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| 1 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | Neuroendocrine regulation of somatic growth in fishes显示文摘Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth.Among the possible growth-regulating pathways in vertebrates,components of the somatotropic axis are thought to have the greatest influence.There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish.This includes research into growth hormone,upstream hypothalamic hormones,insulin-like growth factors,and downstream signaling molecules.Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism.Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo.In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis,including emerging research using genetic modified models.These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. | DAI XiangYan ZHANG Wei ZHUO ZiJian HE JiangYan YIN Zhan | 2015 | Science China(Life Sciences)2015，58，2： | 5 |
| 3 | A stochastic logical model-based approximate solution for energy management problem of HEVs显示文摘The development of control algorithms to improve the energy efficiency of hybrid electric vehicles(HEVs)has attracted extensive attentions due to the advancement of the powertrain on fuel economy and emission reduction.The objective of the energy management control for HEVs is to distribute the driver demand power between the engine and the motor to maximize the efficiency.Deterministic dynamic programming(DP)has been applied to solve the problem,but it just | Jiangyan ZHANG Yuhu WU | 2018 | Science China(Information Sciences)2018，61，7： | 3 |
| 4 | Adaptive coordinated control of engine speed and battery charging voltage显示文摘In this paper, the control problem of auxiliary power unit (APU) for hybrid electric vehicles is investigated. An adaptive controller is provided to achieve the coordinated control between the engine speed and the battery charging voltage. The proposed adaptive coordinated control laws for the throttle angle of the engine and the voltage of the power- converter can guarantee not only the asymptotic tracking performance of the engine speed and the regulation of the battery charging voltage, but also the robust stability of the closed loop system under external load changes. Simulation results are given to verify the performance of the proposed adaptive controller. | Jiangyan ZHANG Xiaohong JIAO | 2008 | 控制理论与应用(英文版)2008，6，1： | 3 |
| 5 | Dynamical model of HEV with two planetary gear units and its application to optimization of energy consumption显示文摘A hybrid electric vehicle(HEV) that uses multiple planetary gear units with clutches as transmission system is advanced for the powertrain performance, because the operation of the clutches can lead to distinct operating modes, and the induced possible operating modes provide additional freedom to deal with the energy optimal control problem. Under each operating mode, the powertrain mechanical system has specific dynamical behavior. In order to develop model-based optimization schemes that can tackle the transient operations of the vehicle, exact dynamical modeling is investigated focusing on a hybrid powertrain system that uses a two-planetary-gear transmission box with two clutches. It shows that according to the states of the two clutches, the powertrain system has the power-split mode, parallel mode and the electric vehicle(EV) mode. Finally, an analysis for the calculation of the desired driving torque and its application to the dynamic programming(DP)-based energy management indicate the significance of the developed exact dynamical models. | Jiangyan ZHANG Shota INUZUKA Takafumi KOJIMA Tielong SHEN Junichi KAKO | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 6 | Influences of Tibetan Plateau uplift on provenance evolution of the paleo-Pearl River显示文摘A comparative analysis of the geochemical characteristics of sediments from the Oligocene Zhuhai Formation(32-23.8 Ma),the Miocene Zhujiang Formation(23.8-16.5 Ma),and the Hanjiang Formation(16.5—10.5 Ma) and a comprehensive analysis of the geochemical characteristics of rocks surrounding the paleo-Pearl River drainage contribute to understanding the influences of the Tibetan Plateau uplift on provenance evolution of the paleo-Pearl River.The results show that the geochemical characteristics of sediments from the Oligocene Zhuhai Formation are very different from the geochemical characteristics of sediments from the Miocene Zhujiang and Hanjiang Formations.The ∑ rare earth elements(REE) of mudstone is relatively high in the Zhuhai Formation,204.07-293.88 ppm(average 240.46 ppm),and low in the Zhujiang and Hanjiang Formations,181.32-236.73 ppm(average 203.83 ppm) and 166.84-236.65 ppm(average199.04 ppm),respectively.The chemical index of alteration(CIA) for these samples has a similar trend to the∑ REE:the CIA of the Zhuhai Formation is relatively high and the CIA of the Zhujiang and Hanjiang Formations is relatively low.The uplift of the Tibetan Plateau is crucial to the westward expansion of the paleo-Pearl River drainage. | Ye Yu Changmin Zhang Shaohua Li Rui Zhu Jiangyan Liu Chenggang Qin Zhongtao Zhang | 2015 | Chinese Journal Of Geochemistry2015，34，2： | 2 |
| 7 | Adaptive idling control scheme and its experimental validation for gasoline engines显示文摘In this paper, the idle speed control problem is investigated for spark-ignition(SI) engines. To scope with physical model parameter-free control scheme, a nonlinear adaptive control law is proposed for the speed regulation loop. The stability analysis result shows that the idle speed converges to the set value and the estimated parameter converges to an equivalent static value of the intake manifold. Furthermore, the proposed fuel injection control law consists of a feedforward and a simple feedback loop. Finally, the proposed control scheme is validated based on a full-scaled six-cylinder gasoline engine test bench. | Jiangyan ZHANG Jinwu GAO Tielong SHEN | 2017 | Science China(Information Sciences)2017，60，2： | 1 |
| 8 | Cascaded cast shadow detection method in surveillance scenes 显示文摘 | Miao Qi Jiangyan Dai Qi Zhang | 2014 | Optik2014，125，3： | 1 |
| 9 | Challenges and solutions in automotive powertrain systems显示文摘Automotive powertrain mainly consisting of combustion engine,motor and battery(i.e.special for hybrid powertrain)is a very complicated integration system,and the research on the automotive powertrain control techniques remains hot-spot in past decades.This paper proposes some challenging issues and control solutions of automotive powertrain system from the perspective of the dynamic system theory.The typical characteristics of automotive powertrain system are analysed for control development,and the several control applications using model-based and model-free control design are demonstrated with sufficient experimental validation.In addition,some open issues for future powertrain control development are summarised. | Tielong Shen Mingxin Kang Jinwu Gao Jiangyan Zhang Yuhu Wu | 2018 | Journal of Control and Decision2018，5，1： | 1 |
| 10 | A logical network approximation to optimal control on a continuous domain and its application to HEV control显示文摘The finite-time horizon optimal control problem is investigated for discrete-time dynamical systems defined on a continuous domain.First,the original optimal control problem in the continuous domain is approximated as one on a finite-valued domain based on a special quantification process.Under suitable assumptions,convergence analysis of the approximate optimal cost of the quantified system to the optimal cost of the original system was established with error estimation.Thereafter,the approximate problem is solved using a logical network-based method that is proposed based on the semi-tensor product of the matrix.Finally,the proposed scheme is applied to deal with the optimal control problem of a hybrid electric vehicle(HEV)powertrain system,and its effectiveness is shown by a series of simulation results. | Yuhu WU Jiangyan ZHANG Tielong SHEN | 2022 | Science China(Information Sciences)2022，65，11： | 1 |
| 11 | Catalytic wet oxidation of pchlorophenol over supported noble metal catalysts 显示文摘 | Qin Jiangyan Zhang Qinglin Chang Karlt | 2001 | Applied Catalysis: Envirohmental2001，29，： | 1 |
| 12 | Ultrasensitive quantification of mature microRNAs by real-time PCR based on ligation of a ribonucleotide-modified DNA probe 显示文摘 | ZHANG Jiangyan LI Zhengping WANG Hui | 2011 | Chem Commun2011，47，： | 1 |
| 13 | Journal of Chemical & Engineering Data 显示文摘 | Wu Yongjun Zhang Lijun Gao Congli Ma Jiangyan Ma Xinghua Han Runping | 2009 | 54(12): 3229-32342009，54，12： | 1 |
| 14 | Catalytic wet oxidation of p-chlorophenol over supported noble metal catalysts显示文摘 | Qin Jiangyan Zhang Qinglin Chuang K T | | 0，，： | 1 |
| 15 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding显示文摘Dear Editor,The constant evolution of SARS-CoV-2 has resulted in the emergence of circulating variants during the COVID-19 pandemic.Recently,a newly emerged B.1.1.529(Omicron)variant raised global concern.Compared with the original SARS-CoV-2 strain and other variants of concern(VOCs),the Omicron variant has more than 30 mutations on its spike(S)protein,of which 16 mutations are located in the receptor-binding domain(RBD). | Yingdan Wang Wuqiang Zhan Jiangyan Liu Yanqun Wang Xiang Zhang Meng Zhang Lin Han Yunping Ma Lu Lu Yumei Wen Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang | 2022 | Cell Research2022，32，9： | 1 |
| 16 | 1α,25(OH)2D3对斑马鱼脂肪组织中脂肪酸氧化的促进显示文摘文章简介1α,25(OH)2D3被认为是哺乳类动物的矿物质代谢的重要调控激素,但其在动物脂肪组织代谢中的精确机制却不够清晰。肝细胞微小体中的细胞色素P450酶2R1(CYP2R1)是活化维生素D3的第一步,即25位的羟基化的羟基化酶,此功能在脊椎动物中是保守。 | Xuyan Peng Guohui Shang Wenqing Wang Xiaowen Chen Qiyong Lou Gang Zhai Dongliang Li Zhenyu Du Yali Ye Xia Jin Jiangyan He Yi Zhang 殷战 | 2018 | 科学新闻2018，0，4： | 0 |
| 17 | Revisiting the benchmark problem of starting control of combustion engines显示文摘Starting of combustion engines is a typical transient operating mode that has sigrdficant influence to the engine performance.Due to the distinct variations in the pathes of air intake and fuel injection,the model of the engine system contains considerable uncertain parameters.To search effective control schemes that guarantee desired performance,engine starting control is proposed as a benchmark challenge problem.As a challenging result,a model-based control scheme is developed perviously.In this work,the benchmark problem is revisited and a modification for the fuel injection path control of the previous work is proposed by integrating a time sequence regressive based parameter tuning strategy.Validation by the benchmark problem simulator shows that although the new strategy has simple structure,similar control performance is obtained.Especially,the new strategy has potential extensibility with learning based methods to further improve the performance of the benchmark problem on engine starting control. | Jiangyan ZHANG Zhenhui XU Jinwu GAO | 2019 | Control Theory and Technology2019，17，2： | 0 |
| 18 | A color-based FHGC approach facilities DNA-based clinical molecular diagnostics显示文摘The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and reduce hands-on time,thus improving precision,repro-ducibility,and traceability.Multiple genotypes can be detected simultaneously without incurring high costs.^(1)During the experiment,the polymerase chain reaction(PCR)product or buffer forced through the membrane matrix,PCR products are apprehended by a probe attached to the membrane. | Ruyi Zhang Dongyang Deng Min Ren Jiangyan He Fang Chen Shujuan Yan | 2023 | Genes & Diseases2023，10，4： | 0 |
| 19 | Functional analysis of zona pellucida domain protein Dusky in Tribolium castaneum显示文摘The zona pellucida domain protein Dusky(Dy)plays a vital role in wing morphogenesis in insects,but little information on its function has been reported.In this study,we found that dy regulated wing cell size,larval and pupal duration,and the metabolism of amino acid and 20-hydroxyecdysone in Tribolium castaneum.Using RNA-seq,413 differentially expressed genes were identified between physiological buffer-injected and dy-double-stranded RNA-treated larvae,including 88 downregulated genes and 325 upregulated genes.Among these genes,dy knockdown increased CYP18A1 expression to elevate the 26-hydroxylation of 20-hydroxyecdysone,which ultimately led to growth defects in wing cells.Silencing of dy upregulated the transcription of genes encoding tyrosine aminotransferase,4-hydroxyphenylpyruvate dioxygenase,homogentisate 1,2-dioxygenase,and Pale to promote the catabolism of tyrosine and phenylalanine,which eventually reduced amino acid content.Furthermore,dy knockdown upregulated 4E-BP expression,and 4E-BP silencing partially phenocopied dy RNA interference-mediated wing morphogenesis.These results suggest that Dy controls 20-hydroxyecdysone and amino acid metabolism to regulate wing morphogenesis in the insect. | Chengjun Li Liu Yang Youwei Wang Huanyu Du Jiangyan Zhang Yaoyao Lu Bin Li Keping Chen | 2022 | Insect Science2022，29，2： | 0 |
| 20 | On-board torque management approach to the E-COSM benchmark problem with a prediction-based engine assignment显示文摘This paper proposes an energy management strategy for the benchmark problem of E-COSM 2021 to improve the energy efficiency of hybrid electric vehicles(HEVs)on a road with a slope.We assume that HEVs are in a connected environment with real-time vehicle-to-everything information,including geographic information,vehicle-to-infrastructure information and vehicle-to-vehicle information.The benchmark problem to be solved is based on HEV powertrain control using traffic information to achieve fuel economy improvements while satisfying the constraints of driving safety and travel time.The proposed strategy includes multiple rules and model predictive control(MPC).The rules of this strategy are designed based on external environment information to maintain safe driving and to determine the driving mode.To improve fuel economy,the optimal energy management strategy is primarily considered,and to perform real-time energy management via RHC-based optimization in a connected environment with safety constraints,a key issue is to predict the dynamics of the preceding vehicle during the targeted horizon.Therefore,this paper presents a real-time model-based optimization strategy with learning-based prediction of the vehicle’s future speed.To validate the proposed optimization strategy,a powertrain control simulation platform in a traffic-in-the-loop environment is constructed,and case study results performed on the constructed platform are reported and discussed. | Bo Zhang Jiangyan Zhang Fuguo Xu | 2022 | Control Theory and Technology2022，20，2： | 0 |
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