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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil显示文摘After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer's disease, with similar effects to donepezil. | Ren'an Qin Desheng Zhou Jiajun Wang Hua Hu Yang Yang Xiaoxuan Yao Xiaopeng Sun | 2012 | Neural Regeneration Research2012，7，9： | 8 |
| 3 | Microwave Synthesis of Cuprous Oxide Micro-/Nanocrystals with Different Morphologies and Photocatalytic Activities显示文摘Cuprous oxide micro-/nanocrystals were synthesized by using a simple liquid phase reduction process under microwave irradiation.Copper sulfate was used as the starting materials and macromolecule surfactants served as the templates.The morphologies phase and optical properties of them are characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM) and ultraviolet-visible diffuse reflection absorptive spectra (UV-vis/DRS),respectively.The crystals had four different shapes,namely spheres,strips,octahedrons,and dandelions.The photocatalytic behavior of the cuprous oxide particles were investigated by monitoring the degradation of rhodamine B.In spite of the different morphologies,all of the cuprous oxide micro-/nanocrystals exhibited photocatalytic activities under visible light irradiation in the following order:dandelions,strips,spheres,and octahedral crystals.The photocatalytic degradation rates of rhodamine B are 56.37%,55.68%,51.83% and 46.16%,respectively.The morphology affects significantly the photocatalytic performance. | Qingwei Zhu Yihe Zhang Jiajun Wang Fengshan Zhou Paul K. Chu | 2011 | Journal of Materials Science & Technology2011，27，4： | 5 |
| 4 | MoS_2 decorated lignin-derived hierarchical mesoporous carbon hybrid nanospheres with exceptional Li-ion battery cycle stability显示文摘Lignin is the most abundant and important macromolecule in organic matter and its yield is second only to cellulose. Lignin is abundant in source, low in price, and has a large number of active groups such as methoxy group and carboxyl group, so it has great utilization value. We used lignin as a carbon source to prepare porous carbon nanosphere(PCN) materials, and in-situ synthesized the MoS_ 2 on its surface. The high specific surface area(462.8 m^2/g), large pore volume and good electron conductivity of the porous carbon scaffold facilitated the reversible electro-chemical reaction of S towards metallic Li, and thus the nano-hybrid showed a high specific energy and excellent cycle stability which still remained 520m Ah/g after 50 cycles. | Feng Chen Long Wu Zeping Zhou Jiajun Ju Zhengping Zhao Mingqiang Zhong Tairong Kuang | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 5 | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats显示文摘In this study, rat models of Parkinson's disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. | Qingwei Zhou Jiajun Chen Shihong Yi Yongwei Lou Weimin Tang Yongmao Liu Pengguo Zhang | 2012 | Neural Regeneration Research2012，7，27： | 2 |
| 6 | InSe/hBN/graphite heterostructure for high-performance 2D electronics and flexible electronics显示文摘Two-dimensional(2D)materials as channel materials provide a promising alternative route for future electronics and flexible electronics,but the device performance is affected by the quality of interface between the 2D-material channel and the gate dielectric.Here we demonstrate an indium selenide(lnSe)/hexagonal boron nitride(hBN)/graphite heterostructure as a 2D field-effect transistor(FET),with InSe as channel material,hBN as dielectric,and graphite as gate.The fabricated FETs feature high electron mobility up to 1,146 cm2·V^-1·s^-1 at room temperature and on/off ratio up to 1010 due to the atomically flat gate dielectric.Integrated digital inverters based on InSe/hBN/graphite heterostructures are constructed by local gating modulation and an ultrahigh voltage gain up to 93.4 is obtained.Taking advantages of the mechanical flexibility of these materials,we integrated the heterostructured InSe FET on a flexible substrate,exhibiting little modification of device performance at a high strain level of up to 2%.Such high-performance heterostructured device configuration based on 2D materials provides a new way for future electronics and flexible electronics. | Liangmei Wu Jinan Shi Zhang Zhou Jiahao Yan Aiwei Wang Ce Bian Jiajun Ma Ruisong Ma Hongtao Liu Jiancui Chen Yuan Huang Wu Zhou Lihong Bao Min Ouyang Sokrates T.Pantelides Hong-Jun Gao | 2020 | Nano Research2020，13，4： | 1 |
| 7 | ANIONIC SPECIES OF SiO_2-CONTAINING SODIUM ALUMINATE SOLUTIONS显示文摘The anionic species of the SiO2-containing sodium aluminate solutions prepared by differentmethods have been investigated by Raman spectra and ultraviolet spectra.It was found thatthese solutions have different SiO2-containing anions.The solution prepared by leaching in-dustrial sinter of soda-lime sintering process contains polvsilicate ions with Si-O-Si radicals. | LIU Miaoxiu ZHOU Peifang CHEN Nianyi Shanghai Institute of Metallurgy,Academia Sinica,Shanghai,ChinaLI Yu Shanghai University of Science and Technology,Shanghai,ChinaKE Jiajun Institute of Chemical Metallurgy,Academia Sinica,Beijing,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，12： | 1 |
| 8 | Promoter-mediated transcrip- tional dynamics 显示文摘 | Zhang Jiajun Zhou Tianshou | 2014 | Biophys J2014，106，2： | 1 |
| 9 | Comment on 'binomial moment equations for chemical reaction net- Norks' 显示文摘 | Zhang Jiajun Huang Lifang Zhou Tianshou | 2014 | Phys Rev Lett2014，112，08： | 1 |
| 10 | Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus显示文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. | Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 11 | Facile synthesis of two-dimensional MoS_(2)/WS_(2) lateral heterostructures with controllable core/shell size ratio by a one-step chemical vapor deposition method显示文摘Heterostructures based on two-dimensional(2D) transition-metal dichalcogenides(TMDCs) possess unique electronic and optical properties, which open up unprecedented opportunities in nanoscale optoelectronic devices. Synthesizing high-quality 2D TMDC heterostructures with different core/shell size ratios is of great significance for practical applications. Here, we report a simple one-step chemical vapor deposition(CVD) method for fabricating MoS2/WS2 lateral heterostructures with controllable core/shell size ratio. An ultrathin MoO3/WO3 film prepared by thermal evaporation was used as the precursor, and a step-like heating process was adopted to separately grow MoS2 and WS2 monolayers by taking advantage of the different melting points of MoO3 and WO3 sources. High-quality MoS2/WS2 lateral heterostructures with sharp interfaces were fabricated by optimizing the key growth parameters. Furthermore, the core/shell size ratio of heterostructures could be easily controlled by changing the thickness ratio of MoO3/WO3 film, and an approximately linear dependence between them is revealed. Compared with MoS2 or WS2 monolayers, the MoS2/WS2 heterostructure exhibited a shortened exciton lifetime owing to the type-Ⅱ energy band alignment, which is conducive to the application of high-performance devices. This work provides a facile strategy for the synthesis of 2D lateral heterostructures with controllable size ratio. | Baofan Sun Jiajun Chen Xinyi Zhou Min Liu Yaping Wu Yuanzheng Xia Xu Li Zhiming Wu Junyong Kang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，10： | 1 |
| 12 | Noise-induced coherent switch显示文摘Taking the famous genetic toggle switch as an example,we numerically investigated the effect of noise on bistability.We found that extrinsic noise resulting from stochastic fluctuations in synthesis and degradation rates and from the environmental fluctuation in gene regulatory processes can induce coherent switch,and that there is an optimal noise intensity such that the noise not only can induce this switch,but also can amplify a weak input signal.In addition,we found that the intrinsic noise introduced through the Poisson τ-leap algorithm cannot induce such a switch. | YUAN ZhanJiang ZHANG JiaJun ZHOU TianShou | 2008 | Science China Chemistry2008，51，6： | 1 |
| 13 | Analytical distribution and tunability of noise in a model of promoter progress 显示文摘 | Zhang Jiajun Chen Luonan Zhou Tianshou | 2012 | Biophys J2012，102，6： | 1 |
| 14 | Promoter-mediated transcrip- tional dynamics 显示文摘 | Zhang Jiajun Zhou Tianshou | 2014 | Biophys J2014，106，2： | 1 |
| 15 | Influence of ball milling on sintering behavior and electrical properties of (Li, Na, K)NbO3 lead-free piezoceramics显示文摘 | CHENG Liqian ZHOU Jiajun WANG Ke | 2012 | J Mater Sci2012，47，69： | 1 |
| 16 | Comment onBinomial moment equations for chemical reaction networks显示文摘 | Zhang Jiajun Huang Lifang Zhou Tianshou | 2014 | Phys Rev Lett2014，112，08： | 1 |
| 17 | Upregulation of Rpn10 promotes tumor progression via activation of the NF-κB pathway in clear cell renal cell carcinoma显示文摘The ubiquitin-proteasome system(UPS)plays a central role in regulating protein homeostasis in tumor progression.The proteasome subunit Rpn10 is associated with the progression of several tumor types.However,little is known regarding the role of Rpn10 in clear cell renal cell carcinoma(ccRCC).In this study,we found that overexpression of Rpn10 increased ccRCC cell proliferation,migration,and invasion.Silencing Rpn10 expression resulted in decreased cell proliferation,migration,and invasion in ccRCC cells.Knockdown of Rpn10 inhibits tumor growth and cell proliferation in vivo.Furthermore,we demonstrated that Rpn10 increased cell proliferation,migration,and invasion via regulation of the nuclear factor kappa B(NF-κB)pathway.Rpn10 directly promoted inhibitor of nuclear factor-kappa B alpha(IκBcx)degradation through the UPS.Moreover,we observed that upregulation of Rpn10 or downregulation of kBa in ccRCC was associated with poor prognosis.We found that the combination of these two parameters was a more powerful predictor of poor prognosis than either parameter alone.Collectively,these findings provide evidence that Rpn10 promotes the progression of ccRCC by regulation of the NF-κB pathways and is a prognostic indicator for patients with ccRCC. | Tingting Huang Wei Tian Qingqing Zhou Jiajun Li Zhiyuan Jiang Jinsi Chen Chao Ge Hua Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 1 |
| 18 | Physical limits of feedback noise-suppression in biological networks 显示文摘 | Zhang Jiajun Yuan Zhanjiang Zhou Tianshou | 2009 | Phys Biol2009，6，4： | 1 |
| 19 | Dynamic Response of Tension Plate for UHVDC Transmission Lines Under Ice Shedding Loads显示文摘Ice shedding problems have severely threatened the safety of overhead transmission lines and caused enormous ruptures or failures of the conductors and their accessories.It is of great importance to study the dynamic properties of the transmission lines under ice shedding loads.To perform such analysis,the dynamic behavior of two typical strain sections for UHVDC transmission lines under different ice shedding conditions were simulated in this paper.Then,the dynamic response of the key tension plate as well as its buckling properties was analyzed based on the extacted ice shedding results.Finally,laboratory tests were conducted at the China Electric Power Research Institute to assess the critical value of the buckling of the tension plate.The results show that the key tension plate studied in this paper is primarily influenced by the loads along the transmission lines after taking its dynamic response and buckling properties under synthetic ice shedding conditions into consideration.The short-term fluctuation of the tension should be the major focus in tension plate designs. | Jiajun Si Lixian Zhou Kuanjun Zhu Hongyan Zhao Bin Liu Xiaoming Rui Shengchun Liu | 2022 | CSEE Journal of Power and Energy Systems2022，8，3： | 1 |
| 20 | An investigation of fretting behavior of ion-plated TiN, magnetron-sputtered MoS2 and their composite coatings显示文摘 | Xu Guizhen Zhou Zhongrong Liu Jiajun | 1999 | Wear1999，225，： | 1 |
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