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| 1 | A new choice of stent for transjugular intrahepatic portosystemic shunt creation: Viabahn ePTFE covered stent/bare metal stent combination显示文摘Objectives:To compare the clinical outcomes in terms of structure and function between the insertion of a transjugular intrahepatic portosystemic shunt(TIPS) created with the Viabahn ePTFE covered stent/bare metal stent(BMS) combination and the Fluency ePTFE covered stent/BMS combination.Methods:A total of 101 consecutive patients who received a TIPS from February 2016 to August 2018 in our center were retrospectively analyzed.Sixty-four subjects were enrolled in the Viabahn group and 37 were enrolled in the Fluency group.The geometry characteristics of the TIPS were calculated,and the associated occurrence of shunt dysfunction,survival,overt hepatic encephalopathy,and variceal rebleeding were evaluated.Results:The technical success rate was 100%.After the insertion of the TIPS,the rate of shunt dysfunction during the first 3 months was significantly different between the Viabahn and Fluency groups(1.6% and 13.5%,respectively;p=0.024).Multivariate analysis indicated that the angle of portal venous inflow(α) was the only independent risk factor for shunt dysfunction(hazard ratio=1.060,95% confidence interval=1.009-1.112,p=0.020).In addition,3 months after the TIPS insertion,the a angle distinctly increased from 20.9°±14.3°-26.9°±20.1°(p=0.005) in the Fluency group but did not change significantly in the Viabahn group(from 21.9°±15.1°-22.9°± 17.6°,p=0.798).Conclusions:Shunt dysfunction was related to the a angle owing to the slight effect on the a angle after the implantation of the TIPS.The Viabahn ePTFE covered stent/BMS combination was more stable in structure and promised higher short-term stent patency compared with the Fluency ePTFE covered stent/BMS combination. | Jiacheng Liu Jie Meng Chen Zhou Qin Shi Chongtu Yang Jinqiang Ma Manman Chen Bin Xiong | 2021 | Journal of Interventional Medicine2021，4，1： | 9 |
| 2 | Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling显示文摘The B7-family inducible costimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization.This costimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase Lck.TMD-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and costimulatory signaling activity of ICOS.TMD-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in vivo.When transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target cells.Therefore,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology. | Zurong Wan Xingxing Shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong Wanli Liu Hai Qi | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 3 | Analysis of negative DSA findings in patients with acute nonvariceal gastrointestinal bleeding: A retrospective study of 133 patients显示文摘Purpose: To analyze causes of acute nonvariceal gastrointestinal bleeding(GIB) with negative digital subtraction angiography(DSA) results.Materials and methods: The clinical and follow-up data of 133 patients-recruited between February 2008 and November 2016-with acute nonvariceal GIB and negative DSA results were included in this study. DSA results,diagnoses, and clinical outcomes were recorded.Results: The DSA results were negative in all 133 patients. Of the total, 55 patients(41.4%) chose to undergo surgery and 78(58.6%) opted for conservative treatment. Within 30 days, there was no significant difference in the rebleeding or mortality rates between the two groups(P <.05). Of all 133 patients, 76(57.1%) had upper GIB and 57(42.9%) had lower GIB;within 30 days, the rebleeding rate in the upper GIB group(44.7%, 34/76) was significantly higher than that in the lower GIB group(26.3%, 15/57). There was no significant statistical difference(P <.05) within 30 days in the mortality rates between the two groups.Among patients with upper GIB, 26(34.2%, 26/76) opted to undergo surgery and 50(65.8%, 50/76) chose conservative treatment;within 30 days, the rebleeding rate in the group that chose surgery(61.5%, 16/26) was higher than that in the conservative treatment group(36%, 18/50). There was no significant difference(P <.05)within 30 days in the mortality rate between the two groups.Among the patients with lower GIB, 29(50.9%, 29/57) chose to undergo surgery and 28(49.1%, 28/57) opted for conservative treatment. Within 30 days, the rebleeding rate in the surgery group(13.8%, 4/29) was lower than that in conservative treatment group(39.3%, 11/28). There was no significant difference(P <.05) within 30 days in the mortality rate between the two groups.Sixteen patients underwent prophylactic arterial embolization;in 6 of these, bleeding was stopped for 30 days.DSA was then repeated in these 16 patients after a median interval of 1 day, and a positive bleeding site was found in 9 of the 16. Causes of bleeding were found in 111 patients by surgery or endoscopy, whereas the causes remained unknown in 22 patients.Conclusions: Upper GIB with negative DSA results was stopped by conservative treatment, whereas lower GIB required surgery to detect the culprit bleeding site. Rare causes of GIB should be considered and appropriate management selected in a timely manner in order to detect unusual causes. | Tianhe Ye Lian Yang Qi Wang Jiacheng Liu Chen Zhou Chuansheng Zheng Bin Xiong | 2019 | Journal of Interventional Medicine2019，2，1： | 3 |
| 4 | An inferred functional impact map of genetic variants in rice显示文摘Interpreting the functional impacts of genetic variants(GVs)is an important challenge for functional genomic studies in crops and next-generation breeding.Previous studies in rice(Oryza sativa)have focused mainly on the identification of GVs,whereas systematic functional annotation of GVs has not yet been performed.Here,we present a functional impact map of GVs in rice.We curated haplotype information for 17397026 GVs from sequencing data of 4726 rice accessions.We quantitatively evaluated the effects of missense mutations in coding regions in each haplotype based on the conservation of amino acid residues and obtained the effects of 918848 non-redundant missense GVs.Furthermore,we generated high-quality chromatin accessibility(CA)data from six representative rice tissues and used these data to train deep convolutional neural network models to predict the impacts of 5067405 GVs for CA in regulatory regions.We characterized the functional properties and tissue specificity of the GV effects and found that large-effect GVs in coding and regulatory regions may be subject to selection in different directions.Finally,we demonstrated how the functional impact map could be used to prioritize causal variants in mapping populations.This impact map will be a useful resource for accelerating gene cloning and functional studies in rice,and can be freely queried in RiceVarMap V2.0(http://gffzz90f9113514c343b0h9wof0ok5696v6pf5.ffgz.tsg.suse.edu.cn). | Hu Zhao Jiacheng Li Ling Yang Gang Qin Chunjiao Xia Xingbing Xu Yangmeng Su Yinmeng Liu Luchang Ming Ling-Ung Chen Lizhong Xiong Weibo Xie | 2021 | Molecular Plant2021，14，9： | 3 |
| 5 | Standardization of tritiated water by the CIEMAT/NIST and TDCR methods显示文摘The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods. | WU YongLe LIU HaoRan LIANG JunCheng LIU JiaCheng XIONG WenJun YUE HuiGuo LIU SenLin YANG YuanDi YUAN DaQing | 2015 | Science China(Technological Sciences)2015，58，3： | 1 |
| 6 | Metabolic and proteostatic differences in quiescent and active neural stem cells显示文摘Adult neural stem cells are neurogenesis progenitor cells that play an important role in neurogenesis.Therefore,neural regeneration may be a promising target for treatment of many neurological illnesses.The regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and active.Quiescent adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell pool.Active adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural circuits.This review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein homeostasis.Furthermore,we discuss the physiological significance and underlying advantages of these diffe rences.Due to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms. | Jiacheng Yu Gang Chen Hua Zhu Yi Zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong | 2024 | Neural Regeneration Research2024，19，1： | 1 |
| 7 | In situ formation of the loop snare technique for retrieval of foreign bodies from vessels显示文摘Purpose: To investigate the feasibility and effectiveness of in situ formation of the loop snare technique for retrieval of foreign bodies from vessels. Materials and methods: We retrospectively reviewed in situ formation of the loop snare technique for retrieval of foreign bodies in 6 patients. After placing the guide wire and the loop of the gooseneck snare on each side of the tubes, the soft tip of the guide wire was caught with the gooseneck snare to form a new loop structure. The foreign body was retrieved with the new loop snare by combining the gooseneck snare and the guide wire. We reviewed the application of this technique in 6 patients with fractured central venous catheters without free ends. Results: With in situ formation of the loop snare technique, the internal ruptured catheter was successfully removed from all of the 6 patients in about 2 to 4 min. There were no complications such as arrhythmia or heart valve injury in the 6 patients with the distal end of the fragment in the pulmonary artery or right atrium. Conclusion: The in situ formation loop snare technique is an effective and fast means of retrieving tubular foreign bodies without free ends from vessels. Further research is needed to investigate the practical utility of the method for retrieval of all kinds of foreign bodies. | Qi Wang Chen Zhou Jiacheng Liu Bin Xiong Chuansheng Zheng Gansheng Feng | 2018 | Journal of Interventional Medicine2018，1，4： | 0 |
| 8 | Management of non‐cirrhotic extrahepatic portal vein obstruction‐related portal hypertension in adult patients显示文摘To The Editor:Non‐cirrhotic extrahepatic portal vein obstruction(EHPVO)is a hepatic vascular disorder characterized by the obstruction of the extrahepatic portal vein with or without the involvement of the intrahepatic portal veins or the splenic or superior mesenteric vein in the absence of cirrhosis.1 In most cases,EHPVO leads to the development of portal cavernoma.EHPVO is commonly complicated with portal hypertension;in fact,a study revealed that 30%of patients with portal hypertension‐related variceal bleeding are ultimately diagnosed with EHPVO.In addition,EHPVO is the most common cause of upper gastrointestinal bleeding in children,accounting for approximately 70%of pediatric portal hypertension cases. | Jiacheng Liu Yaowei Bai Bin Xiong | 2022 | Portal Hypertension & Cirrhosis2022，1，3： | 0 |
| 9 | Integration of LNG Regasification Process in Natural Gas-Fired Power System with Oxy-Fuel Combustion显示文摘Oxy-fuel combustion power systems can utilize the cold energy released during the liquefied natural gas(LNG)regasification to reduce the power consumption of CO_(2) capture,but the specific LNG cold energy consumption of CO_(2) capture is still too large.To recover more CO_(2) with the limited LNG cold energy at a low energy cost,a novel natural gas-fired oxy-fuel power system with the cascade utilization of LNG cold energy is proposed in this work,where the LNG cold energy could be sequentially utilized in the air separation unit and the CO_(2) recovery process.The new system is evaluated with the Aspen Plus software.The results show that the net electrical efficiency and the specific primary energy consumption for CO_(2) avoided(SPECCA)of the new system are comparable to those of the chemical looping combustion cycle,and superior to those of the conventional O_(2)/CO_(2) cycles.Moreover,the specific LNG needed for CO_(2) avoided(SLNCC)of the new system is more than 67.2%lower than the existing oxy-fuel power systems utilizing the LNG cold energy.Furthermore,it is found that the O_(2) purity of 97.0 mol.%and the CO_(2) capture ratio of 97.0%are optimal conditions,because the SPECCA,the specific exergy consumption for CO_(2) avoided(SECCA)and the SLNCC are at the minimum of 1.87 GJLHV⋅t_(CO_(2))^(−1),2.60GJ⋅t_(CO_(2))^(−1) and 1.88tLNG⋅t_(CO_(2))^(−1),respectively.Meanwhile,the net electrical efficiency and the exergy efficiency of the new system reach 51.51%and 49.23%,respectively. | LIU Rong XIONG Yongqiang KE Liying LIANG Jiacheng CHEN Dengjie ZHAO Zhongxing LI Yajun | 2022 | Journal of Thermal Science2022，31，5： | 0 |
| 10 | Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application显示文摘Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other xenobiotics.AOX-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic agents.Computational models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism liability.In this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated metabolism.AOMP integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both tasks.AOMP significantly outperformed the benchmark methods in both cross-validation and external testing.Using AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro experiments.Furthermore,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at http://gffzz614802becf7e49c4s9wof0ok5696v6pf5.ffgz.tsg.suse.edu.cn. | Jiacheng Xiong Rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu Xiaohong Liu Zhenghao Li Kaixian Chen Mingyue Zheng | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 11 | αExtractor: a system for automatic extraction of chemical information from biomedical literature显示文摘Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature. | Jiacheng Xiong Xiaohong Liu Zhaojun Li Hongzhong Xiao Guangchao Wang Zhenjiang Niu Chaoyuan Fei Feisheng Zhong Gang Wang Wei Zhang Zunyun Fu Zhiguo Liu Kaixian Chen Hualiang Jiang Mingyue Zheng | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 12 | Splenic artery embolization for treatment of portal hypertension due to essential thrombocythemia显示文摘Philadelphia‐negative myeloproliferative neoplasms(MPNs)are significantly associated with the development of splanchnic vein thrombosis,which leads to portal hypertension.Here,we report two rare cases of portal hypertension caused by essential thrombocythemia(a type of MPN).Splenic artery embolization was performed to prevent variceal rebleeding,and during follow‐up,no rebleeding occurred in these two cases. | Jiacheng Liu Xiaoming Liu Bin Xiong | 2022 | Portal Hypertension & Cirrhosis2022，1，2： | 0 |
| 13 | Management of traumatic peripheral artery pseudoaneurysm:A 10-year experience at a single center显示文摘Purpose: This study aimed to report our 10-year experience with the management of iatrogenic(penetrating trauma) and traumatic(blunt or penetrating trauma) peripheral artery pseudoaneurysms, based on data from a tertiary referral center.Methods: From January 2012 to December 2021, the medical records of consecutive patients with iatrogenic and traumatic peripheral artery pseudoaneurysms were retrospectively reviewed. Patient demographics, clinical features, imaging data, treatment details, and follow-up results were analyzed.Results: Sixty-one consecutive patients were included in this study;48(79%) were men and 13(21%) women,with a mean age of 49.4 ± 13.4 years(range 24–73 years). There were 42 patients(69%) who underwent open surgery, 18(29%) undergoing endovascular embolization or stent implantation, and one(2%) undergoing ultrasound-guided thrombin injection. All patients successfully underwent open or interventional treatment. The median follow-up was 46.8 months(2.5–117.9 months), and the overall reintervention rate was 10%. Of these,one(5%) patient in the interventional treatment group and five(12%) patients in the open surgery group underwent reintervention. The overall complication rate was 8%, with complications occurring only in the open surgery group. No deaths occurred in the peri-operative period. No late complications, such as thrombosis or pseudoaneurysm recurrence, were observed.Conclusion: Peripheral artery pseudoaneurysms arising from iatrogenic or traumatic causes can be effectively treated by both open surgery and interventional procedures in selected patients with acceptable mid-and long-term outcomes. | Yingliang Wang Hai Zheng Wei Yao Shuguang Ju Yaowei Bai Chaoyang Wang Chen Zhou Jiacheng Liu Chongtu Yang Songjiang Huang Tongqiang Li Yang Chen Bin Xiong | 2023 | Journal of Interventional Medicine2023，6，1： | 0 |
| 14 | An Edge-assisted, Object-oriented Random Forest Approach for Refined Extraction of Tea Plantations Using Multi-temporal Sentinel-2 and High-resolution Gaofen-2 Imagery显示文摘As a consumed and influential natural plant beverage,tea is widely planted in subtropical and tropical areas all over the world.Affected by(sub)tropical climate characteristics,the underlying surface of the tea distribution area is extremely complex,with a variety of vegetation types.In addition,tea distribution is scattered and fragmentized in most of China.Therefore,it is difficult to obtain accurate tea information based on coarse resolution remote sensing data and existing feature extraction methods.This study proposed a boundary-enhanced,object-oriented random forest method on the basis of high-resolution GF-2 and multi-temporal Sentinel-2 data.This method uses multispectral indexes,textures,vegetable indices,and variation characteristics of time-series NDVI from the multi-temporal Sentinel-2 imageries to obtain abundant features related to the growth of tea plantations.To reduce feature redundancy and computation time,the feature elimination algorithm based on Mean Decrease Accuracy(MDA)was used to generate the optimal feature set.Considering the serious boundary inconsistency problem caused by the complex and fragmented land cover types,high resolution GF-2 image was segmented based on the MultiResolution Segmentation(MRS)algorithm to assist the segmentation of Sentinel-2,which contributes to delineating meaningful objects and enhancing the reliability of the boundary for tea plantations.Finally,the object-oriented random forest method was utilized to extract the tea information based on the optimal feature combination in the Jingmai Mountain,Yunnan Province.The resulting tea plantation map had high accuracy,with a 95.38%overall accuracy and 0.91 kappa coefficient.We conclude that the proposed method is effective for mapping tea plantations in high heterogeneity mountainous areas and has the potential for mapping tea plantations in large areas. | Juanjuan YU Xiufeng HE Jia XU Zhuang GAO Peng YANG Yuanyuan CHEN Jiacheng XIONG | 2023 | Journal of Geodesy and Geoinformation Science2023，6，1： | 0 |
| 15 | Molecular targeted therapy causes hepatic encephalopathy in patients after Transjugular intrahepatic portosystemic shunt(TIPS):A case report and literature review显示文摘We report two cases of hepatic encephalopathy caused by molecular targeted drugs after the Transjugular intrahepatic portosystemic shunt(TIPS)procedure in our center.The liver toxicities and anti-angiogenic effects induced by targeted drugs may generate an imbalance in ammonia metabolism,elevating blood ammonia levels.TIPS diverts partial blood supply from the liver,aggravates liver impairment,and shunts ammonia-rich blood from the intestine into the systemic circulation.These may be the mechanisms leading to hepatic encephalopathy caused by molecular targeted drugs following TIPS.When clinicians choose molecular targeted therapy as the second or third targeted therapy for patients who have undergone TIPS,the consequence of drug-induced hepatic encephalopathy should also be considered. | Chen Zhou Yang Chen Jiacheng Liu Qin Shi Bin Xiong | 2022 | Journal of Interventional Medicine2022，5，1： | 0 |
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