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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Mechanism of an antifungal action of selected cyclic peptides 显示文摘 | Graz M Jamie H Versluis C | 2001 | Pharmazie2001，56，： | 1 |
| 4 | The neglec- ted role of proaetive behavior and outcomes in newcomer socialization显示文摘 | Alan M S Jamie A G Helena C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 5 | Fetal aortic valve stenosis and evolution of hypoplastic left heart syndrome:patient selection for fetal intervention显示文摘 | Kaarin M Doff B Jami C | | 0，，11： | 1 |
| 6 | Targeted disruption of the α1,3-galactosytransferase gene in cloned pigs显示文摘 | Todd D V Jeremy B Shu-Hung Chen Carol J P Suyapa B Jeff A M Peter M J Kenneth J M Ashley E Lamborn Jamie L Cowell-Lucero Kevin D W Alan C Irina A P David L A | 2002 | Nat Biotechnology2002，20，3： | 1 |
| 7 | Obstructive sleep ap- nea and the metabolic syndrome in community - based Chinese a- dults in Hong Kong显示文摘 | Jamie C M Lam Bing Lam Chi-leung Lam | 2006 | Respiratory Medicine2006，100，： | 1 |
| 8 | Proteome analysis of the penicillin producer Penicillium chry- sogenurn: characterization of protein changes during the in- dustrial strain improvement 显示文摘 | JAMI M S BARREIRO C GARCIA-ESTRADA C | 2010 | Molecular Cellular Pro- teomics2010，9，6： | 1 |
| 9 | The neglected role of proactive behavior and outcomes in newcomer s-ialization 显示文摘 | ALAN M S JAMIE A G HELENA C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 10 | Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis显示文摘 | Serign J Ceesay Climent Casals-Pascual Jamie Erskine Samuel E Anya Nancy O Duah Anthony JC Fulford Sanie SS Sesay Ismaela Abubakar Samuel Dunyo Omar Sey Ayo Palmer Malang Fofana Tumani Corrah Kalifa A Bojang Hilton C Whittle Brian M Greenwood David J Conw | 2008 | The Lancet2008，，9649： | 1 |
| 11 | Modifications to physicochemical and nutritional properties of hard -to -cook beans (Phaseolus vulgaris L) by extrusion cooking显示文摘 | MARTIN-CABREJAS M A JAMIE L KARANJA C et al | 1999 | Journal of Agricultural and Food Chemistry1999，47，3： | 1 |
| 12 | Electrochemical fabrication of nickel manganese gallium alloy powder显示文摘 | Jamie W M A Ccpcutt R C Chen G Z | 2003 | Adv English Mater2003，5，9： | 1 |
| 13 | Isothermal Strand-Displacement Amplification Applications for High-Throughput Genomics显示文摘 | John C Detter Jamie M Jett Susan M Lucas Eileen Dalin Andre R Arellano Mei Wang John R Nelson Jarrod Chapman Yunian Lou Dan Rokhsar Trevor L Hawkins Paul M Richardson | 2002 | Genomics2002，，6： | 1 |
| 14 | Fetal aortic valve stenosis and evolution of hypoplastic left heart syndrome: patient selection for fetal intervention显示文摘 | Kaarin M Doff B Jami C etal | 2006 | Circulation2006，113，21： | 1 |
| 15 | Novel immunohistoehemical localization of 28 000 molecular-weight( Mr ) calcium binding protein ( calbindin-D28k ) in enterochromaffin cells of the human appendix and neuroendoerine tumors(carcinoids and small-cell carcinomas)of the midgut and foregut 显示文摘 | Katsetos C D Jami M M Krishna L et al | 1994 | Arch Pathol Lab Med1994，118，6： | 1 |
| 16 | Obstructive sleep apnoea : definitions, epidemiology and natural history显示文摘 | Lam Jamie C M Sharma S K Lam B | 2010 | India J Med Res2010，131，： | 1 |
| 17 | Risk perception and knowledge of COVID-19 in patients with celiac disease显示文摘BACKGROUND We recently demonstrated that the odds of contracting coronavirus disease 2019(COVID-19)in patients with celiac disease(CeD)is similar to that of the general population.However,how patients with CeD perceive their COVID-19 risk may differ from their actual risk.AIM To investigate risk perceptions of contracting COVID-19 in patients with CeD and determine the factors that may influence their perception.METHODS We distributed a survey throughout 10 countries between March and June 2020 and collected data on demographics,diet,COVID-19 testing,and risk perceptions of COVID-19 in patients with CeD.Participants were recruited through various celiac associations,clinic visits,and social media.Risk perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COVID-19 when compared to the general population.Logistic regression was used to determine the influencing factors associated with COVID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and comorbidities such as cardiac conditions,respiratory conditions,and diabetes.Data was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD completed the survey.From them,6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COVID-19 compared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COVID-19 when compared to infections in general due to their CeD(56.1%vs 26.7%,P<0.0001).Consequently,34.8%reported taking extra COVID-19 precautions as a result of their CeD.Members of celiac associations were less likely to perceive an increased risk of COVID-19 when compared to non-members(49.5%vs 57.4%,P<0.0001).Older age(aOR:0.99;95%CI:0.99 to 0.99,P<0.001),male sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated with a lower perception of COVID-19 risk and the presence of comorbidities was associated with a higher perception of COVID-19 risk(aOR:1.38;95%CI:1.22 to 1.54,P<0.001).CONCLUSION Overall,high levels of risk perceptions,such as those found in patients with CeD,may increase an individual’s pandemic-related stress and contribute to negative mental health consequences.Therefore,it is encouraged that public health officials maintain consistent communication with the public and healthcare providers with the celiac community.Future studies specifically evaluating mental health in CeD could help determine the consequences of increased risk perceptions in this population. | Jamie Zhen Juan Pablo Stefanolo María de la Paz Temprano Caroline L Seiler Alberto Caminero Enrique de-Madaria Miguel Montoro Huguet Vivas Santiago Sonia Isabel Niveloni Edgardo Gustavo Smecuol Luis Uzcanga Dominguez Elena Trucco Virginia Lopez Carolina Olano Pasquale Mansueto Antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F Verdú Benjamin Lebwohl M Ines Pinto-Sanchez | 2021 | World Journal of Gastroenterology2021，27，12： | 0 |
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