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| 1 | Comparison of breast-conserving surgery and mastectomy in early breast cancer using observational data revisited:a propensity score-matched analysis显示文摘Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients. | Kai Chen Zihao Pan Liling Zhu Tingting Hu Min Peng Weijuan Jia Fengxi Su Shunrong Li Erwei Song | 2018 | Science China(Life Sciences)2018，61，12： | 12 |
| 2 | Carbon Sequestration Effects of Shrublands in Three-North Shelterbelt Forest Region, China显示文摘三北方的防风林福雷斯特(TSF ) 节目,是六个关键林地节目之一并且有一个 73 年的构造时期,从 1978 ~ 2050。在这个区域的灌木的碳隐遁的定量分析为在中国理解森林和另外的陆上的生态系统的碳隐遁的全面功能是重要的。这研究在 1978 和 2008 基于遥感图象在 TSF 区域调查了 shrubland 的分发区域,并且从出版报纸与领域调查和以前的数据在联合计算了 shrubland 的碳密度。从 1978 ~ 2008 的碳隐遁数量和率在 TSF 区域为四个分区和灌木的不同类型被分析。结果揭示了那:1 ) 在学习区域和它的四个分区的 shrubland 的区域在过去的三十年期间增加了。为在 2008 的整个区域的 shrubland 的区域是为 25 恢复了年的 1.2 tation。实验在 Yanan 城市里在 Yangjuangou 集水被进行, Shaanxi 省,中国。二个邻近的斜坡为这研究被选择。六个样品地点是 spaced 到沿着山斜坡的脚趾斜坡的从顶点的每 3545 m,和每个样品地点包含了三个采样阴谋。土壤在表面土壤层( 010 厘米和 1020 厘米)的器官的碳和相关物理化学的性质基于土壤采样和实验室分析被测量,并且土壤二氧化碳(公司<潜水艇class=“ a-plus-plus ”> 2 )排出物和环境因素同时在一样的样品地点被测量。结果显示一般来说,一张更高的土壤碳股票被发现在里面吗? | LIU Wenhui ZHU Jiaojun JIA Quanquan ZHENG Xiao LI Junsheng LOU Xuedong HU Lile | 2014 | Chinese Geographical Science2014，24，4： | 11 |
| 3 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 4 | In pursuit of a flawless aphrodite:paving the way to scarless oncoplastic breast surgery显示文摘Introduction Breast cancer is the most commonly diagnosed malig-nancy in women worldwide[1,2]and in the twentieth century,mastectomy was the primary surgical treatment for breast cancer patients.Advances in breast-conserving surgery(BCS)propelled a change in treatment rational from“maximum tolerable”to“minimum effective”ther-apy.Oncoplastic breast surgery aims to restore the shape of the breast and has been widely adopted since the past decade.Although the cosmetic outcome has been sig-nificantly improved,the scar remaining on the surgeried breast skin is still a major pitfall that urges urgent consid-eration.In this editorial,we review a series of techniques that can be incorporated in oncoplastic breast surgery to minimize scarring,signifying the beginning of an era for scarless oncoplastic surgery. | Liling Zhu Shunrong Li Luyuan Tan Xiaolan Zhang Jiannan Wu Fengxi Su Kai Chen Erwei Song | 2019 | Cancer Communications2019，39，1： | 4 |
| 5 | Plant diversity of secondary forests in response to anthropogenic disturbance levels in montane regions of northeastern China 显示文摘 | Zhu Jiaojun Mao Zhihong Hu Lile | 2007 | Journal of Forest Research2007，12，： | 1 |
| 6 | Dispersion of the Mechanical Parts Performance Indicators Based on the Concept of Random Vector显示文摘To solve the precision and reliability problem of various machinery equipments and military vehicles,some military organisations,the industrial sector and the academia at home and abroad begin to pay attention to the statistical distribution of machining dimensions,material properties and service loads,and the system reliability optimization design with constraints and reliability optimization design of various mechanical parts is studied in this way.However,the above researches focus on solving the strength and the life problem,and no studies have been done on the discrete degree and discrete pattern of other performance indicators.The concept of using a random vector to describe the mechanical parts performance indicators is presented;characteristics between the value of the vector variance matrix determinant and the sum of the diagonal covariance matrix in describing the performance indicators of vector dispersion are studied and compared.A clutch diaphragm spring is set as an example,the geometric dimension indicator is described with random vector,and the applicability of using variance matrix determinant and variance matrix trace of geometric dimension vector to describe discrete degree of random vector is studied by using Monte-Carlo simulation method and component discrete degree perturbation method.Also,the effects of different components of diaphragm spring geometric dimension vector on the value of covariance matrix determinant and the sum of covariance matrix diagonal of diaphragm spring performance indicators vector are analyzed.The present study shows that the impacts of the dispersion of diaphragm spring cone angle on every performance dispersion are all ranked first,and far exceed that of other dimension dispersion.So it must be strictly controlled in the production process.The result of the research work provides a reference for the design of diaphragm spring,and also it presents a proper method for researching the performance of other mechanical parts. | XIA Changgao ZHU Pei ZHANG Meng GAO Xiang LU Liling | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 1 |
| 7 | Determination of the tridimensional shape of canopy gaps using two hemispherical photographs显示文摘 | Hu Lile Zhu Jiaojun | 2009 | Agricultural and Forest Meteorology2009，149，： | 1 |
| 8 | Improving gap light index (GLI) to quickly calculate gap coordinates 显示文摘 | Hu Lile Zhu Jiaojun | 2008 | Canadian Journal of Forest Research2008，38，： | 1 |
| 9 | Estimation of canopy gap size and gap shape using a hemispherical photograph显示文摘 | Lile Hu Zhiwen Gong Junsheng Li Jiaojun Zhu | 2009 | Trees2009，，5： | 1 |
| 10 | Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis显示文摘Immunoglobulin G4-related sialadenitis(IgG4-RS)is an immune-mediated fibro-inflammatory disease and the pathogenesis is still not fully understood.The aim of this study was to explore the role and mechanism of interleukin-13(IL-13)in the cellular senescence during the progress of IgG4-RS.We found that the expression of IL-13 and IL-13 receptorα1(IL-13Rα1)as well as the number of senescent cells were significantly higher in the submandibular glands(SMGs)of IgG4-RS patients.IL-13 directly induced senescence as shown by the elevated activity of senescence-associatedβ-galactosidase(SA-β-gal),the decreased cell proliferation,and the upregulation of senescence markers(p53 and p16)and senescence-associated secretory phenotype(SASP)factors(IL-1βand IL-6)in SMG-C6 cells.Mechanistically,IL-13 increased the level of phosphorylated signal transducer and activator of transcription 6(p-STAT6)and mitochondrial-reactive oxygen species(mt ROS),while decreased the mitochondrial membrane potential,ATP level,and the expression and activity of superoxide dismutase 2(SOD2).Notably,the IL-13-induced cellular senescence and mitochondrial dysfunction could be inhibited by pretreatment with either STAT6 inhibitor AS1517499 or mitochondria-targeted ROS scavenger Mito TEMPO.Moreover,IL-13 increased the interaction between p-STAT6 and c AMP-response element binding protein(CREB)-binding protein(CBP)and decreased the transcriptional activity of CREB on SOD2.Taken together,our findings revealed a critical role of IL-13 in the induction of salivary gland epithelial cell senescence through the elevated mitochondrial oxidative stress in a STAT6–CREB–SOD2-dependent pathway in IgG4-RS. | Mengqi Zhu Sainan Min Xiangdi Mao Yuan Zhou Yan Zhang Wei Li Li Li Liling Wu Xin Cong Guangyan Yu | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 11 | Monolithic integration of nanorod arrays on microfluidic chips for fast and sensitive one-step immunoassays显示文摘Here,we present integrated nanorod arrays on microfluidic chips for fast and sensitive flow-through immunoassays of physiologically relevant macromolecules.Dense arrays of Au nanorods are easily fabricated through one-step oblique angle deposition,which eliminates the requirement of advanced lithography methods.We report the utility of this plasmonic structure to improve the detection limit of the cardiac troponin I(cTnI)assay by over 6x 105-fold,reaching down to 33.9fg mL^(-1)(-1.4fM) compared with an identical assay on glass substrates.Through monolithic integration with microfluidic elements,the device enables a flow-through assay for quantitative detection of cTnI in the serum with a detection sensitivity of 6.9 pg mL^(-1)(-0.3 pM)in<6 min,which was 4000 times lower than conventional glass devices.This ultrasensitive detection arises from the large surface area for antibody conjugation and metal-enhanced fluorescent signals through plasmonic nanostructures.Moreover,due to the parallel arrangement of flow paths,simultaneous detection of multiple cancer biomarkers,including prostate-specific antigen and carcinoembryonic antigen,has been fulfilled with increased signal-to-background ratios.Given the high performance of this assay,together with its simple fabrication process that is compatible with standard mass manufacturing techniques,we expect that the prepared integrated nanorod device can bring on-site point-of-care diagnosis closer to reality. | Ye Wang Jiongdong Zhao Yu Zhu Shurong Dong Yang Liu Yijun Sun Liling Qian Wenting Yang Zhen Cao | 2021 | Microsystems & Nanoengineering2021，7，4： | 0 |
| 12 | Therapy Response of Chinese Herbal Medicine in Advanced Liver Cancer: A Retrospective Observational Clinical Trial显示文摘 | Guangmei Lv Liling Zhu Haijun Wan Ping Li Jing Zhang Ruoqu Wei Chongfeng Niu ShengnaiZheng Yongling Gong | 2016 | Journal of Pharmacy and Pharmacology2016，4，3： | 0 |
| 13 | Research on Regulation Method of Energy Storage System Based on Multi-Stage Robust Optimization显示文摘To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust optimization.This approach aims to regulate the energy storage system by using a multi-stage robust optimal control method,which helps overcome the limitations of traditional methods in terms of time scale.The goal is to effectively utilize the energy storage power station system to address issues caused by unpredictable variations in environmental energy and fluctuating load throughout the day.To achieve this,a mathematical model is constructed to represent uncertain energy sources such as photovoltaic and wind power.The generalized Benders Decomposition method is then employed to solve the multi-stage objective optimization problem.By decomposing the problem into a series of sub-objectives,the system scale is effectively reduced,and the algorithm’s convergence ability is improved.Compared with other algorithms,the multi-stage robust optimization model has better economy and convergence ability and can be used to guide the power dispatching of uncertain energy and energy storage systems. | Zaihe Yang Shuling Wang Runhang Zhu Jiao Cui Ji Su Liling Chen | 2024 | Energy Engineering2024，121，3： | 0 |
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