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| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | Positron-emission tomography for hepatocellular carcinoma:Current status and future prospects显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer mortality worldwide.Various imaging modalities provide important information about HCC for its clinical management.Since positron-emission tomography(PET)or PET-computed tomography was introduced to the oncologic setting,it has played crucial roles in detecting,distinguishing,accurately staging,and evaluating local,residual,and recurrent HCC.PET imaging visualizes tissue metabolic information that is closely associated with treatment.Dynamic PET imaging and dual-tracer have emerged as complementary techniques that aid in various aspects of HCC diagnosis.The advent of new radiotracers and the development of immuno-PET and PET-magnetic resonance imaging have improved the ability to detect lesions and have made great progress in treatment surveillance.The current PET diagnostic capabilities for HCC and the supplementary techniques are reviewed herein. | Ren-Cai Lu Bo She Wen-Tao Gao Yun-Hai Ji Dong-Dong Xu Quan-Shi Wang Shao-Bo Wang | 2019 | World Journal of Gastroenterology2019，25，32： | 6 |
| 3 | Structural basis for differential recognition of brassinolide by its receptors显示文摘Brassinosteroids,a group of plant steroid hormones,reg-ulate many aspects of plant growth and development.We and other have previously solved the crystal structures of BRI1(LRR)in complex with brassinolide,the most active brassinosteroid identifi ed thus far.Although these studies provide a structural basis for the recognition of brassi-nolide by its receptor BRI1,it still remains poorly under-stood how the hormone differentiates among its con-served receptors.Here we present the crystal structure of the BRI1 homolog BRL1 in complex with brassinolide.The structure shows that subtle differences around the brassinolide binding site can generate a striking effect on its recognition by the BRI1 family of receptors.Structural comparison of BRL1 and BRI1 in their brassinolide-bound forms reveals the molecular basis for differential binding of brassinolide to its different receptors,which can be used for more effi cient design of plant growth regulators for agricultural practice.On the basis of our structural studies and others’data,we also suggest possible mech-anisms for the activation of BRI1 family receptors. | Ji She Zhifu Han Bin Zhou Jijie Chai | 2013 | Protein & Cell2013，4，6： | 6 |
| 4 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 5 | Construction of a few-layer g-C_3N_4/α-MoO_3 nanoneedles all-solid-state Z-scheme photocatalytic system for photocatalytic degradation显示文摘The suppression of the recombination of electrons and holes(e–h) and the enhancement of the light absorption of semiconductors are two key points toward efficient photocatalytic degradation.Here,we report a few-layer g-C_3N_4/α-MoO_3 nanoneedles(flg-C_3N_4/α-MoO_3 NNs) all-solid-state Z-scheme mechanism photocatalyst synthesized via a typical hydrothermal method in a controlled manner.The recombination of the photo-induced e–h pairs could be effectively restrained by the Z-scheme passageway between the flg-C_3N_4 and α-MoO_3 NNs in the composite,which could also promise a high redox ability to degrade pollutants.And it became possible for the prepared photocatalyst to absorb light in a wide range of wavelengths.The detailed mechanism was studied by electron spin-resonance spectroscopy(ESR).The low-dimensional nanostructure of the two constituents(α-MoO_3 NNs with one-dimensional structure and flg-C_3N_4 with two-dimensional structure) endowed the composite with varieties of excellent physicochemical properties,which facilitated the transfer and diffusion of the photoelectrons and increased the specific surface area and the active sites.The 10 wt% flg-C_3N_4/α-MoO_3 NNs showed the best photocatalytic performance toward RhB degradation,the rate of which was 71.86%,~2.6 times higher than that ofα-MoO_3 NNs. | Xiaoni Zhang Jianjian Yi Hanxiang Chen Mao Mao Liang Liu Xiaojie She Haiyan Ji Xiangyang Wu Shouqi Yuan Hui Xu Huaming Li | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
| 6 | Highly efficient, mild, bromide- free and acetic acid -free dioxygen oxidation of p - nitrotoluene to p - nitrobenzoie acid with metal phthaloeyanine catalysts 显示文摘 | Song X F She Y B Ji H B | 2005 | Org Process Res Dev2005，9，： | 1 |
| 7 | Correlation Analysis Between the Treating Depth of PVD and the Subsidence of Soft Ground Foundation of Expressway显示文摘 | Chen Ji Bin Zhao Qi Hua Peng She Qin Xiong Ping Hua | 2012 | Advanced Materials Research2012，，446： | 1 |
| 8 | Regulation of the expression and activity of betal,4-galactosyltransferase Ⅰ by focal adhesion kinase显示文摘 | Ji Shu-ying Zhu Xiao-yu Chen She | 2003 | Mol Cell Biochem2003，252，12： | 1 |
| 9 | Correlation Analysis Between the Treating Depth of PVD and the Subsidence of Soft Ground Foundation of Expressway显示文摘 | Chen Ji Bin Zhao Qi Hua Peng She Qin Xiong Ping Hua | 2012 | Advanced Materials Research2012，，446： | 1 |
| 10 | Recent development of room temperature ionic liquids in separatiion science and technology 显示文摘 | XU Ai-mei SUN Xiao-qi SHE Zhen-bao CHEN Ji LI De-qian | 2006 | Journal of Molecular Science2006，22，5： | 1 |
| 11 | Constitutively active PKB/Akt inhibited apoptosis and down-regulated β1,4-galactosyltransferase 1 in hepatocarcinoma cells显示文摘 | Xiaoyu Zhu She Chen Xianglei Yin Aiguo Shen Shuying Ji Zonghou Shen Jianxin Gu | 2003 | Biochemical and Biophysical Research Communications2003，，2： | 1 |
| 12 | Highly efficient, mild, bromide-free and acetic acid-free dioxygen oxidation of p-nitrotoluene to p-nitrobenzoic acid with metal phthalocyanine catalysts显示文摘 | Song X She Y Ji H | 2005 | Organic Process Research & Development2005，9，3： | 1 |
| 13 | A Mild and Efficient Procedure for the Preparation of Chromone-2-carboxylates显示文摘A mild and efficient procedure to build up various chromone-2-carboxylates was developed. Condensation of diverse 2-hydroxyacetophones with tetr-butyl oxalate in the presence of sodium ethoxide could be accomplished rapidly under mild condition. Cyclo- dehydration was carried out to achieve chromone-2-carboxylates in one-pot with impressive yield. Advantages over conventional methods with diethyl oxalate were observed in yield and reaction time. | Juan Hong YU Yu She YANG Ru Yun JI | 2006 | Chinese Chemical Letters2006，17，8： | 1 |
| 14 | Production of fungal protein by A spergillus aw am orivar:kaw achi grow n in Shoch u distillery waste water显示文摘 | SHE ERU M KEN JI K | 1994 | J Ferment Bioeng1994，78，2： | 1 |
| 15 | Highly Efficient,Mild,Bromide-free and Acetic Acid-free Dioxygen Oxidation of p-nitrotoluene to p-nitrobenzoic Acid with Metal Phthalocyanine Catalysts 显示文摘 | SONG Xu-feng SHE Yuan-bin JI Hong-bing | 2005 | Org Process Res Dev2005，9，： | 1 |
| 16 | Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent显示文摘A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBVactivity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 mmol/L and 2530 mmol/L, respectively. | Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU Yun Ji | 2007 | Chinese Chemical Letters2007，18，7： | 1 |
| 17 | Highly effcient, mild, bromide-free and acetic acid-free dioxygen oxidation of p-nitrotoluene to p-nitrobenzoic acid with metal phthalocyanine catalysts显示文摘 | SONG X SHE Y JI H | 2005 | Org Process Res Dev2005，9，3： | 1 |
| 18 | Highly efficient,mild,bromide-free and acetic acid-free dioxygen oxidation of p-nitrotoluene to p-nitrobenzoic acid with metal phthalocyanine catalysts显示文摘 | SONG Xu Feng SHE Yuan Bin JI Hong Bing | 2005 | Org Process Res Dev2005，9，3： | 1 |
| 19 | Highly efficient, mild, bromide-free and acetic acid-free dioxygen oxidation of pnitrotoluene to p-nitrobenzoic acid with metal phthalocyanine catalysts 显示文摘 | Song X F She Y B Ji H B | 2005 | Organic Process Research & Development2005，9，： | 1 |
| 20 | Correlation Analysis Between the Treating Depth of PVD and the Subsidence of Soft Ground Foundation of Expressway显示文摘 | Chen Ji Bin Zhao Qi Hua Peng She Qin Xiong Ping Hua | 2012 | Advanced Materials Research2012，，446： | 1 |
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