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| 1 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 2 | Effects of soaking process on arsenic and other mineral elements in brown rice显示文摘One of the main food crops in the world,rice can accumulate high levels of arsenic from flooded paddy soils,which seriously threatens human health.Soaking,a common processing method for brown rice products,especially for brown rice noodles,was investigated in this study.Japonica rice(Dao Hua Xiang No.2)and Indica rice(Ye Xiang You No.3)were selected for studying the effects of soaking on arsenic concentrations,species,and distributions.Results revealed that soaking can efficiently remove arsenic in these two rice varieties,and the main part of removal is endosperm with the maximal rate of about 40%.Inorganic arsenic(I-As)(about 85%)is the main species of arsenic reduction.Meanwhile,the variations of four other elements(i.e.,Mg,Ca,Zn,and Fe)were analyzed.Collectively,the findings of this study indicate that soaking can efficiently remove arsenic in brown rice under controlled soaking conditions,which thereby reduces the arsenic intake for brown rice customers. | Fan Zhang Fengying Gu Huili Yan Zhenyan He Bolun Wang Hao Liu Tingting Yang Feng Wang | 2020 | Food Science and Human Wellness2020，9，2： | 5 |
| 3 | Vinyl-functionalized multicolor benzothiadiazoles: design,synthesis, crystal structures and mechanically-responsive performance显示文摘Benzothiadiazole(BTD) has been extensively used as a building block in optical materials. In this work, a class of π-conjugated BTD-based luminogens BTD-685, BTD-580, BTD-675 and BTD-565 were designed by varying donor units and facilely synthesized by Heck coupling reaction. It was found that their emission in solid state covered the regio from orange, red to near infrared fluorescence. Investigation on photo-physical property manifested that they had strong solvatochromic behavior except symmetric 2-vinylpyridine substituted BTD-565. Crystal X-ray diffraction analysis revealed that they involved in multi weak intermolecular interactions. And loose molecular packing implied that they can be easily rearranged under external force stimuli.Indeed, all compounds showed reversible mechanically-responsive behavior in solid state. Interestingly, the vinylpyridinecontaining BTD-565 exhibited hypochromatic mechanochromic behavior, whereas others showed bathochromic mechanochromism behavior. It was worth mentioning that BTD-675 had self-recovery behavior after grinding. The powder X-ray diffraction study showed that these chromic processes may be mainly attributed to the reversible morphological changes between crystalline and amorphous phase upon grinding or fuming. These observations suggested that the vinyl-functionalized benzothiadiazoles can be considered as a type of excellent candidates in mechanically-responsive chromic materials. | Jianhua Chen Fengying Ye Yan Lin Zhao Chen Shenghua Liu Jun Yin | 2019 | Science China Chemistry2019，62，4： | 2 |
| 4 | Death causes and pathogens analysis of systemic lupus erythematosus during the past 26 years显示文摘 | Yunyun Fei Xiaochun Shi Fengying Gan Xuemei Li Wen Zhang Mengtao Li Yong Hou Xuan Zhang Yan Zhao Xiaofeng Zeng Fengchun Zhang | 2014 | Clinical Rheumatology2014，，1： | 1 |
| 5 | Optimal production control in a discrete manufacturing system with unreliable machines and random demands 显示文摘 | FengY Houmin Yan | 2000 | IEEE Transactions on Automatic Control2000，45，12： | 1 |
| 6 | Preparation of hydroxyapatite-containing titania coating on titanium substrate by micrcarc oxidation显示文摘 | Ni Jiahua Shi Yulong Yan Fengying | 2008 | Mater Res Bull2008，43，8： | 1 |
| 7 | Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis显示文摘体细胞原子转移(SCNT ) 和单性生殖是复制和开发的其他的形式,造区分的体细胞原子核上的新生活周期并且分别地复制母亲的染色质。在前面的纸(阳光 F,等, CellRes 2007;17:117-134 .) ,我们显示出那“ erase-and-rebuild ”策略在正常开发被使用转变母亲的基因表达式侧面到 zygotic。这里,如果一样的策略也适用于 SCNT 和单性生殖,我们调查。在染色质和染色质因素(CF ) 之间的关系用免疫化学的 andGFP 熔化蛋白质试金在 SCNT 和单性生殖期间被检验。从这些研究的结果显示了那此后不久原子的转移, CF 的一个多数从体的原子核分裂了并且被再分配到鸡蛋的细胞质。在卵子发生的檫除过程在 SCNT 在起始的阶段期间被重获。立即在他们的形成以后的大多数 CF enteredpseudo-pronuclei。在单性生殖,所有 parthenogenotes 经历了正常卵子发生,并且因此在开发的开始前把大多数 CF 从染色体移开。CF 是随后有女职业人员原子核的 re-associated 及时并且在使肥沃的胚胎的类似于那的顺序。把数据基于这些,我们断定进程在正常开发观察了的“ erase-and-rebuild ”也发生在 SCNT 并且在单性生殖,以改变的方式的虽然。这个过程为在这些的抄写 reprogramming 负责过程。在 SCNT “擦掉”过程被压缩,效率被损害,它多半贡献经常在原子转移(nt ) 观察的发展缺点胚胎。而且,,从这研究的结果显示一颗卵的细胞质包含大多数并非所有,为装配 zygotic 的必要部件编程序并且能装配他们到不同起源的适当双染色质上。 | Tianlong Gao Junke Zheng Fengying Xing Haiyan Fang Feng Sun Ayong Yan Xun Gong Hui Ding Fan Tang Hui Z Sheng | 2007 | Cell Research2007，17，2： | 1 |
| 8 | Field emission properties of amorphous GaN ultrathin films fabricated by pulsed laser deposition显示文摘Amorphous gallium nitride (a-GaN) films with thicknesses of 5 and 300 nm are deposited on n-Si (100) substrates by pulsed laser deposition (PLD), and their field emission (FE) properties are studied. It shows that compared with thicker (300 nm) a-GaN film, better FE performance is obtained on ultrathin (5 nm) a-GaN film with a threshold field of 0.78 V/μm, which is the lowest value ever reported. Furthermore, the current density reaches 42 mA/cm2 when the applied field is 3.72 V/μm. These experimental results unambiguously confirm Binh's theoretical analysis (Binh et al. Phys Rev Lett, 2000, 85(4): 864-867) that the FE performance would be prominently enhanced with the coating of an ultra-thin wide band-gap semiconductor film. | WANG FengYing WANG RuZhi ZHAO Wei SONG XueMei WANG Bo YAN Hui | 2009 | Science in China(Series F)2009，52，10： | 0 |
| 9 | 父代应激调控子代肝脏糖异生显示文摘人群流行病学和动物实验的研究均表明,紧张、焦虑等心理应激可导致和(或)促进多个疾病的发生发展,但其对子代的影响,目前尚不清楚。 | Ling Wu Yan Lu Yang Jiao Bin Liu Shangang Li Yao Li Fengying Xing Dongbao Chen Xing Liu Jiejie Zhao Xuelian Xiong Yanyun Gu Jieli Lu 陈学进 李小英 | 2017 | 科学新闻2017，19，4： | 0 |
| 10 | New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic alterations and predictive biomarkers in sera have not been defined.Here,we enrolled 34 treatment-naive patients with ESCC and collected their pre-and post-esophagectomy sera together with the sera from 34 healthy volunteers for a metabolomic survey.Our comprehensive analysis identified ESCC tumor-associated metabolic alterations as represented by a panel of 12 serum metabolites.Notably,postoperative abrosia and parenteral nutrition substantially perturbed the serum metabolome.Furthermore,we performed an examination using sera from carcinogen-induced mice at the dysplasia and ESCC stages and identified three ESCC tumor-associated metabolites conserved between mice and humans.Notably,among these metabolites,the level of pipecolic acid was observed to be progressively increased in mouse sera from dysplasia to cancerization,and it could be used to accurately discriminate between mice at the dysplasia stage and healthy control mice.Furthermore,this metabolite is essential for ESCC cells to restrain oxidative stress-induced DNA damage and cell proliferation arrest.Together,this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse,presented evidence for refining parenteral nutrition composition,and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis. | Lei Liu Jia Wu Minxin Shi Fengying Wang Haimin Lu Jibing Liu Weiqin Chen Guanzhen Yu Dan Liu Jing Yang Qin Luo Yan Ni Xing Jin Xiaoxia Jin Wen-Lian Chen | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 11 | Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis显示文摘Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of periodontitis.This study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic background.Materials and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern China.Among them,complete periodontal charts were available for 69 Chinese patients with 103 teeth.Correlation and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,respectively.Multiple linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal section.Conclusions:The prevalence of PMFM-DLR in Eastern China was relatively high in our cohort.The morphological features of DLR were correlated with the periodontal status of mandibular first molars.This study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR. | Feifei MAO Meng WANG Shuai ZHOU Yan ZHAO Jiaping HUANG Fengying YIN Haiping YANG Pei-hui DING | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，3： | 0 |
| 12 | The detailed anti-tumor mechanisms of daphnanetype diterpenoids from Genkwa flos显示文摘Genkwa flos is a well-known traditional Chinese medicine, which exhibits abundant biological activities such as antiinflammatory, analgesic, immunoregulatory activities and anti-rheumatic arthritis activity. Recent pharmacological studies showed that Genkwa flos might also have the antitumor effect. Daphnane-type diterpenoids (DDs) are one of the main anti-tumor constitutions in Genkwa flos. However, the underlying anticancer molecular mechanisms of this type of compounds are still unclear. This review aims to give a systematic summary of DDs from Genkwa flos to better understand the anti-tumor activitiy by focusing on cell arrest, apoptosis, topoisomerase inhibition, melanin inhibition and the reverse of multi-drug-resistance (MDR). In addition, we are also going to make an overview of the mechanisms identified up to now. The significant findings may provide that DDs in Genkwa flos is a promising targeted-cancer agent. | Jingjie Chen Xinyue Shang Fengying Han Yan Zhang Guodong Yao Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，1： | 0 |
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