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| 1 | Positive association of RhoC gene overexpression with tumour invasion and lymphatic metastasis in gastric carcinoma显示文摘Worldwide estimates establish gastric carcinoma as the second most frequent cause of cancer deaths. Tumour invasion and metastasis is the biggest impediment to gastric carcinoma cure. Active migration of tumour cells is now considered as the pivotal step in cancer invasion and metastasis. RhoC is a member of the Ras-superfamily of small guanosine triphosphatases that can regulate many cellular functions, especially cytoskeletal organization and cell locomotion. Overexpressing RhoC in vitro in the poorly metastatic cell line from human melanoma may induce a highly metastatic phenotype.1 The recent development of laser capture microdissection (LCM) affords the opportunity to further evaluate the role RhoC plays in the invasion and metastasis of gastric carcinoma cells in their native tissue environment. | WANGZhen-ning XUHui-mian JIANGLi ZHOUXin LUChong ZHANGXue | 2005 | Chinese Medical Journal2005，，6： | 48 |
| 2 | The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research显示文摘Alfalfa(Medicago sativa)is one of the most important forage crops in the world;however,its molecular genetics and breeding research are hindered due to the lack of a high-quality reference genome.Here,we report a de novo assembled 816-Mb high-quality,chromosome-level haploid genome sequence for‘Zhongmu No.1’alfalfa,a heterozygous autotetraploid.The contig N50 is 3.92 Mb,and 49165 genes are annotated in the genome.The alfalfa genome is estimated to have diverged from M.truncatula approximately 8 million years ago.Genomic population analysis of 162 alfalfa accessions revealed high genetic diversity,weak population structure,and extensive gene flow from wild to cultivated alfalfa.Genome-wide association studies identified many candidate genes associated with important agronomic traits.Furthermore,we showed that MsFTa2,a Flowering Locus T homolog,whose expression is upregulated in salt-resistant germplasms,may be associated with fall dormancy and salt resistance.Taken together,these genomic resources will facilitate alfalfa genetic research and agronomic improvement. | Chen Shen Huilong Du Zhuo Chen Hongwei Lu Fugui Zhu Hong Chen Xiangzhao Meng Qianwen Liu Peng Liu Lihua Zheng Xiuxiu Li Jiangli Dong Chengzhi Liang Tao Wang | 2020 | Molecular Plant2020，13，9： | 21 |
| 3 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 4 | Expression of tumor related genes NGX6,NAG-7,BRD7 in gastric and colorectal cancer显示文摘AIM: NGX6, NAG-7 and BRD7 genes are tumor related genes, which have been newly cloned by positional candidate cloning strategy. This study was designed to investigate the expression levels of NGX6, NAG-7 and BRD7 genes in human gastric and colorectal cancer tissues, and their corresponding normal tissues, and to investigate whether these genes play a role in the pathogenesis of gastric and colorectal cancers.METHODS: Reverse transcription-polymerase chain reaction (RT-PCR), dot hybridization and Northern blot analysis were used to compare the expression levels of NGX6, NAG-7 and BRD7 genes in 34 gastric cancer tissues and 34 colorectal cancer tissues with their corresponding normal tissues of the same patients, respectively.RESULTS: Among the 34 colorectal cancer specimens and the 34 gastric cancer specimens, the expression of NGX6 in 25 colorectal cancer tissues was absent or very weak (73.5 %) by RT-PCR analysis. The down-regulation rate of NGX6 in colorectal cancer tissues was significantly higher than that in corresponding normal tissues (26.5 %,9/34)(P<0.005). Moreover, the down-regulation of NGX6 was significantly correlated with lymph node and/or distance metastases. Patients with lymph node and/or distance metastasis had much higher down-regulation rate of NGX6 than patients without metastases (93.8 % vs 55.6 %, P<0.05).However no correlation was found between the expression of NGX6 and pathologic type of colorectal cancer in this study, and also the expression of NGX6 did not display any difference between gastric cancer and corresponding normal tissues (58.8 % vs 70.6 %, P>0.25). Dot hybridization and Northern blot analysis confirmed the results of RT-PCR.Furthermore, NAG-7 and BRD7 mRNA was not up- or downregulated in gastric and colorectal cancers compared with their corresponding normal tissues in our study.CONCLUSION: The down-regulation of NGX6 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcinoma. In addition, the expression levels of NAG-7, and BRD7 did not alter in gastric and colorectal cancers. This seems to suggest that NAG-7and BRD7 genes may not play a role in gastric and colorectal carcinogenesis. | Xiao-MeiZhang Shou-RongSheng Xiao-YanWang Jie-RuWang JiangLi | 2003 | World Journal of Gastroenterology2003，9，8： | 10 |
| 5 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 6 | Prevalence and Risk Factors of Anemia of Pregnant Women--6 Provinces in China,2014−2018显示文摘What is already known about this topic?Anemia during pregnancy is a global public health problem affecting both maternal and children’s health.The“National Nutrition Plan(2017–2030)”and“Healthy China Action(2019–2030)”issued by the State Council of China in 2017 and 2019,respectively,specified nutrition targets:by 2030,the anemia rate in pregnant women should be reduced to less than 10%.The anemia prevalence of pregnant women reported by the Chinese Nutrition and Health Surveillance in 2006 and 2010–2012 was 42.0%and 17.2%,respectively.What is added by this report?Past surveillance in 2010–2012 did not divide pregnant women by gestation week,and the sample size was only 4,315 cases.In this study,the information of 206,753 registered pregnant women from their first antenatal care(ANC)examination to childbirth was collected from 2014 to 2018.The overall prevalence of anemia among pregnant women was 41.98%.What are the implications for public health practice?The overall prevalence of anemia among pregnant women in the monitoring areas was high,far from the target of 10%.Anemia remains a serious health problem among pregnant women in China.It is urgent to develop effective strategies and take measures to reduce the prevalence of anemia in China. | Huanqing Hu Aiqun Huang Qi Yang Wei Zhao Yu Ma Jiangli Di | 2020 | China CDC weekly2020，2，14： | 7 |
| 7 | Present Situation of Eutrophication of Landscape Water Body and Its Prevention and Control Measures显示文摘At present,all kinds of pollutants are discharged into the landscape water body,and the landscape water body is mostly static or slow flow state. This leads to the deepening of water pollution,eutrophication,blackening of water body,and stench and flood disasters occur frequently. This makes the urban landscape water lose its ornamental value,affects the effective operation of ecological function,and will also endanger the health of residents. Reclaimed water is one of the common methods of modern landscape water,but reclaimed water contains a lot of nitrogen and phosphorus,which will make the eutrophication of water body increase,and easily lead to ' algal blooms',water quality deterioration,and loss of landscape function. Therefore,understanding the current situation of landscape water eutrophication and effective prevention and control measures has become one of the water environment problems to be solved. | Qingyu LU Wei XIN Jiangli NIE Yan ZHANG Yi PEI | 2019 | Asian Agricultural Research2019，11，3： | 7 |
| 8 | Construction of phospholamban antisense RNA recombinant adenoassociated virus vector and its effects in rat cardiomyocytes显示文摘Aim: To construct a recombinant adeno-associated virus (rAAV) vector containing gene encoding phospholamban antisense RNA (asPLB), and analyse its effect on expression of PLB, expression and activity of sarco-endoplasmic reticulum Ca^2+-ATPase (SERCA), and the change of intracellular free Ca^2+ concentration ([Ca^2+]i) in rat cardiomyocytes. Methods: The target gene encoding PLB antisense RNA was inserted inversely into the adeno-associated virus plasmid pAAV-MCS digested by corresponding restricted endonuclease enzyme. The recombinant plasmid and pAAV-RC and pHelper were co-transfected into 293 cell. At the same time, a viral production positive control (rAAV-LacZ) and negative control were performed. The recombinant viruses were used to transfect the cultured rat cardiomyocytes. Site β-Galactosidase staining were performed to observe the transfer efficiency. Reverse transcription-PCR and Western blot were used to determine the mRNA and protein expression of PLB and SERCA. The activity of SERCA and the [Ca^2+]i were measured. Results: The rAAV vectors were constructed successfully and were transfected into rat cardiomyocytes effectively.The PLB mRNA and protein expression were reduced in rat cardiomyocytes transfected by rAAV-asPLB compared with controls. The activity of SERCA was increased. In rest state, the level of [Ca^2+]i in the rAAV-asPLB transfected groupdecreased. The level of [Ca^2+]i increased when induced by isoproterenol.Conclusion: AAV-asPLB vector was constructed successfully, which disrupted the expression of PLB, enhanced the activity of SERCA, reduced the resting [Ca^2+]i, and improved the cardiac function. | JiangLI,Shen-jiangHU JianSUN Zhao-huiZHU XiaZHENG Guo-zhongWANG Yu-meiYAO Nai-yunCHEN Xiao-yanZHAO | 2005 | Acta Pharmacologica Sinica2005，26，1： | 6 |
| 9 | Preparation of Gd_2O_3:Eu^(3+) downconversion luminescent material and its application in dye-sensitized solar cells显示文摘Gd_2O_3 :Eu^(3+) downconversion luminescent powder was prepared using the homogeneous precipitation method. Its optical properties were analyzed and it was introduced into a dye-sensitized solar cell (DSSC). As a luminescence medium, Gd_2O_3 :Eu^(3+) improved light harvesting via conversion luminescence and increased the photocurrent of the DSSC. As a p-type dopant insulating rare earth oxides form an energy barrier, and the Gd_2O_3 :Eu^(3+) elevated the energy level of the oxide film and increased the photovoltage. The photoelectric conversion efficiency for a DSSC with Gd_2O_3 :Eu^(3+) doping (6 : 100) reached 7.01%, which was 17.4% higher than the photoelectrical conversion efficiency of a DSSC without Gd 2 O 3 :Eu 3+ doping. | LI QingBei LIN JianMing WU JiHuai LAN Zhang WANG JiangLi WANG Yue PENG FuGuo HUANG MiaoLiang XIAO YaoMing | 2011 | Chinese Science Bulletin2011，56，28： | 5 |
| 10 | Reconstructing the extraordinary palaeoflood events during 3200-2800 a BP in the upper reaches of Hanjiang River Valley, China显示文摘Palaeoflood hydrology study is a leading subject in global change study. Through field investigation in the upper reaches of Hanjiang River, palaeoflood slackwater deposits(SWD) were found in the bedrock gorges of the Yunxi reach. The results of field observation, laboratory analysis including particle-size distribution and magnetic susceptibility, and comparison with modern flood deposits, the SWD were identified as the most typical Holocene palaeoflood deposits of the Hanjiang River. By using stratigraphic correlation and OSL dating method, the palaeoflood event was dated to be 3200–2800 a BP at the turn from the middle to late Holocene. According to the palaeoflood peak stage and hydraulic parameters, the peak discharges of the palaeoflood were reconstructed as 48,830–51,710 m3/s by using the slope-area method. At same time, the flood peak discharges of 1983, 2005 and 2010 severe floods were reconstructed with the same method and hydraulic parameters in the same cross section. The error between the reconstructed and gauged discharges was 1.99%–4.21%. This showed that the reconstructed palaeoflood peak discharges were reliable. The flood peak discharge-frequency relationship at 10,000-year time scale was established by a combination of the gauged flood, historical flood and palaeoflood hydrological data. These results are very important for hydraulic engineering and flood mitigation on the Hanjiang River. | ZHA Xiaochun HUANG Chunchang PANG Jiangli ZHOU Yali | 2014 | Journal of Geographical Sciences2014，24，3： | 5 |
| 11 | Extraordinary hydro-climatic events during the period AD 200?300 recorded by slackwater deposits in the upper Hanjiang River valley, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Shuyan Yin Hongxia Su Liang Zhou Jianchao Yang | 2013 | Palaeogeography Palaeoclimatology Palaeoecology2013，，： | 4 |
| 12 | Extraordinary Floods of 4100?4000<ce:hsp sp='0.25'/>a BP recorded at the Late Neolithic Ruins in the Jinghe River Gorges, Middle Reach of the Yellow River, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Hongxia Su Yuqing Li | 2010 | Palaeogeography Palaeoclimatology Palaeoecology2010，，1： | 4 |
| 13 | Microstructure and properties of Ga-modified 0.7BiFeO_3-0.3BaTiO_3 solid solution显示文摘Binary solid solutions 0.7Bi (GaxFe1-x)O3-0.3BaTiO3 (x = 0, 0.025, 0.05, 0.1) ceramics were prepared by traditional ceramic process. All the ceramic samples showed single perovskite phase except the sam- ple with x = 0.1. The effects of gallium doping on microstructure, ferromagnetic, ferroelectric, dielectric properties and conductivity were investigated. The results indicated that Ga-dopant could improve the sintering ability of the solid solution when the Ga content x was below 0.05. When x was over 0.05, the sintering ability of the solid solution was weakened, and the phase structure of 0.7BiFeO3-0.3BaTiO3 solid solution changed from rhombohedral phase into tetragonal ferroelectric phase. The electrical resistivity increased with the Ga content increasing. Both ferroelectricity and ferromagnetism were observed in all the ceramic samples. With the Ga content increasing, the remanent magnetization Mr increased and the magnetic coercive field Hc decreased. However, the remanent polarization Pr fluctu- ated, increasing firstly and decreasing later. | LIU XiaoHui XU Zhuo QU ShaoBo WEI XiaoYong CHEN JiangLi | 2007 | Chinese Science Bulletin2007，52，20： | 4 |
| 14 | Combating maternal mortality in China:experience,challenges and opportunities显示文摘Since the People’s Republic of China founded,especially over the last 15 years,maternal mortality rate(MMR)has fallen dramatically.In 2014,China has achieved the target of a reduction of 75%MMR from 1990 to 2015(MDG 5)ahead of schedule.This achievement can be attributed to the improvement of legislation and policy,government commitment and investment on maternal health,extensive international cooperation,implementation of the maternal health program,development of maternal and child health(MCH)service system and development of MCH surveillance systems.Although China has achieved MDG 5,there are many kinds of difficulties and challenges in achieving the post-2015 Sustainable Development Goals(SDGs).Therefore,multi-strategy actions need to be considered to seize the opportunities to further reduce the MMR in the future. | Jiangli Di Qi Yang Xi Jin | 2017 | Global Health Journal2017，1，3： | 4 |
| 15 | Growth of covellite crystal onto azurite surface during sulfurization and its response to flotation behavior显示文摘In this work,the growth of copper sulfide crystal onto azurite surfaces during sulfurization and its response to flotation are investigated.Filed emission scanning electron microscopy-energy dispersive X-ray spectroscopy(FESEM) and X-ray diffraction(XRD) studies confirmed that the sulfurization of azurite is not limited to the mineral surface,but rather penetrates into the bulk to form covellite crystal(synCuS),creating favorable conditions for the stable adsorption of xanthate and greatly promoting the azurite flotation.Additionally,as demonstrated by X-ray photoelectron spectroscopy(XPS) and time of flight secondary ion mass spectrometry(TOF-SIMS) analyses,a redox reaction occurred during this process,and Cu(Ⅱ) onto the mineral surface was reduced to Cu(Ⅰ).Correspondingly,reduced S^(2-) was oxidized to(S_(2))^(2-),(S_n)^(-2),and even to deeper oxidation state S~0,(S_(x)O_(y))^(n-) and SO_(4)^(2-).Excess sodium sulfide strengthens copper sulfide to form onto the azurite surface,and provides enough raw material for crystal copper sulfide to grow,resulting in the formation of 'flake-like' covellite with a better crystallinity.However,the floatability of azurite decreased dramatically under this condition,because the generated massive colloidal copper sulfide in flotation pulp deteriorates the flotation environment,resulting in a decreased effective adsorption of collector onto azurite surfaces. | Jinpeng Cai Peilun Shen Dianwen Liu Xiaolin Zhang Jianjun Fang Chao Su Xingcai Yu Jiangli Li Han Wang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 4 |
| 16 | DESIGN OF A NOVEL DEXTEROUS ROBOT HAND显示文摘In the robotic community more and more hands are developed. Based on the experience of HIT Hand and DLR Hand II, a smaller and easier manufactured dexterous robot hand with multisensory function and high integration is jointly developed. The prototype of the hand is successfully built. It has 4 fingers in total 13-DOFs (degree of freedom). Each finger has 3-DOFs and 4 joints, the last 2 joints are mechanically coupled by means of four-bar linkage mechanism. It also has an additional DOF to realize motion of the thumb relative to the palm. The fingertip force can reach up to 10 N. Full integration of mechanical body, actuation system, multisensory system and electronics is a significant feature. DSP based control system is implemented in PCI bus architecture and the serial communication between the hand and DSP needs only 2 lines. | JiangLi LiuHong XieZongwu JinMinghe GaoXiaohui HirzingerG | 2004 | Chinese Journal of Mechanical Engineering2004，17，3： | 3 |
| 17 | Geochemical characterization of loess-paleosol sequences:Comparison between the upper reaches of the Hanjiang and Weihe river valleys,China显示文摘This paper aims to compare the geochemical characteristics of loess-paleosol sequences in the upper reaches of the Hanjiang and Weihe river valleyswhich are located in the semi-humid temperate zone and humid subtropical zonerespectively. The Mituosi(MTS) profile in the upper reaches of the Hanjiang River valley and the Yaohecun(YHC) profile in the Weihe River valley were selected for this comparative research. The stratigraphic characteristicscompositionchemical weathering intensityleaching rates of Ca and Namobility of major elementsand transport features of Na and Fe were analyzed with respect to depth and compared between the two profiles. This study reached the following conclusions.(1) The composition of the loess-paleosol sequences in two regions are quite similar to the average composition of the upper continental crust(UCC)indicating that the loess in the two regions came from multiple sources and was mixed well. Thereforethe loess in the two regions is considered aeolian loess.(2) Compared with the loess-paleosol sequence in the Weihe River valleythe loess-paleosol sequence in the upper reaches of the Hanjiang River valley features a darker color; a higher chemical index of alteration(CIA) value; higher leaching rates of Na and Ca; higher migration ratio(relative to K) of AlSiMgand Na; and lower migration ratio of Fe and Ca. This evidence indicates that the loess-paleosol sequence in the humid subtropical environment experienced stronger chemical weathering intensity than the loess-paleosol sequence in the semi-humid temperate zone.(3) Both the YHC profile and MTS profile record a period of climate deterioration at 6000–5000 a BP. The period punctuated the mid-Holocene Climatic Optimum(8500–3100 a BP) in the study area. | BIAN Hongyan PANG Jiangli HUANG Chunchang ZHOU Yali | 2017 | Journal of Geographical Sciences2017，27，1： | 3 |
| 18 | Extraordinary floods related to the climatic event at 4200 a BP on the Qishuihe River, middle reaches of the Yellow River, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Hongxia Su Yaofeng Jia | 2010 | Quaternary Science Reviews2010，，3： | 3 |
| 19 | A BODIPY-based Fluorescent Probe for Thiophenol显示文摘 | Dongxiang Zhang Ning Xu Liman Xian Haoying Ge Jiangli Fan Jianjun Du Xiaojun Peng | 2018 | Chinese Journal of Chemistry2018，36，2： | 3 |
| 20 | Incidence and Risk Factors of Hypertensive Disorders of Pregnancy—8 Provinces,China,2014–2018显示文摘Summary What is already known about this topic?As a major cause of maternal and neonatal mortality and morbidity,hypertensive disorders of pregnancy(HDP)are a global public health problem affecting maternal and children’s health.What is added by this report?The incidence of HDP was 6.40%among 277,632 pregnant women.With the progress of pregnancy,the proportion of pregnant women with high normal blood pressure(BP)and the incidence of HDP increased gradually.The incidence of HDP increased with pregnancy age,body mass index,and BP of pregnant women during first trimester.What are the implications for public health practice?To reduce the incidence of HDP effectively,we should pay more attention to older women who plan to become pregnant,measures should be taken to control BP and weight in pre-pregnancy. | Wei Zhao Jiangli Di Aiqun Huang Qi Yang Huanqing Hu | 2021 | China CDC weekly2021，3，22： | 3 |
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