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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 3 | Size-Dependent Sex Investment in a Gynodioecious Wild Strawberry: the Effect of Sex Morph and Inflorescence Architecture 显示文摘 | Ashman T L Jennifer P Christy D | 2001 | Int J Plant Sci2001，162，2： | 1 |
| 4 | MMR: An algorithm for clustering categorical data using rough set theory显示文摘 | Parmar D Wu T Jennifer B | 2007 | Data and Knowledge Engineering2007，63，3： | 1 |
| 5 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 6 | Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans显示文摘 | Jennifer T Coull Matt E.P Jones Talmage D Egan Chris D Frith Mervyn Maze | 2004 | Neuroimage2004，，1： | 1 |
| 7 | Optical and durability properties of infrared transmitting thin films显示文摘 | Jennifer D T K Walter T P | 1997 | Applied Optics1997，36，10： | 1 |
| 8 | Allelopathic actions of the alkaloid 12-epi-hapalindole Eisonitrile and calothrixin A from cyanobacteria of the genera FischereIla and Calothrix 显示文摘 | Nga T D Rodney W Rickards Jennifer M R | 2000 | Journal of Ap- plied Phycology2000，12，35： | 1 |
| 9 | A relative approach for determining ring strain energies of heterobicyclic alkenes显示文摘 | JENNIFER H JOHN D GODDARD W T | 2009 | Tetrahedron2009，65，23： | 1 |
| 10 | Analysis of mycolic acids by high-performance liquid chromatography and fluorimetric detection implications for the identification of mycobacteria in clinicalsamples 显示文摘 | Steven R H Jennifer D T | 1995 | Journal of Chromatography A1995，692，： | 1 |
| 11 | Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation显示文摘 | George E G Rainer S Jennifer D T | 2000 | Blood2000，95，： | 1 |
| 12 | Sue- cessful treatment of pan - resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high - dose tigecycline and colistin显示文摘 | HUMPHRIES R M KELESIDIS T B JENNIFER D | 2010 | J Med Microbiol2010，59，11： | 1 |
| 13 | Size denpendent sex allocation in a genodioecious strawberry:The effect of sex morph or inflorescence architecture显示文摘 | Ashman T L Jennifer P Chriaty D | 2001 | International Journal of Plant Science2001，162，： | 1 |
| 14 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 15 | Using soil temperature and moisture to predict forest soil nitrogen mineralization显示文摘 | Jennifer D K Wayne T S | 2002 | Biology Fertile Soils2002，36，： | 1 |
| 16 | Nitrogen deposition and cycling across an elevation and vegetation gradient in southern Appalachian forests显示文摘 | JENNIFER D K JAMES M V WAYNE T S | 2008 | International Journal of Environmental Studies2008，65，3： | 1 |
| 17 | Improving CKD-MBD management in haemodialysis patients: barrier analysis for im- plementing better practice显示文摘 | Nigel D T Eugenie P Jennifer B | 2011 | Nephrology Dialysis Transplanta- tion2011，26，4： | 1 |
| 18 | Optical and durability properties of infrared transmitting thin films显示文摘 | Traylor Kruschwits Walter T | 1997 | Applied Optics1997，36，10： | 1 |
| 19 | Performance study of pattern reconfigurable antennas in MIMO communication systerns 显示文摘 | Joshua D Boerman Jennifer T Bernhard | 2008 | IEEE Transactions on Antennas and Propagation2008，56，1： | 1 |
| 20 | Optiacl and durability prozrties of infrared transmiting thin films显示文摘 | Jennifer D T K Walter T P | 1997 | Applied Optics1997，36，10： | 1 |
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