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| 1 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Molecular mechanisms of insulin resistance and associated diseases显示文摘 | Mlinar B Marc J Jane A | 2007 | Clin Chim Acta2007，375，12： | 1 |
| 4 | Changes oflipid composition and saturation level in leaves and rootsfor heat-stressed and heat-acclimated creeping bent-grass显示文摘 | JANE L A RKINDA L E HUANG B R | 2004 | Environmental and Experimental Botany2004，51，： | 1 |
| 5 | Enhancement of fruit sensory quality by post-harvest applications of acetaldehyde and ethanol: blueberries, tomatoes, pears显示文摘 | PAZ O JANES H W PREVOST B A | 1982 | Food Science1982，47，1： | 1 |
| 6 | Mechanical Factors in the Incidence of Knee Pain in Adolescents and Young Adults显示文摘 | Paul B Jane A | 1984 | The Journal of Bone and Joint Surgery1984，66，5： | 1 |
| 7 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 8 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 9 | Enhancement of fruit sensory quality by post-harvest applications of acetaldehyde and ethanol: blueberries, tomatoes, pears显示文摘 | PAZ O JANES H W PREVOST B A | 1982 | Food Science1982，47，： | 1 |
| 10 | Right median nerve electrical stimulation to hasten awakening from coma显示文摘 | COOPER J B JANE J A ALVES W M | 1999 | Brain lnj1999，13，4： | 1 |
| 11 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 12 | Soluble polymers in water purification 显示文摘 | Brian A Jane B | 1995 | Polymer Science1995，20，6： | 1 |
| 13 | Lung Cancer Incidence Trends Among Men and Women - United States, 2005-2009显示文摘 | Henley S Jane Richards Thomas B Underwood J Michael Eheman Christie R Plescia Marcus McAfee Timothy A | 2014 | Morbidity and Mortality Weekly Report2014，，1： | 1 |
| 14 | Linear epitope mapping of an Sm B/B' polypeptide显示文摘 | JANES J A HARLEY J B | 1992 | J Immunol1992，148，： | 1 |
| 15 | Incidence rates of dislocateion,pulmonary embolism,and deep infection during the first six months after elective total hip replacement 显示文摘 | Charlotte B Jane A Elena Losina | 2003 | J Bone Joint Surg (Am)2003，85，： | 1 |
| 16 | Spatial and temporal expression ofthe Grainyhead-like transcription factor family duringmurine development显示文摘 | Auden A Caddy J Wilanowski T Ting S B Cunnin-gham J M Jane S M | 2006 | Gene Expr Patterns2006，6，： | 1 |
| 17 | Soluble polymers in water of purification 显示文摘 | Brian A Jane B | 1995 | Prog Polym Sci1995，20，： | 1 |
| 18 | Synthesis of a triphenylphosphine reagent on non-cross-linked polystyrene support: Application to the staudinger/aza-wittig reaction 显示文摘 | Charette A B Boezio A A Janes M K | 2000 | Organic Letters2000，2，24： | 1 |
| 19 | Incidence rates of dislocation,pulmonary embolism,and deep infection during the first six months after total hip replacement显示文摘 | Charlotte B Jane A Losina E | 2003 | J Bone Joint Surg Am2003，85，1： | 1 |
| 20 | Flavor, color and other characteristics of beef lentissimo muscle heated to seven interhal temperatures between 55°C and 85°C 显示文摘 | Jane A B Jean A C Kropf D H et | 1987 | Journal of Food Science1987，52，3： | 1 |
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