to current February and April precipitation at low altitude(P<0.05),whereas male trees were sensitive to current June temperature at high altitude but to January precipitation at low altitude(P<0.05).Our results indicated that the responses of tree-ring growth to cli-mate are sex dependent and can be changed with altitude elevation. | Kechao Huang Yongmei Liao Tingfa Dong Yanxia Yang Jundong He Huihui Huan Qibing Zhang Xiao Xu | 2018 | Journal of Plant Ecology2018，11，5： | 2 |
| 13 | Ferroelectric materials for vibrational energy harvesting显示文摘Energy harvesting is an appealing technology that makes use of the ambient energy which is otherwise wasted. Piezoelectric materials directly convert the elastic energy to the electric energy, and thus have a great advantage in scavenging vibrational energy for simplicity in device structure with relatively high power density. This paper provides an overview on the research of piezoelectric materials in energy harvesting in recent decades, from basics of piezoelectricity and working principle of energy harvesting with piezoelectric materials, to the progress of development of high-performance piezoelectrics including ceramics, single crystals and polymers, then to experimental attempts on the device fabrication and optimization, finally to perspective applications of piezoelectric energy harvesting(PEH). The criteria for selection of materials for PEH applications are introduced. Not only the figure of merit but also maximum allowable stress of materials are taken into account in the evaluation of their potential in achieving high energy density and output power density. The influence of the device configuration on the performance is also acknowledged and discussed. The magnitude and distribution of induced stress in the piezoelectric unit upon excitation by the vibration source play an important role in determining the output power density and can be tuned via proper design of device configuration without changing its resonant frequency. Approaches to address the issue of frequency match accompanying with the resonant mode are illustrated with literature examples. Usage of PEH devices can be extended to a variety of vibration sources in everyday life as well as in nature. Some appealing applications of PEH, such as in implantable and wearable devices, are reviewed. | SONG JunDong WANG Jin | 2016 | Science China(Technological Sciences)2016，59，7： | 2 |
| 14 | Video object segmentation of still background显示文摘 | Wu Zeju Chen Jundong LiuYun | 2004 | Journal of Qingdao University of Science and Technology2004，25，5： | 1 |
| 15 | miR-34a inhibits the migration and invasion of esophageal squamous cellcarcinoma by targeting Yin Yang-1显示文摘 | Jihua Nie Xin Ge Yangyang Geng Han Cao Wei Zhu Yang Jiao Jinchang Wu Jundong Zhou Jianping Cao | 2015 | Oncology Reports2015，，： | 1 |
| 16 | Studies on Surface Properties and Cell Adhesion Properties of BSA Modified DBM Scaffold显示文摘As a scaffold material for bone tissue engineering, demineralized bone matrix(DBM) has such a limited ability to load cells and growth factors that the surface of the DBM scaffold was modified with bovine serum albumin(BSA) with different concentrations to improve the protein stmcture and physicochemical properties of the scaffold surface so as to enhance the adhesion of the cells. And the appropriate BSA concentration was explored. Compared with DBM, the scaffold with BSA coating had a smaller pore size and a lower porosity, also, the degradation rate was accelerated and the hydrophilic property was improved. Cells adhesion was observed inside the DBM seaffold before and after it had been modified, and the BSA modified scaffold had a good cell compatibility. Wlien the concentration of BSA was 20 mg/mL, the adhesion ability of the cells to modified scaffold was significantly increased, and the cell proliferation was facilitated. | SUN Mengjie FENG Wei WANG Bowei HAN Bing ZOU Jundong YANG Chunying LIU Zhihui | 2019 | Chemical Research in Chinese Universities2019，35，4： | 1 |
| 17 | Associationbe- tweenpl6 INK4apromoter methylation and non-small cell- lungcancer: ameta - analysis 显示文摘 | Jundong Gu Yanjun wen Siwei zhu | 2013 | PLoS One2013，8，60： | 1 |
| 18 | Clofibrate induces heme oxy- genase 1 expression through a PPARu - independent mechanism in human cancer cells 显示文摘 | Shuai W Bethany NH Jundong Z | 2013 | Cell Physiol Bioehem2013，32，5： | 1 |
| 19 | PEG-related polymer resins as synthetic supports显示文摘Combinatorial chemistry has become a significant part of the discovery and optimization process for novel drugs,affinity ligands,and catalysts.The polymeric supports play a key role in combinatory chemistry.Therefore,various kinds of functional polymer resins have been exploited as supports,reagents,and catalysts in organic synthesis.In comparison to the conventional Merrifield resins,the poly(ethylene glycol)(PEG)-related polymer resins have advantages including good compatibilities with polar solvents,good solvent absorbency and swelling properties.This review focuses primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis. | WANG Zheng1,YANG RuLei1,ZHU JunDong & ZHU XiaoXia2 1School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China 2Département de chimie,Université de Montréal,Montréal,QC H3C 3J7,Canada | 2010 | Science China Chemistry2010，53，9： | 1 |
| 20 | Video object segmentation of still background 显示文摘 | Wu Zeju Chen Jundong | 2004 | Journal of Qingdao University of Science and Technology2004，25，5： | 1 |
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