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| 1 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | Scalable synthesis of nanoporous silicon microparticles for highly cyclable lithium-ion batteries显示文摘Nanoporous silicon is a promising anode material for high energy density batteries due to its high cycling stability and high tap density compared to other nanostructured anode materials.However,the high cost of synthesis and low yield of nanoporous silicon limit its practical application.Here,we develop a scalable,low-cost top-down process of controlled oxidation of Mg2Si in the air,followed by HCl removal of MgO to generate nanoporous silicon without the use of HF.By controlling the synthesis conditions,the oxygen content,grain size and yield of the porous silicon are simultaneously optimized from commercial standpoints.In situ environmental transmission electron microscopy reveals the reaction mechanism;the Mg2Si microparticle reacts with O2 to form MgO and Si,while preventing SiO2 formation.Owing to the low oxygen content and microscale secondary structure,the nanoporous silicon delivers a higher initial reversible capacity and initial Coulombic efficiency compared to commercial Si nanoparticles(3,033 mAh/g vs.2,418 mAh/g,84.3%vs.73.1%).Synthesis is highly scalable,and a yield of 90.4%is achieved for the porous Si nanostructure with the capability to make an excess of 10 g per batch.Our synthetic nanoporous silicon is promising for practical applications in next generation lithium-ion batteries. | Jiangyan Wang William Huang Yong Seok Kim You Kyeong Jeong Sang Cheol Kim Jeffrey Heo Hiang Kwee Lee Bofei Liu Jaehou Nah Yi Cui | 2020 | Nano Research2020，13，6： | 9 |
| 3 | Accelerated Ageing Tests for Evaluations of a Durability Performance of Glass-fiber Reinforcement Polyester Composites显示文摘The paper presented accelerated ageing test results of a durability study on ortho-phthalic anhydride-type unsaturated polyester resin(191#) and its glass-fiber reinforcement polyester composites(GFRPC).The samples were exposed in an artificial xenon arc lamp ageing cell or a thermo-oxidative ageing cell.Morphology and gloss of the specimens were investigated by using a microscope and a gloss-meter,respectively.The tensile strength,bending strength and inter-laminar shear strength(ILSS) of GFRPC were tested before and after exposure,and were considered to evaluate the durability performance of this material.The polyester resin was analyzed by fourier transform infrared(FT-IR) spectroscopy.The results showed that the glossiness of the specimens got worse and some cracks appeared on their surface during the course of ageing,the tensile strength and bending strengths of the specimens first increased and then decreased.The ILSS of the composites decreased after they were aged in the xenon arc lamp cell,but increased while they were aged in the thermo-oxidative cell.The changes of these trends become more obvious during ageing in the xenon arc lamp cell,so the main influencing factor leading to the failure of this material is UV irradiation. | Yunying Wang Jiangyan Meng Qing Zhao Shuhua Qi | 2010 | Journal of Materials Science & Technology2010，26，6： | 6 |
| 4 | Human papillomavirus 16 physical status detection in preinvasive and invasive cervical carcinoma by multiplex real-time polymerase chain reaction显示文摘Objective: To explore an ideal approach for detecting the physical status of HPV-16 in clinic use and to investigate the integrated HPV-16 in CINs and cervical cancer. Methods: Multiplex real-time PCR method was established to quantify the copy numbers of E2 and E6 genes (E2/E6) for analysis of the physical status of HPV-16 DNA and this assay was compared to Southern blot analysis. HPV-16-containing paraffin-embedded tissues including 49 CINs and 51 cervical squamous cancers were detected using the method. Results: (1) The cutoff ratio of E2/E6 to distinguish pure episomal from mixed HPV-16, was 0.81 in the multiplex real-time PCR; (2) The agreement rate between multiplex real-time PCR and Southern blot was 81.5% (the Kappa statistic was 0.844, P<0.001); (3) HPV-16 DNA existed in an episomal form in 57.1% and mixed form in 42.9% of CIN I lesions; The concomitant form of HPV-16 (>70%) constituted the majority in CIN II and CIN III; HPV-16 DNA mostly integrated into the host chromosome (s) in squamous cervical cancers (68.6%); (4) The incidence of HPV-16 integration was increased with the degree of cervical lesions; (5) The frequency of pure integrated HPV-16 in stage II+III (88%) was signifi- cantly higher than that in stage I (33.3%). Conclusion: (1) Mutiplex real-time PCR provides a rapid, sensitive and reliable method for clinic detection of the physical state of HPV-16 DNA; (2) The integration of the HPV-16 DNA is a very early and important event in the progression from preinvasive to invasive cervical cancer; (3) The pure integrated status of HPV-16 in cervical cancer may be associated with poor prognosis of cervical cancer, but further study will be needed to prove its prog- nostic significance. | Ying Zheng Zhilan Peng Jiangyan Lou He Wang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 5 |
| 5 | A novel battery scheme:Coupling nanostructured phosphorus anodes with lithium sulfide cathodes显示文摘Lithium-ion batteries are approaching their theoretical limit and can no longer keep up with the increasing demands of human society.Lithium-sulfur batteries,with a high theoretical specific energy,are promising candidates for next generation energy storage.However,the use of Li metal in Li-S batteries compromises both safety and performance,enabling dendrite formation and causing fast capacity degradation.Previous studies have probed alternative battery systems to replace the metallic Li in Li-S system,such as a Si/Li2S couple,with limited success in performance.Recently,there is a focus on red P as a favorable anode material to host Li.Here,we establish a novel battery scheme by utilizing a P/C nanocomposite anode and pairing it with a Li2S coated carbon nanofiber cathode.We find that red P anode can be compatible in ether-based electrolyte systems and can be successfully coupled to a Li2S cathode.Our proof of concept full-cell displays remarkable specific capacity,rate and cycling performances.We expect our work will provide a useful alternative system and valuable insight in the quest for next generation energy storage devices. | David Sichen Wu Guangmin Zhou Eryang Mao Yongming Sun Bofei Liu Li Wang Jiangyan Wang Feifei Shi Yi Cui | 2020 | Nano Research2020，13，5： | 4 |
| 6 | Decoding lithium batteries through advanced in situ characterization techniques显示文摘Given the energy demands of the electromobility market,the energy density and safety of lithium batteries(LBs)need to be improved,whereas its cost needs to be decreased.For the enhanced performance and decreased cost,more suitable electrode and electrolyte materials should be developed based on the improved understanding of the degradation mechanisms and structure–performance correlation in the LB system.Thus,various in situ characterization technologies have been developed during the past decades,providing abundant guidelines on the design of electrode and electrolyte materials.Here we first review the progress of in situ characterization of LBs and emphasize the feature of the multi-model coupling of different characterization techniques.Then,we systematically discuss how in situ characterization technologies reveal the electrochemical processes and fundamental mechanisms of different electrode systems based on representative electrode materials and electrolyte components.Finally,we discuss the current challenges,future opportunities,and possible directions to promote in situ characterization technologies for further improvement of the battery performance. | Mei Yang Ruyi Bi Jiangyan Wang Ranbo Yu Dan Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 4 |
| 7 | Hollow Micro-/Nanostructure Reviving Lithium-sulfur Batteries显示文摘Higb-energy-density lhiumslu(Li-S)bttries are drawing dramatic research interests to fulill the ever-increasing demands of etrical vehicles.However,chllenges with the insulating poperty of sulfur and its lihistion products aund its large volume expansion,aund the sutle eflet of lthiumn polysulides,hinder the commer-cial application of Li-S butteries.Lots of material design concepts have bocn developed to address the failure modes.Among them,bollw micro-/anostructures with abundant compositional und geometrical feasibility have been prored fuitful in adresing the cureut obstacles of LiS bttries Here,lypical examples of designing hollw mi-co-/anostructures to address the problemns of Li-S bttries and sinultuneously improve the practical capacity and lifespan are highlightedl.In purticular,the great efeet of structural engineering on minimizing volume change,inhi-biting the shutle efiet and catalyzing plysulide conversion are disussed systeatically. Fially fuure dreetions of hollow nanostrucure design to enhance the progress of Li-S butteries are also provided. | ZHAO Jilu YANG Mei Yang Nailiang WANG Jiangyan WANG Dan | 2020 | Chemical Research in Chinese Universities2020，36，3： | 3 |
| 8 | Effects of the interplanetary magnetic field clock angle on the shape of bow shock显示文摘Using the global magnetohydrodynamics(MHD) simulation model, we investigated the effects of the interplanetary magnetic field(IMF) clock angle on the shape of bow shock, including its rotational asymmetry and subsolar point. For general northward IMF( z component Bz > 0), the rotational symmetry of the bow shock is broken by the effects of fast magnetosonic Mach number(Mms), and the cross-sectional line of the bow shock is an ellipse with the semi-major axis along the direction perpendicular to the IMF. The ratio or D-value between semi-major and semi-minor axis can be used to illustrate the extent of asymmetry of the bow shock. On the basis of the multiple parameters fitting, we obtain the changing relationship of both semi-axes with the clock angle and the distance away from the Earth. For general southward IMF(Bz < 0), the cross sectional line of the bow shock is highly asymmetrical under the multiple effects of magnetopause and Mms. The effects of IMF clock angle on subsolar point depend mainly on the changing subsolar point of magnetopause as an obstacle. The distance of subsolar point of bow shock from the Earth increases with the increasing IMF clock angle for Bz > 0, and decreases with the increasing IMF clock angle for Bz < 0. | WANG JiangYan HUANG ZhaoHui WANG Chi LIU ZiQian | 2015 | Science China Earth Sciences2015，58，7： | 2 |
| 9 | Efficient sequential harvesting of solar light by heterogeneous hollow shells with hierarchical pores显示文摘In nature,sequential harvesting of light widely exists in the old life entity,i.e.cyanobacteria,to maximize the light absorption and enhance the photosynthesis efficiency.Inspired by nature,we propose a brand new concept of temporally-spatially sequential harvesting of light in one single particle,which has purpose-designed heterogeneous hollow multi-shelled structures(HoMSs)with porous shells composed of nanoparticle subunits.Structurally,HoMSs consist of different band-gap materials outside-in,thus realizing the efficient harvesting of light with different wavelengths.Moreover,introducing oxygen vacancies into each nanoparticle subunit can also enhance the light absorption.With the benefit of sequential harvesting of light in HoMSs,the quantum efficiency at wavelength of 400 nm is enhanced by six times compared with the corresponding nanoparticles.Impressively,using these aforementioned materials as photocatalysts;highly efficient photocatalytic water splitting is realized,which cannot be achieved by using the nanoparticle counterparts.This new concept of temporally-spatially sequential harvesting of solar light paves the way for solving the ever-growing energy demand. | Yanze Wei Jiawei Wan Nailiang Yang Yu Yang Yanwen Ma Songcan Wang Jiangyan Wang Ranbo Yu Lin Gu Lianhui Wang Lianzhou Wang Wei Huang Dan Wang | 2020 | National Science Review2020，7，11： | 2 |
| 10 | Controllable Synthesis of Hollow Multishell Structured Co3O4 with Improved Rate Performance and Cyclic Stability for Supercapacitors显示文摘Hollow multishelled structures(HoMSs)Co3O4 with specially appointed shell number(double-,triple-and quadruple-)were accurately prepared by a sequential templating approach.Due to the superiorities of inimitable porous multishelled structure,triple-HoMSs Co3O4 achieved the best performance among all the samples with a specific capacitance of 1028.9 F/g at 10 mV/s and 688.2 F/g at 0.5 A/g,respectively.Furthermore,the electrode delivered a high rate performance(89.8%retention at 10 A/g)and excellent cycle stability(6.8%loss over 2000 cycles),showing a great promise for practical application in the future. | WANG Cong WANG Jiangyan HU Wenping WANG Dan | 2020 | Chemical Research in Chinese Universities2020，36，1： | 1 |
| 11 | Color edge detection using multiscale quaternion convolution显示文摘 | XU JIANGYAN YE LINNING LUO WANG | 2010 | International Journal of Imaging Systems and Tcchnology2010，20，4： | 1 |
| 12 | Ultrasensitive quantification of mature microRNAs by real-time PCR based on ligation of a ribonucleotide-modified DNA probe 显示文摘 | ZHANG Jiangyan LI Zhengping WANG Hui | 2011 | Chem Commun2011，47，： | 1 |
| 13 | Construction Progress of Chinese Meridian Project PhaseⅡ显示文摘The Chinese Meridian Project(CMP)is the Space Environment Ground Based Comprehensive Monitoring Network of China,a national major science and technology infrastructure project.The CMP consists of the Space Environment Monitoring System,Data Communication System,and Science Application System.Its construction has been divided into two steps:the PhaseⅠwas from 2008 to 2012;the PhaseⅡstarted at the end of 2019,expected to be completed at the end of 2023.Beyond 2023,the CMP as a whole will be in operation to make observations.This report introduces the construction progress of CMP PhaseⅡin the past two years,covering the construction progress of both the Data Communication System and the Science Application System.As for the Space Environment Monitoring System,this report mainly gives an introduction to the construction progress of large-scale advanced monitoring equipment,such as,the solar radio telescope,interplanetary scintillation telescope,incoherent scatter radar,high frequency radar,MST radar,and large-aperture Helium Lidar.In addition,this paper presents the construction plan for the next two years and the future outlook as well. | WANG Chi XU Jiyao LÜDaren YUE Xinan XUE Xianghui CHEN Gang YAN Jingye YAN Yihua LAN Ailan WANG Jiangyan WANG Xin TIAN Yufang | 2022 | 空间科学学报2022，42，4： | 1 |
| 14 | Progress and Perspectives of Hollow Multishelled Structures显示文摘Hollow multishelled structure(HoMs)has drawn tremendous attention due to its abundant attractive properties and promising applications.However,for a long time,the limited synthesis method hindered the development of HoMs.The sequential templating approach developed by our group,has greatly enriched its composition and'structure diversity.The progress in HoMS synthesis promotes the discovery of its characteristics as well as widens its application area.Typicall,the recently explored temporal-spatial ordering characteristic of HoMS has shown great promise in drug delivery and cascade catalysis application areas.Here,we summarize the current development progress of HoMS in the aspects of both synthesis and application,with a focus discussion on how to shape its application performance by manipulating its composition and structure features.In addition,we discuss the current challenges and providethe future potentials holdingfor HoMs. | Jiangyan Wang Mei Yang Dan Wang | 2022 | Chinese Journal of Chemistry2022，40，10： | 1 |
| 15 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding显示文摘Dear Editor,The constant evolution of SARS-CoV-2 has resulted in the emergence of circulating variants during the COVID-19 pandemic.Recently,a newly emerged B.1.1.529(Omicron)variant raised global concern.Compared with the original SARS-CoV-2 strain and other variants of concern(VOCs),the Omicron variant has more than 30 mutations on its spike(S)protein,of which 16 mutations are located in the receptor-binding domain(RBD). | Yingdan Wang Wuqiang Zhan Jiangyan Liu Yanqun Wang Xiang Zhang Meng Zhang Lin Han Yunping Ma Lu Lu Yumei Wen Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang | 2022 | Cell Research2022，32，9： | 1 |
| 16 | 1α,25(OH)2D3对斑马鱼脂肪组织中脂肪酸氧化的促进显示文摘文章简介1α,25(OH)2D3被认为是哺乳类动物的矿物质代谢的重要调控激素,但其在动物脂肪组织代谢中的精确机制却不够清晰。肝细胞微小体中的细胞色素P450酶2R1(CYP2R1)是活化维生素D3的第一步,即25位的羟基化的羟基化酶,此功能在脊椎动物中是保守。 | Xuyan Peng Guohui Shang Wenqing Wang Xiaowen Chen Qiyong Lou Gang Zhai Dongliang Li Zhenyu Du Yali Ye Xia Jin Jiangyan He Yi Zhang 殷战 | 2018 | 科学新闻2018，0，4： | 0 |
| 17 | Functional analysis of zona pellucida domain protein Dusky in Tribolium castaneum显示文摘The zona pellucida domain protein Dusky(Dy)plays a vital role in wing morphogenesis in insects,but little information on its function has been reported.In this study,we found that dy regulated wing cell size,larval and pupal duration,and the metabolism of amino acid and 20-hydroxyecdysone in Tribolium castaneum.Using RNA-seq,413 differentially expressed genes were identified between physiological buffer-injected and dy-double-stranded RNA-treated larvae,including 88 downregulated genes and 325 upregulated genes.Among these genes,dy knockdown increased CYP18A1 expression to elevate the 26-hydroxylation of 20-hydroxyecdysone,which ultimately led to growth defects in wing cells.Silencing of dy upregulated the transcription of genes encoding tyrosine aminotransferase,4-hydroxyphenylpyruvate dioxygenase,homogentisate 1,2-dioxygenase,and Pale to promote the catabolism of tyrosine and phenylalanine,which eventually reduced amino acid content.Furthermore,dy knockdown upregulated 4E-BP expression,and 4E-BP silencing partially phenocopied dy RNA interference-mediated wing morphogenesis.These results suggest that Dy controls 20-hydroxyecdysone and amino acid metabolism to regulate wing morphogenesis in the insect. | Chengjun Li Liu Yang Youwei Wang Huanyu Du Jiangyan Zhang Yaoyao Lu Bin Li Keping Chen | 2022 | Insect Science2022，29，2： | 0 |
| 18 | Hollow multishelled structural TiN as multi-functional catalytic host for high-performance lithium-sulfur batteries显示文摘Lithium-sulfur(Li-S)battery has attracted extensive attention because of its ultrahigh theoretical energy density and low cost.However,its commercialization is seriously hampered by its short cycling life,mainly due to the shuttle of soluble lithium polysulfides(LiPSs)and poor rate capability due to sluggish reaction kinetics.Although significant efforts have been devoted to solving the problems,it is still challenging to simultaneously address all the issues.Herein,titanium nitride hollow multishelled structure(TiN HoMS)sphere is designed as a multi-functional catalytic host for sulfur cathode.TiN,with good conductivity,can effectively catalyze the redox conversion of S and LiPSs,while its surficial oxidation passivation layer can strongly anchor LiPSs.Besides,HoMS enables TiN nanoparticle subunits to expose abundant active sites for anchoring and promoting conversion of LiPSs,while the multiple shells provide physical barriers to restrict the shuttle effect.In addition,HoMS can buffer the volume expansion of sulfur and shorten the charge transport pathway.As a result,the sulfur cathode based on triple-shelled TiN HoMS exhibits an initial specific capacity of 1016 mAh·g-1 at a high sulfur loading of 2.8 mg·cm-2 and maintains 823 mAh·g-1 after 100 cycles.Moreover,it shows a four times higher specific capacity than the one without TiN host at 2 C. | Wei Xu Ruyi Bi Mei Yang Jiangyan Wang Ranbo Yu Dan Wang | 2023 | Nano Research2023，16，11： | 0 |
| 19 | Uniform Asymptotics for Finite-Time Ruin Probabilities of Risk Models with Non-Stationary Arrivals and Strongly Subexponential Claim Sizes显示文摘This paper considers the one-and two-dimensional risk models with a non-stationary claim-number process.Under the assumption that the claim-number process satisfies the large deviations principle,the uniform asymptotics for the finite-time ruin probability of a one-dimensional risk model are obtained for the strongly subexponential claim sizes.Further,as an application of the result of onedimensional risk model,we derive the uniform asymptotics for a kind of finite-time ruin probability in a two dimensional risk model sharing a common claim-number process which satisfies the large deviations principle. | XU Chenghao WANG Kaiyong PENG Jiangyan | 2024 | Wuhan University Journal of Natural Sciences2024，29，1： | 0 |
| 20 | Effects of Dietary Protein Variations at Different Life-stages on Vocal Dominance of the African Clawed Frogs显示文摘How nutritional conditions during early development affect an organism’s phenotype at adulthood is still poorly understood despite a plethora of research on developmental plasticity.The'environmental matching'hypothesis predicts that individuals will have high fitness providing that their adult environment'matches'what they experienced during development.In contrast,the'silver spoon'hypothesis predicts that individuals who obtain better developmental resources will be generally superior.Here we tested these two hypotheses and examined the underlying hormonal mechanisms by manipulating the early dietary protein content of African clawed frogs(Xenopus laevis)for a year with a 2×2 factorial experimental design.We found that only a lowprotein food during development enhanced the vocal competition ability of male X.laevis,and that vocal dominance was associated with higher cortisol levels but not related with testosterone content.These results were not congruent with the'environmental matching'hypothesis or with the'silver spoon'hypothesis,suggesting the behavioral plasticity during development is more complex than our expectation in amphibians. | Yan CAO Jiangyan SHEN Xiaocui WANG Song TAN Ping LI Jianghong RAN Yezhong TANG Jingfeng CHEN | 2020 | Asian Herpetological Research2020，11，3： | 0 |
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