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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Effect of alkalinity on nitrite accumulation in treatment of coal chemical industry wastewater using moving bed biofilm reactor显示文摘Nitrogen removal via nitrite(the nitrite pathway) is more suitable for carbon-limited industrial wastewater. Partial nitrification to nitrite is the primary step to achieve nitrogen removal via nitrite. The effect of alkalinity on nitrite accumulation in a continuous process was investigated by progressively increasing the alkalinity dosage ratio(amount of alkalinity to ammonia ratio, mol/mol). There is a close relationship among alkalinity, pH and the state of matter present in aqueous solution. When alkalinity was insufficient(compared to the theoretical alkalinity amount), ammonia removal efficiency increased first and then decreased at each alkalinity dosage ratio, with an abrupt removal efficiency peak. Generally, ammonia removal efficiency rose with increasing alkalinity dosage ratio. Ammonia removal efficiency reached to 88% from 23% when alkalinity addition was sufficient. Nitrite accumulation could be achieved by inhibiting nitrite oxidizing bacteria(NOB) by free ammonia(FA) in the early period and free nitrous acid in the later period of nitrification when alkalinity was not adequate. Only FA worked to inhibit the activity of NOB when alkalinity addition was sufficient. | Baolin Hou Hongjun Han Shengyong Jia Haifeng Zhuang Qian Zhao Peng Xu | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 3 | Curative effect of acupuncture on quality of life in patient with depression: a clinical randomized single-blind placebo-controlled study显示文摘OBJECTIVE:To evaluate the effect of acupuncture on the quality of life in patients with depression by clinical randomized single-blind placebo-controlled study.METHODS:one hundred and sixty-three cases of depression according with the inclusion criteria were randomly divided into a group of acupuncture dredging liver and regulating flow of theosophy(group 1),a group of acupoint shallow stab(group 2)and a group of non-acupoint shallow stab(group 3)at 1∶1∶1 ratio,and treated with acu-puncture,moxibustion,and intradermal embedding of needle,twice a week,for a total of 12 weeks.Scale of Quality of Life(SF-36)was used to measure the scores at four different time points and evaluate the effect of acupuncture on the quality of life of the patients with depression.RESULTS:At each time point after treatment,in scores of the 8 items,physical function,physical role,bodily pain,general physical condition,energy,social function,emotional function and mental health there were statistically significant differences among the 3 groups(P<0.0125).CONCLUSION:Acupuncture can effectively improve the quality of life of patients with depression. | Fan Ling Fu Wenbin Chen Zhao Xu Nenggui Liu Jianhua LǚAiping Li Ziping Su Shengyong Wu Taixiang Ou Aihua | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 12 |
| 4 | Anoxic degradation of nitrogenous heterocyclic compounds by activated sludge and their active sites显示文摘The potential for degradation of five nitrogenous heterocyclic compounds(NHCs), i.e.,imidazole, pyridine, indole, quinoline, and carbazole, was investigated under anoxic conditions with acclimated activated sludge. Results showed that NHCs with initial concentration of 50 mg/L could be completely degraded within 60 hr. The degradation of five NHCs was dependent upon the chemical structures with the following sequence:imidazole > pyridine > indole > quinoline > carbazole in terms of their degradation rates.Quantitative structure–biodegradability relationship studies of the five NHCs showed that the anoxic degradation rates were correlated well with highest occupied molecular orbital.Additionally, the active sites of NHCs identified by calculation were confirmed by analysis of intermediates using gas chromatography and mass spectrometry. | Peng Xu Hongjun Han Haifeng Zhuang Baolin Hou Shengyong Jia Dexin Wang Kun Li Qian Zhao | 2015 | Journal of Environmental Sciences2015，27，5： | 5 |
| 5 | Influence of phenol on ammonia removal in an intermittent aeration bioreactor treating biologically pretreated coal gasification wastewater显示文摘A laboratory-scale intermittent aeration bioreactor was investigated to treat biologically pretreated coal gasification wastewater that was mainly composed of NH_3-N and phenol.The results showed that increasing phenol loading had an adverse effect on NH_3-N removal;the concentration in effluent at phenol loading of 40 mg phenol/(L·day) was 7.3 mg/L, 36.3%of that at 200 mg phenol/(L·day). The enzyme ammonia monooxygenase showed more sensitivity than hydroxylamine oxidoreductase to the inhibitory effect of phenol, with32.2% and 10.5% activity inhibition, respectively at 200 mg phenol/(L·day). Owing to intermittent aeration conditions, nitritation-type nitrification and simultaneous nitrification and denitrification(SND) were observed, giving a maximum SND efficiency of 30.5%.Additionally, ammonia oxidizing bacteria(AOB) and denitrifying bacteria were the main group identified by fluorescent in situ hybridization. However, their relative abundance represented opposite variations as phenol loading increased, ranging from 30.1% to 17.5%and 7.6% to 18.2% for AOB and denitrifying bacteria, respectively. | Chunyan Xu Hongjun Han Shengyong Jia Qian Zhao | 2016 | Journal of Environmental Sciences2016，28，5： | 5 |
| 6 | Morphological adaptation of sheep's rumen epithelium to high-grain diet entails alteration in the expression of genes involved in cell cycle regulation, cell proliferation and apoptosis显示文摘Background: The objectives of this study were to characterize changes in the relative m RNA expression of candidate genes and proteins involved in cell cycle regulation, cell proliferation and apoptosis in the ruminal epithelium(RE) of sheep during high-grain(HG) diet adaptation.Results: Twenty sheep were assigned to four groups with five animals each. These animals were assigned to different periods of HG diet(containing 40% forage and 60% concentrate mix) feeding. The HG groups received an HG diet for7(G7, n = 5), 14(G14, n = 5) and 28 d(G28, n = 5), respectively. In contrast, the control group(CON, n = 5) was fed the forage-based diet for 28 d. The results showed that HG feeding linearly decreased(P < 0.001) the ruminal p H, and increased the concentrations of ruminal total volatile fatty acid(linear, P = 0.001), butyrate(linear, P < 0.001), valerate(quadratic P = 0.029) and the level of IGF-1(quadratic, P = 0.043) in plasma. The length(quadratic, P = 0.004), width(cubic, P = 0.015) and surface of the ruminal papillae(linear, P = 0.003) were all enlarged after 14 d of HG diet feeding.HG feeding cubically increased the number of cell layers forming the stratum corneum(SC, P < 0.001) and the thickness of the SC(P < 0.001) and stratum basale(P < 0.001). The proportion of basal layer cells in the RE decreased(linear, P < 0.001) in the G0/G1-phase, but it increased linearly(P = 0.006) in the S-phase and cubically(P = 0.004) in the G2/M-phases. The proportion of apoptosis cells in G7, G14 and G28 was reduced compared to the CON(quadratic, P <0.001). HG diet feeding linearly decreased the m RNA expression of Cyclin E1(P = 0.021) and CDK-2(P = 0.001) and(P = 0.027) the protein expression of Cyclin E1. Feeding an HG diet linearly increased the m RNA expression of genes IGFBP-2(P = 0.034) and IGFBP 5(P < 0.009), while linearly decreasing(P < 0.001) the IGFBP 3 expression. The expression of cell apoptosis gene Caspase 8 decreased(quadratic, P = 0.012), while Bad m RNA expression tended to decrease(cubic, P = 0.053) after HG feeding.Conclusions: These results demonstrated sequential changes in rumen papillae size, cell cycle regulation and the genes involved in proliferation and apoptosis as time elapsed in feeding a high-grain diet to sheep. | Lei Xu Yue Wang Junhua Liu Weiyun Zhu Shengyong Mao | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 4 |
| 7 | Phase-field simulation of dendritic solidification using a full threaded tree with adaptive meshing显示文摘Simulation of the microstructure evolution during solidifi cation is greatly benefi cial to the control of solidifi cation microstructures. A phase-fi eld method based on the full threaded tree(FTT) for the simulation of casting solidifi cation microstructure was proposed in this paper, and the structure of the full threaded tree and the mesh refi nement method was discussed. During dendritic growth in solidifi cation, the mesh for simulation is adaptively refi ned at the liquid-solid interface, and coarsened in other areas. The numerical results of a threedimension dendrite growth indicate that the phase-fi eld method based on FTT is suitable for microstructure simulation. Most importantly, the FTT method can increase the spatial and temporal resolutions beyond the limits imposed by the available hardware compared with the conventional uniform mesh. At the simulation time of 0.03 s in this study, the computer memory used for computation is no more than 10 MB with the FTT method, while it is about 50 MB with the uniform mesh method. In addition, the proposed FTT method is more effi cient in computation time when compared with the uniform mesh method. It would take about 20 h for the uniform mesh method, while only 2 h for the FTT method for computation when the solidifi cation time is 0.17 s in this study. | Yin Yajun Zhou Jianxin Liao Dunming Pang Shengyong Shen Xu | 2014 | China Foundry2014，11，6： | 4 |
| 8 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 9 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 10 | Quantitative structure–biodegradability relationships for biokinetic parameter of polycyclic aromatic hydrocarbons显示文摘Prediction of the biodegradability of organic pollutants is an ecologically desirable and economically feasible tool for estimating the environmental fate of chemicals. In this paper,stepwise multiple linear regression analysis method was applied to establish quantitative structure biodegradability relationship(QSBR) between the chemical structure and a novel biodegradation activity index(qmax) of 20 polycyclic aromatic hydrocarbons(PAHs). The frequency B3LYP/6-311+G(2df,p) calculations showed no imaginary values, implying that all the structures are minima on the potential energy surface. After eliminating the parameters which had low related coefficient with qmax, the major descriptors influencing the biodegradation activity were screened to be Freq, D, MR, EHOMOand To IE. The evaluation of the developed QSBR mode, using a leave-one-out cross-validation procedure, showed that the relationships are significant and the model had good robustness and predictive ability. The results would be helpful for understanding the mechanisms governing biodegradation at the molecular level. | Peng Xu Wencheng Ma Hongjun Han Shengyong Jia Baolin Hou | 2015 | Journal of Environmental Sciences2015，27，4： | 2 |
| 11 | Simple non-fullerene electron acceptors with unfused core for organic solar cells显示文摘Two simple electron acceptors based on unfused bithiophene core and 1,1-dicyanomethylene-3-indanone end group were easily prepared via three synthetic steps. These acceptors exhibited broad absorption in the range of 300 nm to 800 nm, aligned energy levels and high crystallinity. When combined with a wide band gap donor polymer in non-fullerene solar cells, an initial power conversion efficiency of 2.4% was achieved. The relatively low efficiencies were due to the large phase separation in blended thin films, which is originated from their high aggregation tendency in thin films. Our results suggest that these electron acceptors with unfused core are promising candidates for commercial application of solar cells due to the low cost starting materials and facile synthesis. | Yao Li Yunhua Xu Fan Yang Xudong Jiang Cheng Li Shengyong You Weiwei Li | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 12 | Agricultural soil monitoring of PCDD/Fs in the vicinity of a municipal solid waste incinerator in Eastern China:Temporal variations and possible sources显示文摘 | Xu Mengxia Yan Jianhua Lu Shengyong | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
| 13 | Low impedance nature of 12 acupoints on the limbs,and the unexpected dependence on limb angle显示文摘OBJECTIVE: To better understand the working mechanism of acupuncture, we investigated the skin electrical impedance distribution around acupoints, and the impedance changes at 12 original acupoints bilaterally after bending the limbs.METHODS: We measured the skin electrical impedance in three study subjects in the frequency range of 40 to 10 k Hz using the four-electrode method with a sharp probe and a large reference electrode.A measurement matrix of 7 mm × 7 mm with spacing of 2.0(or 3.0) mm was measured to obtain 2 D impedance mapping of acupoints. The impedance spectra of 12 original acupoints were measured at the 0° position and the 90° position.RESULTS: The electrical impedance of some acupoints, such as Yangchi(TE 4), was 16 times lower than that of the surrounding area, showing a recognizable small central area of low impedance with a diameter of less than 4 mm. In contrast, other acupoints, such as Laogong(PC 8), had an electrical impedance that was not significantly different from that of the surrounding area. When the limb was bent from a straight position(0o) to a vertical position(90o), the electrical impedance of the 12 original acupoints showed varied trends, either increasing or decreasing by a factor of up to ten times, or remaining at the same level.CONCLUSION: Not all acupoints tested show the property of low impedance, which might be related to the varied depth of the openings of superficial collaterals. The unexpected dependence of acupoint impedance on limb angle is a novel discovery, which implies that the channel paths are located in interstitial structures in the limbs. It might be possible to determine an optimized limb position for each particular acupuncture treatment in clinical practice. | Xu Jingjing Yang Fan Han Danhong Wang Zhenhai Hong Yuankai Han Hongbin Xu Shengyong | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 1 |
| 14 | Study on Drying Edible Soya-bean Oil Using Solar Energy显示文摘Soya-bean oil (bean dregs) was dried in a solar energy drying system. Characteristics of the process were measured and the corresponding curves were done. The practicability of this process has been discussed. The results showed that the solar drying system could completely meet technological requirements of drying soy-bean oil, and it was feasible in technology to use the solar drying system to dry the vegetable oil. | LIU Shengyong LIU Peng SHEN Xiaozhen XU Guizhuan SU Chaojie CAI Xianjie | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，4： | 1 |
| 15 | Nanometer-scale Modification and Welding of Silicbn and Metallic Nanowires with a High-in- tensity Electron Beam 显示文摘 | Xu Shengyong Tian Mingliang Wang Jinguo | 2005 | Small2005，1，12： | 1 |
| 16 | Genetic variation in scaly hair-fin anchovy Setipinna tenuifilis (Engraulididae) based on the mitochondrial DNA control region显示文摘 | Shengyong Xu Na Song Zhichuang Lu Jun Wang Shanshan Cai Tianxiang Gao | 2013 | Mitochondrial DNA2013，，3： | 1 |
| 17 | Laboratory and greenhouse evaluation of a new entomopathogenic strain of Beau- veria bassiana for control of the onion thrips Thrips tabaci 显示文摘 | Wu Shengyong Gao Yulin Xu Xuenong | 2013 | Biocontrol Science and Technology2013，23，7： | 1 |
| 18 | Agricultural soil monitoring of PCDD/Fs in the vicinity of a municipal solid waste incinerator in Eastern China: temporal variations and possible sources显示文摘 | XU Mengxia YAN Jianhua LU Shengyong | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 19 | PCDD/Fs concentrations of agricultural soil in the vicinity of fluidized bed incinerators of co-firing MSW with coal in Hangzhou,China显示文摘 | YAN Jianhua XU Mengxia LU Shengyong | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 20 | The status and development trends of the wall- board industry in China 显示文摘 | Shengyong Xu | 2011 | Global Gypsum Magazine2011，，3： | 1 |
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