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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 3 | Prevalence,serotype diversity, and antimicrobial resistance of Salmonellain imported shipments of spice offered for entry to theUnited States, FY2007-FY2009 显示文摘 | JANE MV D DARIA K THOM AS S H | 2013 | Food Microbiology2013，34，： | 1 |
| 4 | Effect of water chemistry on calcium carbonate deposition on metal and polymer surfaces 显示文摘 | Zhen W Jane H D Lorraine F F | 2010 | Journal of Colloid and Interface Science2010，343，1： | 1 |
| 5 | Comparison of isolation meth- ods for the determination of buckwheat volatile compounds 显示文摘 | PROSEN H KOKALJ M JANES D | 2010 | Food Chem2010，121，1： | 1 |
| 6 | Cloning, expression and charac- terization of a blood group B active recombinant oL-galactosidase from soybean显示文摘 | Melissa O Davis D Jane H | 1996 | Biochemistry Molecular Biology Inter1996，39，3： | 1 |
| 7 | Temperature-dependent behavior of low-temperature-grown GaAs nonalloyed ohmic contacts显示文摘 | Ueng H J Chen N P Janes D B | 2001 | Journal of Applied Physics2001，90，11： | 1 |
| 8 | 查看详情显示文摘 | Jane H W Robert D B Phirtu S | | 0，，： | 1 |
| 9 | Improved alignment method for noisy high resolution ECG and Hoher records using multiscale cross correlation显示文摘 | Laciar E Jane R Brooks D H | 2003 | IEEE Trans Biomed2003，50，3： | 1 |
| 10 | Differential protein expression of two photosystem II subunits,PsbO and PsbP,in an albino mutant of Bambusa edulis with chloroplast DNA aberration显示文摘 | Lin C S Liu N T Liao D C Yu J S Tsao H Lin C H Sun C W Jane W N Tsay H S Chen J J W Lai E M Lin N S Chang W C Lin C C | 2008 | AMER SOC Horticulture Science2008，133，2： | 1 |
| 11 | Dynamics of the $1S2 glutamate binding domain of GluR2 measured u- singIUFNMRspectroscopy显示文摘 | Ahmed A H Loh A P Jane D E etal | 2007 | J BiolChem2007，282，17： | 1 |
| 12 | New algorithm for QT interval analysis in 24-hour Holter ECG:performance and applications显示文摘 | LAGUNA P THAKOR N V CAMINAL P JANE R YOON H R BAYES D L A MARTI V GUINDO J | 1990 | Medicai & Biological Engineering & Computing1990，28，： | 1 |
| 13 | Comparison of isolation methods for the determination of buckwheat volatile compounds显示文摘 | PROSEN H KOKALJ M JANES D | 2010 | Food Chem2010，121，： | 1 |
| 14 | Flavor, color and other characteristics of beef lentissimo muscle heated to seven interhal temperatures between 55°C and 85°C 显示文摘 | Jane A B Jean A C Kropf D H et | 1987 | Journal of Food Science1987，52，3： | 1 |
| 15 | Primary structure of myosin from the striated adductor muscle of the Atlantic scallop, Pecten rnaximus, and expression of the regulatory domain显示文摘 | Janes D P Patel H Chantler P D | 2000 | J Muscle Res Cell Motil2000，21，5： | 1 |
| 16 | Demonstration of a bubble-free annular-vortex membrane bioreactor for batch culture of red beet cells显示文摘 | Janes D A Thomas N H Callow J A | 1987 | BiotechnologyTechniques1987，1，4： | 1 |
| 17 | Js there a cris is in nursing retontion in New South Wales显示文摘 | Denise D Jane H Glenn J | | 0，，05： | 1 |
| 18 | Synthesis of potent inhibitors of histidinol dehydrogenase 显示文摘 | Jane E D Mark J F Kenneth H | 1996 | Bioorg Med Chem Lett1996，6，17： | 1 |
| 19 | De-alloying of type 316 stainless steels in hot eoneentrated sodium hydroxide solution 显示文摘 | Jane D Dong Z H Benjamin L | 2004 | Corrosion Science2004，46，9： | 1 |
| 20 | Hierarchically Structured Sulfur/Carbon NanocompositeMaterial for High-Energy Lithium Battery显示文摘 | Liang Chengdu Nancy J D Jane Y H | 2009 | Chemistry of Materials2009，21，： | 1 |
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