|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human activities and elevational constraints restrict ranging patterns of snub-nosed monkeys in a mountainous refuge显示文摘Both natural conditions and anthropogenic factors affect the survivability,distribution,and population density of wildlife.To understand the extent and how these factors drive species distributions,a detailed description of animal movement patterns in natural habitats is needed.In this study,we used satellite telemetry to monitor elevational ranges favored by endangered golden snub-nosed monkeys(Rhinopithecus roxellana),in the Qinling Mountains,central China.We investigated the abundance and distribution of food resources through sampling vegetation quadrats at different elevations and sampled anthropogenic activities using field surveys.Our results indicated that although there was no significant variation in food resources between low-(<1500 m)and middle-elevations(1500–2200 m),monkeys were found most often in areas above 1500 m,where there was less anthropogenic development(e.g.houses and roads);however,monkeys rarely ranged above 2200 m and had limited food availability at this altitude.There was limited human disturbance at this elevation.We suggest that both human activity and ecological constraints(i.e.food resources)have considerable effects on elevational use of R.roxellana in the Qinling Mountains.This study highlights the critical roles these factors can play in shaping the vertical distribution of high-altitude primates.This research provides useful insights for habitat-based conservation plans in which human disturbance management and habitat restoration should be prioritized. | Pengzhen HUANG Kun BIAN Zhipang HUANG Qi Li Derek WDUNN Gu FANG Jiahui LIU Mengyao WANG Xianfeng YANG Ruliang PAN Cunlao GAO Kaichuang SI Baoguo LI Xiaoguang QI | 2021 | Integrative Zoology2021，16，2： | 3 |
| 2 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 3 | HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells显示文摘The hematopoietic function of HOXC4 has not been extensively investigated.Our research indicated that induction of HOXC4 in co-culture system from D10 significantly promoted productions of most hematopoietic progenitor cells.CD34−CD43+cells could be clearly classified into CD34−CD43^(low) and CD34−CD43^(high) sub-populations at D14.The former cells had greater myelogenic potential,and their production was not significantly influenced by induction of HOXC4.By contrast,the latter cells had greater potential to differentiate into megakaryocytes and erythroid cells,and thus had properties of erythroid–megakaryocyte common progenitors,which abundance was increased by∼2-fold when HOXC4 was induced from D10.For CD34−CD43^(low),CD34+CD43+,and CD34−CD43^(high) sub-populations,CD43 level served as a natural index for the tendency to undergo hematopoiesis.Induction of HOXC4 from D10 caused more CD43+cells sustain in S-phase with up-regulation of NF-κB signaling,which could be counteracted by inhibition of NF-κB signaling.These observations suggested that promotion of hematopoiesis by HOXC4 is closely related to NF-κB signaling and a change in cell-cycle status,which containing potential of clinical applications. | Jiahui Zeng Wencui Sun Jing Chang Danying Yia Lijiao Zhu Yonggang Zhang Xu Pan Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen FengMa | 2020 | Blood Science2020，2，4： | 1 |
| 4 | Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials显示文摘Background: The HOX genes are master regulators of embryogenesis that are also involved inhematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles inhematopoiesis and leukemogenesis.Methods: We established HOXA9-inducible human embryonic stem cells (HOXA9/hESCs) with normalpluripotency and potential for hematopoiesis, which could be used to analyze gene function with highaccuracy. HOXA9/hESCs co-cultured with aorta–gonad–mesonephros-derived stromal cells (AGM-S3) wereinduced to overexpress HOXA9 with doxycycline (DOX) at various times after hematopoiesis started andthen subjected to flow cytometry.Results: Induction of HOXA9 from Day 4 (D4) or later notably promoted hematopoiesis and also increasedthe production of CD34+ cells and derived populations. The potential for myelogenesis was significantlyelevated while the potential for erythrogenesis was significantly reduced. At D14, a significant promotion ofS phase was observed in green fluorescent protein positive (GFP+) cells overexpressing HOXA9. NF-κBsignaling was also up-regulated at D14 following induction of HOXA9 on D4. All of these effects could becounteracted by addition of an NF-κB inhibitor or siRNA against NFKB1 along with DOX.Conclusions: Overexpression of HOXA9 starting at D4 or later during hematopoiesis significantly promotedhematopoiesis and the production of myeloid progenitors while reduced the production of erythroidprogenitors, indicating that HOXA9 plays a key role in hematopoiesis and differentiation of hematopoieticlineages. | Jiahui Zeng Danying Yi Wencui Sun Yuanlin Liu Jing Chang Lijiao Zhu Yonggang Zhang Xu Pan Yong Dong Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen Feng Ma | 2021 | Cell Regeneration2021，10，1： | 0 |
| 5 | A dual enzyme-phosphate hybrid nanoflower for glutamate detection显示文摘The enzyme hybrid nanoflower has gained interests in biosensors due to their simple synthesis and high efficiency.In this study,glutamate oxidase(GLOX)and horseradish peroxidase(HRP)hybrid nanoflowers(GLOX&HRP-HNFs)were successfully prepared for the detection of glutamic acid(Glu).The effects of the synthesis conditions on the activity of GLOX&HRP-HNFs were investigated.Results revealed that the maximum activity of GLOX&HRP-HNFs was under 4 mM phosphate radical,2.5 mM MnSO4,0.04 mg/mL GLOX,and 0.16 mg/mL HRP.After immobilization,no significant differences were observed in optimum pH and temperature values of the GLOX and HRP.The GLOX&HRP-HNFs exhibited higher storage stability and resistance to organic solvents than free GLOX and HRP.Additionally,the GLOX&HRP-HNFs maintained 69%of its primary activity after 6 cycles.More important,the GLOX&HRP-HNFs exhibited a good linear range from 1 to 100μM(R^(2)=0.9979)and a low limit of detection(LOD)of 0.59μM for glutamate.These results suggest that the GLOX&HRP-HNFs is a promising candidate for applications in biosensing for the detection of glutamate. | Peikun Li Jiahui Jia Zixin Geng Saizhao Pang Ruirui Wang Muhammad Bilal Hongjie Bian Jiandong Cui Shiru Jia | 2023 | Particuology2023，，12： | 0 |
| 6 | RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm-hemogenesis transition and promotion effect during the late stage of hematopoiesis显示文摘Runt-related transcription factor 1(RUNX1)is required for definitive hematopoiesis;however,the functions of most human RUNX1 isoforms are unclear.In particular,the effects of RUNX1-205(a novel splice variant that lacks exon 6 in comparison with RUNX1b)on human hematopoiesis are not clear.In this study,a human embryonic stem cell(hESC)line with inducible RUNX1-205 overexpression was established.Analyses of these cells revealed that induction of RUNX1-205 overexpression at early stage did not influence the induction of mesoderm but blocked the emergence of CD34+cells,and the production of hematopoietic stem/progenitor cells was significantly reduced.In addition,the expression of hematopoiesis-related factors was downregulated.However,these effects were abolished when RUNX1-205 overexpression was induced after Day 6 in co-cultures of hESCs and AGM-S3 cells,indicating that the inhibitory effect occurred prior to generation of hemogenic endothelial cells,while the promotive effect could be observed during the late stage of hematopoiesis.This is very similar to that of RUNX1b.Interestingly,the mRNA expression profile of RUNX1-205 during hematopoiesis was distinct from that of RUNX1b,and the protein stability of RUNX1-205 was much higher than that of RUNX1b.Thus,the function of RUNX1-205 in normal and diseased models should be further explored. | Wencui Sun Jiahui Zeng Jing Chang Yuan Xue Yonggang Zhang Xu Pan Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxing Liu Bo Chen Feng Ma | 2020 | Journal of Molecular Cell Biology2020，12，5： | 0 |
| 7 | The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma显示文摘Diffuse large B cell lymphoma(DLBCL)is one of the most prevalent lymphoid malignancies.The current standard of care can cure about two-thirds of DLBCL patients.1 Primary testicular diffuse large B-cell lymphoma(PT-DLBCL)is a rare but highly aggressive form of mature B-cell lymphoma that accounts for approximately 1%-9%of testicular malignancies.Different from nodal DLBCL,PT-DLBCL has a markedly worse prognosis because of inferior response to the current treatment regimens and significant extranodal tropism.2 Three main questions remained unresolved in the field of PT-DLBCL research. | Zhouliang Bian Benhong Gu Guohai Shi Jiahui Guo Dong Li Hanlin Zengg Bin Jiang Daliu Min Hengchuan Su Yanjie Zhang | 2024 | Genes & Diseases2024，11，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员