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| 1 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 2 | Liquefaction macrophenomena in the great Wenchuan earthquake显示文摘On May 12,2008 at 14:28,a catastrophic magnitude Ms 8.0 earthquake struck the Sichuan Province of China.The epicenter was located at Wenchuan(31.00oN,103.40oE).Liquefaction macrophenomena and corresponding destruction was observed throughout a vast area of 500 km long and 200 km wide following the earthquake.This paper illustrates the geographic distribution of the liquefaction and the relationship between liquefaction behavior and seismic intensity,and summarizes the liquefaction macrophenomena,including sandboils and waterspouts,ground subsidence,ground fi ssures etc.,and relevant liquefaction features.A brief summary of the structural damage caused by liquefaction is presented and discussed.Based on comparisons with liquefaction phenomena observed in the 1976 Tangshan and 1975 Haicheng earthquakes,preliminary analyses were performed,which revealed some new features of liquefaction behavior and associated issues arising from this event.The site investigation indicated that the spatial non-uniformity of liquefaction distribution was obvious and most of the liquefi ed sites were located in regions of seismic intensity VIII.However,liquefaction phenomena at ten different sites in regions of seismic intensity VI were also observed for the fi rst time in China mainland.Sandboils and waterspouts ranged from centimeters to tens of meters,with most between 1 m to 3 m.Dramatically high water/sand ejections,e.g.,more than 10 m,were observed at four different sites.The sand ejections included silty sand,fi ne sand,medium sand,course sand and gravel,but the ejected sand amount was less than that in the 1976 Tangshan earthquake.Possible liquefaction of natural gravel soils was observed for the fi rst time in China mainland. | Chen Longwei Yuan Xiaoming Cao Zhenzhong Hou Longqing Sun Rui Dong Lin Wang Weiming Meng Fanchao Chen Hongjuan | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 14 |
| 3 | Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer(NSCLC)显示文摘Purpose: A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in advanced non-small-cell lung cancer(NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.Patients and methods: EGFR gene typing in 33 advanced NSCLC patients received gefitinib(250 mg/day) were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively.Results: The overall objective response rate(ORR) and median progression-free survival(PFS) in the 33 patients treated by gefitinib were 45.5% and 3.0(2.0-4.0) months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients(P<0.01). Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients(P<0.05, P<0.01, respectively). However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR(P<0.01). Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS(P<0.05). Conclusions: EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients. | Lian Chen Rui Chen Zhe Zhu Yichen Zhang Zhengwei Wen Yun Li Xiaoming Li Yuwen Luo Liyu Ma Shuguang Lin Xin Chen | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 4 | Audio Zero-Watermark Scheme Based on Discrete Cosine Transform-Discrete Wavelet TransformSingular Value Decomposition显示文摘Traditional watermark embedding schemes inevitably modify the data in a host audio signal and lead to the degradation of the host signal.In this paper,a novel audio zero-watermarking algorithm based on discrete wavelet transform(DWT),discrete cosine transform(DCT),and singular value decomposition(SVD) is presented.The watermark is registered by performing SVD on the coefficients generated through DWT and DCT to avoid data modification and host signal degradation.Simulation results show that the proposed zero-watermarking algorithm is strongly robust to common signal processing methods such as requantization,MP3 compression,resampling,addition of white Gaussian noise,and low-pass filtering. | Min Lei Yu Yang XiaoMing Liu MingZhi Cheng Rui Wang | 2016 | China Communications2016，13，7： | 7 |
| 5 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 6 | A pH-responsive TiO_2-based Pickering emulsion system for in situ catalyst recycling显示文摘Developing methods for efficient product/catalyst separation and catalyst recycling is meaningful in multi-phase catalytic reactions. Here, we reported a p H-responsive emulsion system stabilized by interfacially active TiO_2 nanoparticles for achieving in situ product/catalyst separation and catalyst recycling. In this system, emulsification and demulsification process could be easily engineered through tuning the p H values. The emulsion droplets were destroyed completely at a p H value of 3–4, and the solid catalyst distributed in the aqueous phase could be used to the next reaction cycle after removal of the organic product and adjusting the p H to 7–8. Such a p H triggered switchable Pickering emulsion catalytic system not only shows good recyclability of the solid catalyst but also high catalytic efficiency,and could be recycled more than 10 cycles. | Yajuan Hao Yanfang Liu Rui Yang Xiaoming Zhang Jian Liu Hengquan Yang | 2018 | Chinese Chemical Letters2018，29，6： | 5 |
| 7 | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling显示文摘Alcoholic liver disease(ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine(SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD in vivo model(the NIAAA model) was used to test the protective functions of SAMC. It was observed that SAMC(300 mg/kg, by gavage method) effectively ameliorated ALD-induced body weight reduction, steatosis,insulin resistance, and inflammation without affecting the health status of the control mice, as demonstrated by histological, biochemical, and molecular biology assays. By using biophysical assays and molecular docking, we demonstrated that SAMC directly targeted insulin receptor(INSR) protein on the cell membrane and then restored downstream IRS-1/AKT/GSK3 b signaling. Liver-specific knock-down in mice and siRNA-mediated knock-down in AML-12 cells of Insr significantly impaired SAMC(250 mmol/L in cells)-mediated protection. Restoration of the IRS-1/AKT signaling partly recovered hepatic injury and further contributed to SAMC’s beneficial effects. Continuous administration of AKT agonist and recombinant IGF-1 in combination with SAMC showed hepato-protection in the mice model.Long-term(90-day) administration of SAMC had no obvious adverse effect on healthy mice. We conclude that SAMC is an effective and safe hepato-protective complimentary agent against ALD partly through the direct binding of INSR and partial regulation of the IRS-1/AKT/GSK3 b pathway. | Pingping Luo Ming Zheng Rui Zhang Hong Zhang Yingxia Liu Wei Li Xiaoming Sun Qian Yu George LTipoe Jia Xiao | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 4 |
| 8 | Load Distribution Research on Pitch Bearing of Wind Turbine Generators显示文摘变桨轴承是风电机组传动与控制系统的关键部件,安装形式特殊且承受复杂的轴向、径向力和倾覆力矩等交变载荷。文中基于经典的赫兹弹性接触理论,建立了刚性套圈承受多向力和倾覆力矩的双排四点接触球变桨轴承的力学模型。在此基础上,应用弹性等理论研究套圈变形对轴承载荷分布的影响,推导轴承外载荷和滚动体接触力等载荷作用下转盘轴承内、外套圈的弯曲变形方程,联立非线性超越方程组给出了四点接触球转盘轴承分布载荷的求解方法。以某型号变桨轴承为例,分别采用刚性和柔性套圈2种模型对轴承载荷分布进行了计算和对比分析。结果表明2种模型下轴承载荷分布有显著区别,柔性套圈模型下的承载区间减小,载荷分布更加均匀,滚动体的承载能力有很大的提升。相关力学问题的研究可为变桨轴承结构设计提供必要的理论依据。 | RUI Xiaoming ZHENG Hui HUANG Haoran | 2013 | 中国电机工程学报2013，33，32： | 3 |
| 9 | Comprehensive identification and analyses of the Hsf gene family in the whole-genome of three Apiaceae species显示文摘Apiaceae is a major family from Apiales and includes many important vegetable and medicinal crops.Heat shock transcription factors(Hsf)play important roles in heat tolerance during plant development.Here,we conducted systematic analyses of the Hsf gene family in three Apiaceae species,including 17 Apium graveolens(celery),32 Coriandrum sativum(coriander),and 14 Daucus carota(carrot).A total of 73 Hsf genes were identified in three representative species,including Arabidopsis thaliana,Vitis vinifera,and Lactuca sativa.Whole-genome duplication played important roles in the Hsf gene family’s expansion within Apiaceae.Interestingly,we found that coriander had more Hsf genes than celery and carrot due to greater expansion and fewer losses.Twenty-seven branches of the phylogenetic tree underwent considerable positive selection in these Apiaceae species.We also explored the expression patterns of Hsf genes in three plant organs.Collectively,this study will serve as a rich gene resource for exploring the molecular mechanisms of heat tolerance.Additionally,this is the first study to report on the Hsf gene family in Apiaceae;thus,our research will provide guidance for future comparative and functional genomic studies on the Hsf gene family and others in Apiaceae. | Qiaoying Pei Tong Yu TongWu Qihang Yang Ke Gong Rong Zhou Chunlin Cui Ying Yu Wei Zhao Xi Kang Rui Cao Xiaoming Song | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 10 | Impact of TID on response to pulsed X-ray irradiation in the bipolar operational amplifier显示文摘Groups of a typical operational amplifier–μA741 were irradiated in a cobalt unit,each group accumulating a different total ionizing dose(TID).The results showed that the TID caused power consumption current and slew rate(SR)to degenerate in ultra-linearity,owing to a severe reduction in the current gain of the internal LPNP transistors.Pulsed X-ray irradiation experiments were carried out on theμA741 groups with different values,and the results revealed that the impact on the response to the pulsed X-ray irradiation was greater when the devices absorbed more TID.The mechanism for this is explained on the basis of the circuit construction of theμA741;the sensitive parameters of the circuit were obtained via simulation on SPICE.The simulation results additionally showed that if the sensitive parameters were optimized,the duration of interruption caused by the pulsed X-ray irradiation would be reduced significantly.In addition,several proposals are provided for hardening the devices. | LI Rui Bin WANG Gui Zhen CHEN Wei MA Qiang LIU Yan LIN Dong Sheng YANG ShanChao BAI XiaoYan QI Chao JIN XiaoMing | 2015 | Science China(Technological Sciences)2015，58，2： | 2 |
| 11 | A Semiempiri-cal formula for residual strain of cohesive soil under ran-dom earthquake loading显示文摘 | Yuan Xiaoming Meng Shangjiu Sun Rui | 2003 | Eeathquake Engineering & Engineering Vibration2003，2，2： | 1 |
| 12 | Digit and letter alexia in carbon monoxide poisoning显示文摘This study examined a 24-year-old patient with delayed encephalopathy, who was admitted to hospital with complaints of headache and visual impairment 1 week after acute carbon monoxide poisoning. The results of a visual field assessment, electroencephalography and head magnetic resonance imaging indicated damage to the cerebral cortex. After a 2-week treatment period, the patient had recovered from the visual impairment, but exhibited digit- and letter-reading difficulty. The Chinese aphasia battery and the number and letter battery supplement were conducted. The results revealed that the patient exhibited digit and letter alexia, while the ability to read Chinese characters was preserved. In contrast, the patient exhibited a deficit in Chinese character writing, while number and letter writing remained intact. Following treatment, reading and writing ability was improved and electroencephalographic abnormalities were ameliorated. Overall, our experimental findings demonstrated that delayed encephalopathy following acute carbon monoxide poisoning was characterized by digit and letter alexia. | Qingyu Shen Xiaoming Rong Rui Pan Ying Peng Wei Peng Yamei Tang | 2012 | Neural Regeneration Research2012，7，21： | 1 |
| 13 | Dynamic Response of Tension Plate for UHVDC Transmission Lines Under Ice Shedding Loads显示文摘Ice shedding problems have severely threatened the safety of overhead transmission lines and caused enormous ruptures or failures of the conductors and their accessories.It is of great importance to study the dynamic properties of the transmission lines under ice shedding loads.To perform such analysis,the dynamic behavior of two typical strain sections for UHVDC transmission lines under different ice shedding conditions were simulated in this paper.Then,the dynamic response of the key tension plate as well as its buckling properties was analyzed based on the extacted ice shedding results.Finally,laboratory tests were conducted at the China Electric Power Research Institute to assess the critical value of the buckling of the tension plate.The results show that the key tension plate studied in this paper is primarily influenced by the loads along the transmission lines after taking its dynamic response and buckling properties under synthetic ice shedding conditions into consideration.The short-term fluctuation of the tension should be the major focus in tension plate designs. | Jiajun Si Lixian Zhou Kuanjun Zhu Hongyan Zhao Bin Liu Xiaoming Rui Shengchun Liu | 2022 | CSEE Journal of Power and Energy Systems2022，8，3： | 1 |
| 14 | Topology optimization of space vehicle structures considering attitude control effort显示文摘 | KANG Zhan WANG Xiaoming WANG Rui | 2009 | Finite Elements in Analysis and Design2009，45，： | 1 |
| 15 | Exploring potential of different X-ray imaging methods for early-stage lung cancer detection显示文摘Purpose To explore the potential of X-ray imaging for early-stage lung cancer screening and to help finding an optimal lung cancer screening method.Methods Experimentally and simulatively comparing performances of different X-ray techniques(absorption-contrast imaging and phase-contrast imaging)for model lung cancer samples.Results Absorption imaging shows performance equal to or better than that of low-radiation dose.Conclusion Absorption imaging is still the most promising imaging method for early lung cancer detection. | Kun Li Yu Chen Rui Sun Bei Yu Gang Li Xiaoming Jiang | 2020 | Radiation Detection Technology and Methods2020，4，2： | 1 |
| 16 | Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells显示文摘 | XiaoHua Liu Jing Shen Rui Zhan XingXing Wang XiaoMing Wang ZhiQing Zhang Xue Leng ZhiHua Yang LingJia Qian | 2008 | BBA - Proteins and Proteomics2008，，2： | 1 |
| 17 | Study of chloride binding and diffusion in GGBS concrete显示文摘 | Rui Luo Yuebo Cai Changyi Wang Xiaoming Huang | 2002 | Cement and Concrete Research2002，，1： | 1 |
| 18 | Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells显示文摘 | XiaoHua Liu Jing Shen Rui Zhan XingXing Wang XiaoMing Wang ZhiQing Zhang Xue Leng ZhiHua Yang LingJia Qian | 2008 | BBA - Proteins and Proteomics2008，，2： | 1 |
| 19 | High-performance all-solution-processed inverted quantum dot light-emitting diodes enabled by water treatment显示文摘All-solution-processed inverted quantum dot(QD)light-emitting diodes(QLEDs)with transparent bottom cathodes can be directly connected to the n-type thin-film transistors,offering a feasible solution for low-cost active matrix-driven QD displays.However,the subsequent solution-deposition of the hole-transporting layer destroys the underneath QD films,resulting in largely deteriorated device performance.Various strategies have been implemented to prevent QD film from dissolution,but all at a heavy cost of device performance suffering from either reduced efficiency or increased driving voltage.Here,a facile and effective water-treatment approach for QD film to fabricate inverted QLEDs through all solution processing is reported.The water treatment substitutes the long-chain oleate ligands with hydroxyl groups,resulting in significantly improved non-polar solvent resistance of the QD films.Importantly,the QD films reserve their excellent photoluminescence efficiency after water treatment.With the water-treated QD film as the emissive layer,all-solution-processed inverted red QLED with a peak external quantum efficiency of 19.6%,a turn-on voltage of 1.8 V,and a T50 operational lifetime of 150,000 h at 100 cd·m^(-2) was achieved.Furthermore,efficient and low-voltage-driven green and blue QLEDs can also be prepared with this method.This work provides a feasible strategy for the fabrication of high-performance all-solution-processed inverted QLEDs,paving the way toward achieving QLEDs by all ink-jet printing. | Qianqing Hu Junjie Si Desui Chen Xiaoming Hao Rui Xu Yihang Du Zhuopeng Du Xinquan Gong Hong Zhao Peiqing Cai Qi Ai Xin Yao Yu Yan Zenan Zhang Muzhi Cai Wei Liu Yongyin Kang Zugang Liu | 2023 | Nano Research2023，16，7： | 0 |
| 20 | Fractional-order Sliding Mode Control of Hybrid Drive Wind Turbine for Improving Low-voltage Ride-through Capacity显示文摘A hybrid drive wind turbine equipped with a speed regulating differential mechanism can generate electricity at the grid frequency by an electrically excited synchronous generator without requiring fully or partially rated converters. This mechanism has extensively been studied in recent years. To enhance the transient operation performance and low-voltage ridethrough capacity of the proposed hybrid drive wind turbine, we aim to synthesize an advanced control scheme for the flexible regulation of synchronous generator excitation based on fractional-order sliding mode theory. Moreover, an extended state observer is constructed to cooperate with the designed controller and jointly compensate for parametric uncertainties and external disturbances. A dedicated simulation model of a 1.5 MW hybrid drive wind turbine is established and verified through an experimental platform. The results show satisfactory model performance with the maximum and average speed errors of 1.67% and 1.05%, respectively. Moreover, comparative case studies are carried out considering parametric uncertainties and different wind conditions and grid faults, by which the superiority of the proposed controller for improving system ongrid operation performance is verified. | Ziwei Wang Wenliang Yin Lin Liu Yue Wang Cunshan Zhang Xiaoming Rui | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，5： | 0 |
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