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| 1 | Distribution of isotopes and chemicals in precipitation in Shule River Basin,northwestern China:an implication for water cycle and groundwater recharge显示文摘The distribution of stable isotopes and ions in precipitation in the Shule River Basin,northwestern China,were investigated to understand the regional water cycle and precipitation input to groundwater recharge.The study found that the mean annual concentrations of Ca2+,Na+,SO42–,Cl–,Mg2+,NO3–,and K+ in the basin were lower than those in other arid areas of northwestern China.The average concentrations of ions in the lower reaches of the Shule River were higher than those in the upper reaches.The results showed that the main ionic concentrations decreased with the increase of precipitation amount,indicating that heavy precipitation cannot only wash crustal aerosols out of the atmosphere,but also create a dilution effect.Cl– and Na+ in precipitation had a strong and positive correlation,suggesting a common origin for the two ions.However,the excess of Na+,combined with non-marine SO42– and NO3–,indicated that some ions were contributed by terrestrial origins.In the extremely arid regions of northwestern China,the evaporation process obviously changes the original relationship between δ2H and δ18O in precipitation,and leads to dexcess values <8‰.δ18O and temperature were significantly correlated,suggested that temperature strongly affected the characteristics of isotopes in the study area.The δ18O value indicates a dominant effect of westerly air masses and southwest monsoon in warm months,and the integrated influence of westerly and Siberian-Mongolian polar air masses in cold months.The d-excess values were generally lower in warm months than those in cold months,indicating that post-condensation processes played a significant role in the water cycle.The results provide reliable precipitation input information that can be used in future groundwater recharge calculations in the study area. | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2016 | Journal of Arid Land2016，8，6： | 6 |
| 2 | Folate-chitosan-gemcitabine core-shell nanoparticles targeted to pancreatic cancer显示文摘Objective:Human pancreatic cancer is one of the most common clinical malignancies.The effect of comprehensive treatment based on surgery is general.The effects of chemotherapy were not obvious mainly because of lack of targeting and chemoresistance in pancreatic cancer.This study aimed to investigate the effects of folate receptor(FR)-mediated gemcitabine FA-Chi-Gem nanoparticles with a core-shell structure by electrostatic spray on pancreatic cancer.Methods:In this study,the levels of expression of FR in six human pancreatic cancer cell lines were studied by immunohistochemical analysis.The uptake rate of isothiocyanate-labeled FA-Chi nanoparticles in FR high expression cell line COLO357 was assessed by fluorescence microscope and the inhibition rate of FAChi-Gem nanoparticles on COLO357 cells was evaluated by MTT assay.Moreover,the biodistribution of PEG-FA-ICGDER02-Chi in the orthotopic pancreatic tumor model was observed using near-infrared imaging and the human pancreatic cancer orthotopic xenografts were treated with different nanoparticles and normal saline control.Results:The expression of FR in COLO357 was the highest among the six pancreatic cancer cell lines.The FR mainly distributed on cell membrane and fewer in the cytoplasm in pancreatic cancer.Moreover,the absorption rate of the FA-Chi-Gem nanoparticles was more than the Chi nanoparticles without FA modified.The proliferation of COLO357 was significantly inhibited by FA-Chi-Gem nanoparticles.The PEG-FAICGDER02-Chi nanoparticles were enriched in tumor tissue in human pancreatic cancer xenografts,while non-targeted nanoparticles were mainly in normal liver tissue.PEG-FA-Gem-Chi significantly inhibited the growth of human pancreatic cancer xenografts(PEG-FA-Gem-Chi vs.Gem,t=22.950,P=0.000).Conclusions:PEG-FA-FITC-Chi nanoparticles might be an effective targeted drug for treating human FR-positive pancreatic cancer. | Jiahua Zhou Junying Wang Qian Xu Shi Xu Jin Wen Zeqian Yu Detong Yang | 2013 | Chinese Journal of Cancer Research2013，25，5： | 5 |
| 3 | Simulation of the anode structure for capacitive Frisch grid CdZnTe detectors显示文摘CdZnTe(CZT)capacitive Frisch grid detectors can achieve a higher detecting resolution.The anode structure might have an important role in improving the weighting potential distribution of the detectors.In this paper, four anode structures of capacitive Frisch grid structures have been analyzed with FE simulation,based on a 3-dimensional weighting potential analysis.The weighting potential distributions in modified anode devices(Model B, C and D)are optimized compared with a square device(Model A).In model C and D,the abrupt weighting potential can be well modified.However,with increased radius of the circular electrode in Model C the weighting potential platform away from the anode becomes higher and higher and in Model D,the weighting potential does not vary too much. | MIN Jiahua SHI Zhubin QIAN Yongbiao SANG Wenbin ZHAO Hengyu TENG Jianyong LIU Jishan | 2009 | Nuclear Science and Techniques2009，20，1： | 2 |
| 4 | Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data显示文摘Objective: To investigate the benefit of epidermal growth factor receptor( EGFR) tyrosine kinase inhibitors( TKIs)with radiotherapy in patients with EGFR mutation-positive metastatic non-small cell lung cancer( NSCLC),compared with TKIs alone.Methods: A total of 103 patients with stage Ⅳ EGFR-mutated NSCLC treated from February 2015 to May 2017 at Sichuan Cancer Hospital were analyzed retrospectively. Fifty patients were treated with EGFR-TKIs( gefitinib or erlotinib) plus radiotherapy( the TKI +RT group) and 53 patients received EGFR-TKIs alone( the TKI group). Tumor response,survival and toxicities were compared between the two groups. Results: Median follow-up time was 11. 7 months( 2. 8-36. 3 months). The overall response rate( ORR) and disease control rate( DCR) in the TKI + RT group vs the TKI group were 62% vs 37. 7%( P = 0. 014) and 88% vs 75. 5%( P =0. 101),respectively. The median progression-free survival( PFS) and median overall survival( OS) in the TKI + RT group were superior to those of the TKI group( 18. 87 months vs 12. 80 months,P = 0. 035 and 23. 10 months vs 18. 30 months,P = 0. 011). OS rates in the TKI + RT group and the TKI group were 56. 0% vs 35. 8% at year 1( P = 0. 04) and 16. 0% vs 3. 8% at year 2( P =0. 036). Multivariate Cox model found that TKI + RT related to significantly better OS( hazard ratio = 0. 209;95% CI,0. 066 to0. 661;P = 0. 008) than TKI alone. Adverse events did not differ significantly between the two groups( P > 0. 050). Conclusion:Compared with EGFR-TKIs alone,EGFR-TKIs combined with radiotherapy was well tolerated and showed benefit in tumor response and survival for EGFR mutation-positive metastatic NSCLC patients. | Wang Ranlin Li Tao Lv Jiahua Sun Chang Shi Qiuling | 2019 | 肿瘤预防与治疗2019，32，5： | 2 |
| 5 | Erratum to: Distribution of isotopes and chemicals in precipitation in Shule River Basin, northwestern China: an implication for water cycle and groundwater recharge显示文摘 | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2017 | Journal of Arid Land2017，9，2： | 1 |
| 6 | Enhancement of the mechanical performance of poly( vinyl chloride)using poly( nbutyl methacrylate ) -grafted multi-walled carbon nanotubes 显示文摘 | Shi Jiahua Yang Bingxing Pramoda K P | 2007 | Nanotechnology2007，18，37： | 1 |
| 7 | Prediction ontribological properties of carbon fiber and TiO2 synergistic reinforced polytetrafluoroethylene composites with artificial neural networks显示文摘 | ZHU Jiahua SHI Yijun FENG Xin | 2009 | Mater Des2009，30，4： | 1 |
| 8 | Preparation and characterization of thermo-responsive amphiphilic triblock copolymer and its self-assembled micelle for controlled drug release显示文摘 | Tianhong Qu Airong Wang Jinfang Yuan Jiahua Shi Qingyu Gao | 2009 | Colloids and Surfaces B: Biointerfaces2009，，1： | 1 |
| 9 | Large-scale preparation of solubilized carbon nanotubes显示文摘 | Qin Yujun Liu Luqi Shi Jiahua | 2003 | Chemistry of Materials2003，15，： | 1 |
| 10 | Large-scale preparation of solubilized carbon nanotubes显示文摘 | Qin Yujun Liu Luqi Shi JiaHua | 2003 | Chemistry of Materials2003，15，： | 1 |
| 11 | Preparation of hydroxyapatite-containing titania coating on titanium substrate by micrcarc oxidation显示文摘 | Ni Jiahua Shi Yulong Yan Fengying | 2008 | Mater Res Bull2008，43，8： | 1 |
| 12 | Large-scale preparation of solubilized carbon nanotubes显示文摘 | Qin Yujun Liu Luqi Shi Jiahua | 2003 | Chem Mater2003，15，： | 1 |
| 13 | The pH-eontrolled morphology transition of polyaniline from nanofihers to nanospheres 显示文摘 | SHI Jiahua WU Qiang LI Runming | 2013 | Nanotechnology2013，24，17： | 1 |
| 14 | microstrtcture,crystallization and dynamic mechanical behaviour of poly(vinylidene fluoride)composites containing poly(methyl methacrylate)grafted multiwalled carbon nanotubes显示文摘 | WANG Mian shi jiahua pramoda k p | 2007 | nanotehnology2007，18，23： | 1 |
| 15 | Binding to m6A RNA promotes YTHDF2-mediated phase separation显示文摘Dear Editor,As one of the most abundant modifications on mRNA in mammal,A^6-methyladenosine(m6A)has been demonstrated to play important roles in various biological processes including nuclear RNA export,mRNA splicing,miRNA processing,mRNA degradation and translation(Shi et al.,2019).Importantly,different m6A reader proteins have been shown to play central roles in these processes. | Jiahua Wang Liyong Wang Jianbo Diao Yujiang Geno Shi Yang Shi Honghui Ma Hongjie Shen | 2020 | Protein & Cell2020，11，4： | 1 |
| 16 | The removal of wall components in Doppler ultrasound signals by using the empirical mode decomposition algorithm显示文摘 | ZHANG Yufeng GAO Yali WANG Le CHEN Jiahua SHI Xinling | 2007 | IEEE Transactions on Biomedical Engineering2007，54，9： | 1 |
| 17 | Optimizing hydrogen plasma etching process of preferred (110)-textured diamond film显示文摘 | Qingkai Zeng Linjun Wang Lingyun Shi Kaifeng Qin Jian Huang Ke Tang Jiahua Min Weimin Shi Yiben Xia | 2013 | Surface & Coatings Technology2013，，： | 1 |
| 18 | Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy显示文摘Immunotherapy combined with effective therapeutics such as chemotherapy and photodynamic therapy have been shown to be a successful strategy to activate anti-tumor immune responses for improved anticancer treatment.However,developing multifunctional biodegradable,biocompatible,low-toxic but highly efficient,and clinically available transformed nano-immunostimulants remains a challenge and is in great demand.Herein,we report and design of a novel carrier-free photo-chemotherapeutic nano-prodrug COS-BA/Ce6 NPs by combining three multifunctional components-a self-assembled natural small molecule betulinic acid(BA),a water-soluble chitosan oligosaccharide(COS),and a low toxic photosensitizer chlorin e6(Ce6)-to augment the antitumor efficacy of the immune adjuvant anti-PD-L1-mediated cancer immunotherapy.We show that the designed nanodrugs harbored a smart and distinctive“dormancy”characteristic in chemotherapeutic effect with desired lower cytotoxicity,and multiple favorable therapeutic features including improved^(1)O_(2)generation induced by the reduced energy gap of Ce6,pH-responsiveness,good biodegradability,and biocompatibility,ensuring a highly efficient,synergistic photochemotherapy.Moreover,when combined with anti-PD-L1 therapy,both nano-coassembly based chemotherapy and chemotherapy/photodynamic therapy(PDT)could effectively activate antitumor immunity when treating primary or distant tumors,opening up potentially attractive possibilities for clinical immunotherapy. | Jianjun Cheng Haitian Zhao Bin Li Hua Zhang Qianyu Zhao Shiyao Fu Ying Han Weihong Lu Jiahua Shi Xin Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 19 | IMPROVEMENTS IN MECHANICALPROPERTIES OF SINGLECRYSTAL SUPERALLOY NASAIR 100显示文摘The NASAIR 100 single crystals solidified with planar, cellular, coarsedendritic and fine dendritic S / L (solid-liquid) interfaces are produced by using . seed .technique in an LMC directional solidification device which can reach higher tempera-tures an | Guo Xiping Shi Zhengxing Fu Hengzhi(Department of Malerials Science and Engineering, NorthwesternPolytechnical Universily, Hi’an, China, 710072)Sun Jiahua(Department of Superalloys, Central Iron and Steel Research InstituteThe Minisiry of Metallurgica | 1995 | Chinese Journal of Aeronautics1995，8，1： | 0 |
| 20 | Nickel-Catalyzed Regiodivergent Asymmetric Cycloadditions of α,β-Unsaturated Carbonyl Compounds显示文摘Regiodivergent asymmetric cycloadditions from the same set of starting materials offer interesting opportunities for rapid construction of optically active cyclic molecules with structural diversity.However,this remains a challenging task due to the difficulty of simultaneously controlling the regio-,diastereo-,and enantioselectivity in the ring formation processes.To address this long-standing problem. | Shi Cao Ziqi Ye Yuehua Chen Yu-Mei Lin Jiahua Fang Yuejiao Wang Boxuan Yang Lei Gong | 2022 | CCS Chemistry2022，4，9： | 0 |
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