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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells显示文摘 | HELEN L W JENNIFER M W FRANCESCA S | 2015 | Journal of Biochemical Pharmacology2015，，93： | 1 |
| 4 | Applications of nanotechnology to biotechnology commentary 显示文摘 | Jennifer L W Naomi J H | 2000 | Current Opinion in Biotechnology2000，11，2： | 1 |
| 5 | Delivery vehicles for zerovalent metal nanoparticles in soil and groundwater 显示文摘 | Schrick Bettina Hydutsky Bianca W Blough Jennifer L | 2004 | Chemistry of Materials2004，16，11： | 1 |
| 6 | Delivery vehicles for zerovalent metal nanopartieles in soil and groundwater 显示文摘 | Bettina S Bianca W H Jennifer L B | 2004 | Chemical Materials2004，16，11： | 1 |
| 7 | Effects of Fixed Versus Random Condition Sequencing Dur- ing Muhielement Functional Analysis 显示文摘 | Hammond Jennifer L Iwata Brian A Rooker Griffin W | 2013 | Journal of Applied Behavior Analysis2013，，46： | 1 |
| 8 | Delivery vehicles for zerovalent metal nanoparticles in soil and groundwater 显示文摘 | Bettina S Bianca W H Jennifer L B | 2004 | Chemistry of Materials2004，16，11： | 1 |
| 9 | Differential phospho- rylation of DNA-PKcs regulates the interplay between end-pro- cessing and end-ligation during nonhomologous end-joining 显示文摘 | Jiang W Crowe Jennifer L Liu X | | Mol Cell0，58，1： | 1 |
| 10 | Photoincorporation of 4,4'-bis(1-anilino-8-naphthalene sulfonic acid) into the apical domain of groEL:specific information from a nonspecific probe 显示文摘 | Jeffrey W Seale Jennifer L Martinez Paul M Horowitz | 1995 | Biochemistry1995，34，： | 1 |
| 11 | Nitroxyl anion donor, angelig salt, does not develop tolerance in rat isolated aortae 显示文摘 | JENNIFER C I JOANNE L F ROBERT E W | 2007 | Hypertension2007，49，4： | 1 |
| 12 | Phylogenetic classification of Cordyceps and the clavicipitaceous fungi显示文摘 | Sung Gi-Ho Nigel L Hywel-Jones Sung Jae-Mo Jennifer Luangsa-ard J Bhushan Shrestha Joseph W Spatafora | 2007 | Studies in Mycology2007，57，： | 1 |
| 13 | Ab initio investigations of dioctahedral interlayer-deficient mica: modelling polymorphs of illite found within gas shale 显示文摘 | GEATCHES G L JENNIFER W | 2014 | Eur Miner2014，26，： | 1 |
| 14 | Comparison of TP53 Mutations Identifled by Oligonucleotide Microarray and Conventional DNA Sequence Analysis显示文摘 | Wen W H Leslie B Jennifer L | 2000 | Cancer Research2000，15，60： | 1 |
| 15 | Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor显示文摘 | JENNIFER L TILLERSON A W MICHAEL C A | 2006 | Behavioural Brain Research2006，172，1： | 1 |
| 16 | Affective transitions in narrative - centered learning environments 显示文摘 | Scott W McQuiggan Jennifer L Robison James C Les- ter | 2010 | Educational Technology & Society2010，，1： | 1 |
| 17 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 18 | The effect of breast support on the kinematics of the breast during the running gait cycle显示文摘 | Joanna C S Jennifer L W Wendy H | 2010 | Jour- nal of Sports Sciences2010，28，0： | 1 |
| 19 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 20 | Enantioselective epoxidation of unfunctionalized olefins catalyzed by salen manganese complexes 显示文摘 | Zhang W Jennifer L L Scott R W | 1990 | J Am Chem Soc1990，112，7： | 1 |
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