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| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | Molecular Mechanisms of Leaf Morphogenesis显示文摘工厂维持能力作为茎的主要侧面的附器在整个他们的生命周期和形式叶子形成侧面的附器。叶子在射击的外部地区开始顶端的分裂组织然后发展成弄平的结构。在大多数植物,叶作为一块太阳的面板工作,在光合作用把二氧化碳和水变换成糖类和氧的地方。为了生产结构,那能最佳地完成这功能,植物精确控制叶子的开始,形状,和极性。而且,叶开发是高度灵活的 ? 但是与保存规章的机制跟随普通主题。叶子可能从被变换成确定的、弄平的结构的侧面的分支演变。许多另外的植物部分例如花的器官,被认为专业化叶子,并且因此,叶开发位于他们的形态发生下面。这里,我们在三维的叶形式怎么被建立的理解考察最近的进展。我们集中基因,植物激素,和机械性质怎么调制叶开发,并且讨论 ? 在叶开始,极性建立和维护,变平的叶,和闰的生长的上下文的这些因素。 | Fei Du Chunmei Guan Yuling Jiao | 2018 | Molecular Plant2018，11，9： | 25 |
| 3 | An improved three-dimensional spherical DDA model for simulating rock failure显示文摘In this paper, a discontinuous numerical model, namely SDDARF3D(three-dimensional spherical discontinuous deformation analysis for rock failure), is proposed for simulating the whole process of rock failure. Firstly, within the framework of the classical discontinuous deformation analysis(DDA) method, the formulation of three-dimensional spherical DDA(3D SDDA) is deduced; secondly, a bonding and cracking algorithm is constructed and the SDDARF3 D model is proposed; thirdly, corresponding VC++ calculation code is developed and some verification examples are calculated. The simulated results can intuitively reproduce the failure phenomena of rock mass, indicating that the proposed SDDARF3 D numerical model is correct and effective. | JIAO YuYong HUANG GangHai ZHAO ZhiYe ZHENG Fei WANG Long | 2015 | Science China(Technological Sciences)2015，58，9： | 13 |
| 4 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 5 | Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer显示文摘把超声(美国) 用于药交货和疾病治疗是重要工作。Sonodynamic 治疗(SDT ) 用在许多肿瘤的美国和一项 sonosensitizerexhibits antineoplastic 活动的全面治疗。在这研究,我们调查了使用新 sonosensitizer 的可行性(sinoporphyrin 钠, DVDMS ) 作为一个可能的候选人装进 liposome-microbubble 建筑群(DLMB ) 对乳癌提高 SDT。DLMB 经由 biotin 卵白素连接被综合并且证实了有好美国反应。导致美国的成穴起了一个关键作用从 DLMB 触发一个增加的收费载重版本并且改进细胞的举起和 DVDMS 的 intratumoral 散开认识到更好的 SDT 效果。DLMB 和美国治疗的联合在 vitro 导致了房间形态学,线粒体损坏,和房间 apoptosis 的重要变化。在 vivo,联合治疗显著地禁止了肿瘤生长,它看起来源于增加的 apoptosis 并且减少了增长活动。DLMB 正美国的 antitumor 效果的重要增加作为一条新途径建议他们的潜在的使用对乳癌支持 SDT 的杀死的活动。 | Yixiang Li Huanxiao An Xiaobing Wang Pan Wang Fei Qu Yan Jiao Kun Zhang Quanhong Liu | 2018 | Nano Research2018，11，2： | 8 |
| 6 | The USDA cucumber (Cucumis sativus L.) collection: genetic diversity, population structure, genome-wide association studies, and core collection development显示文摘Germplasm collections are a crucial resource to conserve natural genetic diversity and provide a source of novel traits essential for sustained crop improvement.Optimal collection,preservation and utilization of these materials depends upon knowledge of the genetic variation present within the collection.Here we use the high-throughput genotyping-by-sequencing(GBS)technology to characterize the United States National Plant Germplasm System(NPGS)collection of cucumber(Cucumis sativus L.).The GBS data,derived from 1234 cucumber accessions,provided more than 23 K high-quality single-nucleotide polymorphisms(SNPs)that are well distributed at high density in the genome(~1 SNP/10.6 kb).The SNP markers were used to characterize genetic diversity,population structure,phylogenetic relationships,linkage disequilibrium,and population differentiation of the NPGS cucumber collection.These results,providing detailed genetic analysis of the U.S.cucumber collection,complement NPGS descriptive information regarding geographic origin and phenotypic characterization.We also identified genome regions significantly associated with 13 horticulturally important traits through genome-wide association studies(GWAS).Finally,we developed a molecularly informed,publicly accessible core collection of 395 accessions that represents at least 96%of the genetic variation present in the NPGS.Collectively,the information obtained from the GBS data enabled deep insight into the diversity present and genetic relationships among accessions within the collection,and will provide a valuable resource for genetic analyses,gene discovery,crop improvement,and germplasm preservation. | Xin Wang Kan Bao Umesh K.Reddy Yang Bai Sue A.Hammar Chen Jiao Todd C.Wehner Axel O.Ramírez-Madera Yiqun Weng Rebecca Grumet Zhangjun Fei | 2018 | Horticulture Research2018，5，1： | 7 |
| 7 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 8 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 9 | From nature to nurture:Essence and methods to isolate robust methanotrophic bacteria显示文摘Methanotrophic bacteria are entities with innate biocatalytic potential to biofilter and oxidize methane into simpler compounds concomitantly conserving energy,which can contribute to copious industrial applications.The future and efficacy of such industrial applications relies upon acquiring and/or securing robust methanotrophs with taxonomic and phenotypic diversity.Despite several dramatic advances,isolation of robust methanotrophs is still a long-way challenging task with several lacunae to be filled in sequentially.Methanotrophs with high tolerance to methane can be isolated and cultivated by mimicking natural environs,and adopting strategies like adaptive metabolic evolution.This review summarizes existent and innovative methods for methanotrophic isolation and purification,and their respective applications.A comprehensive description of new insights shedding light upon how to isolate and concomitantly augment robust methanotrophic metabolism in an orchestrated fashion follows. | Haritha Meruvu Hui Wu Ziyue Jiao Liyan Wang Qiang Fei | 2020 | Synthetic and Systems Biotechnology2020，5，3： | 4 |
| 10 | Transcriptome analysis provides insights into the regulation of metabolic processes during postharvest cold storage of loquat(Eriobotrya japonica)fruit显示文摘Loquat(Eriobotrya japonica)fruit accumulates lignin during postharvest storage under chilling conditions(0℃),while low-temperature conditioning(LTC;5℃for 6 days followed by transfer to 0℃)or heat treatment(HT;40℃for 4 h followed by transfer to 0℃)can alleviate lignification.Here we compared transcriptome profiles of loquat fruit samples under LTC or HT to those stored at 0℃at five time points from day 1 to day 8 after treatment.High-throughput transcriptome sequences were de novo assembled into 53,319 unique transcripts with an N50 length of 1306 bp.A total of 2235 differentially expressed genes were identified in LTC,and 1020 were identified in HT compared to 0℃.Key genes in the lignin biosynthetic pathway,including EjPAL2,EjCAD1,EjCAD3,4CL,COMT,and HCT,were responsive to LTC or HT treatment,but they showed different expression patterns during the treatments,indicating that different structural genes could regulate lignification at different treatment stages.Coexpression network analysis showed that these candidate biosynthetic genes were associated with a number of transcription factors,including those belonging to the AP2,MYB,and NAC families.Gene ontology(GO)enrichment analysis of differentially expressed genes indicated that biological processes such as stress responses,cell wall and lignin metabolism,hormone metabolism,and metal ion transport were significantly affected under LTC or HT treatment when compared to 0℃.Our analyses provide insights into transcriptome responses to postharvest treatments in loquat fruit. | Wenli Liu Jing Zhang Chen Jiao Xueren Yin Zhangjun Fei Qingbiao Wu Kunsong Chen | 2019 | Horticulture Research2019，6，1： | 3 |
| 11 | Microplastic pollution in Yellow River,China:Current status and research progress of biotoxicological effects显示文摘This study aims to comprehensively assess the environmental risks of microplastics in the Yellow River,achieving the following results through comprehensive research.The average microplastic abundances in the river waters and sediments are 5358-654000 n/m3 and 43.57-615 items/kg,respectively,and there are fewer microplastics in water samples than in sediments.Microplastics in the study area can be divided into five types according to their occurrence morphologies,namely fragments,foams,films,fibers,and particles.The most widely distributed pollution types in sediments include debris,fibers,and particles.In contrast,fibers are the dominant type in water samples,accounting for 68.18%‒98.93%.The chemical components of the microplastics include polyethylene,polypropylene,polystyrene,polyethylene terephthalate,and polyvinyl chloride.The microplastics are in four colors,with white accounting for a higher proportion.The grain size of the microplastics in tributaries or lakes of the Yellow River is less than 2 mm,which makes them liable to enter organisms for enrichment.Furthermore,the sources of the microplastics are closely related to agricultural and industrial production and biological activities in habitats and exhibit seasonal and hydrological characteristics.The microplastics in the study area show the adsorption of metals and nonmetals to different degrees,which increases the pollution risks of heavy metals combined with microplastics.In addition,microplastics can accumulate in organisms in the Yellow River and cause physical,biochemical,and other damage to aquatic organisms,thus further posing carcinogenic risks to human beings.Therefore,it is necessary to study,monitor,and control the pollution and effects of microplastics in the Yellow River,in order to provide theoretical references for the control of pollution and ecological risk of microplastics in the river. | Rui-ping Liu Zhi-zhong Li Fei Liu Ying Dong Jian-gang Jiao Ping-ping Sun El-Wardany RM | 2021 | China Geology2021，4，4： | 3 |
| 12 | A comparison of zooplankton assemblages in Nansi Lake and Hongze Lake,potential influences of the East Route of the South-to-North Water Transfer Project,China显示文摘Nansi Lake and Hongze Lake are both water storage lakes along the East Route of the South-to-North Water Transfer project(ESNT).Frequent changes in hydrologic properties are responsible factors for controlling the zooplankton community assemblages in both lakes,so we studied the possible influence of water transfer and environmental factors on zooplankton community structure and abundance.Zooplankton assemblages were investigated seasonally for one year in both lakes;a total of 133 and 122 zooplankton taxa were identified in Nansi Lake and Hongze Lake,respectively.The most dominant rotifer species were littoral,e.g.,Keratella tecta,Keratella valga and Lecane lunaris in Nansi Lake and Brachionus angularis,Brachionus forficula and Polyarthra vulgaris in Hongze Lake.Comparatively,Nansi Lake had a higher Shannon-Wiener diversity index value(5.13),while Hongze Lake had a higher species richness index(4.21).The average number of zooplankton across seasons in Nansi Lake(protozoa:774±63 ind./L,rotifers:4817±212 ind./L,cladocerans:896±14 ind./L,copepod:435±42 ind./L)was comparatively lower than Hongze Lake(protozoa:1238±63 ind./L,rotifers:6576±112 ind./L,cladocerans:1013±20 ind./L,copepod:534±25 ind./L).Canonical correspondence analysis identified differing environmental gradients that were most responsible for influencing zooplankton communities in the two lakes(Hongze Lake:NH4-N,total nitrogen,transparency and pH;Nansi:pH,temperature and total phosphorus).Frequent changes related to water transfer in lakes favoured the diversity of rotifers and protozoa communities.Zooplankton habitat preference,changes in community structure and opportunistic peaks and extinction of certain taxa were also observed in the study lakes. | Kandathil Radhakrishnan DIVYA Shasha ZHAO Yushun CHEN Fei CHENG Lei ZHANG Jiao QIN Thundiparambil Sathrajith ARUNJITH V.Bjorn SCHMIDT Songguang XIE | 2021 | Journal of Oceanology and Limnology2021，39，2： | 3 |
| 13 | Climate change and anthropogenic impacts on marine ecosystems and countermeasures in China显示文摘The ecosystems of China seas and coasts are undergoing rapid changes under the strong influences of both global climate change and anthropogenic activities.To understand the scope of these changes and the mechanisms behind them is of paramount importance for the sustainable development of China,and for the establishment of national policies on environment protection and climate change mitigation.Here we provide a brief review of the impacts of global climate change and human activities on the oceans in general,and on the ecosystems of China seas and coasts in particular.More importantly,we discuss the challenges we are facing and propose several research foci for China seas/coasts ecosystem studies,including long-term time series observations on multiple scales,facilities for simulation study,blue carbon,coastal ecological security,prediction of ecosystem evolution and ecosystem-based management.We also establish a link to the Future Earth program from the perspectives of two newly formed national alliances,the China Future Ocean Alliance and the Pan-China Ocean Carbon Alliance. | JIAO Nian-Zhi CHEN Da-Ke LUO Yong-Ming HUANG Xiao-Ping ZHANG Rui ZHANG Hai-Bo JIANG Zhi-Jian ZHANG Fei | 2015 | Advances in Climate Change Research2015，6，2： | 3 |
| 14 | Evolutionary annotation of conserved long non-coding RNAs in major mammalian species显示文摘Mammalian genomes contain tens of thousands of long non-coding RNAs(lnc RNAs) that have been implicated in diverse biological processes. However, the lnc RNA transcriptomes of most mammalian species have not been established, limiting the evolutionary annotation of these novel transcripts. Based on RNA sequencing data from six tissues of nine species, we built comprehensive lnc RNA catalogs(4,142–42,558 lnc RNAs) covering the major mammalian species. Compared to protein-coding RNAs, expression of lnc RNAs exhibits striking lineage specificity. Notably, although 30%–99% human lnc RNAs are conserved across different species on DNA locus level, only 20%–27% of these conserved lnc RNA loci are detected to transcription, which represents a stark contrast to the proportion of conserved protein-coding genes(48%–80%). This finding provides a valuable resource for experimental scientists to study the mechanisms of lnc RNAs. Moreover, we constructed lnc RNA expression phylogenetic trees across nine mammals and demonstrated that lnc RNA expression profiles can reliably determine phylogenic placement in a manner similar to their coding counterparts. Our data also reveal that the evolutionary rate of lnc RNA expression varies among tissues and is significantly higher than those for protein-coding genes. To streamline the processes of browsing lnc RNAs and detecting their evolutionary statuses, we integrate all the data produced in this study into a database named Phylo NONCODE(http://gffzz4d3d7636fb124c4fhkccxk0u6b9f96wpq.ffgz.tsg.suse.edu.cn/phylo Noncode). Our work starts to place mammalian lnc RNAs in an evolutionary context and represent a rich resource for comparative and functional analyses of this critical layer of genome. | BU DeChao LUO HaiTao JIAO Fei FANG ShuangSang TAN ChengFu LIU ZhiYong ZHAO Yi | 2015 | Science China(Life Sciences)2015，58，8： | 3 |
| 15 | Isolation and Characterization of Monkeypox Virus from the First Case of Monkeypox—Chongqing Municipality,China,2022显示文摘Introduction:The first imported case of monkeypox(MPX)from the mainland of China was reported in September 2022.Herein,the study reports the isolation and characterization of MPX virus(MPXV)in this case.Methods:Clinical specimens including skin blister fluid,oropharyngeal and nasopharyngeal swabs,and blood were collected and inoculated onto Vero cells.The isolated virus was identified as MPXV using quantitative polymerase chain reaction(qPCR),cytopathic effects(CPEs),immunofluorescence assay(IFA)and transmission electron microscopy(TEM).Plaque assays were employed to quantify infectious plaque-forming units(PFUs).The plaque reduction neutralization test(PRNT)was developed to determine the neutralizing antibody(nAb)against MPXV.Results:MPXV replication was confirmed with qPCR.Typical CPEs were observed 48 h postincubation.The isolated virus was named MPXV-B.1-China-C-Tan-CQ01.IFA showed that MPXV reacted with serum of MPX case.Orthopoxvirus morphology was observed using TEM.The virus titer increased to>106 PFU/mL after three passages.The serum PRNT 50%neutralization titer(NT50)was 35 for the MPX patient 6 days after symptom onset.Discussion:The study successfully isolated the first MPXV strain in the mainland of China,MPXV-B.1-China-C-Tan-CQ01.Infectious titration and PRNT methods have been developed.The study provides key resources and technical platforms for further research as well as anti-viral drug and vaccine development against MPX. | Baoying Huang Hua Zhao Jingdong Song Li Zhao Yao Deng Wen Wang Roujian Lu Wenling Wang Jiao Ren Fei Ye Houwen Tian Guizhen Wu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，46： | 3 |
| 16 | The impact of cropland conversion on environmental effect in the Loess Plateau: a pilot study based on the national experimental bases显示文摘Conversion of cropland to forestry and grassland is an important method to reduce soil erosion and improve the biophysicalenvironmentin the Loess Plateau.The feasibility,methods,and environmentaleffectsofcropland conversion were studied based on 11 typicalwatershedsofnational experimentalbasesinstead ofdifferentgeographic areasofthe LoessPlateau.Between 1986 and 2000, cropland,sloping cropland and non-agriculturalland decreased by 8% ,92.5% and 8% respectively, while forestry increased by 15.7% .The land use change notonly decreased annualsoilerosion by 74% , but also increased vegetation coverage by 100% and improved the soil condition and biodiversity.This can be achieved by building basic farmland,increasing capitaland scientific input, and planting treesand grassesaccording to thenaturalbiophysicalrestrictions. | WANG Fei LI Rui JIAO Feng YANG Qingke TIAN Junliang | 2005 | Journal of Geographical Sciences2005，15，4： | 3 |
| 17 | SCF^SImb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila显示文摘 | Hongtao Zhang Changqing Li Hanqing Chen Chuanxian Wei Fei Dai Honggang Wu Wen Dui Wu-Min Deng Renjie Jiao | 2015 | Cell Research2015，25，1： | 3 |
| 18 | Association between mitochondrial DNA haplotype compatibility and increased efficiency of bovine intersubspecies cloning显示文摘重建的胚胎从 intersubspecies 导出体的房间原子转移(SCNT ) 从 intrasubspecies SCNT 比那些有更差的发展潜力。把那家荷兰的一种乳牛奶店基于我们的以前的学习牛( HD )在施主 karyoplast 和接受者胞质之间的 mitochondrial DNA ( mtDNA ) haplotype 相容性为 SCNT 胚胎开发是关键的,我们根据聚合酶链反应限制决定的 mtDNA haplotypes 作为接受者胞质作为施主 karyoplast 和 Luxi 黄小母牛( LY )用 HD 执行了 intersubspecies SCNT 碎片长度多型性( PCR-RFLP )分析。结果证明 intersubspecies mtDNA homotype SCNT 胚胎象改进胚囊 reprogramming 地位一样比 intrasubspecies mtDNA heterotype 胚胎有更高的培植前和培植以后的发展胜任,包括象 Oct4 和 Sox2 那样的 pluripotent 基因的正常 H3K9 dimethylation 模式和倡导者 hypomethylation ,用 LY 卵母细胞建议那 intersubspecies SCNT 维持克隆效率的 HD 并且可以发展成正常的改编 HD 原子核克隆动物 ulti 我们的结果显示 karyoplastcytoplast 相互作用和 mtDNA haplotype 相容性可以影响牛的 intersubspecies SCNT 效率。牛的 intersubspecies SCNT 上的这研究为理解在影响牛的 SCNT 效率的 karyoplast 和胞质之间的 mtDNA haplotype 相容性的机制是珍贵的,并且为克隆的 HD 提供一个其他、经济的资源。 | Hao Yan Zhonghai Yan Qingwen Ma Fei Jiao Shuzhen Huang Fanyi Zeng Yitao Zeng | 2011 | Journal of Genetics and Genomics2011，38，1： | 3 |
| 19 | Preparation of Cu-SiO_2 composite aerogel by ambient drying and the influence of synthesizing conditions on the structure of the aerogel显示文摘A copper-doped silica composite aerogel with high specific surface area was prepared using a sol-gel method at ambient pressure. A drying control chemical additive (DCCA) N,N-dimethylformamide (DMF) was introduced to the composite sol of tetraethyl orthosilicate (TEOS) and copper nitrate (Cu(NO3)2·3H2O) during the synthesizing process. The influence of the preparation conditions including Cu loading, catalyst concentration and heat treatment on the structure of copper-doped silica was investigated. The results showed that the obtained aerogel particles were uniformly distributed. The pore diameter was in a range of 2 to 15 nm. Heavier Cu loading benefited the formation of CuO crystalline, and reduced the specific surface area and pore diameter. When the catalyst concentration was high, the aggregation of Si-O network was reduced with the increase of it. The composite aerogel exhibited a good thermal stability after the heat treatment at high temperature. | LI GuiAn, ZHU TingLiang, DENG ZhongXun, ZHANG YaJuan, JIAO Fei & ZHENG HaiRong College of Physics and Information Technology, Shaanxi Normal University, Xi’an 710062, China | 2011 | Chinese Science Bulletin2011，56，7： | 3 |
| 20 | Closely packed nanoparticle monolayer as a strain gauge fabricated by convective assembly at a confined angle显示文摘 | Chao Zhang Juan Li Shanshan Yang Weihong Jiao Shuang Xiao Mingqing Zou Songliu Yuan Fei Xiao Shuai Wang Lihua Qian | 2014 | Nano Research2014，7，6： | 2 |
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