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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 4 | A randomized trial comparing peripherally inserted central venous catheters and peripheral intrave- nous catheters in infants with very low birth weight 显示文摘 | Janes M Kalyn A Pinelli J | 2000 | J Pediatr Surg2000，35，7： | 1 |
| 5 | Characterization of SU1 isoamylase,a determinant of storage starch structure in maize显示文摘 | Wong K S Jane J L Myers A M James M G | 1998 | Plant physiology1998，117，： | 1 |
| 6 | Technological Globalization and Innovative Centers:the Role of Corporate Technological Leadership and Locational Hierarchy显示文摘 | CANTWELL J A JANE M | | 0，，23： | 1 |
| 7 | Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells 显示文摘 | Steven J Greco Sraboni Sarkar Jane M Johnston | 2008 | Biochemical and Biophysical Research Communications2008，376，3： | 1 |
| 8 | The method of fundamental solutions for 2D and 3D Stokes problems显示文摘 | Young D L Jane S J Fan C M Murugesan K Tsai C C | 2006 | Journal of Computational Physics2006，211，： | 1 |
| 9 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 10 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 11 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 12 | Polysaccharide colloidal particles as delivery systems for macromolecules显示文摘 | Janes KA Calvo P Alonso M J | 2001 | Adv Drug Deliv Rev2001，47，： | 1 |
| 13 | Right median nerve electrical stimulation to hasten awakening from coma显示文摘 | COOPER J B JANE J A ALVES W M | 1999 | Brain lnj1999，13，4： | 1 |
| 14 | A tabletop exercise to assess a hospital emergency blood management contingency plan in a simulated acute blood shortage显示文摘 | Galloway M J Jane G Sudlow L Trattles J Watson J | 2008 | Transfusion Medicine2008，18，5： | 1 |
| 15 | Femoral head avascular necrosis: MR imaging with clinical-pathologic and radionuclide correlation显示文摘 | Leigh J Herman Jane M Burk | 1988 | Radiology1988，166，： | 1 |
| 16 | A randomized trial comparing peripherally inserted central venous catheters and peripheral intravenous catheters in infants with very low birth weight显示文摘 | Janes M Kalyn A Pinelli J | 2000 | J Pediatr Surg2000，35，7： | 1 |
| 17 | Arandomized trial compa-ring peripherally inserted central venous cathers with peripheral intravenous catheters in infants very with birth weight显示文摘 | Janes M Kalyn A Pinelli J | 2000 | J Pediatr Surg2000，35，7： | 1 |
| 18 | Chondromyxoid fibroma of the foot and ankle :40 years'Scottish bone tumour registry expe- rience显示文摘 | Sharma H Jane M J Reid R | 2006 | Int Orthop2006，30，3： | 1 |
| 19 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 20 | Stem cells of the alveolar epithelium 显示文摘 | Mark J D Griffiths Dominique Bonnet Sam M Janes | 2005 | Lancet2005，366，9481： | 1 |
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