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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 4 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 5 | Solubilities of mixtures of carbon dioxide and hydrogen sulfide in water + diethanolamine + 2-amino-2-methyl-1-propanol显示文摘 | Jane I S Li M H | | 0，，01： | 1 |
| 6 | Chondromyxoid fibroma of the foot and ankle :40 years'Scottish bone tumour registry expe- rience显示文摘 | Sharma H Jane M J Reid R | 2006 | Int Orthop2006，30，3： | 1 |
| 7 | Lexical cohesion computed by thesaural relations as an indicator of the structure of text显示文摘 | JANE M GRAEME H | 1991 | Computational Linguistics1991，17，1： | 1 |
| 8 | Lexical cohesion computed by thesauml re- lations as an indicator of the structure of text显示文摘 | Jane M Graeme H | 1991 | Computational Linguistics1991，17，1： | 1 |
| 9 | Comparison of isolation meth- ods for the determination of buckwheat volatile compounds 显示文摘 | PROSEN H KOKALJ M JANES D | 2010 | Food Chem2010，121，1： | 1 |
| 10 | Brownfields Redevelopment,Preferences and Public Involvement:A Case Study of an Ethnically Mixed Neighborhood显示文摘 | Greenberg M Michael H Jane Lewis | 2000 | Urban Studies2000，37，13： | 1 |
| 11 | Pre-Analytical Requirements显示文摘 | John H IAvesey M Jane Ellis | 2008 | Clin Biochem Rev Vol 29 Suppl (1) August2008，，： | 1 |
| 12 | The role of total hip replacement in intertrochantericfractures of the femur显示文摘 | Jumes P Jane M Emil H | | 0，，01： | 1 |
| 13 | The role of total hip replacement in intertrochanteric fractures of the femur显示文摘 | James P Jane M Emil H | 2004 | Clin Orthop2004，429，： | 1 |
| 14 | The power of business models显示文摘 | Scott M Shafer H Jeff Smith Jane C Linder | 2005 | Business Horizons2005，，48： | 1 |
| 15 | Deleterious effects of cool air temperature reversed by root-zone warming in poinsettia显示文摘 | Janes H W Richard M A | 1983 | HortScience1983，18，3： | 1 |
| 16 | Personal computing:Toward a conceptual model of utilization显示文摘 | Ronald L T Christopher A H Jane M H | 1991 | MIS Quarterly1991，15，1： | 1 |
| 17 | Biochemistry and cell biology of mammalian scavenger receptors 显示文摘 | Jane E M Philip R T Shervanthi H V | 2005 | Atherosclerosis2005，182，1： | 1 |
| 18 | Differential protein expression of two photosystem II subunits,PsbO and PsbP,in an albino mutant of Bambusa edulis with chloroplast DNA aberration显示文摘 | Lin C S Liu N T Liao D C Yu J S Tsao H Lin C H Sun C W Jane W N Tsay H S Chen J J W Lai E M Lin N S Chang W C Lin C C | 2008 | AMER SOC Horticulture Science2008，133，2： | 1 |
| 19 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 20 | Efficacy trial of a DNA//rAd5 HIV-1 preventive vaccine显示文摘 | Hammer S M Sobieszczyk M E Janes H | 2013 | N En- gl J Med2013，369，22： | 1 |
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