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| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | Efficiency and patient experience with propofol vsconventional sedation:A prospective study显示文摘AIM: To determine whether anaesthesiologistadministered sedation with propofol(AAP) or endoscopist-administered conscious sedation(EAC) with fentanyl/midazolam shortens colonoscopy duration/total room time. METHODS: This is a prospective, non-randomized, comparative study that enrolled patients greater than 18 years of age undergoing colonoscopy in a single Canadian academic outpatient endoscopy unit over a three-month consecutive period. Colonoscopies in this unit are performed both with AAP and EAC. Patient demographics, procedure-related data and adverse events were documented. Additionally, the level of procedure difficulty, and whether a staff endoscopist, trainee with assistance, or independent trainee, performed the procedure were documented. A validated modified 4-question, 5-point Likert scale telephone survey was used to assess patient satisfaction with colonoscopy. The telephone patient satisfaction survey was conducted 24-72 h following the procedure.RESULTS: Two hundred and thirty patients were enrolled during the study period with 126 patients in the AAP group and 104 patients in the EAC group. Mean procedure time was 18.3 ± 10.1 min in the AAP group and 14.7 ± 7.1 min in the EAC group(P = 0.002). Mean total room time was 36.8 ± 13.7 with AAP and 30.1 ± 11 min with EAC(P < 0.001). Multivariate analysis revealed the use of AAP(P = 0.002), resident participation(P < 0.001), diagnostic interventions(P = 0.033), therapeutic interventions(P < 0.001), lower body mass index(P = 0.008) and American Society of Anaesthesiologist class(P = 0.016), to be predictors of longer total room time. Patient age and gender were not significant predictors. After excluding cases in which trainees were involved, there was no significant difference in procedure time between the two groups(P = 0.941), however total room time was still prolonged in the AAP group(P = 0.019). The amount of pain experienced was lower with AAP(P = 0.02), with a trend toward overall higher patient satisfaction(P = 0.074). There were 2 sedation-related adverse events, both in the AAP group involving a patient with aspiration requiring hospitalization and a patient with hypoxia managed with bronchodilators.CONCLUSION: EAC results in reduced total room time compared to AAP. Resident participation doubles procedure time regardless of sedation type. | Patrick Thornley Mohammad Al Beshir James Gregor Andreas Antoniou Nitin Khanna | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 2 |
| 3 | Increased Quality of Life Among Hepatocellular Carcinoma Patients Treated with Radioembolization, Compared with Chemoembolization显示文摘 | Riad Salem Margaret Gilbertsen Zeeshan Butt Khairuddin Memon Michael Vouche Ryan Hickey Talia Baker Michael M. Abecassis Rohi Atassi Ahsun Riaz David Cella James L. Burns Daniel Ganger Al B. Benson Mary F. Mulcahy Laura Kulik Robert Lewandowski | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 4 | A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation显示文摘 | Gregory T. Everson Norah A. Terrault Anna S. Lok Del R. Rodrigo Robert S. Brown Sammy Saab Mitchell L. Shiffman Abdullah M.S. Al‐Osaimi Laura M. Kulik Brenda W. Gillespie James E. Everhart | 2013 | Hepatology2013，，5： | 2 |
| 5 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 6 | Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma 显示文摘 | Carroll NG Mutavdzic S James AL | 2002 | Thorax2002，57，8： | 1 |
| 7 | Contralateral suppression of DPOAE measured in real time显示文摘 | James AL Mount RJ Harrison RV | | 0，，： | 1 |
| 8 | Evidence for inflammation in asthma显示文摘 | Hogg JC James AL Pare PD | 1991 | Am Rev Respir Dis1991，143，1： | 1 |
| 9 | Evidence-Based Diuretic Therapy for Improving Cardiovascular Prognosis in Systemic Hypertension显示文摘 | Firas J. Al Badarin Mohammad A. Abuannadi Carl J. Lavie James H. O’Keefe | 2011 | The American Journal of Cardiology2011，，8： | 1 |
| 10 | Clinical relevance of airway remodeling in airway diseases显示文摘 | James AL Wenzel S | 2007 | Eur Respir J2007，30，1： | 1 |
| 11 | The use of the interal perimeter to compare airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dunn LA | 1998 | Am Rev Respir Dis1998，138，： | 1 |
| 12 | Evidence for inflammation in asthma显示文摘 | Hogg JC James AL Pare PD | 1991 | Am rev Respir Dis1991，143，32： | 1 |
| 13 | Management of bilateral choanal atresia in the neonate:an institutional review显示文摘 | Gujrathi CS Daniel SJ James AL | 2004 | Int J Pediatr Otorhinolaryngol2004，68，4： | 1 |
| 14 | The use of the internal perimeter to compara airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dumm LA | 1988 | Am Rev Respir Dis1988，138，1： | 1 |
| 15 | Evidence for inflammation in asthma显示文摘 | Hogg JC James AL Pare PD | 1991 | Am Rev Respir Dis1991，143，1： | 1 |
| 16 | Evidence for inflammation in asthma 显示文摘 | Hogg JC James AL Pare PD | 1991 | Am Rev Respir Dis1991，143，3： | 1 |
| 17 | A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor显示文摘 | Grazia Chiellini James W. Apriletti Hikari Al Yoshihara John D. Baxter Ralff C.J. Ribeiro Thomas S. Scanlan | 1998 | Chemistry & Biology1998，，6： | 1 |
| 18 | Airway smooth muscle hyper- trophy and hyperplasia in asthma显示文摘 | James AL Elliot JG Jones RL | 2012 | Am J Respir Crit Care Med2012，185，10： | 1 |
| 19 | Evidence for inflamm- ation in asthma显示文摘 | Hogg JC James AL Pate PD | 1991 | Am Rev Respir Dis1991，143，32： | 1 |
| 20 | Matrix metalloproteinase-1 in cholesteatoma, middle ear granulations and deep meatal skin:a comparative analysis显示文摘 | Banerjee AR James R Narula AA et al | 1998 | Clin Otolarygol1998，23，6： | 1 |
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