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| 1 | Hepatobiliary manifestations in inflammatory bowel disease: The gut,the drugs and the liver显示文摘Abnormal liver biochemical tests are present in up to30%of patients with inflammatory bowel disease(IBD),and therefore become a diagnostic challenge.Liver and biliary tract diseases are common extraintestinal manifestations for both Crohn’s disease and ulcerative colitis(UC),and typically do not correlate with intestinal activity.Primary sclerosing cholangitis(PSC)is the most common hepatobiliary manifestation of IBD,and is more prevalent in UC.Approximately 5%of patients with UC develop PSC,with the prevalence reaching up to 90%.Cholangiocarcinoma and colon cancer risks are increased in these patients.Less common disorders include autoimmune hepatitis/PSC overlap syndrome,IgG4-associated cholangiopathy,primary biliary cirrhosis,hepatic amyloidosis,granulomatous hepatitis,cholelithiasis,portal vein thrombosis,liver abscess,and non-alcoholic fatty liver disease.Hepatitis B reactivation during immunosuppressive therapy is a major concern,with screening and vaccination being recommended in serologically negative cases for patients with IBD.Reactivation prophylaxis with entecavir or tenofovir for 6to 12 mo after the end of immunosuppressive therapy is mandatory in patients showing as hepatitis B surface antigen(HBsAg)positive,independently from viral load.HBsAg negative and anti-HBc positive patients,with or without anti-HBs,should be closely monitored,measuring alanine aminotransferase and hepatitis B virus DNA within 12 mo after the end of therapy,and should be treated if the viral load increases.On the other hand,immunosuppressive therapy does not seem to promote reactivation of hepatitis C,and hepatitis C antiviral treatment does not influence IBD natural history either.Most of the drugs used for IBD treatment may induce hepatotoxicity,although the incidence of serious adverse events is low.Abnormalities in liver biochemical tests associated with aminosalicylates are uncommon and are usually not clinically relevant.Methotrexaterelated hepatotoxicity has been described in 14%of patients with IBD,in a dose-dependent manner.Liver biopsy is not routinely recommended.Biologics-related hepatotoxicity is rare,but has been shown most frequently in patients treated with infliximab.Thiopurines have been associated with veno-occlusive disease,regenerative nodular hyperplasia,and liver peliosis.Routine liver biochemical tests are recommended,especially during the first month of treatment.All these conditions should be considered in IBD patients with clinical or biochemical features suggestive of hepatobiliary involvement.Diagnosis and management of these disorders usually involve hepatologists and gastroenterologists due to its complexity. | María Rojas-Feria Manuel Castro Emilio Suárez Javier Ampuero Manuel Romero-Gómez | 2013 | World Journal of Gastroenterology2013，19，42： | 9 |
| 2 | Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: A prospective study显示文摘 | Javier Fernández Juan Acevedo Miriam Castro Orlando Garcia Carlos Rodríguez de Lope Daria Roca Marco Pavesi Elsa Sola Leticia Moreira Anibal Silva Tiago Seva‐Pereira Francesco Corradi Jose Mensa Pere Ginès Vicente Arroyo | 2012 | Hepatology2012，，： | 4 |
| 3 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 4 | The role of non conventional oil in the attenuation of peak oil显示文摘 | Carlos de Castro Luis Javier Miguel Margarita Mediavilla | 2009 | Energy Policy2009，37，5： | 1 |
| 5 | Does music perception have an impact on quality of life following cochlear implantation?显示文摘 | Luis Lassaletta Alejandro Castro Marta Bastarrica Rosa Pérez-Mora Rosario Madero Josefa De Sarriá Javier Gavilán | 2007 | Acta Oto-Laryngologica2007，，7： | 1 |
| 6 | Determination of a-tocopherol anda-tocopheryl acetate in diets of experimental animal显示文摘 | F JAVIER RUPEREZ CORAL BARBAS MA- RIO CASTRO | 1999 | Journal of Chromatography A1999，839，12： | 1 |
| 7 | Optimization of wind farm tur-bines layout using an evaluative algorithm显示文摘 | Javier Serrao Gonzalez Angel G Gonzalez Rodriguez Jose Castro Mora | 2010 | Renewable energy2010，35，： | 1 |
| 8 | Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: Current evidence and future perspectives显示文摘 | Ana Custodio Jorge Barriuso Javier de Castro Virginia Martínez-Marín Víctor Moreno Nuria Rodríguez-Salas Jaime Feliu | 2013 | Cancer Treatment Reviews2013，，： | 1 |
| 9 | Outcomes and resource use of non-small cell lung cancer (NSCLC) patients treated with first-line platinum-based chemotherapy across Europe: FRAME prospective observational study显示文摘 | Denis Moro-Sibilot Egbert Smit Javier de Castro Carpe?o Krzysztof Lesniewski-Kmak Joachim Aerts Rosa Villatoro Kees Kraaij Karim Nacerddine Yulia Dyachkova Karen T. Smith Kaisa Taipale Allicia C. Girvan Carla Visseren-Grul Philipp A. Schnabel | 2015 | Lung Cancer2015，，2： | 1 |
| 10 | The influence of the initial moisture content of lightweight aggregate on internal cur ing显示文摘 | Michael Golias Javier Castro Jason Weiss | 2012 | Construction and Building Materials2012，35，10： | 1 |
| 11 | Design of the primary mirror segment support system for the E-ELT显示文摘 | Lluis Cavalier Juan Marrero Javier Castro | 2008 | SPIE2008，7012，70： | 1 |
| 12 | Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer显示文摘 | M. Teresa Agulló-Ortu?o C. Vanesa Díaz-García Alba Agudo-López Carlos Pérez Ana Cortijo Luis Paz-Ares Fernando López-Ríos Francisco Pozo Javier de Castro Hernán Cortés-Funes José A. López Martín | 2015 | Journal of Cancer Research and Clinical Oncology2015，，： | 1 |
| 13 | PI3K/Akt signalling pathway and cancer显示文摘 | Juan ángel Fresno Vara Enrique Casado Javier de Castro Paloma Cejas Cristóbal Belda-Iniesta Manuel González-Barón | 2003 | Cancer Treatment Reviews2003，，： | 1 |
| 14 | PI3K/Akt signalling pathway and cancer显示文摘 | Juan ángel Fresno Vara Enrique Casado Javier de Castro Paloma Cejas Cristóbal Belda-Iniesta Manuel González-Barón | 2003 | Cancer Treatment Reviews2003，，2： | 1 |
| 15 | Optimization of wind farm turbines layout using an evolutivealgorithm显示文摘 | Javier serrao Gonzalez angel G Gonzalez Jose Castro Mora | 2010 | Renewable energy2010，35，8： | 1 |
| 16 | Expression Profile as Predictor of Relapse after Adjuvant Treatment in Gastric Cancer显示文摘 | María Sereno Javier Castro Paloma Cejas Miguel García-Cabezas Cristóbal Belda Enrique Casado Jaime Feliu César Gómez Miriam López Manuel Barón | 2012 | Journal of Gastrointestinal Cancer2012，，2： | 1 |
| 17 | Evaluation of adalimumab therapy in multidisciplinary strategy for perianal Crohn’s disease patients with infliximab failure显示文摘 | Ana Echarri Javier Castro Manuel Barreiro Daniel Carpio Santos Pereira Aurelio Lorenzo | 2010 | Journal of Crohn’s and Colitis2010，，6： | 1 |
| 18 | Autonomous indoor ultrasonic positioning system based on a low-cost conditioning circuit显示文摘 | Alberto Sanchez Angel de Castro Santiago Elvira Guillermo Glez-de-Rivera Javier Garrido | 2011 | Measurement2011，，3： | 1 |
| 19 | Arsenic and Heavy Metal Pollution of Soil, Water and Sediments in a Semi-Arid Climate Mining Area in Mexico显示文摘 | Israel Razo Leticia Carrizales Javier Castro Fernando Díaz-Barriga Marcos Monroy | 2004 | Water Air and Soil Pollution (-)2004，，1： | 1 |
| 20 | Vitamin content and amino acid composition of pickled garlic processed with and without fermentation显示文摘 | Alfredo Montano Francisco Javier Casado Antonio De Castro | | 0，，： | 1 |
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