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| 1 | Extensive frontal focused ultrasound Check for updates mediated blood-brain barrier opening for the treatment of Alzheimer's disease:a proof-of-concept study显示文摘Background:Focused ultrasound(FUS)-mediated blood-brain barrier(BBB)opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies,but this is rarely reported in clinical studies.This study was conducted to evaluate the safety,feasibility and potential benefits of repeated extensive BBB opening.Methods:In this open-label,prospective study,six patients with Alzheimer's disease(AD)were enrolled at Severance Hospital in Korea between August 2020 and September 2020.Five of them completed the study.FUS-mediated BBB opening,targeting the bilateral frontal lobe regions over 20 cm^(3),was performed twice at three-month intervals.Magnetic resonance imaging,^(18)F-Florbetaben(FBB)positron emission tomography,Caregiver-Administered Neuropsychiatric Inventory(CGA-NPI)and comprehensive neuropsychological tests were performed before and after the procedures.Results:FUS targeted a mean volume of 21.1±2.7 cm^(3)and BBB opening was confirmed at 95.7%±9.4%of the targeted volume.The frontal-to-other cortical region FBB standardized uptake value ratio at 3 months after the procedure showed a slight decrease,which was statistically significant,compared to the pre-procedure value(-1.6%,0.986 vs 1.002,P=0.043).The CGA-NPI score at 2 weeks after the second procedure significantly decreased compared to baseline(2.2±3.0 vs 8.6±6.0,P=0.042),but recovered after 3 months(5.2±5.8 vs 8.6±6.0,P=0.89).No adverse effects were observed.Conclusions:The repeated and extensive BBB opening in the frontal lobe is safe and feasible for patients with AD.In addition,the BBB opening is potentially beneficial for amyloid removal in AD patients. | So Hee Park Kyoungwon Baik Seun Jeon Won Seok Chang Byoung Seok Ye Jin Woo Chang | 2021 | Translational Neurodegeneration2021，10，4： | 3 |
| 2 | Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis显示文摘 | Yang Min Jin Kim Seong Jeon Yoon Jeen Jong Im Dae Cheung Myung-Gyu Choi Jin-Oh Kim Kwang Lee Byong Ye Ki-Nam Shim Jeong Moon Ji Kim Sung Hong Dong Chang | 2013 | Endoscopy2013，，： | 2 |
| 3 | Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis显示文摘 | Cho S Choi YS Jeon YE | 2012 | Microvasc Res2012，83，2： | 1 |
| 4 | Kisspeptin, leptin,and retinol- binding protein 4 in women with polycystic ovary syndrome显示文摘 | Jeon YE Lee KE Jung JA | 2013 | Gynecol Obstet Invest2013，75，： | 1 |
| 5 | Distribution of AMPA glutamate receptor GluR1 subunit-immunoreactive neurons and their co-localization with calcium-binding proteins and GABA in the mouse visual cortex显示文摘 | Kim TJ Ye EA Jeon CJ | 2006 | Mol Cells2006，21，1： | 1 |
| 6 | Positron Emission Tomography Imaging of Drug‐Induced Tumor Apoptosis with a Caspase‐Triggered Nanoaggregation Probe显示文摘 | Bin Shen Jongho Jeon Mikael Palner Deju Ye Adam Shuhendler Frederick T. Chin Jianghong Rao | 2013 | Angew Chem Int Ed2013，，40： | 1 |
| 7 | Expression of vascular endothelial growth facfor(VEGF)and its soluble receptor-1 in endometriosis显示文摘 | Cho S Choi YS Jeon YE | 2012 | Microvasc Res2012，83，3： | 1 |
| 8 | Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment显示文摘 | Byoung Seok Ye Sang Won Seo Chi Hun Kim Seun Jeon Geon Ha Kim Young Noh Hanna Cho Cindy W. Yoon Hee Jin Kim Eun Young Jang Jeongmin Lee Jung-Hyun Kim Juhee Chin Jong Min Lee Jeong-Hun Kim Joon-kyung Seong Chang-Hun Kim Yearn Seong Choe Kyung Han Lee Duk L | 2014 | Neurobiology of Aging2014，，2： | 1 |
| 9 | The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma显示文摘 | Kwak YE Jeon NK Kim J | 2007 | Ann N Y Acad Sci2007，1095，： | 1 |
| 10 | Rapid eye movement sleep behav- ior disorder after bilateral subthalamic stimulation in Parkinson' s disease显示文摘 | Kim YE Jeon BS Paek SH | 2015 | J Clin Neurosci2015，22，2： | 1 |
| 11 | Expression of vascular endothelial growth factor (VEGF) and its soluble receptor -I in endometriosis 显示文摘 | Cho S Choi YS Jeon YE | 2012 | Microvasc Res2012，83，2： | 1 |
| 12 | Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa显示文摘Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference specimens.Awide geographic and taxonomic range of fungal taxa are detailed.In the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are introduced.Newly introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,C.quinquefoliae,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,M.pongdueatensis,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,O.ratnapurensis,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,P.dimocarpi,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,S.pseudorosae,Sigarispora ononidis and Towyspora aestuari.New combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium pini.Descriptions,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,Petrakia echinata,Phragmoporthe conformis and Pseudocamarosporium pini.The new species of Basidiomycota are Agaricus coccyginus,A.luteofibrillosus,Amanita atrobrunnea,A.digitosa,A.gleocystidiosa,A.pyriformis,A.strobilipes,Bondarzewia tibetica,Cortinarius albosericeus,C.badioflavidus,C.dentigratus,C.duboisensis,C.fragrantissimus,C.roseobasilis,C.vinaceobrunneus,C.vinaceogrisescens,C.wahkiacus,Cyanoboletus hymenoglutinosus,Fomitiporia atlantica,F.subtilissima,Ganoderma wuzhishanensis,Inonotus shoreicola,Lactifluus armeniacus,L.ramipilosus,Leccinum indoaurantiacum,Musumecia alpina,M.sardoa,Russula amethystina subp.tengii and R.wangii are introduced.Descriptions,illustrations,notes and/or reference specimens are designated for Clarkeinda trachodes,Dentocorticium ussuricum,Galzinia longibasidia,Lentinus stuppeus and Leptocorticium tenellum.The other new genera,species new combinations are Anaeromyces robustus,Neocallimastix californiae and Piromyces finnis from Neocallimastigomycota,Phytophthora estuarina,P.rhizophorae,Salispina,S.intermedia,S.lobata and S.spinosa from Oomycota,and Absidia stercoraria,Gongronella orasabula,Mortierella calciphila,Mucor caatinguensis,M.koreanus,M.merdicola and Rhizopus koreanus in Zygomycota. | Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke Verbeken Alfredo Vizzini Josef Vlasák Kerstin Voigt Dhanushka N.Wanasinghe Yong Wang Gothamie Weerakoon Hua An Wen Ting Chi Wen Nalin N.Wijayawardene Sarunyou Wongkanoun Marta Wrzosek Yuan Pin Xiao Jian Chu Xu Ji Ye Yan Jing Yang Shu Da Yang Yu Hu Jin Feng Zhang Jie Zhao Li Wei Zhou Derek Peršoh Alan J.L.Phillips Sajeewa S.N.Maharachchikumbura | 2016 | Fungal Diversity2016，，3： | 1 |
| 13 | Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus显示文摘 | Hye-Young Chun Jae-Wook Chung Hyoun-Ah Kim Jeong-Moon Yun Ja-Young Jeon Young-Min Ye Seung-Hyun Kim Hae-Sim Park Chang-Hee Suh | 2007 | Journal of Clinical Immunology2007，，5： | 1 |
| 14 | Acupuncture Alters Pro-inflammatory Cytokines in the Plasma of Maternally Separated Rat Pups显示文摘Objective: To investigate the potential alleviating effects of acupuncture on maternal separation(MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups. Methods: On postnatal day 15, rat pups were randomly assigned to 4 groups(n=6 per group) using a random number table: normal, MS, MS with acupuncture stimulation at Shenmen(HT 7) acupoint(MS+HT 7), and MS with acupuncture stimulation at Chengshan(BL 57) acupoint(MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS, MS+HT 7 and MS+BL 57 groups were maternally separated and individually maintained. Acupuncture stimulation was performed at HT 7 or BL 57 acupoints once a day for 7 consecutive days. A tail suspension test was performed to measure immobility time of rats and the plasma was collected on postnatal day 21, then levels of corticosterone(CORT), interleukin(IL)-1β, IL-6 and glial cell-derived neurotrophic factor(GDNF) in plasma were measured. Results: Compared with the normal group, the immobility time and the plasma levels of CORT, IL-1β, IL-6 and GDNF in the MS group were significantly increased(P<0.05 or P<0.01). Compared with the MS group, the immobility time and the plasma levels of CORT, IL-1β, IL-6 and GDNF were significantly reduced in the MS+HT 7 group(P<0.05 or P<0.01). Moreover, the immobility time and plasma levels of IL-1β and IL-6 in the MS+HT 7 group were significantly lower than those in the MS+BL 57 group(P<0.05). Conclusion: Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS, indicating that acupuncture can help to relieve MS-induced depression. | Dongsoo Kim Chang-Hwan Bae Ye Lee Jun Hyongjun Jeon Sungtae Koo Seungtae Kim | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 1 |
| 15 | Kisspeptin,leptin,and retinolbinding protein 4 in women with polycystic ovary syndrome显示文摘 | Jeon YE Lee KE Jung JA | 2013 | Gynecol Obstet Invest2013，75，4： | 1 |
| 16 | Kisspeptin, leptin, and retinol- binding protein 4 in women with polycystic ovary syndrome 显示文摘 | Jeon YE Lee KE Jung JA | 2013 | Gy- neeol Obstet Invest2013，75，4： | 1 |
| 17 | Characterization of human mono- clonal autoantibody Fab fragments against oxidized LDL 显示文摘 | Jeon YE Seo CW Yu ES | 2007 | Mol Immunol2007，44，5： | 1 |
| 18 | Effect of intravenous amantadine on dopaminergic-drug-resistant freezing of gait显示文摘 | Kim YE Yun JY Jeon BS | 2011 | Parkinsonism Relat Disord2011，17，： | 1 |
| 19 | Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis显示文摘 | Yang Min Jin Kim Seong Jeon Yoon Jeen Jong Im Dae Cheung Myung-Gyu Choi Jin-Oh Kim Kwang Lee Byong Ye Ki-Nam Shim Jeong Moon Ji Kim Sung Hong Dong Chang | 2013 | Endoscopy2013，，： | 1 |
| 20 | Expression of vascular endothelial growth factor(VEGF) and its soluble receptor-1 in endometriosis 显示文摘 | Cho S Choi YS Jeon YE | 2012 | Microvasc Res2012，83，2： | 1 |
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