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| 1 | Effect of Jiawei Shenfu decoction on tumor necrosis factor-alpha and nuclear factor-kappa B in patients who have chronic heart failure with syndromes of deficiency of heart Yang显示文摘OBJECTIVE:To examine the clinical efficacy of Jiawei Shenfu decoction on tumor necrosis factor-alpha (TNF-cα) and nuclear factor-kappa B (NF-KB) levels in patients who have chronic heart failure with syndromes of deficiency of heart Yang.METHODS:A total of 63 patients with syndromes of deficiency of heart Yang (chronic heart failure)were enrolled.Patients were randomly divided into the control group and Jiawei Shenfu group.All patients received standard medications for treatment of chronic heart failure.Patients in the Jiawei Shenfu group were additionally provided Jiawei Shenfu decoction one dose daily.Treatments continued for 4 consecutive weeks.The primary endpoint was the change in plasma B-type natriuretic peptide (BNP),NF-KB,and TNF-cα levels during 4 weeks of treatment.RESULTS:At the 4-week follow-up,a significant reduction in BNP levels compared with baseline was observed in both groups,but the Jiawei Shenfu decoction group showed a significantly greater reduction than did the control group.The Jiawei Shenfu group also showed superior performance regarding the Minnesota Living with Heart Failure Questionnaire score,the Chinese medicine syndrome score,heart rate,left ventricular ejection fraction,and 6-min walking distance compared with the control group.The degree of changes in NF-KB and TNF-α levels in the Jiawei Shenfu group was more significant than that in the control group.CONCLUSION:Routine medicine combined with Jiawei Shenfu decoction for patients with heart Yang deficiency syndrome in chronic heart failure can improve the left ventricular ejection fraction and cardiac function,and reduce BNP levels.The mechanism may be related to inhibition of pro-inflammatory cytokines and the NF-KB-induced kinase pathway,leading to amelioration of the inflammatory response. | Yu Mei Guo Hangyuan Ye Lingling Bian Jiaping Ma Lijuan Zheng Chunli | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 6 |
| 2 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2显示文摘Mutations and transient conformational movements of the receptor binding domain(RBD)that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).To mitigate viral escape,we developed a cocktail of neutralizing antibodies(NAbs)targeting epitopes located on different domains of spike(S)protein.Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs,targeting the N-terminal domain(NTD)and RBD domain of S,effective at n M concentrations.Remarkably,a combination of RBD-targeting NAbs and NTD-binding NAbs,FC05,enhanced the neutralization potency in cell-based assays and an animal model.Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM)structures of antigen-binding fragments bound to S unveil determinants of immunogenicity.Combinations of immunogens,identified in the NTD and RBD of S,when immunized in rabbits and macaques,elicited potent protective immune responses against SARS-CoV-2.More importantly,two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge,without observable antibody-dependent enhancement of infection.These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD. | Li Zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng Jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang Hong-Ying Qiu Lei Wang Zhen Cui Qing Ye Geng Chen Kui-Kui Lu Yin Chen Yu-Tao Chen Hong-Xing Pan Jiaping Yu Wenrong Yao Bao-Li Zhu Jianping Chen Yong Liu Cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu | 2021 | National Science Review2021，8，8： | 4 |
| 3 | Research on Photovoltaic Performance Reduction due to Dust Deposition: Modelling and Experimental Approach显示文摘Photovoltaic(PV) power generation technology is the main renewable energy utilization technology. However, dust deposition severely affects the PV power generation efficiency and decreases the production capacity of PV power plants. In this study, the factors affecting PV technology were divided into the following three types: occlusion, corrosion, and temperature rise. A dust-collecting PV model considering dust deposition and rainfall scouring was established;a PV performance index was proposed. By conducting experiments with different dust mass densities, it was found that the short-circuit current(SCC), open-circuit voltage(OCV), and PV output power of PV decreased with the increase in dust mass density. In the initial stage of dust deposition, dust exhibited the greatest effect on the performance of PV. In the later stage of dust deposition, the effect of dust deposition became stable. The initial 10 g/m^2 dust decreased the PV output power by 34%. In addition, the conversion efficiency and fill factor(FF) decreased with the increase in dust mass density;both of them were exponential functions. When the dust mass density was low(less than 30 g/m^2), the dust mass density increased by 10 g/m^2, and the conversion efficiency decreased by an average of 3.4%. Finally, by conducting economic calculations, it was found that a PV power plant where dust has not removed for one year will cause 12% loss of power generation. | CHEN Yingya WANG Dengjia LIU Yanfeng DONG Yu LIU Jiaping | 2019 | Journal of Thermal Science2019，28，6： | 3 |
| 4 | Comparing Intra-Arterial Chemotherapy Combined With Intravesical Chemotherapy Versus Intravesical Chemotherapy Alone: A Randomised Prospective Pilot Study for T1G3 Bladder Transitional Cell Carcinoma After Bladder-Preserving Surgery显示文摘 | Junxing Chen Zhijun Yao Shaopeng Qiu Lingwu Chen Yu Wang Jianyong Yang Jiaping Li | 2013 | CardioVascular and Interventional Radiology2013，，6： | 1 |
| 5 | Uterine Artery Embolization Combined with Local Methotrexate and Systemic Methotrexate for Treatment of Cesarean Scar Pregnancy with Different Ultrasonographic Pattern显示文摘 | Fan Lian Yu Wang Wei Chen Jiaping Li Zhongping Zhan Yujin Ye Yunxiao Zhu Jia Huang Hanshi Xu Xiuyan Yang Liuqin Liang Jianyong Yang | 2012 | CardioVascular and Interventional Radiology2012，，2： | 1 |
| 6 | Novel polyacrylonitrile nanoeomposites containing Na-montmorillonite and nano SiO2 particle显示文摘 | Yu Tianshi Lin Jiaping Xu Jiafu | 2005 | Polymer2005，411，15： | 1 |
| 7 | Novel polyacryloni- trile/Na-MMT/siliea nanoeomposite: co-incorporation of two different folan nano materials into polymer matrix显示文摘 | Yu Tianshi Lin Jiaping Xu Jiafu | 2007 | Composites Seienee and Technology2007，67，1516： | 1 |
| 8 | Nanocomposites of vinyl chloride-acrylonitrile copolymer and silica 显示文摘 | Yu Tianshi Lin Jiaping Xu Jiafu | 2005 | Journal of Polymer Science: Part B: Polymer Physics2005，43，： | 1 |
| 9 | Nanocompositcs of vinyl chloride - acrylonitrilc copolymer and silica 显示文摘 | Yu Tianshi Lin Jiaping Xu Jiafu | 2005 | Journal of Polymer Science: Part B: Polymer Physics2005，43，： | 1 |
| 10 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 11 | 基于关键截面响应值的桥梁预警模型和分级设置研究显示文摘随着越来越多桥梁的老化,除了耗费巨资拆除重建,对其进行加固维修是另外一种即经济又便捷的选择。而桥梁的健康监测可以实时的提供数据,以此来对桥梁结构和其相关的力学响应值进行评估,从而提前避免桥梁结构失效而带来的损伤。本文基于实际工程,对一连续刚构桥进行了体外预应力加固并布设了健康监测系统。基于竣工荷载试验的数据展开讨论了预警模型的建立和分级评估分级预警。 | YU JIAPING 孙全胜 | 2018 | 低温建筑技术2018，40，12： | 1 |
| 12 | 显示文摘 | Yu Tianshi Lin Jiaping Xu Jiafu | 2005 | Polymer2005，46，： | 1 |
| 13 | Novel polyacrylonitrile nanocomposites containing Na-montmorillonite and nano SiO2 particle显示文摘 | Tianshi Yu Jiaping Lin | 2005 | Polymer2005，46，： | 1 |
| 14 | The Images of Hua Mulan in Chinese and American films显示文摘Hua Mulan is a famous woman in ancient China. In modern society, multimedia technology is used to present a classic image of women in ancient China. Through the analysis towards the Disney animated film Mulan (1998) and the Chinese film Mulan (2009), the author gets the different opinions toward Chinese women in both modern China and the United States and analysis the culture behind the two films. As a new cultural carrier, the two films add the American values such as the idea of independence and the modern Chinese values when display the image of ancient Chinese female. So the interpretation towards the films can reveal the cultural difference between China and America. The cultural difference then in turn explains the importance of cultural diversity to promote the richness of film production. | Yu Jiaping | 2017 | 校园英语2017，，9： | 0 |
| 15 | Electricity Price of Hybrid Power System and Decision Making of Renewable Energy Investment Capacity显示文摘In the existing electricity market,the traditional power suppliers and renewable energy generators coexist in the power supply side. In the power supply side,renewable energy generators generate power by wind and other natural conditions,leading renewable energy output a certain randomness. However,the low marginal generating cost and the reduction of carbon emissions,and thus brings a certain advantage for renewable energy compared to alternative energy. Electricity,as a special commodity,stable and adequate power supply is a necessary guarantee for economic and social development. Power shortage situation is not allowed in the power system,and the extra power needs to be handled for the purpose of safety. In this paper,the hybrid power generated by renewable energy generators and traditional energy generators is used as power supply,and then the electricity market sells hybrid power to electricity consumers,the hybrid power system determines the optimal daytimeprice,nighttime price,and the optimal installed capacity of the renewable energy suppliers. We find that the installed capacity of renewable energy increases first and then decreases with the increase of the price sensitivity coefficient of traditional energy supply. Electricity demand is negatively related to electricity price in the current period,and is positively related to price in the other period. The average price of day and night is only related to the total potential demand of day and night and the total generation probability of renewable energy. The price difference between daytime and nighttime is positively related to potential electricity demand,and negatively related to the sensitivity coefficient of electricity price. | Jiaping XIE Weisi ZHANG Yu XIA Ling LIANG Lingcheng KONG | 2018 | Journal of Systems Science and Information2018，9，3： | 0 |
| 16 | Biology Migration and Distribution Characteristics of Trace Elements in Reconstructed Soil with Coal Gangue Filling显示文摘With mixed gangue,coarse gangue and washed gangue as well as the maize in the reclaimed land in Luling Mine of Huaibei as the research object,the biology migration and distribution characteristics of trace elements in the reconstructed soil with different types of coal gangue filling were studied,the contents of Cu,Pb,Zn,Sn,Hg,Cd and Cr were determined,and the distribution characteristics of the trace elements in the coal gangue and different organs of the maize were analyzed.The results showed that the contents of trace elements were the highest in washed gangue and the least in coarse gangue in the gangue used for the reclamation,and there were significant differences in the enrichment ability of trace elements in different organs of maizes that were planted in reclamation land,of which fruit was weaker than other organs,while leaf presented strong absorption ability. | Chuangang GONG Jiaping YAN Jie LIU Huaijun YU | 2016 | Agricultural Science & Technology2016，17，9： | 0 |
| 17 | Withdrawal Intention of Farmers from Vacant Rural Homesteads and Its Influencing Mechanism in Northeast China: A Case Study of Jilin Province显示文摘The effective use of land in Northeast China is of great significance for ensuring national food security and regional rural revitalization.In this study,based on the survey data collected from Jilin Province,Northeast China,we analyzed the vacancy rates of rural homesteads in suburban,outer suburban,and remote villages,as well as the withdrawal intention of rural-settled farmers,urbansettled farmers,and farmers with urban and rural dual residency from vacant homesteads.From the perspective of farmers’perceptions,this study constructed a theoretical framework of the influence mechanism of their withdrawal intention and analyzed such mechanism by constructing a structural equation model.The results indicated that:1)rural homestead vacancy rates increased with distance from the village to the city.2)rural-settled farmers showed a low withdrawal intention for vacant rural homesteads,followed by urban and rural dual-residence farmers,and urban-settled farmers showed the highest withdrawal intention.3)the relative importance of the factors influencing withdrawal intention is in the following order:policy awareness>interest perception>living environment perception>family characteristics.Finally,this study discussed the reformation of the homestead system and rural homestead transition in Northeast China,which can provide policy support to increase the potential of cultivated land and promote sustainable rural development and urban-rural coordination. | YU Jiaping LI Jing LO Kevin HUANG Shanlin | 2023 | Chinese Geographical Science2023，33，4： | 0 |
| 18 | Green building research from design to operation in the past 20 years: A perspective显示文摘dented levels during the past centuries.Along with the rapid urbanization crossing the world,serious environmental and energy issues have become global challenges.To address these challenges,the promotion of green building is critical because the construction industry consumes about 40%of the total energy and accounts for 30%of the total greenhouse gas emissions.The goals of green buildings is twofold:1)enhancing indoor environmental quality(IEQ),promoting human health and productivity;2)conserving energy,limiting pollutants and carbon dioxide emissions. | Borong LIN Yi WANG Jiaping LIU Juan YU | 2020 | Frontiers of Structural and Civil Engineering2020，14，5： | 0 |
| 19 | Genome transfer for the prevention of female infertility caused by maternal gene mutation显示文摘Poor oocyte quality is associated with early embryo developmental arrest and infertility.Maternal gene plays crucial roles in the regulation of oocyte maturation,and its mutation is a common cause of female infertility.However,how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive.Here,we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutationecaused female infertility.We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation(ZGA)during the maternal-zygotic transition.We next perform genome transfer at the oocyte(spindle transfer or polar body transfer)and zygote(early pronuclear transfer or late pronuclear transfer)stages to validate the feasibility of preventing Zar1 mutationecaused infertility.We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring.Moreover,those pups grow to adulthood and show normal fertility.Therefore,our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation. | Dandan Bai Jin Sun Yanping Jia Jiqing Yin Yalin Zhang Yanhe Li Rui Gao Xiling Du Kunming Li Jiaming Lin Zhifen Tu Yu Wang Jiaping Pan Shanshan Liang Yi Guo Jingling Ruan Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Fengchao Wang Xiaoming Teng Wenqiang Liu Shaorong Gao | 2020 | Journal of Genetics and Genomics2020，47，6： | 0 |
| 20 | Degradation of limestone calcined clay cement(LC^(3))mortars under sulfate attack显示文摘石灰石-煅烧粘土水泥是一种新型的低碳水泥体系,其力学性能与传统硅酸盐水泥相比,可以有效降低水泥生产过程的中的能耗与碳排放。本文采用宏观测试与微观表征相结合的方法,研究了石灰石-煅烧粘土水泥砂浆在硫酸盐侵蚀作用下的劣化规律,结果表明相较于纯硅酸盐水泥体系,掺入石灰石与煅烧粘土可以显著减少硫酸盐侵蚀作用下砂浆试件的膨胀率和动弹性模量损失,延缓砂浆试件的劣化过程。这主要是由于煅烧粘土与石灰石的加入会细化砂浆的孔隙结构,有效抑制硫酸盐向试件内部的传输与扩散,从而显著降低钙矾石、石膏等导致膨胀的侵蚀产物的生成,提升砂浆试件的抗硫酸盐侵蚀能力。 | Cheng Yu Zhen Li Jiaping Liu | 2023 | Low-carbon Materials and Green Construction2023，1，1： | 0 |
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