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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022,13,3: | 2 |
| 2 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002,,4: | 2 |
| 3 | Self-reported abstinence effects in the first month after smoking cessation显示文摘 | WARD M M SWAN G E JACK L M | 2001 | Addict Behav2001,26,3: | 1 |
| 4 | Supply Chain Design in the Food Industry显示文摘 | Jack G A J Vorst Stephan J van Dijk Adrie J M Beulens | 2001 | The International Journal on Logistics Management2001,12,2: | 1 |
| 5 | Self-generated Validity and Other Effects of Measurement on Belief, Attitude, Intention and Behavior 显示文摘 | Feldman Jack M Lynch John G | 1988 | Journal of Applied Psychology1988,73,8: | 1 |
| 6 | Severe sepsis exacerbates cell-mediat- ed immunity in the lung due to an altered dendritic cell cytokine profile 显示文摘 | Haitao W Cory M H Jack G | 2006 | Am J Pathol2006,168,6: | 1 |
| 7 | The role of friction film in friction,wear and noise of automotive brakes显示文摘 | Rhee SK Jack M g Tsang P H S | 1991 | Wear1991,146,11: | 1 |
| 8 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004,,3: | 1 |
| 9 | Fourier transform Processors based on SAW chirp filters 显示文摘 | JACK M A PAIGE E G S | 1978 | Wave Electron1978,3,: | 1 |
| 10 | Fourier transform processors based on SAW chirp filters显示文摘 | JACK M A PAIGE E G S | 1978 | Wave Electron1978,3,: | 1 |
| 11 | The effects of peer feedback on team member behavior显示文摘 | Peter G D Richard R R Jack W M | 1997 | Group and Organization Management1997,22,4: | 1 |
| 12 | Retrospective comparison of azithromycin,clarithromycin,and erythromycin for the treatment of foals with Rhodococcus equi pneumonia显示文摘 | Giguere S Jacks S Roberts G D Hernandez J Long M T Ellis C | | 0,,: | 1 |
| 13 | Modeling and simulating multi-echelon food systems显示文摘 | Jack G A J van der Vorst Adrid J M Beulens Paul van Beek | 2000 | European Journal of Operational Research2000,122,: | 1 |
| 14 | Pathological parameters of radical prostatectomy for clinical stages Tlc versus T2 prostate adenocarcinoma: decreased pathological stage and increased de- tection of transition zone tumors显示文摘 | Jack G S Cookson M S Coffey C S etal | 2002 | J Urol2002,165,2: | 1 |
| 15 | Automotive friction material evolution during the past decade显示文摘 | JACK M G Stang PH Rhee S K | 1984 | Wear1984,100,: | 1 |
| 16 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0,,: | 1 |
| 17 | Characterization and sur face properties of amino-acid-modified carbonate-containing hydroxyapatite particles显示文摘 | Jack K S Vizcarra T G Trau M | 2007 | Langmuir2007,23,12: | 1 |
| 18 | Superconductivity up to 29 K inSrFe2As2 and BaFe2As2 at high pressures显示文摘 | Patricia L Alireza Y T Chris Ko Jack Gillett Chiara M Petrone Jacqueline M Cole Gilbert G Lonzarich Suchitra E Sebastian | 2009 | Journal of Physics: Condensed Matter2009,,1: | 1 |
| 19 | Identifying sources of uncertainty to generate supply chain redesign strategies 显示文摘 | BEULENS A J M JACK G A J VAN DER VORST | 2002 | International Journal of Physical Distribution & Logistics Man- agement2002,32,6: | 1 |
| 20 | Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia显示文摘 | JACK M G RICHARD S E LUIGI F | 2004 | Blood2004,104,8: | 1 |