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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | A High Index of Suspicion: The Key to an Early Diagnosis of Wilson’s Disease in Childhood显示文摘 | Icíar Sánchez-Albisua Teresa Garde Loreto Hierro Carmen Camarena Esteban Frauca Angela de la Vega María Carmen Díaz Javier Larrauri Paloma Jara | 1999 | Journal of Pediatric Gastroenterology & Nutrition1999，，2： | 1 |
| 5 | Chilling of drought-hardened and no-hardened plants of different chilling-sensitive maize lineschanges in water relations and ABA contents显示文摘 | Javier P D Jose I J Manuel S D | 1997 | Plant Sci1997，122，： | 1 |
| 6 | Technology Shocks and Monetary Policy:Assessing the Fed's Performance显示文摘 | Gali J Lopez D S Javier V | 2004 | Journal of Monetary Economics2004，50，： | 1 |
| 7 | Chilling of drought-hardened and no-hardened plants of different chilling-sensitive maize lines-changes in water relations and ABA content显示文摘 | Javier P D Jose I J Manuel S D | 1997 | Plant Sciences1997，122，： | 1 |
| 8 | Transistor paint:high mobilities in small bandgap polymer semiconductor based on the strong acceptor,diketopyrrolopyrrole and strong donor,dithienopyrrole显示文摘 | Toby L N Tomasz M Y Jun Y L Mishra S P Belot J A Balliet C L Javier A E Kowalewski T McCullough R D | 2010 | Advanced Materials2010，22，41： | 1 |
| 9 | Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis显示文摘 | Javier M Elena S Glynis D | 2002 | J Virol2002，76，10： | 1 |
| 10 | The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families显示文摘 | Ana Sánchez de Abajo Miguel de la Hoya Javier Godino Vicente Furió Alicia Tosar Pedro Pérez-Segura Eduardo Díaz-Rubio Trinidad Caldés | 2005 | Familial Cancer2005，，2： | 1 |
| 11 | Genome histories clarify evolution of the expansin superfamily: new insights from the poplar genome and pine ESTs显示文摘 | Cosgrove D J Javier S Robert E C | 2006 | Plant Res2006，119，： | 1 |
| 12 | Late season nitrogen fertilization of soybeans: effects on leaf senescence, yield and environment显示文摘 | Flavio H GutieR Javier D S Helena R | 2004 | Nutrient Cycling in Agroecosystems2004，68，： | 1 |
| 13 | Cancer CXC chemokine networks and tumour angiogenesis显示文摘 | Robert M S Marie D B Javier M | 2006 | Eur J Cancer2006，42，6： | 1 |
| 14 | Characterising Mycobacterium tuberculosis Rv1510c protein and determining its sequences that specifically bind to two target cell lines显示文摘 | Ricardo Vera-Bravo Elizabeth Torres John J. Valbuena Marisol Ocampo Luis E. Rodríguez álvaro Puentes Javier E. García Hernando Curtidor Jimena Cortés Magnolia Vanegas Zuly J. Rivera Andrea Díaz Martha N. Calderon Manuel A. Patarroyo Manuel E. Patarroyo | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 15 | Organizing multi-agent systems显示文摘 | Javier V S Virginia D Frank D | 2005 | Autonomous Agents and Multi-Agent System2005，3，： | 1 |
| 16 | Chilling of drought-hard- ened and non-hardened plants of different chilling-sensitive maize lines changes in water relations and ABA contents 显示文摘 | Javier P de J Jose I J Manuel S D | 1997 | Plant Science1997，122，1： | 1 |
| 17 | Illumination compensation and normalization in eigenspace-based face recognition:a comparative study of different pre-processing approaches显示文摘 | JAVIER R D S QUINTEROS J | 2008 | Pattern Recognition Letters2008，29，14： | 1 |
| 18 | Pockmarks, collapses and blind valleys in the Gulf of Cádiz显示文摘 | Ricardo León Luís Somoza Teresa Medialdea Francisco Javier Hernández-Molina Juan Tomás Vázquez Victor Díaz-del-Rio Francisco Javier González | 2010 | Geo - Marine Letters (-)2010，，3： | 1 |
| 19 | Performing the best composition of supported Co/SiC catalyst for selective FTS diesel production显示文摘 | Ana Raquel de la Osa Antonio de Lucas Luz Sánchez-Silva Javier Díaz-Maroto José Luis Valverde Paula Sánchez | 2011 | Fuel2011，，： | 1 |
| 20 | Double-guidewire technique for difficult bile duct cannulation: a multicenter randomized, controlled trial显示文摘 | Alberto Herreros de Tejada Jose Luis Calleja Gonzalo Díaz Virginia Pertejo Jesús Espinel Guillermo Cacho Javier Jiménez Isabel Millán Fernando García Luis Abreu | 2009 | Gastrointestinal Endoscopy2009，，4： | 1 |
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